62 replies to this topic

[stablemind]

Aniracetam potentiates the AMPA receptor which activates the glutamate receptors, which is highly involved in LTP and the release of BDNF. Theoretically speaking, this should help with LTM, but I have yet to come across enough anecdotal evidence pointing to an improvement in subject LTM.

Piracetam also effects the AMPA and glutamate receptors but it seems it does so very weakly.

Oxiracetam positively modulates the AMPA and glutamate receptors as well, and ALSO increases the release of the excitatory D-AA and glutamate which may make Oxiracetam a better candidate for LTM potentiation.

Pramiracetam and Oxiracetam both increase HACU (high affinity choline uptake) which does not occur in either Aniracetam or Piracetam. HACU is the rate limiting step to acetylcholine synthesis.

That said, it seems anecdotally speaking and according to the poll on "The BEST Racetam", it seems that Aniracetam, out of the big 4, is the least favored racetam. Theoretically speaking Aniracetam looks really good, but in reality it seems to cause fatigue and brain fog for a large number of users.

Source: examine.com

[deh707]

Aniracetam potentiates the AMPA receptor which activates the glutamate receptors, which is highly involved in LTP and the release of BDNF. Theoretically speaking, this should help with LTM, but I have yet to come across enough anecdotal evidence pointing to an improvement in subject LTM.

Piracetam also effects the AMPA and glutamate receptors but it seems it does so very weakly.

Oxiracetam positively modulates the AMPA and glutamate receptors as well, and ALSO increases the release of the excitatory D-AA and glutamate which may make Oxiracetam a better candidate for LTM potentiation.

Pramiracetam and Oxiracetam both increase HACU (high affinity choline uptake) which does not occur in either Aniracetam or Piracetam. HACU is the rate limiting step to acetylcholine synthesis.

That said, it seems anecdotally speaking and according to the poll on "The BEST Racetam", it seems that Aniracetam, out of the big 4, is the least favored racetam. Theoretically speaking Aniracetam looks really good, but in reality it seems to cause fatigue and brain fog for a large number of users.

Source: examine.com

Aniracetam only leaves me lethargic and brain-foggy at doses higher than 500mg. Most people give up on it before going below the standard 750mg dose.

I find 250mg to be my sweet spot.

[stablemind]

Aniracetam potentiates the AMPA receptor which activates the glutamate receptors, which is highly involved in LTP and the release of BDNF. Theoretically speaking, this should help with LTM, but I have yet to come across enough anecdotal evidence pointing to an improvement in subject LTM.

Piracetam also effects the AMPA and glutamate receptors but it seems it does so very weakly.

Oxiracetam positively modulates the AMPA and glutamate receptors as well, and ALSO increases the release of the excitatory D-AA and glutamate which may make Oxiracetam a better candidate for LTM potentiation.

Pramiracetam and Oxiracetam both increase HACU (high affinity choline uptake) which does not occur in either Aniracetam or Piracetam. HACU is the rate limiting step to acetylcholine synthesis.

That said, it seems anecdotally speaking and according to the poll on "The BEST Racetam", it seems that Aniracetam, out of the big 4, is the least favored racetam. Theoretically speaking Aniracetam looks really good, but in reality it seems to cause fatigue and brain fog for a large number of users.

Source: examine.com

Aniracetam only leaves me lethargic and brain-foggy at doses higher than 500mg. Most people give up on it before going below the standard 750mg dose.

I find 250mg to be my sweet spot.

I agree most people give up before going on a lower dose. For me, Oxiracetam's benefits did not appear until I lowered the dose to 100 mg. At higher doses of 500 mg+ I did not notice any cognitive benefits.

It seems that the initial brain fog that occurred from Aniracetam has subsided, however I have not noticed any immediate cognitive improvements as I have with the other racetams. Perhaps my NMDA/AMPA pathways are already functioning normally. Oxi/Pram seem to have the strongest effects for me, so maybe I'm more responsive to substances that strongly affect the cholinergic pathways.