2208 replies to this topic

[Shorty]

I just performed my first IM Cerebrolysin injection and almost fainted. I felt extreme dizziness, was sweating profusely and felt slightly nauseous. I'm not sure wether to attribute this to Cerebrolysin or to the fact there was a 21 gauge needle in my leg. I have never had symptoms this extreme when a doctor was drawing my blood and the symptoms seemed to worsen the more I injected which forced me to pull out the needle before the injection was finished. Not sure where to go from here... Should I give it another try? Use a higher gauge needle perhaps?

[marke53]

Shorty you could have possibly injected into a vain. Did you aspirate? I just did my first IM injection today with no problems. Barely felt it.

Edited by marke53, 08 January 2013 - 12:28 AM.

[Shorty]

I tried to aspirate and didn't see any blood so I proceeded. It's possible that I didn't pull hard enough though so I will put greater emphasis on that next time.

It really isn't an experience that I want to repeat as it felt like what I imagine a seizure to be like. My whole body vibrated, vision became blurry, felt on the verge to fainting... really unpleasant but all symptoms subsided after a few minutes.

I'm not sure I really hit a vein as I saw no blood on the needle, but thanks for pointing it out marke.

Edited by Shorty, 08 January 2013 - 01:44 AM.

[jillin]

Shorty, you probably did hit a vein and on top of that, it also sounds like you produced air bubbles when you aspirated the needle. Aspirating the needle incorrectly can easily form air bubbles -- to correctly do it, you should aspirate only slightly and wait a few seconds to half a minute to see if blood is indeed flowing back into the needle. If you did hit a vein, it would be pretty obvious as the blood within the vein you struck is under pressure -- it won't take much for the blood to flow back into the needle even if there was fluid within the needle to begin with. This is just a guess, but chances are your symptoms were caused by an air embolism. Now, you should be extremely thankful as air embolisms are lethal if the air bubbles are large enough to occlude normal perfusion.

[Shorty]

Shorty, you probably did hit a vein and on top of that, it also sounds like you produced air bubbles when you aspirated the needle. Aspirating the needle incorrectly can easily form air bubbles -- to correctly do it, you should aspirate only slightly and wait a few seconds to half a minute to see if blood is indeed flowing back into the needle. If you did hit a vein, it would be pretty obvious as the blood within the vein you struck is under pressure -- it won't take much for the blood to flow back into the needle even if there was fluid within the needle to begin with. This is just a guess, but chances are your symptoms were caused by an air embolism. Now, you should be extremely thankful as air embolisms are lethal if the air bubbles are large enough to occlude normal perfusion.

Jesus Christ my Symptoms DO sound like air embolism. I made sure there were no bubbles in the syringe before injecting, but I didn't know air could still get in while aspirating. Thank you so much for informing me about this! I will now refrain from self-administered injections as I do not seem qualified enough. Is there anything I should know regarding the air in my body or am I save now?

[jillin]

You should be fine, small air bubbles within your venous system gets readily absorbed -- it's the large ones that occlude circulation altogether that you should worry about. If you want to take extra precautions, keep away from strenuous activities for today -- you don't want to increase your blood pressure or heart rate as that can dislodge any possible remaining air bubbles; don't take any medications with vasoconstriction properties. However, the rate in which venous O2 aggregates gets absorbed by the venous system is pretty rapid and these extra precautions might be an overkill.

[lourdaud]

Jesus Christ my Symptoms DO sound like air embolism. I made sure there were no bubbles in the syringe before injecting, but I didn't know air could still get in while aspirating. Thank you so much for informing me about this! I will now refrain from self-administered injections as I do not seem qualified enough. Is there anything I should know regarding the air in my body or am I save now?

I think you should be completely fine, what you describe happened to me twice when I first started injecting cerebrolysin, and I don't think it was because of any air bubbles, but rather because I did it first thing in the morning, hungover and on an empty stomach.. probably due to using a rather thick needle and injecting one whole 10 ml as well (for what it's worth, 10 ml for some reason feels like way too much today, half a year later).

I don't think you should let this stop you, just be careful and follow normal medical procedure and you'll get it in no-time. IM injections is really nothing to worry about..

[Mr Matsubayashi]

I think you will be fine

gizzurp
I just received my first package of cerebrolysin from International aging systems today and injected my first dose.
About 30 seconds after I removed the needle from my leg I had the most ridiculous head rush I have ever had
My vision started to gray out so I slid off my chair onto the floor and the next thing I knew I was lying face down on the hardwood floor, barely able to recall what had happened for the last 30 seconds.
My head was aching and I felt really spacey, numb and my hands felt really weak
For the next few hours I felt tired and little out of it, but relatively normal.
It is now 8 hours after doing the shot and I feel really calm, focused and happy, which I have been feeling for the last 5 hours. I really like it.
I have passed out from cutting my finger in the past

semi-retarded-individual
Sounds like a vasovagal response due to your fear of needles

chrono
About a month ago I was getting an injection in my mid-back, and I had an experience like the one described.
My doctor said that sometimes this kind of thing can just happen, without much obvious causation.

