2208 replies to this topic

[Synaptic-Enthusiastic]

Sunshine:

If and when you´ll get your hands on the NPEP please post away your impressions! Im thinking it might be the ideal "maintenance" substance to extend to the most the "on day" feeling without the-literal- pain in the ass the injectons are. I found the experience different in terms of time. The first time I tried it, it took me only 2 days to respond. The first day I was only aware of a little mood improvement, and the second day it came like an avalanche: smell, recall, creativity, verbal fluency, sleep, relaxation (or non-anxiety) coordination, retention, visuospatial capabilities (wich has always been my downside), sight, hearing, all enhanced incredibly.

I upped the dosage to 10 ml. a day, every 12 hours IM. And, as the studies point out, it is dose dependent. More stuff, more effect.

Shame that IV´s are so unpractical, and of course If I were to up the dosage to 20 ml. It´d be quite an expense.

This I found very interesting as to the possible reason behind permanent effects on patients:
"One interesting possibility is the cerebrolysin may be stimulating stem cells in the brain and repair processes that we do not understand" (wiseyoung.wordpress.com/category/cure/) as opossed to acting on the production or reuptake of neurotransmitters.

Here´s a controversial tought: I´d rather have a shorter lifespan as a consequence of the substance but feeling and thinking like this in that time, than to live to be a 120 years old sluggsh and apathic. Most people make that choice, without much tought, when they make choices for food, alcohol, steroids, or other drugs. Who knows? Cerebrolysin It may even be 99% beneficial for the body and mind, and free of serious unwanted side effects, but... if there is a price tag, so far, I´d pay. (The wiser part of me however, suggests to seek for the same results by all- natural means, but, in our society, what is REALLY natural? We´re techologically dependent to an incredible degree. Anyone needs glasses? Creams? Insulin for diabetes? The "all natural" logic would leave out of the life equation ice from a fridge let alone something as complex as Cerebrolysin )

However Im going to be watching my brain closely through studies just to check everything is in order, with the help of an open minded neurologist that I´ll hope Im able to find soon.

Cheers everyone!

[dreamwolf]

What is the legal status of cerebrolysin? I wanted to give it a go and ordered a supply from drugspro and that was subsequently seized. I stumbled upon a google search result that said it was illegal to import in the United States. PM me if needed.

Thank you!

[sunshinefrost]

Sunshine:

If and when you´ll get your hands on the NPEP please post away your impressions! Im thinking it might be the ideal "maintenance" substance to extend to the most the "on day" feeling without the-literal- pain in the ass the injectons are.

Synaptic,
I ordered 90 pills of memoprove and I too feel that this version of Cerebrolysin is interesting for many reasons. I will be able to compare the similarities and effects between cerebrolysin and memoprove. I am aware that memoprove isn't as potent. The price of cerebrolysin isn't that much of a factor but the hassel comes when i'm at work and did not have the time to take the dose. It's a pain, it takes time and people at the pharmacy think i'm a drug addict when i buy 30 seringes over the counter.

This I found very interesting as to the possible reason behind permanent effects on patients:
"One interesting possibility is the cerebrolysin may be stimulating stem cells in the brain and repair processes that we do not understand" (wiseyoung.wordpress.com/category/cure/) as opossed to acting on the production or reuptake of neurotransmitters.

You read my mind. I wanted to copy/paste that same passage right here. I also enjoyed that conclusion.

Dreamwolf, i'm pretty sure this substance is not controlled in usa, not 100% sure. see above, Crackalackn has some and he seems to be from texas, assuming he's still there.

Edited by sunshinefrost, 10 January 2012 - 02:38 AM.

[dreamwolf]

I may attempt to order from IAS then. The letter I received claimed that the shipment was classified as 'steroids', though I would not classify cerebrolysin as anything similar to an anabolic. First time I've had something ordered for personal use intercepted, also the first time I ordered anything injectable. I would prefer to take something oral of course, but what I have read over the years has convinced me otherwise.

I also see another user is from the 'States and they had no problems receiving their shipment.

Thank you!

