384 replies to this topic

[maxwatt]

Clin Exp Dermatol. 1979 Mar;4(1):81-5.
Photodynamic inactivation of virus warts: a controlled clinical trial.
Stahl D, Veien NK, Wulf HC.
PMID: 376193

You might try it topically and get some sun afterward.

[Raptor87]

Isn't there just a isomer of uracil that you can order from some internet- pharmacy?

I really dont like any studies of a drug that says DNA.....!

Besides methylene blue is labelled toxic, even in chem- school?

[aaron43]

I doubt I want to go off the Wellbutrin just now. I've been on it for a month and mood wise it has been a significant improvement, now I basically need something that makes me more social. The reports of Methylene Blue making people strike up conversations with random strangers (one of the few things I absolutely cannot do - next to asking out girls I actually like [1]) sounded really promising there but the risk seems to be definitely there. So I guess I need to find something else...

Maybe I will email that doc who wrote that article.

As for DXM, I know it is a dissociative (kind of like Ketamin). I tried it once or twice in my teens at 300 and 450mg and absolutely hated the effects although some of my friends seemed to quite enjoy it.

[1] I have no problem in dealing with the ones I do not particularly like - well up to heavy make out sessions...

Isn't there just a isomer of uracil that you can order from some internet- pharmacy?

I really dont like any studies of a drug that says DNA.....!

Besides methylene blue is labelled toxic, even in chem- school?

I want to put all this to rest.
Light being able to penetrate skin and get to dna with a high enough energy to cause damage is skeptic by itself. Especially if those worries are founded off studies that use focused lasers that focus more energy to a point than the sun in real life can, and in those studies, there is no skin protecting the membranes from light.
But rest assured these are worries enough in themselves so I thought of how to get around this. The main problem for MB is toxicity in singlet oxygen production (light through the skin, reacts with methylene blue in body, which causes singlet oxygen production that forms hydrogen peroxide...which could explain why my wart is going away.) This singlet oxygen is the worry, the body naturally produces it as way of naturally getting rid of viruses among others, but having excess can increase the chances of dna mutations. (remember all of this is based of the hypothetical fact that light can reach through the skin with the proper amount of energy). So if singlet oxygen is the worry..how do we get around that? because I find this compound way too interesting to abandon without thoroughly looking into:

First I want to point out this fear, and the "over-hypedness it gets" - Formation of singlet oxygen from solutions of vitamin E. --even Vitamin E, with light directly pointed on it can cause the worst that MB can cause.

Vitamin E, itself is a SINGLET OXYGEN QUENCHER - “Vitamin E detoxifies peroxides, thus preventing generation of the even more toxic hydroxyl and superoxide radicals and singlet oxygen (O-).”

“In mammalian biology, singlet oxygen is one of the reactive oxygen species, which is linked to oxidation of LDL cholesterol and resultant cardiovascular effects. Polyphenol antioxidants can scavenge and reduce concentrations of reactive oxygen species and may prevent such deleterious oxidative effects.[5]” Cell and Molecular Cell Biology concepts and experiments Fourth Edition. Gerald Karp. Page 223 2005

The main source of polyphenols is dietary, since they are found in a wide array of phytochemical-bearing foods. For example, honey; most legumes; fruits such as apples, blackberries, blueberries, cantaloupe, cherries, cranberries, grapes, pears, plums, raspberries, and strawberries; and vegetables such as broccoli, cabbage, celery, onion and parsley are rich in polyphenols. Red wine,[4] chocolate, green tea, olive oil, argan oil, bee pollen and many grains are sources. Ingestion of polyphenols occurs by consuming a wide array of plant foods; correspondingly, the role of dietary supplements as a method of realizing these health benefits is the subject of considerable discussion.

