2208 replies to this topic

[blind12]

New study from nov 14...

http://www.ncbi.nlm....pubmed/23152192

Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio...

Makes sense as the pro-nerve growth factors have a high affinity towards p75(NTR) "death receptor".

Edited by blind12, 27 November 2012 - 02:20 PM.

[Rior]

New study from nov 14...

http://www.ncbi.nlm....pubmed/23152192

Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio...

Alzheimer's disease (AD) is characterized by degeneration of neocortex, limbic system, and basal forebrain, accompanied by accumulation of amyloid-β and tangle formation. Cerebrolysin (CBL), a peptide mixture with neurotrophic-like effects, is reported to improve cognition and activities of daily living in patients with AD. Likewise, CBL reduces synaptic and behavioral deficits in transgenic (tg) mice overexpressing the human amyloid precursor protein (hAPP). The neuroprotective effects of CBL may involve multiple mechanisms, including signaling regulation, control of APP metabolism, and expression of neurotrophic factors. We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF). Immunoblot analysis demonstrated that levels of pro-NGF were increased in saline-treated hAPP tg mice. In contrast, CBL-treated hAPP tg mice showed levels of pro-NGF comparable to control and increased levels of mature NGF. Consistently with these results, immunohistochemical analysis demonstrated increased NGF immunoreactivity in the hippocampus of CBL-treated hAPP tg mice. Protein levels of other neurotrophic factors, including BDNF, NT3, NT4, and CNTF, were unchanged. mRNA levels of NGF and other neurotrophins were also unchanged. Analysis of neurotrophin receptors showed preservation of the levels of TrKA and p75(NTR) immunoreactivity per cell in the nucleus basalis. Cholinergic cells in the nucleus basalis were reduced in the saline-treated hAPP tg mice, and treatment with CBL reduced these cholinergic deficits. These results suggest that the neurotrophic effects of CBL might involve modulation of the pro-NGF/NGF balance and a concomitant protection of cholinergic neurons. © 2012 Wiley Periodicals, Inc.

For some time, I've assumed that at least part of Cbl's method of action involved BDNF. If Cbl essentially only interacts with NGF, that leaves a BNDF-modulating treatment to be wanted. That said, I might suggest Dihexa as a possibility? (In the future, when it becomes available.)

Dihexa is a micropeptide capable of crossing the BBB and can be taken orally. It's effects are as follows:

In bench assays using living nerve cells to monitor new neuronal connections, Harding, Wright, and their colleagues found Dihexa to be seven orders of magnitude more powerful than BDNF, which has yet to be effectively developed for therapeutic use. In other words, it would take 10 million times as much BDNF to get as much new synapse formation as Dihexa.

So of course, it's essentially 10,000,000x as powerful as BNDF. What that says clinically? I suppose none of us can be sure until it's tested in the correct setting, however it seems like it may be a terrific augmentative therapy to Cbl. Essentially, you would have NGF stimulation, combined with the 18-some amino acids provided by Cbl, on top of the BDNF stimulation of Dihexa. Could be too much at once and cause brain fog/other issues, but I see it as an interesting theoretical stack.


Edit: Source, of course: http://www.sciencedaily.com/releases/2012/10/121011090653.htm

Edited by Rior, 28 November 2012 - 03:04 AM.

[Mr Matsubayashi]

I received an email from EVER Neuro Pharma GmbH regarding the validity of my product. It is real, the brain symbol on the ampules and holographic seal are country specific as suspected by the language on the boxes correlating with these features.

Success

Edited by Mr Matsubayashi, 28 November 2012 - 01:23 PM.

[protoject]

Thanks for the work Mastsubayashi. looks like youre doing some digging that maybe not everyone does. it's good to know what we're getting.

On another note, this is gonna sound completely nuts but wouldnt it be interesting to see what would happen if we could get entire populations , i.e. longecity forum CBL buyers, to petition against the shitty prices and decide not to buy because of that. Maybe it would force the sellers to sell at a much cheaper rate. I know it sounds nuts....

i just think the cbl was really not worth 400 dollars, honestly . 1 month of 10mL per day cycling weekends off I think is honestly only worth maybe 100 not 400. The benefit wasnt so strong that i could justify wasting that 400 dollars.

