354 replies to this topic

[Galantamine]

Once you've been infected with borellia burgdorferi you do not ever completely get rid of it,

This is certainly not true.

[Logan]

Funk, how much Perika are you taking?

[nameless]

I don't recall if I asked this before, but are you concerned at all with taking 800mcg of folic acid daily, from the B-Compleet?

I just ran out of MultiBasics and am hesitant to pay for yet another bottle (it's pricey, as you know) and the ImmInst multi is still apparently in limbo, so I thought I might put a 'do it yourself' multi together. So I looked at what you had done, but the high dose of folic acid would scare me -- even 400mcg scares me.

And for minerals, have you ever looked at the Thorne multi- mineral supplements? Curious what you think of them, either Trace minerals (citrates) or Pic-mins (picolinates). On the plus side they use reasonable doses, are relatively inexpensive and have no extra calcium. On the negative side are some odd combinations I rarely have seen, like selenium citrate -- no idea how bioavailable it is.

Edited by nameless, 04 September 2010 - 05:48 AM.

[FunkOdyssey]

Once you've been infected with borellia burgdorferi you do not ever completely get rid of it,

This is certainly not true.

Bring your citations and I'll bring mine. If you want a little preview of what's in store you can check out this link, but I have some additional research I never had an opportunity to present in previous debates: http://www.mindandmu...showtopic=41942

Edited by FunkOdyssey, 04 September 2010 - 08:49 AM.

[FunkOdyssey]

Funk, how much Perika are you taking?

I was taking 300mg tid initially, then 600mg qd (morning). I switched back to 5mg escitalopram recently in order to experiment with apiprazole (SJW interferes with its metabolism).

[FunkOdyssey]

I don't recall if I asked this before, but are you concerned at all with taking 800mcg of folic acid daily, from the B-Compleet?

I just ran out of MultiBasics and am hesitant to pay for yet another bottle (it's pricey, as you know) and the ImmInst multi is still apparently in limbo, so I thought I might put a 'do it yourself' multi together. So I looked at what you had done, but the high dose of folic acid would scare me -- even 400mcg scares me.

And for minerals, have you ever looked at the Thorne multi- mineral supplements? Curious what you think of them, either Trace minerals (citrates) or Pic-mins (picolinates). On the plus side they use reasonable doses, are relatively inexpensive and have no extra calcium. On the negative side are some odd combinations I rarely have seen, like selenium citrate -- no idea how bioavailable it is.

Yeah that was definitely not ideal, and actually I've since dropped the b-complex and am only taking Vitamin C separately. The only b-vitamin I'm supplementing now is B-12. The other b-vitamins are so abundant in even a poor diet, its difficult to imagine a deficiency occurring.

I haven't looked at the thorne multi-mineral supplements but I will tomorrow.

[nameless]

I seem to recall Natrol making a buffered C with extra Bs, if you wanted to go that route, but I think you are right, it's sort of hard to get a B deficiency if you eat a normal diet.

Looking over the Thornes again, I am considering some of their regular multis too. I initially dismissed them entirely, due to their rather large doses. But then I realized if a person only took one cap daily, or 1/6th the total dose, their amounts become somewhat reasonable. E would be around 60IU and thiamine a little highish, but still within acceptable ranges, I'd think. I have to look at them in more detail though, as they have around 7+ varieties. But at first glance it seems pretty close to the equivalent of 1 cap of the MultiBasics I was taking, at about half the cost.

[aLurker]

FunkOdyssey, how is the dexmethylphenidate+bupropion experiment coming along so far?

[Rational Madman]

I hope you don't consider this to be indelicate, but how's the post-marriage life? Do you think there's potential with your current girlfriend? I always enjoyed the liberty as a bachelor, but there's certainly something comforting with having a steady girlfriend---especially one that's willing to look beyond your deficits, and temper your worst attributes. So I wish you the best of the luck in this endeavor, and as a former serial cheater, I offer my apology for our collective indiscretions.

Edited by Rol82, 27 October 2010 - 10:23 PM.