[Synaptic-Enthusiastic]

Sunshine:

Where did you order the oral version from? Are they reliable? Thanks!

[sunshinefrost]

I ordered from Quick2You, LLC

i really don't have a way of telling if this is real or not. leap of faith but i know what cere brings ... so i'll be able to see past the placebo effect right away.
I should receive it in 2weeks. i'll let you know.

[hooter]

Daily:

*) 1-2g of omega-3s (four to six fish oil capsules)
*) 4.8g Piracetam
*) Cacao Nibs
*) Vitamin D

I'm taking 10ml IV Cerebrolysin 5 days a week. I'm currently at 10 out of 20.

Day 1:

"The injection was followed by a burst of euphoria and immediate sharpening of sight. Only notable side effects were extremely mild dizziness, a feeling of warmth and a slight tremor in my hands for roughly 10 minutes. All negative perceptions have subsided.

All my neurological functions seem significantly amplified. Physical and speculative perception is greatly enhanced. Audiovisual frame-rate has also been increased. I'm feeling permeated with brilliant natural serenity and am experiencing great fluidity of thought.

Memory and logical reasoning have also undergone considerable improvement. Furthermore, It seems that both my mood and stress threshold have been positively affected.

Day 10:

I'm having a lot of trouble sleeping on the days that I get the injection, but it's getting easier. Light and all reflections of light are more vivid. I seem to not have such a distinct 'spot of focus' but feel like I am aware of all my surroundings simultaneously. The combination of Piracetam and Cerebrolysin makes me feel more Sherlock (from the BBC series if you've seen it) than human. I am automatically analyzing everything. Reading body language of other people comes naturally without effort. Sometimes I deduce extremely awkward things that are not obvious to anyone else. I'm extraordinarily pleased. The anti-depressant effects are incredible.

I have had a refractory depression for 8-9 years and this is the most noticeable improvement I've experienced out of any medication.

If reality was a dial, it's just turned to the right by several ticks. Everything seems more 'real'. It's like upgrading your graphics card and turning up the graphics settings on a video game. It's much easier to distinguish overlapping stimuli such as multiple ongoing conversations. It really hits straight to the ego, and I feel like a computer.

Edited by hooter, 14 January 2012 - 12:08 AM.

[sunshinefrost]

All my neurological functions seem significantly amplified. Physical and speculative perception is greatly enhanced. Audiovisual frame-rate has also been increased. I'm feeling permeated with brilliant natural serenity and am experiencing great fluidity of thought.

Memory and logical reasoning have also undergone considerable improvement. Furthermore, It seems that both my mood and stress threshold have been positively affected.

Day 10:

I'm having a lot of trouble sleeping on the days that I get the injection, but it's getting easier. Light and all reflections of light are more vivid. I seem to not have such a distinct 'spot of focus' but feel like I am aware of all my surroundings simultaneously. The combination of Piracetam and Cerebrolysin makes me feel more Sherlock (from the BBC series if you've seen it) than human. I am automatically analyzing everything. Reading body language of other people comes naturally without effort. Sometimes I deduce extremely awkward things that are not obvious to anyone else. I'm extraordinarily pleased. The anti-depressant effects are incredible.

I have had a refractory depression for 8-9 years and this is the most noticeable improvement I've experienced out of any medication.

If reality was a dial, it's just turned to the right by several ticks. Everything seems more 'real'. It's like upgrading your graphics card and turning up the graphics settings on a video game. It's much easier to distinguish overlapping stimuli such as multiple ongoing conversations. It really hits straight to the ego, and I feel like a computer.

I love this BBC Serie !! I thought it was way better than Sherlock Holmes: a game of shadows. He looks smarter... actually he's Sherlock on NZT (the clear pill)

From what you present here IV seems to be roughly 5 stronger than IM (don't ask me how i came up with this number). I'm glad to see that cere seems to increase the piracetam's verbal fluency properties. Piracetam alone usually makes me dull. I hope that IV cerebrolysin can ease your depression even after the treatment. please get back to the board if you can to let us know.

As for Memoprove, they are already here, very fast ! i'm starting on monday !