Now, I come to find, there are many singlet oxygen quenchers out there, that are much more common than we think. So is this aspect of MB and it's singlet oxygen production overyhyped?
Lycopene as the most efficient biological carotenoid singlet oxygen quencher
Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers.
Determination of singlet oxygen-specific versus radical-mediated lipid peroxidation in photosensitized oxidation of lipid bilayers: effect of beta-carotene and alpha-tocopherol.
Kinetic study of the quenching reaction of singlet oxygen by common synthetic antioxidants (tert-butylhydroxyanisol, tert-di-butylhydroxytoluene, and tert-butylhydroquinone) as compared with alpha-tocopherol.
Lymphocyte Lycopene Concentration and DNA Protection from Oxidative Damage Is Increased in Women after a Short Period of Tomato Consumption
Singlet oxygen induced DNA damage <-- Confirms that singlet oxygen scavengers negate increases in singlet oxygen on dna



No singlet oxygens? No problem

Isn't there just a isomer of uracil that you can order from some internet- pharmacy?

I really dont like any studies of a drug that says DNA.....!

Besides methylene blue is labelled toxic, even in chem- school?

Toxic is right! Methylene Blue is a microdrug. Check its MSDS sheet: http://www.sciencest...msds/C2100.html

Playing around with pure methylene blue is no joke. If you are going to handle it, make sure it is in a diluted solution.

Stop man, you can't even buy MB pure. Even if you did, your not gonna die like you just made it sound. Doctors deem it safe enough to use in high amounts so its not like cyanide which your makin it sound like or even recreational drugs that thousands of people use but doctors dont. If you take Vitamin C in high doses, your likely to have ill effects...so in turn...Vitamin C is no joke.

I do agree about worries that come from studies that mention DNA. I feel like just because it says DNA in the title, we have to look at the reasons behind it. The reason behind it is singlet oxygen production. And how do you get rid of singlet oxygen? Singlet oxygen scavengers.
-Lycopene
-Vitamin E
-Beta-Carotene

From all the reading I would suggest, if this is your worry and you decide to do MB, simply supplement with a combination of Lycopene and Vitamin E. They work together for the maximum singlet oxygen scavenger potential.

Edited by aaron43, 23 June 2011 - 07:02 PM.

[Raptor87]

And you say that you dont learn anything!

I will take this drug if I decide not to have children in the future!

[aaron43]

And you say that you dont learn anything!

I will take this drug if I decide not to have children in the future!

lol but read this abstract about that idea
http://www.sciencedi...010782402005152
"Furthermore, unlike methylene blue, diltiazem significantly compromised sperm viability."

[Raptor87]

Just take it easy with the dosing!


http://en.wikipedia....iki/Akinetopsia
http://www.scienceda...90323050512.htm
http://www.unisci.co...021/0201023.htm

I hope you aren't all hyper because everything is slow!

Edited by Brainfogged, 27 June 2011 - 11:52 PM.

[aaron43]

Just take it easy with the dosing!


http://en.wikipedia....iki/Akinetopsia
http://www.scienceda...90323050512.htm
http://www.unisci.co...021/0201023.htm

I hope you aren't all hyper because everything is slow!

First off, I just want to say thank you for giving me something to talk about. I know you guys don't take MB very serious, but it seems so incredible to me that I must continue too look into it, and just thanks for adding more knowledge to my arsenal.

You had me worried at first, I have never imagined that was possible and I thought..could it be? I looked into those articles you provided

" In addition, the 11 Alzheimer's patients who were still able to drive took the driving test: They performed adequately on all aspects of the test except the portion that measures their own knowledge of their location on the road. They tended to drift out of their lane, either across the middle or to the right, and they had difficulty knowing how close or far away they were from the car in front of them.
"These people weren't just bad drivers. They were bad drivers in a particular way," says Duffy. "They couldn't judge where they were in their lane, which mirrors what we've found in the laboratory." "

"Many of these patients are basically blind to the kinds of cues most of us absorb unconsciously every day. It's almost like they're walking around with their eyes closed," says Duffy, "