[FunkOdyssey]

FunkOdyssey, how is the dexmethylphenidate+bupropion experiment coming along so far?

I decided to stop the dexmethylphenidate for a bit to see what the bupropion alone is doing, and also until I get acclimated to the 300mg I just started today (after 7 days of 150mg). It's been a rocky start, energy is way up and way down at unusual times, sleep is disrupted, bit of anxiety. That's what I expected though, things should smooth out with more time. I'll see if I can update the regimen tomorrow, it's very outdated.

I hope you don't consider this to be indelicate, but how's the post-marriage life? Do you think there's potential with your current girlfriend? I always enjoyed the liberty as a bachelor, but there's certainly something comforting with having a steady girlfriend---especially one that's willing to look beyond your deficits, and temper your worst attributes. So I wish you the best of the luck in this endeavor, and as a former serial cheater, I offer my apology for our collective indiscretions.

No it's cool -- things are pretty good. There may be potential with the current girlfriend, too early to say I think. Thanks for the well wishes.

[j03]

Does combining St. John's Wort and Modafinil lower the seizure threshold?  Or is it different than Wellbutrin + SJW?  

Have you ever tried combining SJW with a nicotine patch for ADD and energy? 

[Galantamine]

Once you've been infected with borellia burgdorferi you do not ever completely get rid of it,

This is certainly not true.

Bring your citations and I'll bring mine. If you want a little preview of what's in store you can check out this link, but I have some additional research I never had an opportunity to present in previous debates: http://www.mindandmu...showtopic=41942

Even the most serious borellia infection is completely curable (neuroborreliosis). I see a lot of hypochondriasis in your original post, although I'm not a psychiatrist. The antibiotics you are continually using are quite deleterious to your GI biomass, and have little efficacy in combating spirochetes.

No offense to you, but I can only imagine the amount of panic you have spread to particularly susceptible people who post/lurk on this forum. Please see another physician.

[FunkOdyssey]

Even the most serious borellia infection is completely curable (neuroborreliosis).

I appreciate your taking the time to respond, however you failed to provide any evidence to support your position.

Let me show you how this works:

J Am Acad Dermatol. 1993 Feb;28(2 Pt 2):312-4.
Recurrent erythema migrans despite extended antibiotic treatment with minocycline in a patient with persisting Borrelia burgdorferi infection.

Liegner KB, Shapiro JR, Ramsay D, Halperin AJ, Hogrefe W, Kong L.

Department of Medicine, Northern Westchester Hospital Center, Mount Kisco, NY.
Abstract

Erythema migrans recurred in a patient 6 months after a course of treatment with minocycline for Lyme disease. Polymerase chain reaction on heparinized peripheral blood at that time demonstrated the presence of Borrelia burgdorferi-specific DNA. The patient was seronegative by Lyme enzyme-linked immunosorbent assay but showed suspicious bands on Western blot. Findings of a Warthin-Starry stain of a skin biopsy specimen of the eruption revealed a Borrelia-compatible structure. Reinfection was not believed to have occurred. Further treatment with minocycline led to resolution of the erythema migrans.

PMID: 8436647

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Infection. 1996 Jan-Feb;24(1):64-8.
Azithromycin and doxycycline for treatment of Borrelia culture-positive erythema migrans.

Strle F, Maraspin V, Lotric-Furlan S, Ruzić-Sabljić E, Cimperman J.

Dept. of Infectious Diseases, University Medical Centre Ljubljana, Japlijeva, Slovenia.
Abstract