Edited by sunshinefrost, 14 January 2012 - 02:42 AM.

[Gamerzneed]

I wonder how crazy hardcore clear and intelligent you would be if you mixed cererbolysin with a cns stimulant like adderall which is used by a lot of people with A.D.D. Cerebrolysin definately sounds like a very natural way to improve symptoms of A.D.D. and brain fog, I'm just wondering if this could be taken longterm (forever) if cycled every 3 months and achieve maximum effects consistantly without any bad side effects.

Edited by Gamerzneed, 14 January 2012 - 03:14 AM.

[hooter]

I love this BBC Serie !! I thought it was way better than Sherlock Holmes: a game of shadows. He looks smarter... actually he's Sherlock on NZT (the clear pill)

From what you present here IV seems to be roughly 5 stronger than IM (don't ask me how i came up with this number). I'm glad to see that cere seems to increase the piracetam's verbal fluency properties. Piracetam alone usually makes me dull. I hope that IV cerebrolysin can ease your depression even after the treatment. please get back to the board if you can to let us know.

As for Memoprove, they are already here, very fast ! i'm starting on monday !

Piracetam used to make me depressed, after Cerebrolysin it does exactly the opposite. Quite baffling.

[hooter]

I wonder how crazy hardcore clear and intelligent you would be if you mixed cererbolysin with a cns stimulant like adderall which is used by a lot of people with A.D.D. Cerebrolysin definately sounds like a very natural way to improve symptoms of A.D.D. and brain fog, I'm just wondering if this could be taken longterm (forever) if cycled every 3 months and achieve maximum effects consistantly without any bad side effects.

10ml IV Cerebrolysin already makes it incredibly hard to sleep, at least for me. Mixing it with Adderall would probably make you stay up for 40 days straight.

Another strange thing is that I used to get depressed and angry from Piracetam, but since Cerebrolysin it makes me euphoric and motivated. This persists for at least 3 days of which I am sure. I will of course report with a comprehensive review when I get more shots/finish treatment.

And I wouldn't necessarily say IV is 5 times stronger than IM, because you need to take note that the piracetam is synergistic. It appears that cerebrolysin is somehow cholinergic or contributes to ACH receptor density so taking choline is seemingly unnecessary. (Again, for me. This is all based on individual physiology.)

However I would guess it to be anywhere from 3 to 5 times stronger, since I've tried intramuscular injection as well. The effects on perceptual 'smoothness' (the difference between a low and high framerate in video games) and direct perception of environmental light refraction are definitely at least 5 times stronger with the IV route. The rest can be attributed to synergy. Either way it's really hard to distinguish, which is why I opted for IV in the first place.

The funniest thing about IV cerebrolysin with piracetam is that this combination has a recreational value. About 10-15 minutes after injection I still feel euphoric, relaxed to an inhuman degree and absolutely resistant to stress.

I've heard that acetyl-carnitine with ALA can potentiate the effects of cerebrolysin, but personally I'm not trying it due to a lack of funds.

Edited by hooter, 14 January 2012 - 11:43 AM.

[Synaptic-Enthusiastic]

Great posts Hooter!

How long does it take for the substance to be completely administered? Who administers the IV to you? How would you rate pain from the IV?

Thanks!!

(I had to rotate site of injection, so Im currently placing them in the quadricep to give the gloutes a break. Can anyone- Science guy- suggest a "schedule" for rotation? 5ml injections twice a day...Sigh... Well, If it were easy everybody would do it)

[ScienceGuy]

I'm just wondering if this could be taken longterm (forever) if cycled every 3 months and achieve maximum effects consistantly without any bad side effects.

You might like to check out THIS thread that discusses the subjects of both taking CEREBROLYSIN long-term and also whether or not CEREBROLYSIN in fact NEEDS to be cycled AT ALL: CEREBROLYSIN - Does not NEED to be cycled?

