77 replies to this topic

[Hedgehog]

There are some papers mentioned by hedgehog in this POST. Polydatin does metabolize to resveratrol in significant amounts.

Right, I am not sure of the benefits of taking polydatin. Yes, it does absorb much better (and dissolves easier, of course) but as niner mentioned, its pretty quickly metabolized to resveratrol in the liver and then glucuronidated just like resveratrol.
The main thing would be if the AUCs and T1/2s were better for an equivalent dose of the two........



edit for typos

This would be a very good paper experiment. I would try to make sure all subjects are RATS and then figure out how it compares... Also most study don't carry the same units if you also want to look at AUC

In this study....
TMAX 20-30mins

• T1/2 50mg/kg = 107min
• T1/2 100mg/kg = 301mins
• T1/2 300mg/kg = 425mins

I believe the T1/2 for normal resveratrol delivery is about 8-15mins? Also notice how the polydatin also has a pretty long half life. Since it has a sugar molecule the body may not tag it as being as bad as resveratrol....

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[2tender]

I think the difference may be moot. However, people that cannot tolerate the best Resveratrol available, and I doubt there are many, may find Polydatin more amenable. Perhaps alternating Resveratrol with Polydatin on an EOD basis may have some benefit? Thoughts?

[maxwatt]

I think the difference may be moot. However, people that cannot tolerate the best Resveratrol available, and I doubt there are many, may find Polydatin more amenable. Perhaps alternating Resveratrol with Polydatin on an EOD basis may have some benefit? Thoughts?

I suspect merely taking a larger dose of resveratrol would be equally effective to taking polydatin, and more cost-effective. But without actual comparative pharmacological data, we won't know. There is reason to believe mixing the two will produce a larger AUC, but the benefit of that is unclear. I do know one individual who was unable to tolerate resverarol, but who could manage polydatin; it did not cause the intestinal problems she experienced with res. She is currently using about 300 mg a day of 99% pure micronized resveratrol, which seems to be her upper limit.

[Hedgehog]

I think the difference may be moot. However, people that cannot tolerate the best Resveratrol available, and I doubt there are many, may find Polydatin more amenable. Perhaps alternating Resveratrol with Polydatin on an EOD basis may have some benefit? Thoughts?

I suspect merely taking a larger dose of resveratrol would be equally effective to taking polydatin, and more cost-effective. But without actual comparative pharmacological data, we won't know. There is reason to believe mixing the two will produce a larger AUC, but the benefit of that is unclear. I do know one individual who was unable to tolerate resverarol, but who could manage polydatin; it did not cause the intestinal problems she experienced with res. She is currently using about 300 mg a day of 99% pure micronized resveratrol, which seems to be her upper limit.

I used these two experiments and did a little math... Please double check

http://www.ncbi.nlm....pubmed/12065739 (resveratrol metabolism)
http://www.ncbi.nlm....pubmed/19397265 (polydatin to resveratrol metabolism)

Both experiments used rats 50mg/kg. Both I believe are pretty sound experiments. The only thing that might skew the results are that the resveratrol metabolism used cyclodextrin as a carrier for resveratrol.

Results Polydatin-->Resveratrol

AUC (0-T) 77 mg min/mL
AUC Infinity 78 mg min/mL
Cmax 393 ng/mL
Tmax 20min
T1/2 107 min

Results Resveratrol + cyclodextrin

AUC (0-T) 23 mg min/mL
AUC Infinity 25 mg min/mL
Cmax 798 ng/mL
Tmax 15min
T1/2 20 min

I guess this is somewhat expected... With resveratrol + cyclodextin you get a very short half life but a large amount of resveratrol in the blood.

With polydatin you get a longer half life and more AUC...

Which is better a larger AUC or a quick spike? Does a longer AUC activate SIRT more or does a quick spike?

The percent difference is

AUC (0-T) 107 % edge goes to polydatin
AUC Infinity 104% edge goes to polydatin
Cmax 200% edge goes to resveratrol
Tmax 29% edge goes to polydatin
T1/2 137% edge goes to polydatin

math... please double check
(umol *h)/L --> (to) (mg min) /mL

(umol *h)/L * 10^-6mol/umol * 60min/1hr * 228g/1mol * 10^3mg / g * 1L / 1000 mL = (mg min) /mL

umol/L --> (to) ng / mL
umol/L * 10^-6mol/umol * 228g/mol * 10^9ng/g * 1L / 1000 mL = ng / mL

Edited by maxwatt, 05 January 2010 - 09:35 AM.