Adult patients with typical solitary erythema migrans, participating in prospective therapeutic studies on early Lyme borreliosis at the Lyme borreliosis Outpatient's Clinic, University Department of Infectious Diseases in Ljubljana, in 1991 to 1993, and followed up for 1 year, were included in the study. Only patients who were treated with azithromycin or doxycycline and in whom Borrelia burgdorferi was isolated from the border of the skin lesion prior to institution of antibiotic treatment were selected for presentation in this report. Fifty-eight patients received azithromycin (500 mg twice daily for the first day, followed by 500 mg once daily for 4 days) and 42 patients received doxycycline (100 mg twice daily for 14 days). The median duration of skin lesions after the beginning of treatment was 6.5 (2-30) days in the azithromycin group and 8 (2-35) days in the doxycycline group (non-significant difference). During the follow-up of 12 months one patient in each group developed major later manifestations of Lyme borreliosis and in 19 patients minor manifestations appeared: in nine (15.5%) treated with azithromycin and in ten (23.8%) receiving doxycycline. In one patient in the azithromycin group and in one patient in the doxycycline group B. burgdorferi was isolated from normal appearing skin at the site of previous erythema migrans 2 months after the institution of antibiotic therapy. Five (8.6%) patients receiving azithromycin and nine (21.4%) patients receiving doxycycline reported mild to moderate gastrointestinal discomfort. In addition, five patients treated with doxycycline developed photosensitivity.

PMID: 8852473

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Med J Aust. 1998 May 18;168(10):500-2.
Culture-positive Lyme borreliosis.

Hudson BJ, Stewart M, Lennox VA, Fukunaga M, Yabuki M, Macorison H, Kitchener-Smith J.
Microbiology Department, Royal North Shore Hospital, Sydney, NSW. bhudson@med.usyd.edu.au

Abstract

We report a case of Lyme borreliosis. Culture of skin biopsy was positive for Borrelia garinii, despite repeated prior treatment with antibiotics. The patient had travelled in Europe 17 months before the onset of symptoms, but the clinical details indicate that the organism could have been acquired in Australia. The results of conventional serological and histopathological tests were negative, despite an illness duration of at least two years.

PMID: 9631675

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Eur Neurol. 1995;35(2):113-7.
Seronegative chronic relapsing neuroborreliosis.

Lawrence C, Lipton RB, Lowy FD, Coyle PK.
Department of Medicine, Albert Einstein College of Medicine, New York, N.Y., USA.

Abstract

We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids and free antigen.

PMID: 779683

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Clin Orthop Relat Res. 1993 Dec;(297):238-41.
Chronic septic arthritis caused by Borrelia burgdorferi.

Battafarano DF, Combs JA, Enzenauer RJ, Fitzpatrick JE.

Department of Medicine, Fitzsimons Army Medical Center, Aurora, Colorado 80045-5001.
Abstract

Chronic arthritis occurs in 10% of Lyme disease patients. A patient had chronic septic Lyme arthritis of the knee for seven years despite multiple antibiotic trials and multiple arthroscopic and open synovectomies. Spirochetes were documented in synovium and synovial fluid (SF). Polymerase chain reaction (PCR) analysis of the SF was consistent with Borrelia infection. Persistent infection should be excluded with silver stains and cultures in any patient with chronic monoarticular arthritis and a history of Lyme disease.

PMID: 8242938

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Epidemiol Mikrobiol Imunol. 2001 Feb;50(1):10-6.
[Persistence of Borrelia burgdorferi sensu lato in patients with Lyme borreliosis]

[Article in Czech]

Honegr K, Hulínská D, Dostál V, Gebouský P, Hanková E, Horácek J, Vyslouzil L, Havlasová J.

Infekcní klinika, Fakultní nemocnice, Hradec Králové.
Abstract

In 18 patients with Lyme borreliosis the authors proved the persistence of Borrelia burgdorferi sensu lato by detection of the causal agent by immune electron microscopy or of its DNA by PCR in plasma or cerebrospinal fluid after an interval of 4-68 months. Clinical manifestations common in Lyme borreliosis were present in only half the patients, in the remainder non-specific symptoms were found. In nine subjects with confirmed Borrelia burgdorferi sensu lato in the cerebrospinal fluid the cytological and biochemical finding was normal. Examination of antibodies by the ELISA method was negative in 7 of 18 patients during the first examination and in 12 of 18 during the second examination. In all negative examinations the specific antibodies were assessed by the Western blot or ELISA method after liberation from the immunocomplexes. In the authors' opinion it is advisable to examine repeatedly plasma and other biological material from potentially affected organs by PCR and subjects with persisting or relapsing complaints after the acute form of Lyme borreliosis as well as to examine cerebrospinal fluid in case on non-specific symptoms and concurrent pathic EEG or MR findings.