[5IMON]

Guys quick update spoke with a private doctor about getting my cbl iv infused gonna cost £50 per day for the service including the equipment and filters PLUS cbl price in all it will cost £1500 for a one month cycle of iv what do you guys think?

Is the cost worth the benefit?

[blind12]

Luckily I know a medical student who has been trained in IV injections and cannulas. I now wish I had something to inject.

Any news on the Romanian pharmacies angle yet?

[Candidatus]

blind12: I have posted some information regarding my Cerebrolysin ordered from romanian based website in my log. I can confirm that it is 100% legitimate. The price is 40$ for 5x5ml and 65$ for 5x10ml w/o shipping. I've had it sent via internatinal air mail (basic shipping option), and in was delivered within 5 days to the Czech Republic (EU). The website offers also express mail service, which I would consider for overseas orders. I have absolutely no financial or other ties to this website and I am not promoting it, merely writing a review.

5imon: 1500£ for a month worth of Cerebro would be an ABSULUTELY INSANE price to pay in my opinion, but each to his own.

Edited by Candidatus, 29 November 2012 - 09:27 AM.

[Mr Matsubayashi]

I compiled all the information in this thread to date
I am not a doctor and can not give advice on medical matters
The document is "as is" and will not be maintained


Cerebrolysin 01122012.xlsx

Edited by Mr Matsubayashi, 01 December 2012 - 12:05 PM.

[chairofgold]

Guys quick update spoke with a private doctor about getting my cbl iv infused gonna cost £50 per day for the service including the equipment and filters PLUS cbl price in all it will cost £1500 for a one month cycle of iv what do you guys think?

Is the cost worth the benefit?

Quick answer, not worth it! Outrageously too expensive! I'd go Intramuscular in that case.

blind12: I have posted some information regarding my Cerebrolysin ordered from romanian based website in my log. I can confirm that it is 100% legitimate. The price is 40$ for 5x5ml and 65$ for 5x10ml w/o shipping. I've had it sent via internatinal air mail (basic shipping option), and in was delivered within 5 days to the Czech Republic (EU). The website offers also express mail service, which I would consider for overseas orders. I have absolutely no financial or other ties to this website and I am not promoting it, merely writing a review.

5imon: 1500£ for a month worth of Cerebro would be an ABSULUTELY INSANE price to pay in my opinion, but each to his own.

Could you please provide us with the website? Thanks big in advance Candidatus!!

Edited by chairofgold, 03 December 2012 - 12:03 PM.

[5IMON]

I live in the Uk can anyone provide a website for the equipment needed for IM injection please

I live in the Uk can anyone provide a website for the equipment needed for IM injection please

[5IMON]

ChairOf Gold Can you comment !?
ALso just to clarify did you notice ANY perminent (sp) positive side effects

[Candidatus]

chairofgold: www.gerovitalshop.eu

[chairofgold]

chairofgold: www.gerovitalshop.eu

Bingo! Way cheaper than SHG as they want $90.00 a box with a flat shipping rate of $15.00. At 49.94 Euros a box of 10ml x 5 would equate todays money conversion calculation from euro to dollars to the amount of $65.23 a box with a flat shipping rate of 19.00 Euros or $24.81 at www.gerovitalshop.eu. So you will save even more if you order in bulk!

I already bookmarked the site and will be ordering in the future.

Thanks a million Candidatus! You will be remembered for that. Points in heaven for you!

As far as supplies, please read post number 907. No questions asked there. For IM injections all you need is a 23 gauge 1.5 inch needle, a 5ml empty syringe and a straw filter. All supplies can be bought there with out any questions or hassles.

As far as permanent side effects, well I take it that this would mean long lasting neural changes vs adverse reactions. There are many! One thing I can say with confidence is that it does not wear off, and the effects are cumulative. Everyone experiences different reactions from the medication, however they are for the most part universal vs individual. I have taken the time to read through the threaded posts and I can relate to each one of the experiences, each and every individual has had. For me, it has been the long lost neurological enhancer that I have been searching for a long time.