[sunshinefrost]

New study

http://www.ncbi.nlm....arch&querykey=1

[Efficacy of prolonged therapy of vascular dementia].
[Article in Russian]
[No authors listed]
Abstract
This open study was designed to assess efficacy and safety of long-term therapy with cerebrolysin in 48 patients aged 59-77 years with mild and moderately severe vascular dementia. The slowdown in the progress of this condition during the 3-year treatment period was evaluated. The efficacy and safety of the drug was assessed clinically and with the use of standard scales and neuropsychological tests. The long-term therapy with cerebrolysin was shown to be safe and highly efficacious as indicated by the improvement of cognitive and motor functions both at early and late stages of the treatment regardless of the severity of the disease. It is concluded that long-term therapy with cerebrolysin slows down the progress of vascular dementia and prevent deterioration of cognitive abilities.

[ScienceGuy]

New study

http://www.ncbi.nlm....arch&querykey=1

[Efficacy of prolonged therapy of vascular dementia].
[Article in Russian]
[No authors listed]
Abstract
This open study was designed to assess efficacy and safety of long-term therapy with cerebrolysin in 48 patients aged 59-77 years with mild and moderately severe vascular dementia. The slowdown in the progress of this condition during the 3-year treatment period was evaluated. The efficacy and safety of the drug was assessed clinically and with the use of standard scales and neuropsychological tests. The long-term therapy with cerebrolysin was shown to be safe and highly efficacious as indicated by the improvement of cognitive and motor functions both at early and late stages of the treatment regardless of the severity of the disease. It is concluded that long-term therapy with cerebrolysin slows down the progress of vascular dementia and prevent deterioration of cognitive abilities.

Nice one!

[Synaptic-Enthusiastic]

Thanks Sunshinefrost! Its good to know that long term use seems safe according to a controlled study.

Say, what are your impressions with the oral version of CEREBROLYSIN? Something to report yet? I´ve now mastered the quedaricep injection but still, two shots a day distributed in four spots (two gloutes,two quads) means a lot of pricks to be incorporated to a daily routine.

[sunshinefrost]

Say, what are your impressions with the oral version of CEREBROLYSIN? Something to report yet?

The pills are stuck at the airport. From the FedEx tracking system I can see that health Canada is investigating whether or not this is a controlled substance. It should get here tomorrow or Monday.

I´ve now mastered the quedaricep injection but still, two shots a day distributed in four spots (two gloutes,two quads) means a lot of pricks to be incorporated to a daily routine.

I tried it in the quads and it's unbearable. It's practically pain-free in the buttocks. Just type "buttocks injection" with youtube and you'll know where it's meant to be injected.

[sunshinefrost]

Synaptic-Enthusiastic

I received the Memoprove package today. I shocked-dosed with 3 pills instead of 1 and the similarity with Cerebrolysin is pretty impressive. It could be placebo but I doubt it. One thing I noticed is that the combination with cafeine is a little bit too much, i felt very focused but kinda agitated. I have a hard time not taking cofee everyday... Anyways, i'm pretty confident memoprove works. love to be focused, and I hate to be amorphous... can this be the best nootropic so far ?

[ScienceGuy]

Synaptic-Enthusiastic

I received the Memoprove package today. I shocked-dosed with 3 pills instead of 1 and the similarity with Cerebrolysin is pretty impressive. It could be placebo but I doubt it. One thing I noticed is that the combination with cafeine is a little bit too much, i felt very focused but kinda agitated. I have a hard time not taking cofee everyday... Anyways, i'm pretty confident memoprove works. love to be focused, and I hate to be amorphous... can this be the best nootropic so far ?

Thanks Sunshinefrost! Please do keep posting your feedback on the Memoprove!

One thing though, I couldn't help be somewhat disappointed that MEMOPROVE unecessarily contains LACTOSE, a very common allergen, so I guess those with LACTOSE INTOLERANCE OR ALLERGY won't be able to use this product.

[ScienceGuy]

I´ve now mastered the quedaricep injection but still, two shots a day distributed in four spots (two gloutes,two quads) means a lot of pricks to be incorporated to a daily routine.

USEFUL TIP: You can split each glute and quad into at least TWO injection sites, meaning that you in fact can rotate through a total of at least EIGHT instead of FOUR injection sites...