[Hedgehog]

This still needs to be merged correctly

Results Resveratrol + cyclodextrin

AUC (0-T) 0.02 mg min/mL
AUC Infinity 0.02 mg min/mL
Cmax 798 ng/mL
Tmax 15min
T1/2 20 min

The percent difference is

AUC (0-T) 200 % edge goes to polydatin
AUC Infinity 200% edge goes to polydatin
Cmax 68% edge goes to resveratrol
Tmax 29% edge goes to polydatin
T1/2 137% edge goes to polydatin

[Anthony_Loera]

Darn it Hedge...

It appears like you are talking about my product launch already... hehehe....

Just an FYI since Hedge is completely right when he talks about poly and res (not sure he has ever been wrong...thus far).

Micro Res + Poly is part of a new product that is being tested to fit in a Licaps along with two other active ingredients. I don't expect it to replace the pure micro res product with tween, but it will definitely be our version of a super 100mg resveratrol capsule.

I expect the Micro Res to deal with the spike I personally think is crucial, along with the much longer half life that Poly provides over regular res. Best of both worlds, I think... of course there are the other ingredients that we are also adding which may be interesting to some folks, but that info will come out later.

Cheers
A

[Hedgehog]

Another number to play around with is assuming each study gave the rats the same number of molecules.

resveratrol = 228
polydatin = 390

factor = 390/228 = 1.71

In the experiments above each gave 50mg/kg but one of resveratrol and one of polydatin. These are not equal in the number of molecules delivered to the RATS. However on a weight basis they are.

If we assumed that each rat got the same number of molecules as the resveratrol + cyclodextrin then the cmax resveratrol of polydatin would be about 672 ng/mL assuming everything was linear. The amount given to polydatin rats would have been 85.5kg/mg.

[maxwatt]

Another number to play around with is assuming each study gave the rats the same number of molecules.

resveratrol = 228
polydatin = 390

factor = 390/228 = 1.71

In the experiments above each gave 50mg/kg but one of resveratrol and one of polydatin. These are not equal in the number of molecules delivered to the RATS. However on a weight basis they are.

If we assumed that each rat got the same number of molecules as the resveratrol + cyclodextrin then the cmax resveratrol of polydatin would be about 672 ng/mL assuming everything was linear. The amount given to polydatin rats would have been 85.5kg/mg.

Perhaps combining resveratrol with a lighter weight sugar than the glucoside in polydatin would be an interesting project. I found a paper sugestin that forming a sodium salt where the glycoside attaches at 4' position instead would make a water-soluble compound, but the article is in Chinese and a bit difficult for me to understand from the available translation of the abstract:

Zhong Yao Cai. 2007 Jul;30(7):805-7.
[Study on the stability of resveratrol in rhizoma polygoni cuspidati]
[Article in Chinese]

Chen YB, Sun BX, Chen JX.

College of Life Sciences and Engineering, Shaanxi University of Science & Technology, Xianyang 712081, China. chenyibin@sust.edu.cn
OBJECTIVE: The stability of resveratrol in Rhizoma Polygoni Cuspidati is evaluated all-roundly. METHODS: We not only increase influence intensity by physical, chemical and biological methods but also parallel analyzing the influence results to elicit the opinions. RESULTS: The content of resveratrol is declied greatly by lighting, heating, wet-heating or oxidizing. The content is increased in Rhizoma Polygoni Cuspidati treated with acid or alkali only using sodium hydroxide until pH=11. The content is not increased when its own activated microbe is destroyed. CONCLUSION: Resveratrol is unstable against light, heat, wet-heating and oxidizer. Its own activated microbe has not influenced to it. It has not benefit with acidification. Its solubility and stability increase formed sodium salt with basification.

PMID: 17944191

Edited by maxwatt, 06 January 2010 - 12:11 PM.

[drmz]

Preformulation Stability of trans-Resveratrol and trans-Resveratrol Glucoside (Piceid).
Jensen JS, Wertz CF, O'Neill VA.

Upsher-Smith Laboratories, Inc., 6701 Evenstad Drive, Maple Grove, Minnesota 55369.

