268 replies to this topic

[tham]

Blue light, melatonin and cancer.


Total visual blindness is protective against breast cancer.

" ..... women with NPL (no perception of light) had a significantly lower prevalence
of breast cancer than women with LP (light perception) (odds ratio, 0.43). "


http://www.ncbi.nlm....pubmed/19649715



" A 2004 study of chicken hens by Moore CB and Siopes TD found that
ovarian tumors grew rapidly in LD 16:8 but shrank in LD 8:16. This is
quite amazing. All that was changed were the hours of darkness and
the tumors went away. "

https://www.lowbluel...cancer_faq.asp#


" It was clear from this study that the growth of solid ovarian tumors in the
turkey breeder hen was promoted by long photoperiods and ceased, to the
point of remission, on short photoperiods. "

http://www.ncbi.nlm....ubmed/15159691/



" Q: What other hard evidence do we have that blue light promotes cancer?

A: It’s a well-known fact in medical circles that blind women have a lower
incidence of cancer than their sighted counterparts, and that women who work
evening shifts (and are thus exposed to light when others are sleeping) have a
markedly higher rate of the disease than those who don’t. "



" Q: Are women especially at risk?

A: Unfortunately, they are. There is a growing body of evidence that the increasing
rate of breast cancer may be associated with blue light. It involves the hormones
melatonin and estrogen. Estrogen is known to promote tumor growth, but is
moderated by melatonin. Blue lights, however, suppress the secretion of melatonin,
an antioxidant. "

https://www.lowbluel...cancer_faq.asp#



" Even very low levels of blue light, such as are emitted by a single bright blue LED,
are enough to suppress melatonin levels. It's perhaps important to understand that the
blue light receptors in the retina which affect melatonin levels are independent of our
visual system. In other words we don't 'see' with them. "

http://texyt.com/bri...ce health risks


Nighttime use of special spectacles or light bulbs that block blue light may
reduce the risk of cancer.

http://www.ncbi.nlm....ubmed/19375243/



Nighttime light level co-distributes with breast cancer incidence worldwide.

http://www.ncbi.nlm....ubmed/20680434/



" These results are the first to show that the tumor growth response to exposure to light
during darkness is intensity dependent and that the human nocturnal, circadian melatonin
signal not only inhibits human breast cancer growth but that this effect is extinguished by
short-term ocular exposure to bright, white light at night. "

http://cancerres.aac...5/23/11174.long

[Mind]

Knowing that cancer cells prefer glucose for energy, many Longecity forum participants have suggested a ketogenic or very lo-carb diet (in addition to other treatments)in order to battle cancer. Here is some more evidence that it is probably a beneficial tactic: http://www.scienceda...20626131854.htm

"Most strikingly, our discovery that glucose withdrawal causes both cell death and increased tyrosine phosphorylation is intriguing because increased tyrosine kinase signaling is normally associated with cell

growth

," said Nicholas A. Graham, a senior postdoctoral scholar in Graeber's lab who helped design the project.

To explain the seemingly contradictory result that glucose deprivation reduced viability and at the same time increased signaling, the authors used an unbiased systems-biology approach that included phospho-tyrosine mass spectrometry and other biochemical profiling techniques.

Assessing the "crosstalk" between metabolism and signaling, they discovered that the glucose deprivation activates a positive feedback loop whereby the withdrawal of glucose induces increased levels of reactive oxygen species, which in turn inhibit negative regulators of tyrosine signaling. The resulting supra-physiological levels of tyrosine phosphorylation then generate additional reactive oxygen species.

"Because cancer cells live on the edge of what is metabolically feasible, this amplifying cycle of oxidative stress ultimately overwhelms and kills the cancer cell,