"Akinetopsia, also known as cerebral akinetopsia or motion blindness, is an extremely rare neuropsychological disorder in which a patient cannot perceive motion in their visual field, despite being able to see stationary objects without issue. For patients with akinetopsia, the world becomes devoid of motion. Most of what is known about akinetopsia was learned through the case study of one patient, LM. There is currently no effective treatment or cure for akinetopsia." - wiki

I wouldn't describe it as what is proposed as motion blindless. I do not feel lost when it is happening, I don't even feel hyper really, my accuracy is pinpoint, I was weaving through traffic with ease, and lately I have been actually noticing my increased ability to navigate myself in unfamiliar territory.

I would compare it this:
Your brain works at a certain speed. When the environment itself speeds up, we get confused and the environment blurs past us while our brain tries heroically to catch up. (It's like seeing plants blur by when driving at increased speeds or a high school football player that gets confusion from the increased speed of play that occurs with the much faster collegiate athletes). For the example of driving, it was as if my brain has a baseline speed. When I accelerate to a high speed, my brain can't compensate for the increased speed of the car, and thus sees everything blurry and flashing by. Today, it was like my brain is working at an ultimate speed. A brain speed that matched the increased speed of the environment, as to say, "I was taking it all in stride" and that me going at 97 mph was comparable to my cognitive recognition of walking down the block. Comparable to the term "Making it look easy" because it actually looks easy under these conditions.

Good stuff though man, I am going to continue to keep an eye out. I haven't noticed anything negative yet. I have also noticed tho that, people that feel like they have a very high/very low sex drive, this could help. Its like evens out the sexual drive. I don't think about anything sexual as much now, Im much more focused on my environment in front of me, but when it comes down too the ugly, it works like a champ. I am fully in tune, and there is no repressive effects on my libido or sexual function when there is sexual stimuli present. But when sexual stimuli is not present, MB seems to take away the nagging sexual thoughts that can be very abundant (in mostly males lol) during those times.

I wouldn't describe it as hyper, but as "in tune"

Edited by aaron43, 28 June 2011 - 12:39 AM.

[aaron43]

I would also be interested if I could see the difference in ratio of compound to side effects of methylene blue compared to an adderall or even an SSRI that people are likely to be prescribed

A study in The New England Journal of Medicine on a possible publication bias regarding the efficacy of SSRI medications in the treatment of depression suggests that their effectiveness and risk-benefit ratios may be greatly exaggerated. Of 74 studies registered with the United States FDA, 37 with positive results were published in academic journals, while 22 studies with negative results were not published and 11 with negative results were published in a way that conveyed a positive outcome (one positive study was not published and three negative studies were published with results that were portrayed as negative). Overall, 94% of studies actually published were positive outcomes; when published and unpublished studies were included for analysis, the percentage of positive outcomes was 51%
-- Wiki

[Raptor87]

Watch out for hypomania. MAOIs, tend to do that. I know that this board has had hypomanic outbursts from people taking deprenyl and othr MAOIs, etc. Be aware of what your baseline personality is. If you start to get a bit too grandiose, you might want to cut back a little. Hypomania is not really being more intelligent, but it's easy to mistake it for such.

Actually my first thought was this.

Speed ​​Blindness is a person's impairment in the ability to judge speed, when you've travelled at high speeds.

Speed ​​Blindness can be a safety risk, particularly when a driver leaves the road at high speed and enters the urban area.

http://en.wikipedia.org/wiki/Hypomania
This was my second worry, I would go on a lighter dosage! The condition is a serious condition! You just need a slight advance to treat your problems, don´t go overboard.

[Raptor87]

I really dont get why they dont do more research in drugs that fickle around with hippocampus/amygdala area.

http://en.wikipedia....xperimental_use

But as always these drugs should only be used when in therapy both psychotherapy/CBT at the same time, not the regular monthly prescription without psychological support and lifestyle change.

[nupi]

This just keeps getting better and better, apparently it also reduces wrinkles

http://www.longecity...706#entry468706

Now, where can we get pharmaceutical grade in pill form, that would be much easier to use than a solution...

