2208 replies to this topic

[Izan]

http://psychcentral....ntia/51116.html

[Nero]

The end of that article Izan82 posted just about says it all

“But the fact that it has to be given in regular intravenous infusions means it could be impractical for use on a large scale.”

I have a few questions for Cerebrolysin users

Is there a tolerance?
Russian bear says he's afraid there might be

What's more effective IV or IM?
Betsy from mexico says IV is much more effective

[stablemind]

Day 4:

It's been 2 days since my 2nd IV and I believe I'm starting to feel the memory boosting effects. Over the past few days I noticed I was pretty tired all the time which I attribute to one of Cerebrolysin's side effects. The other side effects were flu like symptoms which occurred shortly after the IV and lasted very briefly. After a lot of short naps, I felt pretty energetic- more so than I felt since my first Cerebrolysin injection. During a long train ride back to my hometown, I noticed myself going over flash cards on my iphone much faster than normal, and my retention scores were higher. I started reminiscing about all the things I did, all the places I went, and all the things I saw in a timetable format, all the way down to minor details such as what I had eaten. This is coming from someone who used to have trouble figuring out what he had for breakfast... I think its effects are somewhat comparable to Pramiracetam's effects except more natural.

Tomorrow morning I'll have my 3rd IV, and possibly try some Green Tea (which usually has enough caffeine to kick my butt)

[Sholrak]

The end of that article Izan82 posted just about says it all

“But the fact that it has to be given in regular intravenous infusions means it could be impractical for use on a large scale.”

I have a few questions for Cerebrolysin users

Is there a tolerance?
Russian bear says he's afraid there might be

What's more effective IV or IM?
Betsy from mexico says IV is much more effective

Might there be tolerance, as it seems. Depending on how many ml you take, how long your breaks are... looks like it develops over a few years.

And, yes, everybody here that tested IM and IV says IV makes the effects more noticeable.

Day 4:

It's been 2 days since my 2nd IV and I believe I'm starting to feel the memory boosting effects. Over the past few days I noticed I was pretty tired all the time which I attribute to one of Cerebrolysin's side effects. The other side effects were flu like symptoms which occurred shortly after the IV and lasted very briefly. After a lot of short naps, I felt pretty energetic- more so than I felt since my first Cerebrolysin injection. During a long train ride back to my hometown, I noticed myself going over flash cards on my iphone much faster than normal, and my retention scores were higher. I started reminiscing about all the things I did, all the places I went, and all the things I saw in a timetable format, all the way down to minor details such as what I had eaten. This is coming from someone who used to have trouble figuring out what he had for breakfast... I think its effects are somewhat comparable to Pramiracetam's effects except more natural.

Tomorrow morning I'll have my 3rd IV, and possibly try some Green Tea (which usually has enough caffeine to kick my butt)

It`s good to hear that! I hope the effects become more consistent over the days.


I have too a sensation of not being in what I do in a day about the 80 percent of the time. I live that moments, yes, but the majority to never be recalled or remembered, and even learned.

I`m starting to think, depression goes when you are growing new connections, and that, somehow, every system in our body, such as adrenal, HPA, pituitary, hipothalamus, thyroid, hippocampus... must be working all together in connection and synegy to let us grow new neural connections. One system disturbed, will lead to learning and memory problems. And that will lead to depression. I believe, stress or incorrect learned behaviours make us produce even more stress, and not being in the zone, so to say.

As sunshinefrost said, the key is to ATTEND every situation. Maybe you have a routine, and in a dettermiate point of the day, get overstressed and you just disconnect your learning, or capacity to attend things.

I`m sure, Cerebrolysin, by providing you Growth Factors directly, will allow you to know how you feel by learning every moment, by not getting distracted by something inconvenient, scary, anxious or stressing. Maybe, the direct growth will put all your systems functioning correctly, quitting all somatizations in your body, and will show you who you realy are to let you learn how to maintain your mind clarity, achieving our native state, and raising oxitocyn levels properly.

Edited by Sholrak, 31 March 2013 - 11:18 PM.

[megatron]

One question: Do veins go across or along your body? Today I actually managed to hit a vein every single time I tried (4 times)! I had to give up since I starting sweating a lot, and felt dizzy.

[troubleis]

One question: Do veins go across or along your body? Today I actually managed to hit a vein every single time I tried (4 times)! I had to give up since I starting sweating a lot, and felt dizzy.

I have to give it to ya'

You dont quit easily.
This, and the fact you keep on shooting CB despite having felt absolutely nothing is almost inspiring. It's sad you dont feel anything when you try so hard. Maybe there is just nothing wrong with your brain?