Mr Matsubayashi
21gauge is too large, go with 25gauge
Next time you inject ensure you take at least 5min, however uncomfortable it might be. Injecting too fast can cause sweating.

Edited by Mr Matsubayashi, 08 January 2013 - 11:35 AM.

[protoject]

you may have injected too fast, it may have been too cold, or, it might have been neither of those things. personally i sweat buckets and shake a little afterwards when injecting myself because of the anxiety associated with sticking a sharp through my skin into my muscle on my hip. so maybe it's just some form of anxiety

[sunshinefrost]

I just performed my first IM Cerebrolysin injection and almost fainted. I felt extreme dizziness, was sweating profusely and felt slightly nauseous. I'm not sure wether to attribute this to Cerebrolysin or to the fact there was a 21 gauge needle in my leg. I have never had symptoms this extreme when a doctor was drawing my blood and the symptoms seemed to worsen the more I injected which forced me to pull out the needle before the injection was finished. Not sure where to go from here... Should I give it another try? Use a higher gauge needle perhaps?

shorty, why on earth are you using gauge 21 ????

[Shorty]

I just performed my first IM Cerebrolysin injection and almost fainted. I felt extreme dizziness, was sweating profusely and felt slightly nauseous. I'm not sure wether to attribute this to Cerebrolysin or to the fact there was a 21 gauge needle in my leg. I have never had symptoms this extreme when a doctor was drawing my blood and the symptoms seemed to worsen the more I injected which forced me to pull out the needle before the injection was finished. Not sure where to go from here... Should I give it another try? Use a higher gauge needle perhaps?

shorty, why on earth are you using gauge 21 ????

I ordered 25g needles but was sent 21g for some reason. Meanwhile the Cerebrolysin had arrived and I was too impatient to reorder so I decided to stick that monster inside my body.

Thanks for all the pointers everyone. I may give it another try and I'll be sure to inject slowly and with a higher gauge needle this time.

[jillin]

Here is a reference of what I use:
https://docs.google....SV3M/edit?pli=1

* 19g x 1 1/2 w/5 micron filter needle @ 1.1mm x 40mm
* 22g x 1 1/2 needle @ 0.7mm x 40mm
* 10ml disposable syringe

Initially, I used 5% lidocaine cream, but the injection site has scarred, and I no longer feel the needle prick.

My routine for injecting Cerebrolysin: (always wear some form of protective gloves)
-alcohol swab the Cere ampoule, break the top
-attach 19g filter needle to 10ml syringe
-withdraw the 10ml of Cere, clear all residual air bubbles within syringe while the 19g filter needle is attached
-remove 19g filter needle, attach the 22g needle, and prime the needle -- making sure there is content within and flowing out from the needle
-alcohol swab the injection site (the thigh -- between the regions of the vastus lateralis and the biceps femoris)
-begin injection, making sure to guide the needle in deep (leaving ~ 2.5mm of visible needle, out of the initial 15mm)
-aspirate very gently (emphasis on gently), wait 10-30 seconds, see no indications of blood flowing back into the syringe, begin introduction of Cerebrolysin

Edited by jillin, 09 January 2013 - 01:34 AM.

[CatChelator]

10ml in one injection/site?

Here is a reference of what I use:
https://docs.google....SV3M/edit?pli=1

* 19g x 1 1/2 w/5 micron filter needle @ 1.1mm x 40mm
* 22g x 1 1/2 needle @ 0.7mm x 40mm
* 10ml disposable syringe

Initially, I used 5% lidocaine cream, but the injection site has scarred, and I no longer feel the needle prick.

My routine for injecting Cerebrolysin: (always wear some form of protective gloves)
-alcohol swab the Cere ampoule, break the top
-attach 19g filter needle to 10ml syringe
-withdraw the 10ml of Cere, clear all residual air bubbles within syringe while the 19g filter needle is attached
-remove 19g filter needle, attach the 22g needle, and prime the needle -- making sure there is content within and flowing out from the needle
-alcohol swab the injection site (the thigh -- between the regions of the vastus lateralis and the biceps femoris)
-begin injection, making sure to guide the needle in deep (leaving ~ 2.5mm of visible needle, out of the initial 15mm)
-aspirate very gently (emphasis on gently), wait 10-30 seconds, see no indications of blood flowing back into the syringe, begin introduction of Cerebrolysin

[jillin]

yes

10ml in one injection/site?