PMID: 11233667

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Ann Rheum Dis. 1998 Feb;57(2):118-21.
Detection of Borrelia burgdorferi by polymerase chain reaction in synovial membrane, but not in synovial fluid from patients with persisting Lyme arthritis after antibiotic therapy.

Priem S, Burmester GR, Kamradt T, Wolbart K, Rittig MG, Krause A.

Charité University Hospital, Department of Medicine III, Rheumatology and Clinical Immunology, Berlin, Germany.
Abstract

OBJECTIVES: To identify possible sites of bacterial persistence in patients with treatment resistant Lyme arthritis. It was determined whether Borrelia burgdorferi DNA may be detectable by polymerase chain reaction (PCR) in synovial membrane (SM) when PCR results from synovial fluid (SF) had become negative after antibiotic therapy. METHODS: Paired SF and SM specimens and urine samples from four patients with ongoing or recurring Lyme arthritis despite previous antibiotic therapy were investigated. A PCR for the detection of B burgdorferi DNA was carried out using primer sets specific for the ospA gene and a p66 gene of B burgdorferi. RESULTS: In all four cases, PCR with either primer set was negative in SF and urine, but was positive with at least one primer pair in the SM specimens. In all patients arthritis completely resolved after additional antibiotic treatment. CONCLUSIONS: These data suggest that in patients with treatment resistant Lyme arthritis negative PCR results in SF after antibiotic therapy do not rule out the intraarticular persistence of B burgdorferi DNA. Therefore, in these patients both SF and SM should be analysed for borrelial DNA by PCR as positive results in SM are strongly suggestive of ongoing infection.

PMID: 961334

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Hum Pathol. 1996 Oct;27(10):1025-34.
Ultrastructural demonstration of spirochetal antigens in synovial fluid and synovial membrane in chronic Lyme disease: possible factors contributing to persistence of organisms.

Nanagara R, Duray PH, Schumacher HR Jr.

Allergy-Immunology-Rheumatology Division, Department of Medicine, Faculty of Medicine, KhonKaen University, Thailand.
Abstract

To perform the first systematic electronmicroscopic (EM) and immunoelectron microscopy (IEM) study of the pathological changes and the evidence of spirochete presence in synovial membranes and synovial fluid (SF) cells of patients with chronic Lyme arthritis. EM examination was performed on four synovial membrane and eight SF cell samples from eight patients with chronic Lyme disease. Spirochetal antigens in the samples were sought by IEM using monoclonal antibody to Borrelia burgdorferi outer surface protein A (OspA) as the immunoprobe. Prominent ultrastructural findings were surface fibrin-like material, thickened synovial lining cell layer and signs of vascular injury. Borrelia-like structures were identified in all four synovial membranes and in two of eight SF cell samples. The presence of spirochetal antigens was confirmed by IEM in all four samples studied (one synovial membrane and three SF cell samples). OspA labelling was in perivascular areas, deep synovial stroma among collagen bundles, and in vacuoles of fibroblasts in synovial membranes; and in cytophagosomes of mononuclear cells in SF cell samples. Electron microscopy adds further evidence for persistence of spirochetal antigens in the joint in chronic Lyme disease. Locations of spirochetes or spirochetal antigens both intracellulary and extracellulary in deep synovial connective tissue as reported here suggest sites at which spirochaetes may elude host immune response and antibiotic treatment.

PMID: 8892586

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Zentralbl Bakteriol. 1999 Jul;289(3):301-18.
Persistence of Borrelia garinii and Borrelia afzelii in patients with Lyme arthritis.

Hulínská D, Votýpka J, Valesová M.