Sound pretty cool about the IV of 20ml.. Maybe i should order some more, and get a DIY iV kit, and give it a try.
I definitely still have some of the positive effect of CB going on.. Still, better memory, more focused, better performing..
I came here because i randomly had to review some work i had done shortly before starting CB, and i compared it to the work i have done on CB.. I dont know what made the change, CB, practice, or study(or a a combo) but my work now is much better. More though behind it. More dedicated somehow.

[Mr Matsubayashi]

Do we know that neuron growth is responsible for the cognitive enhancements seen in some people? Not even Ebewe knows exactly what's in their product. I treat the enhancement as part of the value added whether it is coincides with neuron growth or not.

If I had no percieved cognitive benefit I would need evidence that it has any effect subtle or long term before dropping more money on it. I imaging i would think everyone on this board suffered from the placebo effect too!

Fact is that different people have reported different sensitivities. If Cere isn't giving you gains and you've tried a solid dosing by IV or consistent IM then move on. Take the knowledge you have gained during this experiment as a win and as a story to tell your mates.

Available alternatives are
Cortexin
Semax

[Kompota]

Fact is that different people have reported different sensitivities. If Cere isn't giving you gains and you've tried a solid dosing by IV or consistent IM then move on. Take the knowledge you have gained during this experiment as a win and as a story to tell your mates.

Available alternatives are
Cortexin
Semax

Well the main thing about immediate cognitive effects is that there should be a difference if you are healthy individual or you have some kind of pathology. I have cognitive deficits due to protracted benzodiazepine withdrawal. I do not expect any wonders, it may not be a quick fix, but I am aiming at the long-term goal of healing my CNS.

Could I ask if you don't mind, since you have reported some success with Cerebrolysin - did you have some pathology involved or are you a healthy one just looking for cognitive enhancement ?

[NootropicEU]

Fact is that different people have reported different sensitivities. If Cere isn't giving you gains and you've tried a solid dosing by IV or consistent IM then move on. Take the knowledge you have gained during this experiment as a win and as a story to tell your mates.

Available alternatives are
Cortexin
Semax

Well the main thing about immediate cognitive effects is that there should be a difference if you are healthy individual or you have some kind of pathology. I have cognitive deficits due to protracted benzodiazepine withdrawal. I do not expect any wonders, it may not be a quick fix, but I am aiming at the long-term goal of healing my CNS.

Could I ask if you don't mind, since you have reported some success with Cerebrolysin - did you have some pathology involved or are you a healthy one just looking for cognitive enhancement ?

How long have you been using benzodiazepines? I have a friend who used Valium for over a year, he was taking up to 50mg daily. He tapered it off over 3 months but he still felt significant cognitive deficits. Then he started IM Cerebrolysin for about 4 months and apparently he feels "normal" again.
I don't know if its Cerebrolysin or his brain healed itself.

[Mr Matsubayashi]

Fact is that different people have reported different sensitivities. If Cere isn't giving you gains and you've tried a solid dosing by IV or consistent IM then move on. Take the knowledge you have gained during this experiment as a win and as a story to tell your mates.

Available alternatives are
Cortexin
Semax

Well the main thing about immediate cognitive effects is that there should be a difference if you are healthy individual or you have some kind of pathology. I have cognitive deficits due to protracted benzodiazepine withdrawal. I do not expect any wonders, it may not be a quick fix, but I am aiming at the long-term goal of healing my CNS.

Could I ask if you don't mind, since you have reported some success with Cerebrolysin - did you have some pathology involved or are you a healthy one just looking for cognitive enhancement ?

No known pathology and no drug history. My brain was a virgin.
There is an intuitive connection between neuron growth and the correction of certain disorders but I don't think anyone knows for sure if this is the mechanism that makes Cere such a useful noot for some.

[Kompota]

How long have you been using benzodiazepines? I have a friend who used Valium for over a year, he was taking up to 50mg daily. He tapered it off over 3 months but he still felt significant cognitive deficits. Then he started IM Cerebrolysin for about 4 months and apparently he feels "normal" again.
I don't know if its Cerebrolysin or his brain healed itself.

I took Xanax very occasionally for 4 months and then regularly Clonazepam 1mg a day for 1 month. In retrospect, neuroadaptations in my case were happening very quickly. It appears the profile of my CNS is predisposed to that.

The question is: does stimulation of neurogenesis involve upregulation of GABA receptors ?

