If you chose "Other reasons" for the last answer, please explain.
Made this while sleep deprived so please forgive any mistakes.
Edit: Fixed the poll.
Edited by FunkOdyssey, 22 December 2008 - 03:40 PM.
Posted 21 December 2008 - 03:38 PM
Edited by FunkOdyssey, 22 December 2008 - 03:40 PM.
Posted 21 December 2008 - 04:30 PM
Edited by pycnogenol, 21 December 2008 - 04:42 PM.
Posted 21 December 2008 - 05:05 PM
Melatonin stimulates the production of progenitor cells for granulocytes and macrophages. It also stimulates the production of natural killer cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from natural killer cells and T helper lymphocytes are enhanced by melatonin. Melatonin has the potential therapeutic value to enhance immune function in aged individuals.
Posted 21 December 2008 - 05:13 PM
Posted 22 December 2008 - 03:03 AM
Posted 22 December 2008 - 04:16 AM
Posted 22 December 2008 - 04:51 AM
Am I completely out to lunch on melatonin dosages? I take half a milligram, approximately, which I get by splitting a 3 mg tablet in quarters and losing a bit in the process. I can't imagine half a microgram doing anything. Did the sleep-deprived author of the poll really mean 0.5 mg? 1 mg = 1000 mcg.
Edited by FunkOdyssey, 22 December 2008 - 03:41 PM.
Posted 22 December 2008 - 03:40 PM
Am I completely out to lunch on melatonin dosages? I can't imagine half a microgram doing anything.
Edited by pycnogenol, 22 December 2008 - 03:41 PM.
Posted 22 December 2008 - 05:19 PM
Posted 22 December 2008 - 06:42 PM
Posted 22 December 2008 - 07:13 PM
Posted 23 December 2008 - 03:10 AM
So by the 4 1/2 hour mark, you're down to a concentration of melatonin (from the supplement, I don't know what your endogenous melatonin would be doing) that is probably having no effect. If you wake up at 3 or 4am after taking 3mg of instant release melatonin, I'm guessing this is the reason.
I always thought some kind of really high quality sustained release formulation would be ideal, something that had real pharmacokinetic data behind it, to produce consistent blood levels through the night. I also worry that the super unnaturally high melatonin concentration you produce with a 3mg instant release supplement might desensitize receptors. I have no evidence to suggest that happens -- its just a concern.
Posted 23 December 2008 - 08:15 AM
Edited by rwac, 23 December 2008 - 08:16 AM.
Posted 24 December 2008 - 12:30 AM
Posted 24 December 2008 - 06:09 PM
Posted 27 December 2008 - 10:45 PM
Edited by AgeVivo, 27 December 2008 - 10:46 PM.
Posted 27 December 2008 - 10:50 PM
Melatonin's miracles is a pure invention
I've tried it once to fight jet lag, then started googling and pubmed-ing it. Trials concerning its effect on sleep contradict the initial ones (saying it worked miraculously). Melatonin is correlated with sleep, like white hair is correlated with aging. Melatonin is antioxidant (or isn't, depending on the context) like an apple is an antioxydant.
Posted 28 December 2008 - 11:14 PM
I do the same (without wasting any) getting approx. 750mcg each night that I remember to take it which is about 90% of the time. I dump the 750mcg under my tongue and guessing that I get a more sustained release that way. there is no repulsive taste in my experience, but I put a lot of nasty tasting supps down my throat so I may be immune by now.Am I completely out to lunch on melatonin dosages? I take half a milligram, approximately, which I get by splitting a 3 mg tablet in quarters and losing a bit in the process. I can't imagine half a microgram doing anything. Did the sleep-deprived author of the poll really mean 0.5 mg? 1 mg = 1000 mcg.
Posted 25 January 2009 - 11:41 PM
Posted 28 January 2009 - 10:42 PM
Posted 02 February 2009 - 09:54 AM
Posted 02 February 2009 - 05:53 PM
Posted 04 February 2009 - 06:06 AM
Posted 09 June 2009 - 08:00 PM
Posted 13 June 2009 - 01:59 AM
Posted 12 October 2009 - 06:46 AM
Posted 06 November 2009 - 12:45 AM
Melatonin's miracles is a pure invention
I've tried it once to fight jet lag, then started googling and pubmed-ing it. Trials concerning its effect on sleep contradict the initial ones (saying it worked miraculously). Melatonin is correlated with sleep, like white hair is correlated with aging. Melatonin is antioxidant (or isn't, depending on the context) like an apple is an antioxydant.
If that's the case, it must be causing me to sleep... placebotically? I can't keep my eyes open after taking it. Did a double blind test with melatonin vs. benfotiamine in similar capsules. I had a 100% accuracy in determining when I had been given melatonin because of its soporific effects.
Posted 25 January 2010 - 01:10 AM
Posted 10 April 2010 - 04:32 AM
Posted 14 April 2010 - 03:07 PM
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