...to do this for the respective quad / glute, firstly split the glute / quad into a quadrant (use the upper left quadrant for left glute / quad; and upper right quadrant for right glite / quad); then divide the quadrant horizontally down the middle into two halves, and take the centre point of each of those two halves as your TWO injection sites.

[sunshinefrost]

I've had 3 concussions in my life.... this research is why i'm on cerebrolysin. I'm freaking out thinking i may develop alzheimer

Neurodegenerative disorders such as Alzheimer's disease (AD) are characterized by the loss ofneurotrophic factors, and experimental therapeutical approaches to AD have investigated the efficacy of replacing or augmenting neurotrophic factor activity. Cerebrolysin, a peptide mixture with neurotrophic-like effects, has been shown to improve cognition in patients with AD and to reduce synaptic and behavioral deficits in transgenic (tg) mice overexpressing the amyloid precursor protein (APP). However, it is unclear how long-lasting the beneficial effects of Cerebrolysin are and whether or not behavioral and neuropathological alterations will reappear following treatment interruption. The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice. We demonstrate that, in APP tg mice, Cerebrolysin-induced amelioration of memory deficits in the water maze and reduction of neurodegenerative pathology persist for 3 months after treatment interruption; however, these effects dissipate 6 months following treatment termination. Immunohistochemical analysis demonstrated that the decrease in neocortical and hippocampal amyloid plaque load observed in Cerebrolysin-treated APP tg mice immediately after treatment was no longer apparent at 3 months after treatment interruption, indicating that the beneficial effects of Cerebrolysin at this time point were independent of its effect on amyloid-β deposition. In conclusion, the results demonstrate that the effects of Cerebrolysin persist for a significant period of time following treatment termination and suggest that this prolonged effect may involve the neurotrophic factor-like activity of Cerebrolysin.

[hooter]

I took a week long break from Cerebrolysin injections. I've had 10x10ml IV so far. Its effects on piracetam and cognition are still present. The antidepressant action diminished a little bit, however the situation is more complex. The cerebrolysin seems to have made the piracetam a lot better. Not stronger per se but more all-encompassing. I used to get headaches from doses higher than 2g, but now I can take 9.6g a day without getting any. It seems to make a positive difference on the effects of piracetam.

I will continue the Cerebrolysin in a few days.

Edited by hooter, 23 January 2012 - 06:23 PM.

[Synaptic-Enthusiastic]

I´m currently on a break from my Cerebrolyisin injections cycle that lasted almost 20 days. According to my experience there might be a reason behind the cyling recommendation. Arround day 18 of treatment the pronounced effect that followed the injection diminished by half- according to my perception-. I had to stop the cycle because I was unable to buy the medication on time to continue, and something quite unexpected happened: I got more of the "on" feeling from those rest days!

I think of two possible explanations for this phenomenon:

1) I got habituated to the substance and its effects were more noticable (Which would not explain the pronounced effects after stopping the injections)

Or

2) There could be something of a refractory period in the substance´s mechanism of action. -In a similar way physical excercise needs rest periods. I know CERE is not stressing the organ, but there might be a lot of energy consumption involved in increasing the neurons survival rate-


Sunshine: Great news about memoprove! How is that going? Now, leaving aside hypocondria -which I guess must be very common in a forum like this- What makes you think you might develop Alzheimer´s disease? The study only points out the apparent lack of beneficial changes in brain metabolism from cerebrolysin after 3 months. There is no indication whatsoever about any adverse oposite effect from substance use. - Some substances indeed work in a "gave it- took it away-and-made-it-worst" fashion (say, alcohol, like most people know) but not all substances.

I wonder, if alcohol has the capability to rewire the brain "permanently", would it be far fetched to think that even though the action of cerebrolysin only persists for 3 months after cessation, the "gains" made in brain synapse might remain? Toughts?