[Sholrak]

It's soo strange while some here claim it is almost a panacea, others difficultly can discern any effects from it. Is brain damage/drug abuse/cognitive deficits needed to see the potential of this compound?

For me, I'm 100% sure it will have a positive effect no doubt, I'm in the low part of sanity scale, otherwise I'm done with nootropics. An explanation comes to my mind. As lifechanging drug this seems to be, you really need to start CHANGING YOUR LIFE while on it. Maybe, partners who don't get any effect, you should judge if you have gave all your energy and force to see that change made.

When my Cere arrives, I'm done with drugs, bad sleep habits, laziness, sedentarism, and autodestruction life style LOL. Otherwise, I will find difficult that Cere can change anything.



Also, the fact a lot of users haven't passed for here to say something, means it works perfect and they got what they needed?

[stablemind]

While most of the memory enhancing effects of the drug is still present, I've come to realize that it is no fix for my Bipolar II disorder. I've been able to reduce my lithium dose from 600 mg to 300 mg which is insanely low. Lately I've noticed some feelings of anxiousness, but I believe it is due to the rainy weather rather than the dose reduction. I also notice that I'm slightly melancholic and have made some really stupid impulsive decisions, but again this is probably due to the weather. Although Cereb hasn't cured me of this SAD, it certainly has made it more bearable. I'll update in the next few days when the weather gets better.

[sunshinefrost]

It's soo strange while some here claim it is almost a panacea, others difficultly can discern any effects from it. Is brain damage/drug abuse/cognitive deficits needed to see the potential of this compound?

For me, I'm 100% sure it will have a positive effect no doubt, I'm in the low part of sanity scale, otherwise I'm done with nootropics. An explanation comes to my mind. As lifechanging drug this seems to be, you really need to start CHANGING YOUR LIFE while on it. Maybe, partners who don't get any effect, you should judge if you have gave all your energy and force to see that change made.

When my Cere arrives, I'm done with drugs, bad sleep habits, laziness, sedentarism, and autodestruction life style LOL. Otherwise, I will find difficult that Cere can change anything.



Also, the fact a lot of users haven't passed for here to say something, means it works perfect and they got what they needed?

Cool ! Let us know when you sttart reponding to it. Be carefull with sleep, it really is the best nootropic.

[CatChelator]

Seeing as there's no one else I can tell without getting a weird look, just wanted to say that my Cere has arrived. I bought 4 x 5 x 10ml from nootropic.eu on the 29th of March and it arrived today. Good service.

I hope that I'll be able to provide a balanced report on my experiences. I'm quite prepared for it to do nothing noticeable (which is what I've experienced with all other nootropics) but will do my full cycle in the hope that there'll be subtle long term benefits to my CNS and cognitive ability.

A couple questions. Are people injecting the full 10mls into one site without problem? I've watched one clip online of a ten ml injection that went fine but wondering what the general consensus is.

Another way would be to inject half and then pull out and switch to a new sterile needle and inject the remaining half into a new site. Is that extremely bad hygiene practice? Seems to me that it would be ok if a new needle is being used.

And finally, here is an article that a tutor forwarded to me after he contacted Ever Pharma. Note that it is not published yet so basically it is totally unverified or reviewed, but still is more evidence to add to the pile.

Attached Files

•  Chopp-NEUROPLASTICITY2011.pdf   64.76KB   28 downloads

[megatron]

Seeing as there's no one else I can tell without getting a weird look, just wanted to say that my Cere has arrived. I bought 4 x 5 x 10ml from nootropic.eu on the 29th of March and it arrived today. Good service.

I hope that I'll be able to provide a balanced report on my experiences. I'm quite prepared for it to do nothing noticeable (which is what I've experienced with all other nootropics) but will do my full cycle in the hope that there'll be subtle long term benefits to my CNS and cognitive ability.

A couple questions. Are people injecting the full 10mls into one site without problem? I've watched one clip online of a ten ml injection that went fine but wondering what the general consensus is.

Another way would be to inject half and then pull out and switch to a new sterile needle and inject the remaining half into a new site. Is that extremely bad hygiene practice? Seems to me that it would be ok if a new needle is being used.

And finally, here is an article that a tutor forwarded to me after he contacted Ever Pharma. Note that it is not published yet so basically it is totally unverified or reviewed, but still is more evidence to add to the pile.

You can just inject everything into a singular site. It gets tedious if you have to do multiple injections every day. Also, you would need a lot more injection sites to avoid creating scar tissue.

Edited by Megatrone, 10 April 2013 - 09:52 AM.

[CatChelator]

Hadn't read that article yet - it actually doesn't say much at all.