[ihatesnow]

http://www.scienceda...20706164420.htm

[MrHappy]

http://www.guardian....rticle/10330011

The enzyme-blocking drug, called a kinase inhibitor, targets a number of pathways that control the growth and death of cancer cells.
It acts like several different drugs working at the same time.
Scientists believe switching off cell signals at multiple points should make cancer treatment more successful and delay drug resistance.
Laboratory tests showed that the new drug, given the codename AT13148, can kill a variety of cancer types including sarcoma, breast and prostate. The findings are published in the journal Clinical Cancer Research.
Dr Michelle Garrett, from Cancer Research UK's Cancer Therapeutics Unit at the Institute of Cancer Research in London, said: "Our study shows that this drug is effective against a range of tumour types, and operates by blocking multiple targets.
"These promising results have led to the decision to take the drug into patient trials."
The molecule was discovered by collaborating scientists from Astex Pharmaceuticals, the Cancer Research UK company Cancer Research Technology, and the Institute of Cancer Research.
Dr Julie Sharp, Cancer Research UK's senior science information manager, said: "This is exciting research showing that this experimental drug does the job of several drugs all at once, by targeting numerous weak spots in cancer cells.
"Using one master switch to turn off the different faulty messages forcing cancer cells to keep growing could be an effective way to destroy tumours. It could also reduce the chance of patients becoming resistant to treatment."

[ihatesnow]

http://www.medicalne...ases/247648.php

[ihatesnow]

http://sciencefriday...ring-cells.html

[ihatesnow]

http://www.nytimes.c...1&smid=pl-share

[tham]

Coming back to melatonin, light at night and cancer.


" Women with previous or current breast cancer should be advised not
to work night shifts because of strong experimental evidence demonstrating
accelerated tumor growth by suppression of melatonin secretion. "

http://www.ncbi.nlm....ubmed/22349009/



Melatonin, environmental light, and breast cancer.

" The anticarcinogenic action on MCF-7 cells has been demonstrated at the
physiological concentrations of melatonin attained at night, suggesting thereby
that melatonin acts like an endogenous antiestrogen. "

http://www.ncbi.nlm....ubmed/17541739/



Light at Night, Shiftwork, and Breast Cancer Risk.

http://jnci.oxfordjo...93/20/1513.long



Light at night co-distributes with incident breast but not lung cancer in the
female population of Israel.

" ..... 73% higher breast cancer incidence in the highest LAN exposed communities "

http://www.ncbi.nlm....ubmed/18293150/

http://www.montgomer...ChronoInt08.pdf



Melatonin production and light exposure of rotating night workers.

http://www.ncbi.nlm....ubmed/22324558/



Circadian disruption, sleep loss, and prostate cancer risk:
a systematic review of epidemiologic studies.

http://www.ncbi.nlm....ubmed/22564869/



Correlation of the risk of breast cancer and disruption of the circadian rhythm.

http://www.ncbi.nlm....ubmed/22664950/



Therapeutic actions of melatonin in cancer: possible mechanisms.

http://www.ncbi.nlm....ubmed/18815150/




The Nurses' Health Studies, NHS and NHSII.


Rotating night shifts and risk of breast cancer in women participating
in the nurses' health study.

http://jnci.oxfordjo...93/20/1563.long



Urinary Melatonin Levels and Postmenopausal Breast Cancer
Risk in the Nurses' Health Study Cohort

http://cebp.aacrjour...nt/18/1/74.full



Night Shift Work and the Risk of Endometrial Cancer.

http://cancerres.aac...7/21/10618.full



Night-Shift Work and Risk of Colorectal Cancer in the Nurses’ Health Study.

http://jnci.oxfordjo.../95/11/825.full



No increased risk for ovarian cancer.

Rotating night shift work and risk of ovarian cancer.

http://cebp.aacrjour...t/20/5/934.long



Reduced risk of skin cancers, especially melanomas.

Rotating Night Shifts and Risk of Skin Cancer in the Nurses’ Health Study

" This association was strongest for cutaneous melanoma; working 10 years
or more of rotating night shifts was associated with 44% decreased risk of
melanoma, after adjustment for melanoma risk factors .... darker-haired
women had the lowest risk. "

http://jnci.oxfordjo.../103/7/602.full



Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal.

http://www.ncbi.nlm....pubmed/16217131



Illuminating the deleterious effects of light at night.

http://f1000.com/reports/m/3/18



How Bright the Night ? Light and Human Health.

http://www.illinoisl...rg/health2.html





Night-time lights bring insects, disease.

http://www.environme...insects-disease




Physiological effects of blue and red lights.

http://www.powerwatc...hts-2012-03.pdf




Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Depression.

http://www.hindawi.c...rt/2011/839743/



Light at Night Causes Changes in Brain Linked to Depression.

http://www.scienceda...01117184350.htm



" These results demonstrate dim light at night is sufficient to reduce synaptic spine
connections to CA1. Importantly, the present results suggest that night-time low
level illumination, comparable to levels that are pervasive in North America and
Europe, may contribute to the increasing prevalence of mood disorders. "


http://www.ncbi.nlm....pubmed/21292405

Edited by tham, 20 July 2012 - 05:02 PM.