National Institute of Public Health, Prague, Czech Republic.
Abstract

We repeatedly detected DNA of Borrelia garinii or B. afzelii and Borrelia-like structures in the blood, joint fluid or in the synovium of 10 patients with Lyme arthritis by means of the polymerase chain reaction and immunoelectron microscopy at 2-4-month intervals in the course of two years. All samples were analyzed using primers which amplified the 16S rRNA gene sequence of Borrelia burgdorferi sensu lato and nucleotide sequences for the OspA gene. No cross hybridization occurred with DNA from human cells and with DNA from other bacteria. Capture and labelling with monoclonal antibodies of aggregated antigens, membranes and flagellae were evident in the blood of 7 patients, in 4 synovial membranes and 2 synovial fluids. Borreliae were found in blood capillaries, in collagen and in clusters surrounding inflammatory cells in the synovium of patients with recurrent infections who carried IgM and IgG antibodies to OspA and to 83 kDa core protein. After significant improvement for several weeks after treatment, arthritis recurred in six patients. Synoviocyte hyperplasia, inflammatory infiltration and concentric adventitial fibroplasia were seen in the synovium of the patients with persisting borreliae. Only two patients were infected with B. afzelii, the others with B. garinii.

PMID: 10467661

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Infection. 1989 Nov-Dec;17(6):355-9.
Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis.

Preac-Mursic V, Weber K, Pfister HW, Wilske B, Gross B, Baumann A, Prokop J.

Neurologische Klinik Grosshadern, München, FR Germany.
Abstract

The persistence of Borrelia burgdorferi in patients treated with antibiotics is described. The diagnosis of Lyme disease is based on clinical symptoms, epidemiology and specific IgG and IgM antibody titers to B. burgdorferi in serum. Antibiotic therapy may abrogate the antibody response to the infection as shown in our patients. B. burgdorferi may persist as shown by positive culture in MKP-medium; patients may have subclinical or clinical disease without diagnostic antibody titers to B. burgdorferi. We conclude that early stage of the disease as well as chronic Lyme disease with persistence of B. burgdorferi after antibiotic therapy cannot be excluded when the serum is negative for antibodies against B. burgdorferi.

PMID: 2613324

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Arthritis Rheum. 1993 Nov;36(11):1621-6.
Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis.

Häupl T, Hahn G, Rittig M, Krause A, Schoerner C, Schönherr U, Kalden JR, Burmester GR.

Department of Medicine III, University of Erlangen-Nuremberg, Germany.
Abstract

OBJECTIVE: To document the persistence of Borrelia burgdorferi in ligamentous tissue samples obtained from a woman with chronic Lyme borreliosis. METHODS: Spirochetes were isolated from samples of ligamentous tissue, and the spirochetes were characterized antigenetically and by molecular biology techniques. The ligamentous tissue was examined by electron microscopy. Humoral and cellular immune responses were analyzed. RESULTS: Choroiditis was the first recognized manifestation of Lyme disease in this patient. Despite antibiotic therapy, there was progression to a chronic stage, with multisystem manifestations. The initially significant immune system activation was followed by a loss of the specific humoral immune response and a decrease in the cellular immune response to B burgdorferi over the course of the disease. "Trigger finger" developed, and a portion of the flexor retinaculum obtained at surgery was cultured. Viable spirochetes were identified. Ultramorphologically, the spirochetes were situated between collagen fibers and along fibroblasts, some of which were deeply invaginated by these organisms. The cultured bacteria were identified as B burgdorferi by reactions with specific immune sera and monoclonal antibodies, and by polymerase chain reaction amplification and Southern blot hybridization techniques. CONCLUSION: To our knowledge, this is the first report of the isolation of B burgdorferi from ligamentous tissue. This suggests that tendon tissues serve as a specific site of spirochete residence in human hosts.

PMID: 8240439

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Cent Eur J Public Health. 2004 Mar;12(1):6-11.
Long term and repeated electron microscopy and PCR detection of Borrelia burgdorferi sensu lato after an antibiotic treatment.

Honegr K, Hulínská D, Beran J, Dostál V, Havlasová J, Cermáková Z.