Thanks Megatrone, I'll try doing it all in the one spot.

Edited by jonsnow, 10 April 2013 - 10:33 AM.

[sunshinefrost]

Seeing as there's no one else I can tell without getting a weird look, just wanted to say that my Cere has arrived. I bought 4 x 5 x 10ml from nootropic.eu on the 29th of March and it arrived today. Good service.

I hope that I'll be able to provide a balanced report on my experiences. I'm quite prepared for it to do nothing noticeable (which is what I've experienced with all other nootropics) but will do my full cycle in the hope that there'll be subtle long term benefits to my CNS and cognitive ability.

A couple questions. Are people injecting the full 10mls into one site without problem? I've watched one clip online of a ten ml injection that went fine but wondering what the general consensus is.

Another way would be to inject half and then pull out and switch to a new sterile needle and inject the remaining half into a new site. Is that extremely bad hygiene practice? Seems to me that it would be ok if a new needle is being used.

And finally, here is an article that a tutor forwarded to me after he contacted Ever Pharma. Note that it is not published yet so basically it is totally unverified or reviewed, but still is more evidence to add to the pile.

10 ml in 1 place is a lot ... But some people do it regardless. It causes a lump on the injection site. You may just switch sites to avoid sore spots and yes switching needles is a must.

[csrpj]

Sorry if this has been covered, but is there reason to believe - from experiences or theoretical guesses - that cere would be particularly useful for damage caused from substance abuse, and if so, for particular classes of substances more so than others?

[OpaqueMind]

I have previously offended my brain with every class of drug under the sun, and I have definitely found cerebrolysin useful for going some way in rectifying such insults. However, it is not a magic bullet or cure-all... It supplies the raw materials but you need to supply the stimulation! Along with a regimen of meditation, learning, exercise and healthy eating, it will definately be an ally of yours. The brain grows wherever thoughts direct it, direct it well and realignment is certain.

Do you have anything you're passionate about? Do that... Engage in it with your whole being.! Are you curious about life? Get investigating! The brain is like a muscle, it grows with intense use, and atropies with disuse. Most importantly, you must understand that recovery is certain. The body becomes what thought believes. I made the mistake of believing myself irreversibly brain damaged from drug use, and my brain followed suit. If you need reassurance, there are many resources detailing the recovery of properly brain damaged victims. If you don't, fantastic! You're already well on your way to recovery.

Edited by OpaqueMind, 12 April 2013 - 02:43 PM.

[daouda]

I've had great benefit for my fluoroquinolones-injured brain from CERE. However being chronically poisonned I eventually step back to a worse state than post-CERE after a few weeks or months. I will still do sporadic CERE courses but when most of the FQ will have cleared my system (could be a few years) I plan to try a combination of CERE+hyperbaric Oxygen Therapy (if i can find the funds) to hopefully "fix" my brain for good.

I think (based on the studies I've read) that CERE + HBOT holds great promises for a wide variety of brain insults.

(Also I fully support what OpaqueMind stated above, while on CERE it's very important to provide your brain with stimuli and enforce a positive attitude and good sleep hygiene etc)

[csrpj]

Is CERE good for people with anxiety?

On one hand, I get the impression that it really would be positive. On the other hand, I recently came across a few discouraging posts on reddit:

I've talked to two people who've developed anxiety while using it. I think the "too powerful" comments are based a lot on it's ability to potentiate thought... And negative thoughts to full blown panic attacks.

There really was only one negative effect for me. It brought back my social anxiety. I used to have it in high school and I got over it in time.

Thoughts?

Edited by csrpj, 13 April 2013 - 10:05 AM.

[spookytooth]

I find Cerebrolysin to be slightly anxiolytic. I am also under the impression that stress at university affects me less when on it than usual.

[sunshinefrost]

It supplies the raw materials but you need to supply the stimulation! Along with a regimen of meditation, learning, exercise and healthy eating, it will definately be an ally of yours. The brain grows wherever thoughts direct it, direct it well and realignment is certain.

Well said

[hooter]

Cerebro relieved my anxiety and replaced it with hypomanic overconfidence, so I can't really speak on that note.

[BigGuy1980]

I have found that I like the effects/get better results at 1ml/day rather than 5ml+

I have been studying for board exams, and when I take more that 1ml/day I feel like my brain is working faster than I can handle...

I also take prescribed adderrall with it, so perhaps the effects I have experienced are due to that...

Lastly, make sure you are eating with the cerbro... I notice that it makes me hungry and if I dont eat, I dont think as clearly...