As far as an update from me, I have completed 7 regimes of 5, 10ml ampules all via IV. I still have not the courage to attempt the IM route even though I promised I would, I haven't as of yet. When I do, I will post the results here. I continually feel the effects, the effects of the potentiation of any neurological drug, weather it be imipramine, vilazodone, linon's mane, acetyl l-carnatine arginate, ginko biloba, or a caffeine containing beverage, they all seem to work stronger with the strongest being caffeine. My thoughts are way more creative, fluid like and clean, that is a clean like thinking, sort of like a crystal clear thinking, though not crystal clear. The only time I have thought with perfect crystal clarity and perfect fluidity is when I have had out of body experiences!

As far as memory, I don't see a big improvement but rather a moderate improvement. In my schooling, I have to memorize a jumbo load of information. Although this is the case, when it comes to testing, I see an average 5% to 6% increase in my grades. In otherwords, an 80% is now a 85% and moving towards past 85% and 85% now is a 90% and moving towards past 90%. Or a 90% is now a 95% and moving towards a 96% etc, etc. That is my logical guess. With each class, I receive a different grade, with some classes being that I may excel in and others being that I may struggle in. I still am yet to completely compare all my past grades to grades that i have been receiving since Cbl and of late. I have to use statistical analysis with a 67 percentile to obtain a mean grade. I haven't taken statistics in years though, and when I did take it in community college, I barley got a B, or a 80%. Now my grades consist of minuses and pluses.

For more info please read through this thread. I find it fun and educational and you may too.

In the future, I will be posting more updates.

Good luck all!!

Edited by chairofgold, 04 December 2012 - 09:09 AM.

[Werper]

I just ordered some from www.gerovitalshop.eu. I live in the united states and will let people know how it goes. The only thing I didn't like is when I selected united states it didn't ask for which state. So its just my name, address, and zip code, no state. We'll see.

[c60tester]

So what's the verdict on IV cerebrolysin?

It is more or less effective, if it's more I'd prefer to go that route.

[chairofgold]

If you had a choice between IV vs IM and you had the inside knowledge of what an IV saline lock consist of, I would go IV with Cbl only and only. Never do drugs please, they destroy your neurons and cause depression in the long run.

With that already said, Cbl has been the miracle neurological brain developing dendrite growing medication I and others here have found and for about $65 dollars a box from this site, worth it. Superhumangear is another site that offers this medication. Their price is $90 a box. I have yet to order from gerovitalshop, as I have 5 boxes that I plan on using for the next 5 months, that is 1 box per month. I and others await to here from Werper post #974 as to how his transaction went after he receives the box or boxes. I hope it goes well because that is where I'll be ordering in the future if all goes well with other buyers. In other words, I would like for them to be established as the new reputable sellers that we can rely on for buying bulk Cbl at a reasonable price.

http://www.gerovital...sin®-p-192.html

vs

http://superhumangea...bic-metabolism/

Edited by chairofgold, 06 December 2012 - 01:25 AM.

[daouda]

Please do give us feedback gerovitalshop. Personally I get my CERE from a brick-and-mortar international austian pharmacy (i contact them via email), they require a prescription but it can be in any language (well at least french english spanish german for sure), probably from any country - and the prices are the same than on gerovital!
Gerovital is definitely the cheapest "no prescription" source I have seen on the web. Plus they also sell actovegin (slightly cheaper than the "real austrian pharma!) which someone has stacked with CERE to great effect. And of course, also gervital.
I even think that since its a romanian shop it should be an excellent place for EU shoppers (Romania is a member of the EU, so no custom problems!)
Actually Im surprised not to see more "underground" bulgarian/hungarian/romanian online pharmacies directed towards western europeans. They have many interesting products (cerebrolysin, gerovital, alflutop, essentiale N, etc) that arent available in our western countries.

Superhumangear also source their CERE from romania but the price is almost twice as much. Their actovegin is also cheap though, and they have other stuff that is difficult to get in EU (like placenta extract, glutathione...). I think they send their stuff from hungary.