Resveratrol and resveratrol glucoside (piceid) were evaluated in a preformulation stability study. An HPLC assay was used for the analysis of stressed/reference samples. Samples of solid, crystalline material were held under the following conditions: 40 degrees C/75% RH (both open and protected), ambient fluorescent light (open), 70 degrees C (open), and exposed using a light cabinet to achieve ICH conditions for UV/fluorescent light. Both compounds were found to be stable out to 3 months for both accelerated and ambient conditions with negligible degradation. Exposure to UV and fluorescent light under ICH conditions did not significantly degrade the solid materials for UV exposure at 3 times the ICH limit and for fluorescent light exposure at 1 times the ICH limit. The results presented demonstrate crystalline resveratrol and piceid are stable solids. No evidence of oxidation of either material by atmospheric oxidants was seen. The data reported may help to clarify widely held beliefs that resveratrol is unstable and extremely sensitive to oxidation/degradation.

[Hedgehog]

Preformulation Stability of trans-Resveratrol and trans-Resveratrol Glucoside (Piceid).
Jensen JS, Wertz CF, O'Neill VA.

Upsher-Smith Laboratories, Inc., 6701 Evenstad Drive, Maple Grove, Minnesota 55369.

Resveratrol and resveratrol glucoside (piceid) were evaluated in a preformulation stability study. An HPLC assay was used for the analysis of stressed/reference samples. Samples of solid, crystalline material were held under the following conditions: 40 degrees C/75% RH (both open and protected), ambient fluorescent light (open), 70 degrees C (open), and exposed using a light cabinet to achieve ICH conditions for UV/fluorescent light. Both compounds were found to be stable out to 3 months for both accelerated and ambient conditions with negligible degradation. Exposure to UV and fluorescent light under ICH conditions did not significantly degrade the solid materials for UV exposure at 3 times the ICH limit and for fluorescent light exposure at 1 times the ICH limit. The results presented demonstrate crystalline resveratrol and piceid are stable solids. No evidence of oxidation of either material by atmospheric oxidants was seen. The data reported may help to clarify widely held beliefs that resveratrol is unstable and extremely sensitive to oxidation/degradation.

Yep very stable.

[joe57777]

Preformulation Stability of trans-Resveratrol and trans-Resveratrol Glucoside (Piceid).
Jensen JS, Wertz CF, O'Neill VA.

Upsher-Smith Laboratories, Inc., 6701 Evenstad Drive, Maple Grove, Minnesota 55369.

Resveratrol and resveratrol glucoside (piceid) were evaluated in a preformulation stability study. An HPLC assay was used for the analysis of stressed/reference samples. Samples of solid, crystalline material were held under the following conditions: 40 degrees C/75% RH (both open and protected), ambient fluorescent light (open), 70 degrees C (open), and exposed using a light cabinet to achieve ICH conditions for UV/fluorescent light. Both compounds were found to be stable out to 3 months for both accelerated and ambient conditions with negligible degradation. Exposure to UV and fluorescent light under ICH conditions did not significantly degrade the solid materials for UV exposure at 3 times the ICH limit and for fluorescent light exposure at 1 times the ICH limit. The results presented demonstrate crystalline resveratrol and piceid are stable solids. No evidence of oxidation of either material by atmospheric oxidants was seen. The data reported may help to clarify widely held beliefs that resveratrol is unstable and extremely sensitive to oxidation/degradation.

Yep very stable.

So are there any other comments here? Is polydatin better to take than trans-resveratrol?

[Anthony_Loera]

I have to say the data is so intriguing...

that we have made something now that combines both micronized resveratrol and trans-polydatin for folks.
I suppose it's the first micro-res & polydatin capsule out there.

(yes we added MCT, Quercetin, Biocurcumin as well as a bit of tween...all good stuff in my opinion)

Cheers
A

[malbecman]

I find this pretty humorous, actually, because when the first in vivo resveratrol studies (Sinclair and Auwerx's 2 papers) came out, there was all this interest on here ImmInst in people getting it and taking it, we were
all actually pretty worried that it was very unstable and would isomerize to the cis form or oxidize if you sneezed on it.......

Yep very stable.

[health_nutty]

I find this pretty humorous, actually, because when the first in vivo resveratrol studies (Sinclair and Auwerx's 2 papers) came out, there was all this interest on here ImmInst in people getting it and taking it, we were
all actually pretty worried that it was very unstable and would isomerize to the cis form or oxidize if you sneezed on it.......

Yep very stable.

It is kind of humourous, but really we were intentional mislead by un unscrupulous supplement company.

[browser]

I find this pretty humorous, actually, because when the first in vivo resveratrol studies (Sinclair and Auwerx's 2 papers) came out, there was all this interest on here ImmInst in people getting it and taking it, we were
all actually pretty worried that it was very unstable and would isomerize to the cis form or oxidize if you sneezed on it.......

