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NF-kappaB, a critical key to life extension?


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#31 zorba990

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Posted 12 March 2017 - 10:37 PM

High dose vitamin C actually shortens life. Too much antioxydent will prevent natural response to stress such as exercise. So the longevity genes such as sirt1 will be depressed.
http://mobile.nutrai...ter-Animal-data


Nope.

http://articles.lati...amin-supplement


As far as exercise goes...

http://www.ergo-log....he-elderly.html
Race a cheetah sometime....

Vitamin c works quite well as a pro oxidant when needed as such
https://www.ncbi.nlm...pubmed/25307916
"The data validates the role of Vitamin C as an antioxidant under physiologic conditions exhibiting a cross over role as a pro-oxidant in pathological conditions."

But by all means put your faith in the few studies on NR and see how that works out for you.

#32 pamojja

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Posted 12 March 2017 - 11:06 PM

High dose vitamin C actually shortens life. Too much antioxydent will prevent natural response to stress such as exercise. So the longevity genes such as sirt1 will be depressed.
http://mobile.nutrai...ter-Animal-data

 
Can't agree. Have been using Linus Pauling's therapy (high dose vitamin C, beside comprehensive supplementation) and thereby gradually reversed a 60% disability from a severe PAD (due to a 80% stenosis at abdominal aorta) within 6 years. Also not my experience that high-dose antioxidants prevents adaptation in exercise. Just come back from vacations swimming everyday in the ocean - and gradually increased the distance swam, in fact further than ever before in my live.
 
But beside these anecdotal experiences totally counter to your speculations, please start to understand that animal experiments can't be taken as facts applying exactly to humans for so many different reasons, for example from your link:
 

...  the dose of vitamin E used in the study equates to around 10 grams of alpha-tocopherol for an adult human "which is, in anyone's book, a 'horse dose'."

 

Holy cow: equivalent to a human dose of 10 grams of vitamin E!!! - But the little vitamin C thrown in gets your blame? :wacko:
 

"It's no surprise it caused a shortening of lifespan as it almost certainly would have acted as a pro-oxidant, this having been widely demonstrated in other species. While the dose of vitamin C was lower, equating to around 4 grams for an adult human, humans are among relatively few mammals that have lost the ability to synthesise our own vitamin C. So once again, the dose offered in the diet, along with the vole's self-produced vitamin C, may have behaved as a pro-oxidant."


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#33 DareDevil

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Posted 13 March 2017 - 06:50 AM

Vitamin c inhibits NF-kB

http://www.jimmunol....ent/165/12/7180


and reactivation of the gene that allows us to produce it again will not only extend life, but also eliminate the high(er) blood sugar problem that long term calorie restriction is showing.

https://www.lewrockw...we-live-longer/
"Mammals who make their own vitamin C can live 8-10 times beyond their age of physical maturity. Mammals without this ability have a difficult time reaching 3-4 times. Researchers believe the reinstallation of the gulonolactone oxidase enzyme in humans would extend the lifespan to hundreds of years. "

I have a feeling I will have to self fund such an idea as there seems to be little interest...

Hi Zorba990,

 

I find the study in your link to be quite interesting. 

 

QUOTE:

 

"In this study, we show for the first time that millimolar doses of vitamin C inhibit multiple pathways to NF-κB, including IL-1 and TNF, in endothelial cells. Cytokine stimulation of NF-κB was inhibited before phosphorylation of I-κBα and activation of IKK. This inhibition was not simply due to an antioxidant effect."

 

However, it seems that supplementation with megadoses of vitamin C might be less of a task than integrating an enzyme extension into our genome? If external supplementation wasn't an option I'm sure many here would be advancing research in that area. For now I will content myself with experimentation with Liposomal Vitamin C (more bioavailable than intravenous Vitamin C) megadosing (starting at 3g/day and rising to 15g) as well as considering other NFkB inhibitors.

 

Cheers,

 

DareDevil






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