Actovegin & the brain
http://www.nextbio.c....nb?id=18833103
http://www.ncbi.nlm..../pubmed/7491366

Edited by daouda, 06 December 2012 - 02:34 AM.

[daouda]

I live in the Uk can anyone provide a website for the equipment needed for IM injection please

I live in the Uk can anyone provide a website for the equipment needed for IM injection please

medisave.co.uk
get the 25G 1" needles if you inject in delts, 23G 1.25" if glutes (and obviously the 5 or 10ml syringes depending on the vials of CERE you're getting) + alcohol swabs... and you're set

[Mr Matsubayashi]

So what's the verdict on IV cerebrolysin?

It is more or less effective, if it's more I'd prefer to go that route.

Anecdotal:
hooter
IV v IM: I would guess it to be anywhere from 3 to 5 times stronger, since I've tried intramuscular injection as well. The effects on perceptual 'smoothness' (the difference between a low and high framerate in video games) and direct perception of environmental light refraction are definitely at least 5 times stronger with the IV route

Professional:
Betsy
Based on those experiences it is very clear that IV infusions (5ml Cerebrolysin in 250 ml Hartman sol, 40-50 drops per min) are much more effective than IM injections.
We use 5ml of cerebrolysin in 240 ml hartman solution delivered through a small gauge butterfly stick 40-50 drops per min. The I.M. injections are considered to be a second choice and people use them to continue their treatments when they are not in Mexico.
it is VERY important to give I.V. infusions of CBR slowly in order to avoid side effects such as tremors , nausea and headaches
It is NEVER injected directly into the vein without being diluted, there would definitely be unpleasant side effects.

Cerebrolysin product Monograph:
Doses of up to 5 ml IM and up to 10 ml undiluted IV may be given. Doses between
10 ml up to a maximum of 50 ml are recommended only as a slow intravenous infusion
after dilution with the suggested standard infusion solutions. The duration of the
infusion should be between 15 and 60 mins.

Edited by Mr Matsubayashi, 06 December 2012 - 11:51 AM.

[spookytooth]

gerovitalshop.eu is an amazing find!
has anyone tried Actovegin?
I see there are also tablets available which would be much preferred by me as I am already using Cerebrolysin.

btw I have also been experiencing a certain level of brain fog and tiredness when using 10ml of Cerebrolysin. This doesn't happen when I use 5ml.

[c60tester]

It is NEVER injected directly into the vein without being diluted, there would definitely be unpleasant side effects.

Diluted? Really? With saline? and how much exactly?

Edited by c60tester, 06 December 2012 - 02:05 PM.

[Mr Matsubayashi]

Betsy posted in these forums prior. The instructions below her name were written by her, they clearly describe how she administered the product.

Just for further information, Cerebrolysin Monograph: http://www.hypermed....raph_screen.pdf

Edited by Mr Matsubayashi, 06 December 2012 - 02:13 PM.

[MangekyōPeter]

Yeah, I also injected Cerebrolysin diluted in saline... it's common practice.

[zilla1126]

FYI everyone, I have a contact in Poland who's mother is a pharmacist. It is available there with prescription for 23 euros - for 5ml X five. So, not much cheaper than the last source in Romania mentioned on this thread. Also, I live just a few miles from the USA clinic mentioned by the lady in Mexico that she said prescribes this stuff - so I'm going to check into that. I don't have insurance, so won't do me a lot of good right now.

I'll post back my findings - as well as the results of my use of Cerebrolysin when it arrives from Romania. I have a interesting collection of both inborn and mental deficits, and I'm hoping that Cerebrolysin will do for me what it has done for some others here.
I suspect that I'll be one of those who have the amazing results - but we shall see. I'll be doing 5ml a day, 5 on and 2 off. I'd do 10ml, but I am poor due to the aforementioned deficits.

[chairofgold]

It is NEVER injected directly into the vein without being diluted, there would definitely be unpleasant side effects.

Diluted? Really? With saline? and how much exactly?

