A few weeks ago I came across some threads about Cerebrolysin.
I have used GDC-choline, piracetam and deprenyl in the past.
I ordered the Cerebrosyline at the contact from anony4mous. I received the package four days later. I have to say great support and fast delivery.
Yesterday my girlfriend did the first injection in my buttox. I did not feel anything. After the injection I think I felt a small anesthetic effect my butt. I did not experience any side effects at all.
Afterall injecting isn't a big thing at all, propably that is why most American are on steriods. (your welcome)
I can't say if I really felt something from the Cerebrolysin, maybe a little bit more relaxed.
I have been under very much stress the last couple of months and it seems the pressure I felt on my chest somehow disseapered after an hour. This might be placebo effect.
Yesterday evening I have had diner with some friends, I drink some wine and coffee. When I went to bed but I could not sleep. This morning I saw in the cerebrolysin thread that the effect of caffeine is enhanced a lot. Normally I don't have any problems with falling a sleep.
This morning I took another shot. I just feel fine today and also I am relaxed. I have the feeling that I am more aware. Something I notice a small headache, I can't says if this is related to the cerebrosylin.
Tomorrow it will be the third day and normally then the effect should kick in.
I have a few questions according to cerebrosyline:
- Is it a problem to take it in the afternoon? Or should I take it only in the morning?
- Does anyone notice an affect on other substance (alcohol/ghb/caffeine)?
- I noticed a slit headache, do I need to add some choline source?
To try and at least somewhat answer your questions:
1) I don't think it really matters when you take Cerebrolysin. I think most people take it in the mornings. This way it may not possibly interfere with sleep as much. If it were me, I'd go with morning.
2) There could be an enhanced affect from taking many substances while on cerebrolysin, which seems to have an overall effect on increasing brain function hence it could increase responses too.
3) I did a bit of research on whether choline (or possibly other supplements) may be helpful to take with cerebrolysin. It's kind of inconclusive but the best I could do at the moment.
Not sure about that. Alot of noot users on these forums seem to add a choline source when taking certain supplements such as the "Racetam's" (piracetam, aniracetam, oxiracetam, noopept, phenotropil aka carphedon, ect.) or other supplements/medications
that can increase brain metabolism, which could in some cases burn through precursors (such as choline or another type of nutrient depending on how the body reacts to a given supplement) more quickly, which would explain the need to supplement certain nutrients that are being depleted. However, alot of supplements (like a racetam for instance) have
a more specific mode of action whereas Cerebrolysin seems to have a more
broader restorative mode of action. Therefore, while it can be seen that cerebrolysin speeds up brain metabolism, I'm unsure if any specific supplements (such as a choline source) are needed to load up on precursors since Cerebrolysin may provide the nutrients itself?
Cerebrolysin®
A company called Ebewe in the Germanic country of Austria has developed and gained approval for their injectable product called Cerebrolysin® (CRB).
What makes CRB interesting is that it is specifically aimed at delaying the progression of AD; this is unusual in-itself because the current approved medications, (donepezil and memantine) are merely targeted at improving the symptoms and some of the disease outcomes.
CRB is also different because it can be considered to be the first natural approach to AD. CRB is peptide based, being very careful obtained by standardised enzymatic processes from purified brain proteins and aminoacids (of porcine origin).
CRB is designed to help support the function of neurons. This type of approach is known as neurotrophic and CRB being a neurotrophic factor appears to help support and maintain a number of neurons including those of serotonin, choline (related to Ach) and noradrenaline origin.
Action
What this means, is that CRB appears to be able to except a growth like factor on neurons, particularly those from the dorsal root ganglia. Plus, CRB appears to affect synaptic responses in the hippocampus, the region of the brain believed responsible for the deposit of memories. In other words, Cerebrolysin® helps to maintain and support these vital repair processes in the brain.
In addition, Cerebrolysin® has been shown to decrease amyloid-beta production in the brain. These are the so-called Alzheimer plagues that are seen in the post mortem examinations of AD autopsies. As these plagues are strongly correlated with the damage of AD, their control or reduction may be viewed as a highly significant benefit. Furthermore, there is even some evidence that CRB can decrease the rate of apoptosis (the rate of cell death), a factor that could be linked to the slowing of the progression of the disease.
The underlined info above taken in consideration with studies found while googling (
http://www.google.co...u...mp;oq=&aqi=) appears to suggest that Cerebrolysin's restorative effects (due to increased brain metabolism resulting in increased brain growth factors, which leads to brain repair)
does increase the amount of choline acetylcholintransferase (an enzyme that transfers and uses up choline). Looking at this individual peice of information (just one of the mechanisms behind cerebrolysin), I'm not sure if this would mean it would dry up your body's reserves of choline or not (since there are many nutrients in cerebrolysine that may make up for the fact that it lets the brain more openly use up choline sources). However, one thing seems more fairly certain and that's if taking choline while also taking cerebrolysin, this could lead to overly enhanced effects meaning it may be wise to take choline in a smaller dosage if this is the route you'd wish to take.
http://www.sciencedi...f05ae2419202329On pg.2 of this thread, "anonymous" also mentiioned the headache side-effect. There's some little bits and pieces throughout this thread that may be useful. Sometimes suddenly starting off on a relatively high dosage could have more side effects while the body adjusts. I wouldn't worry too much though:
http://www.antiaging...erebrolysin.htmSafety
To date, no known toxicity or safety concerns have been reported. Side effects during treatment have been rare and generally limited to dizziness, headache and heat sensations, although it is possible that these effects are related to the injection or I.V. being given “too quickly.” Potential contraindications appear to be limited to individual hypersensitivity, severe renal conditions and epilepsy.
Dosage
The normal dose pattern appears to be a 5 ml ampoule injected, (intramuscularly or intravenously) each day for 5-days (e.g. Monday-Friday) and repeated for a period of 4-weeks. Then after a 2-month period free from treatment the program is cycled again as necessary. Therefore, four packages each containing 5x 5ml ampoules are normally enough for 3-months at a time.
There's going to be some numbness when injecting I suppose. Just make sure you don't inject over the area of the sciatic nerve (I'd give this area a wide berth and avoid the central and lower portion of the buttox). There's a few good injection tips earlier in this thread too.
In terms of headache maybe getting outside and exercising could help in terms of the body becoming more acclimated to this more quickly too.
Please keep us informed on your trial with cerebrolysin.
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