[tham]

Time magazine writeup on Tracy Bedrosian's study.

http://healthland.ti...-to-depression/

[MrHappy]

http://www.medicalne...cles/234882.php

A virus that infects humans without causing disease kills breast cancer cells in the laboratory. Researchers from Pennsylvania State University (Penn State) College of Medicine in the US, tested an unaltered form of adeno-associated virus type 2 (AAV2) on three different human breast cancer types representing different stages of cancer and found it targeted all of them. They hope by uncovering the pathways the virus uses to trigger cancer cell death, their work will lead to new targets for anti-cancer drugs. A paper on this work appeared recently in the journal Molecular Cancer.

[ihatesnow]

http://cancer.osu.ed...-Treatment.aspx

[MrHappy]

http://cancer.osu.ed...-Treatment.aspx

Somewhat reminiscent of the work by Dr Stanizlaw Burzynski (spelling?)

[zorba990]

Liposomal curcumin
http://www.ncbi.nlm....pubmed/22679371

[ihatesnow]

http://boards.medsca...42d7d!comment=1

Edited by ihatesnow, 04 September 2012 - 08:58 PM.

[MrHappy]

http://www.cell.com/...t/S0092-8674(12)01012-4

(Sorry, but this link is getting butchered because of the brackets in the URL, so you'll need to copy and paste.)

DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical for various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family of DNA hydroxylases. Here, we report that loss of 5-hmC is an epigenetic hallmark of melanoma, with diagnostic and prognostic implications. Genome-wide mapping of 5-hmC reveals loss of the 5-hmC landscape in the melanoma epigenome. We show that downregulation of isocitrate dehydrogenase 2 (IDH2) and TET family enzymes is likely one of the mechanisms underlying 5-hmC loss in melanoma. Rebuilding the 5-hmC landscape in melanoma cells by reintroducing active TET2 or IDH2 suppresses melanoma growth and increases tumor-free survival in animal models. Thus, our study reveals a critical function of 5-hmC in melanoma development and directly links the IDH and TET activity-dependent epigenetic pathway to 5-hmC-mediated suppression of melanoma progression, suggesting a new strategy for epigenetic cancer therapy.

Edited by MrHappy, 18 September 2012 - 09:30 PM.

[joelcairo]

Interesting. From a practical point of view I would be more interested in TET than IDH2:


Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation
http://www.ncbi.nlm....pubmed/22391558

Altered expression levels of IDH2 are involved in the development of colon cancer
http://www.spandidos...com/etm/4/5/801
"The overexpression of IDH2 has been reported in endometrial, prostate and testicular cancer... In this study, we observed that IDH2 expression was significantly downregulated in early phase but was upregulated in advanced phase colon carcinoma compared to peritumoral tissues."

[Psychonaut]

Just more evidence of what many have known for a long time,

http://www.huffingto..._n_1898208.html

Cannabinoids could almost be the new frontier in medicine, amazing it has taken this long to get the ball rolling.

Now just watch while the pharma companies create drugs using cannabis while the Federal government continues the fight to shut down dispensaries and what people actually voted for in their own states, or what should be everyone's right anyway to grow a simple plant in their yard for whatever their reasons. Getting an extract from a plant with good cannabinoid profiles would be my first go to, if it did not slow down/reverse the cancer you end up with a much better pain killer than any opiate and the best nausea treatment available for chemo.