Yep very stable.

It is kind of humourous, but really we were intentional mislead by un unscrupulous supplement company.

That's true. But which one was the sole unscrupulous supplement company? Seems to me the guys with the special lights out, nitrogen filled manufacturing plant weren't the only ones spreading misinformation. All of the techies were debating how much to take, how to take, whether or not it was stable on places like Usenet sci.life-extension. IIRC it was mentioned that Sigma kept RESV in a deep freeze and under nitrogen. Reports that researchers analyzed the stuff that sat on the shelf for a year and found little degradation were met with disbelief. The stories abounded that RESV was protected in grape skins by such things as Quercetin. How the stuff ever got from the Far East to here ever puzzled me.

[browser]

I have to say the data is so intriguing...

that we have made something now that combines both micronized resveratrol and trans-polydatin for folks.
I suppose it's the first micro-res & polydatin capsule out there.

(yes we added MCT, Quercetin, Biocurcumin as well as a bit of tween...all good stuff in my opinion)

Cheers
A

Is this the stuff with no picture yet that advertises itself as containing two forms of Resveratrol? That's the only new product I see.

I'm not promoting a supplier or brand, just making an inquiry.

[fatboy]

I have to say the data is so intriguing...

that we have made something now that combines both micronized resveratrol and trans-polydatin for folks.
I suppose it's the first micro-res & polydatin capsule out there.

(yes we added MCT, Quercetin, Biocurcumin as well as a bit of tween...all good stuff in my opinion)

Cheers
A

Don't see it on your site yet. ... Never mind, I found it.

Edited by fatboy, 19 March 2010 - 08:38 PM.

[niner]

I find this pretty humorous, actually, because when the first in vivo resveratrol studies (Sinclair and Auwerx's 2 papers) came out, there was all this interest on here ImmInst in people getting it and taking it, we were
all actually pretty worried that it was very unstable and would isomerize to the cis form or oxidize if you sneezed on it.......

Yep very stable.

It is kind of humourous, but really we were intentional mislead by un unscrupulous supplement company.

Yes, that was the main source of the misinformation. One might wonder what other disinformation campaigns are still ongoing. It was shown quite a while ago that resveratrol was stable. Max posted this ages ago:

Resveratrol: Isomeric Molar Absorptivities and Stability

Brent C. Trela and Andrew L. Waterhouse*
Department of Viticulture and Enology, University of California, Davis, California 95616
J. Agric. Food Chem., 1996, 44 (5), pp 1253–1257

Resveratrol has attracted interest as a wine constituent that may reduce heart disease. Published data on the molar absorptivity and chemical stability of cis- and trans-resveratrol have varied greatly. Accurate values for UV absorbance for trans-resveratrol [UV λmax (EtOH) nm (ε) 308 (30 000)] and cis-resveratrol [UV λmax (EtOH) nm (ε) 288 (12 600)] were determined and are used to improve chromatographic quantitation methods. Trials conducted under a variety of commonly encountered laboratory conditions show that trans-resveratrol is stable for months, except in high-pH buffers, when protected from light. cis-Resveratrol was stable only near pH neutrality when completely protected from light.

Keywords: Antioxidant; phenolic; wine; grape; stilbene; isomer; UV spectroscopy; absorptivity

Trela showed 14 years ago that resveratrol was stable under normal conditions. Not only that, but cis-resveratrol is unstable; it is in all likelihood reverting back to trans resveratrol. Any organic chemist will tell you that the trans substitution pattern on a double bond is the more stable form, barring some unusual case like a stabilizing intramolecular hydrogen bond.

Here is a paper from 2007 showing thermal stability of resveratrol at fairly high (100 C) temps:

J Chromatogr A. 2007 Jan 26;1140(1-2):29-34. Epub 2006 Dec 1.
Investigation on phenolic compounds stability during microwave-assisted extraction.
Liazid A, Palma M, Brigui J, Barroso CG.
Département de Génie Chimique, Faculté des Sciences et Techniques de Tanger, Université Abdelmalek Essaadi, Tanger, Morocco.
The stability of 22 phenolic compounds of different families (benzoic acids, benzoic aldehydes, cinnamic acids, catechins, coumarins, stilbens and flavonols) has been studied under conditions of microwave-assisted extraction. The influence on the stability affected by the working temperature between 50 and 175 degrees C has been evaluated, and it has been concluded that all the compounds studied are stable up to 100 degrees C, whereas at 125 degrees C there is significant degradation of epicatechin, resveratrol and myricetin. Conclusions have been drawn on the relationship between the chemical structure and the stability of the compounds; it has been found that those that have a greater number of hydroxyl-type substituents are more easily degraded under the extraction conditions.
PMID: 17141250

In 2004, there was this paper from a Chinese journal, which might have misled people. It was probably dealing with resveratrol in the solution phase, and all chemicals are more prone to degradation, in some cases a lot more, when they are in solution. That's not obvious from the abstract though, so it might have made people think that resveratrol was touchy.