Here is a reference of what I use:
https://docs.google....SV3M/edit?pli=1

* 19g x 1 1/2 w/5 micron filter needle @ 1.1mm x 40mm
* 22g x 1 1/2 needle @ 0.7mm x 40mm
* 10ml disposable syringe

Initially, I used 5% lidocaine cream, but the injection site has scarred, and I no longer feel the needle prick.

My routine for injecting Cerebrolysin: (always wear some form of protective gloves)
-alcohol swab the Cere ampoule, break the top
-attach 19g filter needle to 10ml syringe
-withdraw the 10ml of Cere, clear all residual air bubbles within syringe while the 19g filter needle is attached
-remove 19g filter needle, attach the 22g needle, and prime the needle -- making sure there is content within and flowing out from the needle
-alcohol swab the injection site (the thigh -- between the regions of the vastus lateralis and the biceps femoris)
-begin injection, making sure to guide the needle in deep (leaving ~ 2.5mm of visible needle, out of the initial 15mm)
-aspirate very gently (emphasis on gently), wait 10-30 seconds, see no indications of blood flowing back into the syringe, begin introduction of Cerebrolysin

[crusader]

why are there some recent horror stories with cerebroylsin injections?

falling facedown on the hardwood floor, whole body vibrating and vision going "grey", extreme headrush and confusion

is this just amateur injection methods, or the cerebroylsin itself?

[sunshinefrost]

why are there some recent horror stories with cerebroylsin injections?

falling facedown on the hardwood floor, whole body vibrating and vision going "grey", extreme headrush and confusion

is this just amateur injection methods, or the cerebroylsin itself?

It's the fear of needles, nothing more. Just wait for the whole anecdotal report... You'll understand.

[marke53]

Does anyone here know for a fact if cerebrolysin injected into fat will still cross the bbb?
I did my first 2 5ml injections in my glutes with a 1" needle and am just worried I didnt inject IM.

Just started injections into my quads to be safe.

So far on my 2nd day I haven't noticed much, I do feel a little more foggy than usual though.

[tdmonster99]

To the American user of gerovitalshop.eu, is there any way to order with MasterCard? When I go to checkout and log in to PayPal it looks like it only accepts Visa, Discover and AmEx. If that is the case, I'll just get a prepaid Visa debit card.

[sunshinefrost]

Does anyone here know for a fact if cerebrolysin injected into fat will still cross the bbb?
I did my first 2 5ml injections in my glutes with a 1" needle and am just worried I didnt inject IM.

Just started injections into my quads to be safe.

So far on my 2nd day I haven't noticed much, I do feel a little more foggy than usual though.

keep in mind, some responded after the 13th dose ... good luck. Foggy definitly isn't a side effect of cerebrolysin. You'll know when it starts working.

[Rior]

Does anyone here know for a fact if cerebrolysin injected into fat will still cross the bbb?
I did my first 2 5ml injections in my glutes with a 1" needle and am just worried I didnt inject IM.

Just started injections into my quads to be safe.

So far on my 2nd day I haven't noticed much, I do feel a little more foggy than usual though.

keep in mind, some responded after the 13th dose ... good luck. Foggy definitly isn't a side effect of cerebrolysin. You'll know when it starts working.

Meh I'd say it varies person to person. 10mL, while certainly extremely anxiolytic, certainly created some brain fog for me. 5mL was the perfect dose of alertness and awesomeness for me.

[zilla1126]

Meh I'd say it varies person to person. 10mL, while certainly extremely anxiolytic, certainly created some brain fog for me. 5mL was the perfect dose of alertness and awesomeness for me.

Has anyone looked into why cerebrolysin has any immediate anxiolytic effects? It makes no sense based on what it is supposed to be - a soup of raw materials for your brain to repair itself.

I'd have to think that any immediate effects people get from it are from something that's added to it as filler.

Anyone have knowledge or thoughts on this?

I'm taking 5ml/day myself, and I have noticed none of the immediate effects that others on here mention.

[Shorty]

Is it safe to drink Cerebrolysin? I know it won't have much of an effect, but my 25g needles haven't arrived yet and I have had 5ml sitting in a syringe for 2 days. I haven't stored it very well so there is no way I'm going to inject it, but I also don't want it to completely go to waste.

[sunshinefrost]

Meh I'd say it varies person to person. 10mL, while certainly extremely anxiolytic, certainly created some brain fog for me. 5mL was the perfect dose of alertness and awesomeness for me.

Has anyone looked into why cerebrolysin has any immediate anxiolytic effects? It makes no sense based on what it is supposed to be - a soup of raw materials for your brain to repair itself.

I'd have to think that any immediate effects people get from it are from something that's added to it as filler.