Department of Infectious diseases, University Hospital, Hradec Králové, Czech Republic.
Abstract

The diagnosis of Lyme disease in 18 patients has been proved by detection of Borrelia burgdorferi sensu lato when using immunoelectron microscopy or detecting its nucleic acid by PCR in the plasma or the cerebrospinal fluid. The positive results occurred in the plasma or in the cerebrospinal fluid in the period of 4-68 months after an antibiotic treatment. The typical clinical manifestations of Lyme disease were observed in 9 patients and non-specific symptoms in another 9 patients. According to presented results we can recommend repeated examination using PCR of the plasma and other biological specimens in the individuals with persistent or recurring complaints after an acute form of Lyme disease and its antibiotic treatment. Also examination of the cerebrospinal fluid with non-specific symptoms and simultaneously displayed pathology electroencephalogram and/or magnetic resonance imaging findings can be advantageous.

PMID: 15068199

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J Infect Dis. 1991 Feb;163(2):311-8.
Randomized comparison of ceftriaxone and cefotaxime in Lyme neuroborreliosis.

Pfister HW, Preac-Mursic V, Wilske B, Schielke E, Sörgel F, Einhäupl KM.

Neurological Department, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.
Abstract

In this prospective, randomized, open trial, 33 patients with Lyme neuroborreliosis were assigned to a 10-day treatment with either ceftriaxone, 2 g intravenously (iv) every 24 h (n = 17), or cefotaxime, 2 g iv every 8 h (n = 16). Of the 33 patients, 30 were eligible for analysis of therapeutic efficacy. Neurologic symptoms improved or even subsided in 14 patients of the cefotaxime group and in 12 patients of the ceftriaxone group during the treatment period. At follow-up examinations after a mean of 8.1 months, 17 of 27 patients examined were clinically asymptomatic. In one patient Borrelia burgdorferi was isolated from the cerebrospinal fluid (CSF) 7.5 months after ceftriaxone therapy. CSF antibiotic concentrations were above the MIC 90 level for B. burgdorferi in nearly all patients examined. Patients with Lyme neuroborreliosis may benefit from a 10-day treatment with ceftriaxone or cefotaxime. However, as 10 patients were symptomatic at follow-up and borreliae persisted in the CSF of one patient, a prolongation of therapy may be necessary.

PMID: 1988514

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Infection. 1996 Jan-Feb;24(1):9-16.
Kill kinetics of Borrelia burgdorferi and bacterial findings in relation to the treatment of Lyme borreliosis.

Preac Mursic V, Marget W, Busch U, Pleterski Rigler D, Hagl S.
Max v. Pettenkofer Institut, Ludwig-Maximilians-Universität München, Germany.

Abstract

For a better understanding of the persistence of Borrelia burgdorferi sensu lato (s.l.) after antibiotic therapy the kinetics of killing B. burgdorferi s.l. under amoxicillin, doxycycline, cefotaxime, ceftriaxone, azithromycin and penicillin G were determined. The killing effect was investigated in MKP medium and human serum during a 72 h exposure to antibiotics. Twenty clinical isolates were used, including ten strains of Borrelia afzelii and ten strains of Borrelia garinii. The results show that the kinetics of killing borreliae differ from antibiotic to antibiotic. The killing rate of a given antibiotic is less dependent on the concentration of the antibiotic than on the reaction time. Furthermore, the data show that the strains of B. afzelii and B. garinii have a different reaction to antibiotics used in the treatment of Lyme borreliosis and that different reactions to given antibiotics also exist within one species. The B. garinii strains appear to be more sensitive to antibiotics used in therapy. Furthermore, the persistence of B. burgdorferi s.l. and clinical recurrences in patients despite seemingly adequate antibiotic treatment is described. The patients had clinical disease with or without diagnostic antibody titers to B. burgdorferi.

PMID: 8852456

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J Infect Dis. 1988 Oct;158(4):905-6.
Cultivation of Borrelia burgdorferi from joint fluid three months after treatment of facial palsy due to Lyme borreliosis.

No Abstract

Schmidli J, Hunziker T, Moesli P, Schaad UB.