[aaron43]

This just keeps getting better and better, apparently it also reduces wrinkles

http://www.longecity...706#entry468706

Now, where can we get pharmaceutical grade in pill form, that would be much easier to use than a solution...

Also found this use pretty interesting Back Trouble? Blue Dye Shot May Offer Long-Lasting Pain Relief

andd..
I found this link which has 3 studies that show the direct mechanisms of how MB increases mitochondrial function and energy
http://flipper.diff....items/info/2869

Edited by aaron43, 03 July 2011 - 06:54 PM.

[Raptor87]

This just keeps getting better and better, apparently it also reduces wrinkles

http://www.longecity...706#entry468706

Now, where can we get pharmaceutical grade in pill form, that would be much easier to use than a solution...

Also found this use pretty interesting Back Trouble? Blue Dye Shot May Offer Long-Lasting Pain Relief

andd..
I found this link which has 3 studies that show the direct mechanisms of how MB increases mitochondrial function and energy
http://flipper.diff....items/info/2869

http://www.ncbi.nlm....1714977/?page=1

Old report but there is something on mb and intratecal injections associated with danger.

[niner]

This just keeps getting better and better, apparently it also reduces wrinkles

http://www.longecity...706#entry468706

Now, where can we get pharmaceutical grade in pill form, that would be much easier to use than a solution...

Also found this use pretty interesting Back Trouble? Blue Dye Shot May Offer Long-Lasting Pain Relief

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1714977/?page=1

Old report but there is something on mb and intratecal injections associated with danger.

Both this report and the Back Trouble link involve the injection of high concentration solutions of MB, into lumbar discs or intrathecally, respectively. Neither of these applications, the latter of which is a particularly bad idea, have anything to do with what we're talking about in this thread, either in dose or in method of use. I just didn't want someone to skim this and come away with the false notion that MB is 'dangerous' when used as we're considering it.

[aaron43]

This just keeps getting better and better, apparently it also reduces wrinkles

http://www.longecity...706#entry468706

Now, where can we get pharmaceutical grade in pill form, that would be much easier to use than a solution...

Also found this use pretty interesting Back Trouble? Blue Dye Shot May Offer Long-Lasting Pain Relief

andd..
I found this link which has 3 studies that show the direct mechanisms of how MB increases mitochondrial function and energy
http://flipper.diff....items/info/2869

http://www.ncbi.nlm....1714977/?page=1

Old report but there is something on mb and intratecal injections associated with danger.

Compare the years of the study and article and think what could have changed in 31 years

and Niner, I completely agree, I was hesitant at first to put a study that didn't have to do with nootropic benefits, but I still think that it is interesting that this product really could have so many uses

Edited by aaron43, 04 July 2011 - 07:09 AM.

[Raptor87]

This just keeps getting better and better, apparently it also reduces wrinkles

http://www.longecity...706#entry468706

Now, where can we get pharmaceutical grade in pill form, that would be much easier to use than a solution...

Also found this use pretty interesting Back Trouble? Blue Dye Shot May Offer Long-Lasting Pain Relief

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1714977/?page=1

Old report but there is something on mb and intratecal injections associated with danger.

Both this report and the Back Trouble link involve the injection of high concentration solutions of MB, into lumbar discs or intrathecally, respectively. Neither of these applications, the latter of which is a particularly bad idea, have anything to do with what we're talking about in this thread, either in dose or in method of use. I just didn't want someone to skim this and come away with the false notion that MB is 'dangerous' when used as we're considering it.

My post was strictly anecdotal that's why I mentioned old. Still I got to use a medical term!