Se Pu. 2004 Nov;22(6):583-8.
[Study on thermostability and photo-isomerization of trans-resveratrol by high performance liquid chromatography and liquid chromatography-electrospray ionization-mass spectrometry]
[Article in Chinese]
Liu Y, Wen D, Chen Z, Liao Y, Liu H.
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
The thermostability and photo-isomerization reaction mechanism of trans-resveratrol were studied by using high performance liquid chromatography (HPLC) and liquid chromatography-electrospray ionization-mass spectrometry ( LC-ESI-MS). A reversed-phase Hypersil-ODS column was used with the mobile phase consisting of 60/40 methanol-water, with addition of 0.05% trifluoroacetic acid for HPLC, and 0.1% formic acid and 5 mmol/L ammonium formate for LC-ESI-MS, at a flow rate of 0.5 mL/min. Diode array detection was set at 300 nm and the injection volume was 20 or 10 microL. Mass spectrometric conditions were in the negative mode. The results of thermostability test under 4, 20 and 40 degrees C indicated that the concentration of trans-resveratrol, after storage for 600 h, was decreased slightly under 4 degrees C, decreased by 5% under 20 degrees C, and 10% under 40 degrees C. In addition, the photo-isomerization reaction of trans- and cis-resveratrol under 254 nm and 365 nm UV irradiation was investigated by LC-ESI-MS, showing that the isomerization is based on p-status, and that some secondary reactions are radical induced.
PMID: 15807107

[Anthony_Loera]

Is this the stuff with no picture yet that advertises itself as containing two forms of Resveratrol? That's the only new product I see.

I'm not promoting a supplier or brand, just making an inquiry.

Yes, that's the one with poly.

Edited by Anthony_Loera, 19 March 2010 - 09:37 PM.

[2tender]

There is a small amount of curcumin in in there. Would this be enougn to aggravate any existing gall stones? I think that some people are supposed to avoid curcumin, due to existing conditions, such as this. Comments?

[Anthony_Loera]

Just from the literature, Curcumin seems to prevent gallstones if you do not have them... however if you already have active gallstones it is suggested not to consider taking Curcumin.
I suppose after reading the literature you would argue that curcumin is for younger folks who tend to consider various things that may prevent issues later...

[2tender]

Thanks! It looks like this young senior citizen may pass on this or just use it on an eod basis if used.

[peteo]

So I'm taking 1 cap of Micronized Resveratrol 250mg right now, would I take 2 caps of NitroMX to match? Seems like $$$

[Anthony_Loera]

So what is in that product peteo?

Only 100mg of polydatin, or does it have other things? Does it have micronized resveratrol and polydatin?

A

[peteo]

So what is in that product peteo?

Only 100mg of polydatin, or does it have other things? Does it have micronized resveratrol and polydatin?

A

I'm taking your Nitro250 1 a day

[treonsverdery]

I note from this that sugar conjugated to resveratrol nakes a supplement called polydatin

at a different item here I wrote about how many phramaceutical molecules that are halogenated have hundreds of times greater physiological activity; the claassic being a comparison of cortisone with fluorocortisones which are 700 times more active per milligram Iwrote to sirtris about chlororesveratrol http://www.imminst.o...mp;#entry341659 but they did not reply; it is a public domain idea

replies at imminst noted that haloresveratrol might be an FDA drug with the chlorine atom on the molecule; that sugar conjugated resveratrol is a supplement suggests the idea that a chloro or fluoro molecule which is a supplement could be linked (conjugated) to resveratrol to have much higher bioavailability like the way a Chlorophenoxy group plus DMAE makes centrophenoxine

thus there is an opportunity to "conjugate" a halogenated supplement with resveratrol then see if it has much higher bioavailability

weird possibilities might be
a plant, algae or bacterium which grows at a high chlorine growth medium that then makes herbal organochlorides that can be chemically conjugated to resveratrol
there might even be a technique where you put a branch of leaves at a water container full of likely prechemicals like chlorosucrose or various amino acids then let the leaves dry as herbs once they have absorbed the chemical plus made pharmaceutically valuable metabolites with it

I know thats like cyborgherbalisn yet it might be considered an authentic plant product that way

calcium hypochlorite
magnesium chlorosucrate

It may be possible to make resveratrol with plant tissue culture material; if the tissue culture has nutrients that are halogenated its possible that might be a plant tissue with chlororesveratrol
It would be super beneficial if an herbal organochloride conjugated to resveratrol passed the blood brain barrier giving youthful brains

Edited by treonsverdery, 21 May 2010 - 03:08 AM.