Anyone have knowledge or thoughts on this?

I'm taking 5ml/day myself, and I have noticed none of the immediate effects that others on here mention.

Why doesn't it make sense ? It's a matter of days right now. There are fillers, like mr mitsubayashi said, but they seem to be only amino acids... Some of those may have a subtle effect. But i think most of the immediate effects come from placebo phenomena. Most people aren't used to self inject... So of course the brain will make a big deal out of it, thus probably give you a strong placebo. But still, maybe phenylalanine fo example does give you some kind of unatural effect. P

Is it safe to drink Cerebrolysin? I know it won't have much of an effect, but my 25g needles haven't arrived yet and I have had 5ml sitting in a syringe for 2 days. I haven't stored it very well so there is no way I'm going to inject it, but I also don't want it to completely go to waste.

I'm pretty sure it's safe to drink, but then again i'm sure pharmacist would advise otherwise. I would take it without food.

[Shorty]

I'm pretty sure it's safe to drink, but then again i'm sure pharmacist would advise otherwise. I would take it without food.

Thanks. I did drink it and actually felt a diminished form of the same sort of headache I had after my first injection. So maybe some peptides actually survived digestion.

[tdmonster99]

Cerebrolysin and equipment has been ordered and I will hopefully be able to add to this discussion.

[Shorty]

Adminstered my 2nd injection and everything went well.

Things that were different from my first injection:
- Smaller needle size (26g)
- Different injection site (Ventrogluteal)
- Slower injection speed (~15 sec.)

No pain and no adverse effects.

[marke53]

4th set of injections done
I definitively hit a nerve in my quad, legs been twitching for a few hours now.
I'm starting to feel some effects, seems like my brain fog is starting to be lifted,
More mental clarity, thoughts are forming better, memory seems a little better.
Also I felt a bit more energetic today and ready to win.
Could have just been a good day and a placebo effect or maybe its kicking in.

Also smoked some cannabis and didnt feel like a complete zombie like I normally do

[megatron]

To all of you guys who have used cerebrolysin for a while; would you say it's potentially the best nootropic on the market currently?

[sunshinefrost]

To all of you guys who have used cerebrolysin for a while; would you say it's potentially the best nootropic on the market currently?

I prefer cerebrolysin over other susbtances because it delivers on the long term side and it increases the brain's ability to physically change and adapt. The other noots seem to plateau or do not deliver on the promise for healthy brain improvement. Some noots are pretty amazing a first though and i'm not discrediting them, i was impressed by piracetam and aniracetam at first but I just prefersubstances that have neurogenesis or neurotrophic properties, not just a temporary boost. If studies came out about piracetam enhancing PERMANENTLY the corpus calloseum then i would have a different speech but i didn't find any.

here is a study that was published TODAY:


Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice.


Abstract

Cerebrolysin (Cbl) shows neurotrophic and neuroprotective properties while donepezil (Dnp) is a potent acetylcholinesterase (AChE) inhibitor, both drugs are prescribed for Alzheimer's disease (AD) treatment. Previous studies have shown that the Dnp and Cbl administered separately, modify dendritic morphology of neurons in the prefrontal cortex and hippocampus in senile rodents. Since the deficit of neurotrophic factor activity is implicated in the degeneration of cholinergic neurons of basal forebrain, a combination therapy of Dnp and Cbl has been tested recently in Alzheimer's patients. However, the plastic changes that may underlie this combined treatment have not yet been explored. We present here the effect of the combined administration of Cbl and Dnp on dendritic morphology in brain regions related to learning and memory in aged mice. The Golgi-Cox staining protocol and Sholl analysis were used for studying dendritic changes. Cbl and Dnp were administrated daily for 2 months to 9-months-old mice. Locomotor activity was assessed, as well as the dendritic morphology of neurons in several limbic regions was analyzed. Results showed that Cbl and Dnp induced an increase in locomotor activity without synergistic effect. The Cbl or Dnp treatment modified the dendritic morphology of neurons from prefrontal cortex (PFC), dorsal hippocampus (DH), dentate gyrus (DG), and the shell of nucleus accumbens (NAcc). These changes show an increase in the total dendritic length and spine density, resulting in an improvement of dendritic arborization. Prominently, a synergistic effect of Cbl and Dnp was observed on branching order and total dendritic length of pyramidal neurons from PFC. These results suggest that Dnp and Cbl may induce plastic changes in a manner independent of each other, but could enhance their effect in target cells from PFC.



http://www.ncbi.nlm....pubmed/22826038

Edited by sunshinefrost, 10 January 2013 - 02:28 PM.

[megatron]

Very nice! I will thoroughly read through the 37 pages of this thread, and make up my mind whether to test it or not. From what I've read thus far, it seems very very promising.