[Isochroma]

Here's a bit of data on the safety of higher Methylene Blue doses, from the patent "Methylene Blue Therapy of Parasitic Infections":

"Methylene blue has been approved for oral administration and has been reported to be effective as an antiseptic, disinfectant, and antidote for cyanide and nitrate poisoning. Methylene blue, injected i.v. at a dose of 1 mg/kg body weight, is effective in the treatment of methemoglobinemia, a clinical disorder where more than 1% of the hemoglobin in the blood has been oxidized to Fe 3+ . Drug Facts and Comparisons , page 1655 (J.B. Lippincott Co., St. Louis, Mo. 1989) reports that methylene blue is useful as a mild genitourinary antiseptic for cystitis and urethritis, in the treatment of idiopathic and drug-induced methemoglobemia and as an antidote for cyanide poisoning. Recommended dosages are 55 to 130 mg three times daily, administered orally. Oral absorption is 53% to 97%, averaging 74%, DiSanto and Wagner, J. Pharm. Sci. 61(7) 1086-1090 (1972). Pharmacopeia states that the recommended dose is 50 to 300 mg by mouth; 1 to 4 mg/kg body weight i.v. Side effects include blue urine, occasional nausea, anemia and fever. American Hospital Formulary Service “Drug Information 88” states that the recommended i.v. dosage for children is 1 to 2 mg/kg body weight, injected slowly over several minutes, which can be repeated after an hour. 55 mg tablets are available from Kenneth Manne. 65 mg tablets are available from Star Pharmaceuticals. Methylene Blue Injection (10 mg/ml) is available from American Reagant, Harvey, Kissimmee, Pasadena.

Narsapur anid Naylor reported in J. Affective Disorders 5, 155-161 (1953) that administration of methylene blue orally, at a dosage of 100 mg b.i.d. or t.i.d., or intravenously, 100 mg infused over 10 min, may be effective in treating some types of mental disorders in humans, indicating that the dye may cross the blood-brain barrier and therefore have particular applicability in the treatment of viral infections of the brain and central nervous system. Methylene blue was administered for periods of one week to 19 months to adult humans, with minimal side effects.

The American Hospital Formulary Service “Drug Information 88” reports that methylene blue is absorbed well from the GI tract, with about 75% excreted in urine and via the bile, mostly as stabilized colorless leukomethylene blue. As reported by G. E. Burrows in J. Vet. Pharmacol. Therap. 7, 225-231 (1984), the overall elimination rate constant of methylene blue, in sheep, is 0.0076±0.0016 min −1 , with minimal methemoglobin production at doses as high as 50 mg/kg and no hematologic changes seen up to four weeks after a total close of 30 mg/kg methylene blue. The 24 h LD 50 for intravenous methylene blue administered as a 3% solution was 42.3 mg/kg with 95% confidence interval limits of 37.3 to 47.9 mg/kg, demonstrating that methylene blue can be safely administered at a dosage of up to at least 15 mg/kj. As reported by Ziv and Heavner in J. Vet. Pharmacol. Therap. 7, 55-59 (1984), methylene blue crosses the blood-milk barrier easily."

Edited by Isochroma, 10 July 2011 - 08:44 PM.

[Isochroma]

Further data on MB's safety can be found in this dose-finding study titled "Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine".

Selected excerpts from the above study are below:

"Children were recruited for the three dose levels sequentially. In addition to receiving a total CQ dose of 25 mg/kg (10 mg/kg on days 0 and 1, and 5 mg/kg on day 2), study children received total doses of MB of 36, 54, and 72 mg/kg respectively."

"There were three serious adverse events in 412 patients (0.7%, 95% CI 0.2–2.1). During dose level 2, one child progressed to severe malaria within 24 hours of inclusion into the study and one child died of diarrhoea on day 8. During dose level 3, in one G6PD deficient male child the Hb dropped from 8.7 g/dl at inclusion to 4.7 g/dl on day5 but improved afterwards on iron supplementation. Clinically there were no signs of haemolysis and total serum bilirubin was normal on day 3. In seven other children the Hb value dropped by more than 3 g/dl, three of these were found to be G6PD deficient. There were no major differences in the incidence of other adverse events between study groups and dose levels (data not shown)."