[Anthony_Loera]

Peteo,
I won't leave you in suspense.

One product has this active:
250 mg Pure Micronized Trans-Resveratrol

The other product has:
100 mg Pure Micronized Trans-Resveratrol
100 mg Polydatin (this is actually sheared down as well)
100 mg Sheared Particle BioCurcumin®
100 mg Sheared Particle Quercetin

Regarding cost: What are the high cost ingredients in the second one? Which ingredient(s) do you think are better for you? Do you want a combination with other ingredients that may also be important? Do you have a doctor asking you to take a very strict supplement regimen? Once figure that out, you will understand why the price is the same for both capsules.

Some folks here may want high absorption with 250mg, others may want a combination of high absorption and bioavailability with 100mg of each... what is more important to you? I personally take 2 capsules of the 250mg micronized resveratrol along with 2 capsules of the 250 mg of BioCurcumin and 2 capsules of the 250mg of the Quercetin (yes also Saikosaponin A) at one time. I am over 35 and tend to lean toward a higher amount of res in the plasma.

This product was not made to replace the highly valued 250mg micro-resveratrol product for folks, but simply address folks that wanted a combination of our best ingredients. Kingherbs may be another supplier if you prefer polydatin in bulk powder, and not in capsule form. We don't buy our material from them, but feel they are not bad for polydatin samples.

Now, If I just turned 18 (with limited funds)... I would take the new product with the polydatin.

Cheers

A

Edited by Anthony_Loera, 21 May 2010 - 12:46 PM.

[peteo]

Peteo,
I won't leave you in suspense.

One product has this active:
250 mg Pure Micronized Trans-Resveratrol

The other product has:
100 mg Pure Micronized Trans-Resveratrol
100 mg Polydatin (this is actually sheared down as well)
100 mg Sheared Particle BioCurcumin®
100 mg Sheared Particle Quercetin

Regarding cost: What are the high cost ingredients in the second one? Which ingredient(s) do you think are better for you? Do you want a combination with other ingredients that may also be important? Do you have a doctor asking you to take a very strict supplement regimen? Once figure that out, you will understand why the price is the same for both capsules.

Some folks here may want high absorption with 250mg, others may want a combination of high absorption and bioavailability with 100mg of each... what is more important to you? I personally take 2 capsules of the 250mg micronized resveratrol along with 2 capsules of the 250 mg of BioCurcumin and 2 capsules of the 250mg of the Quercetin (yes also Saikosaponin A) at one time. I am over 35 and tend to lean toward a higher amount of res in the plasma.

This product was not made to replace the highly valued 250mg micro-resveratrol product for folks, but simply address folks that wanted a combination of our best ingredients. Kingherbs may be another supplier if you prefer polydatin in bulk powder, and not in capsule form. We don't buy our material from them, but feel they are not bad for polydatin samples.

Now, If I just turned 18 (with limited funds)... I would take the new product with the polydatin.

Cheers

A

Im over 35. I have been taking 1 250 nitro & 250 Querectin a day(at night) and 1 astra fruit with other vitamins in the morning. Been pretty happy so far.
I'm out of both now so I was looking to reorder but I noticed the NitroMX. I think if I took NitroMX I would need to take 2 caps a day. That would mean i would use 2 bottles a month. To much $$ unless having the 100 mg Micronized Trans-Resveratrol & 100 mg Trans-Resveratrol-3-O-glucoside is equal or better than 1 nitro 250 & 250 Querectin.
What do you think?

Edited by peteo, 21 May 2010 - 01:57 PM.

[mikeinnaples]

I think he answered your question in the post above yours

[peteo]

I think he answered your question in the post above yours

I guess I'm trying to figure out is 100 mg Polydatin is better than 100mg of Pure Micronized Trans-Resveratrol and if so are they going to switch the Nitro250 to this

Edited by peteo, 21 May 2010 - 04:55 PM.