PMID: 3171237

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Infection. 1993 Mar-Apr;21(2):83-8.
Azithromycin versus doxycycline for treatment of erythema migrans: clinical and microbiological findings.

Strle F, Preac-Mursic V, Cimperman J, Ruzic E, Maraspin V, Jereb M.

Department of Infectious Diseases, University Medical Center, Ljubljana, Slovenia.
Abstract

The effectiveness of azithromycin and doxycycline in the treatment of erythema migrans was compared in a prospective randomized trial. One hundred seven adult patients with typical erythema migrans, examined in the Lyme Borreliosis Outpatients' Clinic, University Department of Infectious Diseases in Ljubljana, were included in the study. Fifty-five patients received azithromycin (500 mg twice daily for the first day, followed by 500 mg once daily for four days) and 52 patients received doxycycline (100 mg twice daily for 14 days). The mean duration of skin lesions after the beginning of treatment was 7.5 +/- 5.9 days (median value 5, range 2-28 days) in the azithromycin group and 11.4 +/- 7.8 days (median value 9, range 2 days--8 weeks) in the doxycycline group (p < 0.05). Borrelia burgdorferi was isolated from erythema migrans in 28 patients before therapy: in 13 out of 52 in the doxycycline group and in 15 out of 55 in the azithromycin group. Three months after therapy, the culture was positive in four out of 13 patients treated with doxycycline and in one of the 15 patients who received azithromycin. A biopsy was repeated in all the patients with a positive isolation from the first skin specimen. During the first 12 months' follow-up, three patients treated with doxycycline but none in the azithromycin group developed major manifestations of Lyme borreliosis, while 15 doxycycline recipients and 10 azithromycin recipients developed minor consecutive manifestations.

PMID: 8387966

[niner]

I lol'd at that show of force...

[Sillewater]

ROFL

[rwac]

Funk is a battle-hardened vet of the Benson war. lol.

[e Volution]

LOL indeed! Haha. That is what you call an evidence based smack down! Thank you, come again!

[brundall]

Man, he just got geek-slapped!

[Lufega]

I see a lot of hypochondriasis in your original post, although I'm not a psychiatrist.

Calling someone a hypochondriac on this board is like yelling "bomb" on an airplane. You just don't do it !

[Sillewater]

Interesting article:

Chronic Lyme disease: A dubious diagnosis

[Elus]

Even the most serious borellia infection is completely curable (neuroborreliosis). I see a lot of hypochondriasis in your original post, although I'm not a psychiatrist. The antibiotics you are continually using are quite deleterious to your GI biomass, and have little efficacy in combating spirochetes.

No offense to you, but I can only imagine the amount of panic you have spread to particularly susceptible people who post/lurk on this forum. Please see another physician.

[Galantamine]

Your ability to interpret those abstracts is extremely limited. If you approached this topic with an objective/educated perspective, you would see how laughable this thread really is. No offense, but what you need is a psychologist.

[shp5]

Your ability to interpret those abstracts is extremely limited.

Please, elaborate. If your goal is to protect other board members from an alarmist view of this disease, as you said earlier, then you should probably make a good case to the contrary.

[Thorsten3]

Your ability to interpret those abstracts is extremely limited. If you approached this topic with an objective/educated perspective, you would see how laughable this thread really is. No offense, but what you need is a psychologist.

How are you able to judge whether somebody can interpret something over an internet screen? Do you have telepathic powers? Then you go on to say what a laughable thread this is. It's a regimen designed by the individual to work through his issues. What gives you the right to come in and criticize it? Even if you disagree with points raised and you challenge them, there is no need to throw your toys out of the pram. A bit of an inmature reaction.
I appreciate you had all these lurkers suddenly jumping in with their 'smack down' thrases, but seriously man you didn;t even need to rise to that shit. Just dust off your wounds and pick yourself back up and maybe come back with something even more clever? It's an internet forum not the school playground after all.

Edited by Thorsten, 24 December 2010 - 01:10 PM.

[ajnast4r]

disagreement without a counterargument = trolling