[MrHappy]

http://mobile.bloomb...rs-in-mice.html

A drug made from a plant known as “thunder god vine,” or lei gong teng, that has been used in traditional Chinese medicine, wiped out pancreatic tumors in mice, researchers said, and may soon be tested in humans.
Mice treated with the compound showed no signs of tumors after 40 days or after discontinuing the treatment, according to researchers at the University of Minnesota’s Masonic Cancer Center. The research, funded by the university and the National Institutes of Health. was published today in the journal Science Translational Medicine.
“This drug is just unbelievably potent in killing tumor cells,” said Ashok Saluja, vice chairman of research at the center and the study’s leader, said in a telephone interview. “You could see that every day you looked at those mice, the tumor was decreasing and decreasing, and then just gone.”
The plant, also known as Tripterygium wilfordii, contains triptolide, which earlier studies have shown can cause cancer cells to die. In traditional Chinese medicine, the plant is used as a treatment for rheumatoid arthritis. While the researchers hope to start human trials in six months, Saluja said it’s still a long leap from mice to people.

[MrHappy]

http://news.yale.edu...cer-tumors-mice
Yale researchers manipulated a tiny genetic switch and halted growth of aggressive lung cancer tumors in mice and even prevented tumors from forming.
The activation of a single microRNA managed to neutralize the effects of two of the most notorious genes in cancer’s arsenal, suggesting it may have a role treating several forms of cancer, the researchers report in the Nov. 1 issue of the journal Cancer Research.
“This is pretty much the best pre-clinical data that show microRNAs can be effective in lung cancer treatment,” said Frank Slack, professor of molecular, cellular & developmental biology, researcher for the Yale Cancer Center, and senior author of the paper. “These cancer genes are identical to ones found in many forms of human cancers and we are hopeful the microRNA will be of therapeutic benefit in human cancer.”
Unlike drugs that act upon existing proteins, microRNAs are small pieces of genetic material that can shut down and turn off genes that produce the proteins. Slack and co-author Andrea Kasinski wanted to see if one of these microRNAs, miR-34, could block the actions of K-Ras and p53 genes, which promote proliferation and survival of cancer cells, respectively. Mice with these two mutant genes invariably develop tumors but were cancer-free when researchers activated miR-34. Also, tumor growth was halted in mice that were treated with miR-34 after they had developed cancer.

[Logic]

Piperlongumine may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed

http://en.wikipedia..../Piperlongumine

[MrHappy]

http://www.dkfz.de/e...ancer-Cells.php

Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum) and Heidelberg University Hospital have identified the HDAC11 enzyme as a promising target for new cancer therapies. If this molecule is turned off, cancer cells stop growing and die. Normal cells, however, are not affected by blocking HDAC11. The researchers are now looking for compounds that block selectively HDAC11.

[tham]

Selenium derivatives of celecoxib against cancer.



Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma.

http://www.ncbi.nlm....pubmed/23112250


Synthesis and antitumor properties of selenocoxib-1 against
rat prostate adenocarcinoma cells.

http://www.ncbi.nlm....pubmed/19918950

[tham]

The sulfur compounds, found more in Kyolic, the aged garlic extract -
diallyl disulfide (DAS), diallyl trisulfide (DATS) and s-allylmercaptocysteine (SAMC)
- are potent cancer fighters.


A549, H358 and H1299 are lung adenocarcinoma cell lines. H460 is a large cell
lung cancer line, which comprise about 10 per cent of nonsmall cell lung cancers.


Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells.

" DATS was significantly more effective than either diallyl sulfide or diallyl disulfide
against proliferation of lung cancer cells. "

http://www.ncbi.nlm....les/PMC2656596/



Apoptosis induction in human lung adenocarcinoma cells by oil-soluble allyl sulfides:
triggers, pathways, and modulators.

http://www.ncbi.nlm....pubmed/19197990



Note that p53 is our first-line genetic defence against cancer.

Effects of allyl sulfur compounds and garlic extract on the expression of
Bcl-2, Bax, and p53 in non small cell lung cancer cell lines.

" The level of p53 protein in H460 cell was increased following DADS treatment. "

http://www.ncbi.nlm....ubmed/11048643/

http://www.e-emm.or....s/emm32-3-5.pdf



Aged garlic extract has potential suppressive effect on colorectal adenomas in humans.

http://jn.nutrition....136/3/821S.long


Effects of a series of organosulfur compounds on mitotic arrest and
induction of apoptosis in colon cancer cells.

http://www.ncbi.nlm....ubmed/16170031/



Diallyl trisulfide suppresses the proliferation and induces apoptosis of
human colon cancer cells through oxidative modification of beta-tubulin.

http://www.jbc.org/c...0/50/41487.long

[tham]

One reason why I eat cucumbers often these days.