[daouda]

Lastly, make sure you are eating with the cerbro...

Especially carbs, as CERE is known to increase glucose uptake in the brain.

[CatChelator]

First inject tonight, went fine. Into thigh. Only problem: I found it pretty tricky to hold the cere ampule and draw out the solution. I ended up leaving 0.5-1ml in the ampule and only injecting 9 or so mls. Anyone got any tips on how to get the full 10 ml into the syringe? My hands are generally a bit shaky, i banged the needle around on the inside of the ampule a little bit, figure that's ok though.

Thanks.

[CatChelator]

I have previously offended my brain with every class of drug under the sun, and I have definitely found cerebrolysin useful for going some way in rectifying such insults. However, it is not a magic bullet or cure-all... It supplies the raw materials but you need to supply the stimulation! Along with a regimen of meditation, learning, exercise and healthy eating, it will definately be an ally of yours. The brain grows wherever thoughts direct it, direct it well and realignment is certain.

Do you have anything you're passionate about? Do that... Engage in it with your whole being.! Are you curious about life? Get investigating! The brain is like a muscle, it grows with intense use, and atropies with disuse. Most importantly, you must understand that recovery is certain. The body becomes what thought believes. I made the mistake of believing myself irreversibly brain damaged from drug use, and my brain followed suit. If you need reassurance, there are many resources detailing the recovery of properly brain damaged victims. If you don't, fantastic! You're already well on your way to recovery.

Sound advice, cerebro or not. Brain damage (real or perceived) can be a pretty taxing experience. If you can get beyond the anxious stage and get back into living you're more than half way there.

[sunshinefrost]

A new reseach, from april 12th, that demonstrate neurogenesis ;

Improvement in functional recovery with administration of Cerebrolysin after experimental closed head injury.

AuthorsZhang Y, et al. Show all Journal
J Neurosurg. 2013 Apr 12. [Epub ahead of print]

Affiliation
Departments of Neurosurgery and.

Abstract
Object Cerebrolysin is a unique peptide preparation that mimics the action of neurotrophic factors. This study was designed to investigate the effects of acute treatment of experimental closed head injury (CHI) in rats with Cerebrolysin on neurological function. Methods Adult male Wistar rats (n = 60) were subjected to impact acceleration-induced CHI. Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI). To evaluate functional outcome, the modified neurological severity score (mNSS), foot fault, adhesive removal, and Morris water maze (MWM) tests were performed. Animals were killed on Day 14 (n = 20) after injury, and their brains were removed and processed for measurement of neuronal cells, axonal damage, apoptosis, and neuroblasts. The remaining rats (n = 40) were killed 2 days postinjury to evaluate cerebral microvascular patency by fluorescein isothiocyanate (FITC)-dextran perfusion (n = 16) and to emeasure the exp<b></b>ression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) by using real-time reverse transcriptase-polymerase chain reaction (RT-PCR, n = 8) and by immunohistochemical analysis (n = 16). Results At 14 days post-CHI, the Cerebrolysin treatment group exhibited significant improvements in functional outcomes (the adhesive removal, mNSS, foot-fault, and MWM tests), and significantly more neurons and neuroblasts were present in the dentate gyrus (DG) (p < 0.05) compared with the saline-treated group (p < 0.05). At 2 days post-CHI, the Cerebrolysin group exhibited a significantly higher percentage of phosphorylated neurofilament H (pNF-H)-positive staining area in the striatum (p < 0.05), a significant increase in the percentage of FITC-dextran perfused vessels in the brain cortex (p < 0.05), a significant increase in the number of VEGF-positive cells (p < 0.05), and a significant reduction in the MMP-9 staining area (p < 0.05) compared with the saline-treated group. There was no significant difference in mRNA levels of MMP-9 and VEGF in the hippocampus and cortex 48 hours postinjury between Cerebrolysin- and saline-treated rats that sustained CHI. Conclusions Acute Cerebrolysin treatment improves functional recovery in rats after CHI. Cerebrolysin is neuroprotective for CHI (increased neurons in the dentate gyrus and the CA3 regions of the hippocampus and increased neuroblasts in the dentate gyrus) and may preserve axonal integrity in the striatum (significantly increased percentage of pNF-H-positive tissue in the striatum). Reduction of MMP-9 and elevation of VEGF likely contribute to enhancement of vascular patency and integrity as well as neuronal survival induced by Cerebrolysin. These promising results suggest that Cerebrolysin may be a useful treatment in improving the recovery of patients with CHI.

http://www.ncbi.nlm....ubmed/23581594/