For me I use 5ml of Cbl diluted in 20ml of sterile normal saline solution in a 30ml sterile empty syringe that I aspirated the saline from a 500ml bag of NS also known as 0.9% NS 500ml. I always flush the NS IV lock with 10ml of NS first followed with the diluted Cbl over 20 min followed with another 10ml of NS and then lock off the line with the plastic clamp. I do this twice a day Q 12hr x 2 days followed by the third day of 1 last IVP of Cbl over 20 min and then the lock is discontinued and discarded. So in essence, I don't have the lock in longer than 60 hrs or 2 1/2 days.

As far as establishing an IV normal saline lock, that's a technical practice that can be achieved through practice and education something you can learn through training and EMT paramedics, nurses and physicians all know how to establish an IV line which they learned from lab training followed with clinical training.

Edited by chairofgold, 07 December 2012 - 12:28 PM.

[zilla1126]

Also, I live just a few miles from the USA clinic mentioned by the lady in Mexico that she said prescribes this stuff - so I'm going to check into that. I don't have insurance, so won't do me a lot of good right now.

Ok, I spoke to a lady there who must be one of the upper people in the office and she was a great source of information.

Data dump:

Practice name: The Cole Center For Healing (http://www.colecenter.com/)
Location: West Chester, OH (suburb of Cincinnati)

The lady I spoke to confirmed that used to regularly administer Cerebrolysin on a regular basis, but they were forced to discontinue due to supplier issues. She was vague, but not evasive when I asked about the legality their use of a non-FDA approved drug - so, I don't how that worked.

Anyways, she had nothing but extremely positive things about Cerebrolysin and she said that it was a very sad thing when they had to stop providing it.

[chairofgold]

Also, I live just a few miles from the USA clinic mentioned by the lady in Mexico that she said prescribes this stuff - so I'm going to check into that. I don't have insurance, so won't do me a lot of good right now.

Ok, I spoke to a lady there who must be one of the upper people in the office and she was a great source of information.

Data dump:

Practice name: The Cole Center For Healing (http://www.colecenter.com/)
Location: West Chester, OH (suburb of Cincinnati)

The lady I spoke to confirmed that used to regularly administer Cerebrolysin on a regular basis, but they were forced to discontinue due to supplier issues. She was vague, but not evasive when I asked about the legality their use of a non-FDA approved drug - so, I don't how that worked.

Anyways, she had nothing but extremely positive things about Cerebrolysin and she said that it was a very sad thing when they had to stop providing it.

Cbl is not FDA approved in the USA, thought I wish it was, so no doctor here can prescribe it. I would take it that they stopped administering Cbl due to the risk of administering the med with the risk of putting the doctor/nurse license at risk should there be a revers reaction. I have read that there really can't be a reverse reaction because the medication is very safe but then again you could run into a person that for some strange reason does receive a reaction and gets and goes into some kind of anaphylactic shock, though I doubt that would ever happen but hey stranger things has occurred for the strangest reasons though the likely hood is nil with this med as far as what resent and past studies have shown.

Edited by chairofgold, 07 December 2012 - 03:55 PM.

[Werper]

I received an email from gerovital, which I found encouraging. Seems sincere and legit. Here it is

Dear Sir Christian

Thank you for your order and patience.

Please provide me with the details of your order, the system only recorded your payment but your order.

I wait for your reply so I can ship a.s.a.p. to you.

Also, please confirm the delivery addres and the phone number for the postman.

(deleted my address)
United StatesYour complete satisfaction is my main purpose so please do not hesitate to query, to suggest or to critic anything about our business and/or products.

Our company is based on mutual trust and honesty, we always prioritize the customers' complete satisfaction and best interest therefore all our partners and patients are firstly our friends and only then customers to us.

Please feel free to recommend us as a reliable shop to your true friends.

I am here 24/7 if you need further support.

Warm regards from Romania!


respectfully,

Ileana Aslan

Edited by Werper, 08 December 2012 - 10:31 PM.

[5IMON]

HAS ANYONE WITH ADHD/ADD BEEN ON THIS CYCLE? Can you please report..

[hooter]

HAS ANYONE WITH ADHD/ADD BEEN ON THIS CYCLE? Can you please report..

Yes, it's very helpful. Improves focus and attention span, definitely. Lowers caffeine tolerance.