Cucurbitacin E.


http://carcin.oxford...31/12/2097.long

http://www.ncbi.nlm....pubmed/22842972

http://www.ncbi.nlm....pubmed/22272214


http://www.whfoods.c...odspice&dbid=42

http://en.wikipedia..../Cucurbitacin_E

[tham]

As noted in the neurofibromatosis 2 thread, the following activates merlin.

Curcumin
Sodium valproate



Merlin Is a Potent Inhibitor of Glioma Growth

http://cancerres.aac...68/14/5733.full



Merlin Is a Negative Regulator of Human Melanoma Growth

http://www.plosone.o...ne.0043295.g002

[catrinac]

Polyunsaturated fatty acids cause cancer:
http://www.naturalne...atty_acids.html

Cancer is due to a low respiration, eg, damaged metabolism/ low oxygen state. Also, from resulting lactic acid:
http://www.scienceda...81120171325.htm

[Logic]

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

http://bloodjournal....4/3064.abstract

[Florian Xavier]

Cancer therapy combination: green tea and a phosphodiesterase 5 inhibitor?


http://www.ncbi.nlm....pubmed/23348734

[Fred_CALICO]

I am a "passionate" essential oil.

I know that many people have a bad opinion about it.
Essential oils are not as odors.
If you accept that tea and "curcuma rhizome" contains molecules "beneficial" then please consider the following.
Since I read a patent on the treatment of cancer:
https://data.epo.org...1/document.html

I have a warning PubMed with the term "GERMACRONE."
So the latest news:
http://www.ncbi.nlm....pubmed/23117090


Eur J Pharmacol. 2013 Jan 5;698(1-3):95-102. doi: 10.1016/j.ejphar.2012.10.013. Epub 2012 Oct 29.
Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis.

Liu Y, Wang W, Fang B, Ma F, Zheng Q, Deng P, Zhao S, Chen M, Yang G, He G.

Source

The Genetic Engineering International Cooperation Base of Ministry of Science and Technology, Chinese National Center of Plant Gene HUST Part, College of Life Science and Technology, Huazhong University of Science & Technology (HUST), Luoyu Road 1037, Wuhan 430074, Hubei, China.

Abstract

Germacrone is one of the main bioactive components in the traditional Chinese medicine Rhizoma curcuma. In this study, the anti-proliferative effect of germacrone on the human hepatoma cell lines and the molecular mechanism underlying the cytotoxicity of germacrone were investigated. Treatment of human hepatoma cell lines HepG2 and Bel7402 with germacrone resulted in cell cycle arrest and apoptosis in a dose-dependent manner as measured by MTT assay, flow cytometric and fluorescent microscopy analysis, while much lower effect on normal human liver cell L02 was observed. Flow cytometric analysis revealed that germacrone induced G2/M arrest in the cell cycle progression that was associated with an obvious decrease in the protein expression of cyclin B1 and its activating partner CDK1 with concomitant inductions of p21. Hoechst 33258 and Annexin V/PI staining results showed that the total cell number in apoptosis associated with a dose-dependent up-regulation of Bax and down-regulation of Bcl-2/Bcl-xl was increased. In the meantime, the up-regulation of p53 and reactive oxygen species increase were observed, which suggested thatgermacrone might be a new potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone.
___________________________________________________________________________________________

I personally think the best sources germacrone is not one of Rhizoma curcuma.
The more curious you can research on the composition and therapeutic applications:
Geranium Macrorrhizum (Germacrone)
Kunzea Ambigua (Lédol, globulol ...)

Patent Reference which I initially also about prevention.
tracks

• Ledum groenlandicum
• Helichrysum Italicum
• Ravensara Aromatica

[MrHappy]

TIC10 induces apoptosis in cancer cells and stimulates immune response in neighbouring healthy cells.
http://www.nature.co...suicide-1.12385