[sunshinefrost]

Sunshine: Great news about memoprove! How is that going? Now, leaving aside hypocondria -which I guess must be very common in a forum like this- What makes you think you might develop Alzheimer´s disease? The study only points out the apparent lack of beneficial changes in brain metabolism from cerebrolysin after 3 months. There is no indication whatsoever about any adverse oposite effect from substance use. - Some substances indeed work in a "gave it- took it away-and-made-it-worst" fashion (say, alcohol, like most people know) but not all substances.

Memoprove is just like Cere, at least for now, and from my personal point of view. to be honnest I don't really see the difference between IM and oral form. I was surprised to find i also had underestimated this N-pep-12 compound. I now take 2 a day.

As for alzheimers i was refering to my previous concussions. In wikipedia I found this : "Cumulative effects may include psychiatric disorders and loss of long-term memory. For example, the risk of developing clinical depression has been found to be significantly greater for retired American football players with a history of three or more concussions than for those with no concussion history.^[81] Three or more concussions is also associated with a fivefold greater chance of developing Alzheimer's disease earlier and a threefold greater chance of developing memory deficits.^{[81]" this is scaring the hell out of me.... I had 3 and did drink quite a bit (binge drinking ) on occarions.}

[Baten]

Oh boy. I think my father had at least 3 concussions in his life. Something tells me he's going to become one grumpy, forgetful grandpa some day :P
No way he'd swallow pills to prevent cognitive decline, though.

Right now he's rarely forgets things, has no problems with recall, memory, creativity and the like
I really think you shouldn't freak out too much, sunshinefrost. If anything, you should start caring about decline once you're about 40 or at the very least 35.
Of course, I don't know how old you are.

Edited by Baten, 23 January 2012 - 09:23 PM.

[kornell]

Hello everybody.

Started my first cycle Jan 20 with 1mL per day for 15 days. Yes, i know it's a small dose but something tells me that the first cycle should be taken easy. Get my brain acquainted with the new addition. My reasoning behind it is, because those peptides are readily able to cross the BBB and are circulating around for 48 hours before i pee them out. 3mL of something that wasn't there before is quite an addition inside of something that weights several pounds.

secondly, the next cycle would start June 1 ( or a bit earlier, depends on results) and this time around would be full on 5-10 mL per day for 20 days.

Guys who live in Canada, where are you buying CB? I got mine in Russia, stamp and all but it was a one time trip and I'm not planning on another one soon.

Really excited to be on this forum and hearing everyone's experiences.

Cheers

[Gamerzneed]

Hello everybody.

Started my first cycle Jan 20 with 1mL per day for 15 days. Yes, i know it's a small dose but something tells me that the first cycle should be taken easy. Get my brain acquainted with the new addition. My reasoning behind it is, because those peptides are readily able to cross the BBB and are circulating around for 48 hours before i pee them out. 3mL of something that wasn't there before is quite an addition inside of something that weights several pounds.

secondly, the next cycle would start June 1 ( or a bit earlier, depends on results) and this time around would be full on 5-10 mL per day for 20 days.

Guys who live in Canada, where are you buying CB? I got mine in Russia, stamp and all but it was a one time trip and I'm not planning on another one soon.

Really excited to be on this forum and hearing everyone's experiences.

Cheers

would like to hear your results since it's been a month.

[hooter]

I've only had 10x 10ml injections because it was becoming nearly impossible to sleep. I never felt tired. However the cognitive effects are still mildly present, but only really noticeable in the amplification of piracetam.

Edited by hooter, 22 February 2012 - 07:46 AM.

[MangekyōPeter]

Woohoo guys, got a prescription today for 10ml x 10 I am having major truoble concentrating so I'll probably make the most of it and IV it in the end instead of muscular as i had originally planned.

[themastadon]

Hey all, if cerebrolysin is 3-4x more effective via IV, why aren't more people just purchasing self-administration IV sets? They look pretty effective & cheap

Edit: Looks like IV hookups are pretty difficult to self-administer....finding the vein seems especially problematic for the untrained user.

On an unrelated note, I can't seem to find any cerebrolysin for sale online. Can anyone suggest reputable vendors who are selling at this time? Everything I've found is back-ordered.

Edited by themastadon, 24 February 2012 - 08:05 PM.