Edited by Isochroma, 10 July 2011 - 08:54 PM.

[Elus]

Does anyone have any clue why TauRx changed the structure of their Alzheimer's drug, Rember, to be slightly different than methylene blue? Here are the two structures:

TauRx’s pipeline of therapeutics includes a range of compounds that have arisen from research, preclinical and clinical investigations the Company first performed using rember™. rember™ is TauRx’s ultrapure Tau Aggregation Inhibitor (TAI), with patents pending, a version of methylene blue (methylthionine chloride), a comparatively crude and poorly tolerated compound previously used to treat a variety of conditions. TauRx has discovered and is developing alternative forms of the same active moiety present in rember™ that have been chemically optimized to afford enhanced tolerability and bioavailability, enabling their use at higher doses than rember™. TauRx’s TAIs are backed by a robust patent estate.

That's the only reason I could find for the difference, but it strikes me as a little paradoxical given the evidence that MB can be tolerated fairly well in high concentrations (As Isochroma pointed out).

Edited by Elus, 11 July 2011 - 12:40 AM.

[rwac]

Does anyone have any clue why TauRx changed the structure of their Alzheimer's drug, Rember, to be slightly different than methylene blue? Here are the two structures:

They are the same. The dash without anything at the end indicates an implied methyl group (-CH3).
The + charge can actually be distributed around the molecule and appear at different places.
Same with a double-bond in an aromatic Benzene ring, it moves around.

Edited by rwac, 11 July 2011 - 12:41 AM.

[Isochroma]

Agreed. They are the same structure. The one trotted out by TauRx simply has an extra dose of obfuscation for econo-politial reasons.

Remember, in the American Capitalist FDA-infected corporatist drug development system, the drug company must be as secretive as possible except where it is forced to reveal certain information - in patents and maybe in FDA-required studies. This is to prevent anyone becoming their 'competition', including you yourselves - those who could potentially benefit from a cheaper, available-now version: generic methylene blue which is available at many aquarium stores.

It is also in their interest to imply or outright lie that their 'special formulation' is both safe and effective, while every other formulation is 'inffective', 'dangerous' and might contain enough heavy metals / (insert the fear-mongered contaminant of your choice here) that it will slowly - or quickly - kill ya.

In the case of MB such techniquery is a double-laugh since the doses are so low that even if it was slightly contaminated with heavy metals / name-your-poison-short-of-plutonium it would still be safe within the context of a normal dosing regimen.

[rwac]

If you care about this sort of thing, here's yet another structure of MB.

 MethyleneBlue.gif   5.23KB   11 downloads

You'll notice that there are no double bonds, but instead resonance is shown with delocalized electrons.

[aaron43]

New thought:

Cerebral vasodilators and metabolic activators (enhancers) for the treatment of cerebrovas- cular disorders

Methylene Blue a metabolic enhancer
Hydergine a cerebral vasodilator

[Ark]

Has anyone combined http://en.wikipedia....Sodium_chlorite http://en.wikipedia....eral_Supplement or MMS with Methylene?

Edited by Ark, 11 July 2011 - 11:05 AM.

[niner]

Has anyone combined http://en.wikipedia....Sodium_chlorite http://en.wikipedia....eral_Supplement or MMS with Methylene?

Probably no one who's alive to post about it... MMS is another one of those 'dose yourself with a highly potent oxidant' ideas, like where people drink or inject solutions of hydrogen peroxide. I guess someone somewhere ascribes a good outcome to it. Bad outcomes are a distinct possibility. Calling it a "Mineral Supplement" seems a little shaky, unless you consider chlorine to be a mineral. It might be more realistic to call it Miracle Bleach Supplement. MBS ®

[aaron43]

"Methylene blue (MB) is a metabolic enhancer that has been demonstrated to improve memory retention when given post-training in low doses in a variety of tasks in rats, including inhibitory avoidance, spatial memory (in both normal and metabolically-impaired subjects), object recognition, and habituation to a familiar environment. MB has been also shown to improve memory retention of extinction of fear conditioning in the rat."

"The findings suggest that repeated post-training MB may improve memory consolidation between days of learning by an induction in the enzyme cytochrome oxidase, leading to increased metabolic capacity in brain regions requiring more energy during discrimination learning."

Methylene blue is a true cognitive enhancer and works differently than other nootropics and the racetams. As if it seems to be newly found corner stone in the nootropic world.

[thedevinroy]

But, for prudence's sake, try taking a few days off every week or so to avoid inducing changes in your mitochondria.

What do you mean by that? Is it just a fear of tolerance issues or is there reason (pubmed, please?) to believe that it does cause a negative change? From what I understand, it reduces aging (http://www.fasebj.or.../3/703.full.pdf) by upregulating function while at the same time reducing oxidative stress.

Still waiting on my Methylene Blue to come in... should be here by Monday. Will report back on this thread. I'm going to take a volume of 2.303% and dilute 19x to get a solution where every drop (0.05mL) is a 60.6mcg dose [0.05*0.02303*10^6/19=60.6]. So for example, that's 5mL of solution plus 90mL [(19-1)*5=90] of water. I'm using 1mL micro pipettes from Flowing Visions, so is that drop size smaller or still 0.05mL?

[Delta Gamma]

But, for prudence's sake, try taking a few days off every week or so to avoid inducing changes in your mitochondria.

What do you mean by that? Is it just a fear of tolerance issues or is there reason (pubmed, please?) to believe that it does cause a negative change? From what I understand, it reduces aging (http://www.fasebj.or.../3/703.full.pdf) by upregulating function while at the same time reducing oxidative stress.

Still waiting on my Methylene Blue to come in... should be here by Monday. Will report back on this thread. I'm going to take a volume of 2.303% and dilute 19x to get a solution where every drop (0.05mL) is a 60.6mcg dose [0.05*0.02303*10^6/19=60.6]. So for example, that's 5mL of solution plus 90mL [(19-1)*5=90] of water. I'm using 1mL micro pipettes from Flowing Visions, so is that drop size smaller or still 0.05mL?

Sorry for the lack of a pubmed study, but its more the fact that increased oxygen consumption is only beneficial if there is proper oxygenation of all tissues. I'm more saying this would be a issue in individuals with poor circulation or lung conditions, MB is quite safe in healthy individuals.

Hope that makes sense.

[rwac]

Sorry for the lack of a pubmed study, but its more the fact that increased oxygen consumption is only beneficial if there is proper oxygenation of all tissues. I'm more saying this would be a issue in individuals with poor circulation or lung conditions, MB is quite safe in healthy individuals.

Hope that makes sense.

I would think less circulation/oxygenation in a location would imply a lower concentration of MB.

Edited by rwac, 16 July 2011 - 10:39 PM.

[thedevinroy]

Sorry for the lack of a pubmed study, but its more the fact that increased oxygen consumption is only beneficial if there is proper oxygenation of all tissues. I'm more saying this would be a issue in individuals with poor circulation or lung conditions, MB is quite safe in healthy individuals.

Hope that makes sense.

Na, I don't get the link how mitochondria will change based on uneven distribution of oxygen consumption. It doesn't really make sense. It just seems like a fear, but fear is sometimes a "God-given" thing - an intuition. Intuition is not scientific (yet), but everyone has experienced it. I still have both my lungs and circulation in every organ, so maybe I can't sense your fear as intuitive.

I just don't want people thinking that because they have one lung or poor circulation in one arm, that MB is going to mutate their mitochondria into little swamp monsters who want to take over the world using methylene red, the evil methylene blue that only exists in my imagination. I just don't want anybody to dream about that, or even think about the possibility of methylene red outside my imagination. Nobody should be thinking about mitochondrial swamp monsters protruding from arms and lungs.