2208 replies to this topic

[AwesomeName]

AwesomeName, did you finally try Cerebrolysin for you post benzodiazepine syndrome?

Not yet, trying to get my mercury toxicity and SIBO under control first.

I can't wait though. If it can fix my horrible post-benzo problems then I that will be awesome.

[SLR2009]

Do you think that Cerebolysin will help reverse the brain damage that I got from using inhalants? I'm desperate to get back to myself. Also how does Cerebrolysin compare to PQQ in reversing brain damage?

[formergenius]

Well yesterday was my 5th set of injections. Can't say I notice any benefits alas. I've experienced mild transient headaches and some sleep disturbances this past week. The latter I've been experiencing prior to Cere, yet the former is highly unusual for me. Taking 2 days break, so I'll be starting on Saturday again..
One thing I wonder, and forgive the lack of any scientific thought here, but I was thinking that if one is perpetually stuck in a negative state of mind, wouldn't the newborn neurons merely conform to such perceptions and thoughts? I.E. could it make things worse? Admittedly, that's just a thought born from anxiety. I'm really hoping I'm a late responder of sorts.. enduring this state has become so exhausting. I'm worried Cere might not do much of anything for me, but I'll continue until I run out.

Edited by formergenius, 05 December 2013 - 09:46 PM.

[SLR2009]

Hi formergenius,

What are your symptoms that you were hoping that Cere would repair?

[formergenius]

Hey SLR,
well a lot of things really. I've got HPPD, depersonalization, derealization, anxiety, and pretty severe cognitive deficits, which were all worsened by cocaine I did.. 3 months ago I think. Really regret doing that, because now I've on top of all that depression as well (hopelessness mainly, whereas before I still had hope I could fix this). I thought I would have returned back to baseline by now from that cocaine mistake, but it seems not to be the case. Prior to this I could at least do simple things, like groceries, now I struggle to even get through the day. So that's it in a nutshell. Might it be that the more damage, the longer it takes? I'd thought that those with problems would see the most benefit, as opposed to those seeking for an extra edge.

[SLR2009]

Your issues sound almost identical to mine. I'm sorry that you're going through this.

Life has been hell for me for the last 13 years and the only reason I didn't commit suicide is because I'm strong minded and I want to live and have a life. What also keeps me living is hoping that there will be some cure that will be here soon that will get me back to myself like when I was 14 years old. On the internet when reading what can reverse brain damage it's hard to know what works and what doesn't and I don't have the mental ability to keep trying different things that may or may not work. I've been reading for years that they are very close to reversing brain damage but it's usually vaporware.

My vision is very impaired as though I'm very drunk, I have difficulty movies my eyes, do I have depersonalization?

Anyone use Cerebrolysin at the same time that they go for HBOT?

[Flex]

@ formergenius
Regarding the reversal of cocaine changes( at least some)

I read that acetylcysteine reverses the impairment of glutamte transport.

And methionin (an aminoacid) reverses the hypometylation in the pfc, allbeit huge doses are needed ( 10 grams a day for min. 1 Week) and huge ammounts of b Vitamins are needed to prevent an excess of homocysteine.

Furthermore certain histone deacetylase blocker( afaik group 2) do reverse some epigenetic changes

Please correct me if im wrong

[SLR2009]

formergenius,

Please keep us updated on your progress.

I wish I was starting on Cerebrolysin treatment already but I won't be until I ween myself completely off my anti depressants. It will probably take at least 2 months to get off them.

[fj929]

formergenius,

Please keep us updated on your progress.

I wish I was starting on Cerebrolysin treatment already but I won't be until I ween myself completely off my anti depressants. It will probably take at least 2 months to get off them.

I wouldn't recomended you do this. Getting off of an SSRI can cause a slew of uncomforatble long term symptoms that don't necessisarrily start the day you get off. Your not going to know what is making you sick the ssri wd or cerebro.

[formergenius]

@SLR: Sorry you have to go through this as well. Hope you'll find something that helps.
@Flex: Thanks for the suggestions; I'll keep that in mind.

So today is week 2 day 2 (7th set of injections). Nothing to report alas. I'll keep at it.

[Sholrak]

@SLR: Sorry you have to go through this as well. Hope you'll find something that helps.
@Flex: Thanks for the suggestions; I'll keep that in mind.

So today is week 2 day 2 (7th set of injections). Nothing to report alas. I'll keep at it.

Tell us when you notice something. It's OK take some time to notice it, but you'll end noticing it.

I believe, it's subtleness is what makes it so BIG. Patience.

The more damage or missfunction you have, the more revolutionary it will seem to you.

[Flex]

As far as I understood it. this means that activation of the Hedgehog signal pathway, generates new neurons.
If yes, it would be very interresting.
Or did I missunderstood it( my english is´nt quite well)?


Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke.
http://www.ncbi.nlm....pubmed/23696546

Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.
http://www.ncbi.nlm....pubmed/24013066

Edited by Flex, 09 December 2013 - 12:12 AM.

[SLR2009]

Thanks guys,

I've decided not to go off my anti-depressants but to lessen the dosage.

If I'm going to take 10 ML 5 days a week for 1 month then how many vials do I need to purchase?

I don't plan on doing IM. I won't be doing the IV myself, I will be having someone do it for me, maybe at a hospital.

Should I purchase Cerebrolysin from drugscase or nootropic.eu?

Looking forward to hearing from you.

[Flex]

Since here in germany the customs law doesnt allow to order beyond of EU, I personaly cant tell You which one is better.

This site says its scam
http://www.scamadvis...e.com-safe.html

I´ve ordered once from Superhumangear but failed to inject properly, since then I stored the rest.

And I´ve recently ordered from nootropic.eu, but cant say anything untill arrivement.

[spookytooth]

Since here in germany the customs law doesnt allow to order beyond of EU, I personaly cant tell You which one is better.

This site says its scam
http://www.scamadvis...e.com-safe.html


I´ve ordered once from Superhumangear but failed to inject properly, since then I stored the rest.

And I´ve recently ordered from nootropic.eu, but cant say anything untill arrivement.

Flex, I would advise you to obtain a prescription and order Cerebrolysin from
Austria.

Edited by spookytooth, 09 December 2013 - 06:38 AM.

[Flex]

I would gladly get a perscription.
But the chances are low.

Because I have to go from Doc to Doc, to find one who is willed to perscribe it to me.
It would need several weeks or more.

The docs where i´ve been are very conservative -.-

Do You believe or know that nootropic.eu is not trustworthly ?

Edited by Flex, 09 December 2013 - 02:44 PM.

[Keizo]

I would gladly get a perscription.
But the chances are low.

Because I have to go from Doc to Doc, to find one who is willed to perscribe it to me.
It would need several weeks or more.

The docs where i´ve been are very conservative -.-

Do You believe or know that nootropic.eu is not trustworthly ?

I received mine form there. I haven't died at least. It looks genuine (will take the time to email EVER at least before I order more, soon) and does something extremely positive very much in line with what is described in this thread.

It's not a good money-making scheme to sell truly dangerous preparations for people to inject. Because the price is very low per unit, and people would find out and then no one would want to sell that batch. If there indeed are fake Cere ampules out there that someone went through the effort to create...what makes more sense is saline and colorant, or actual cerebrolysin. I would think that if they are going to put something that does anything in the ampule, they might as well put cerebrolysin in there. Apparently there was some batch of cerebrolysin with a non-existing serial/batch number, and there was nothing wrong with it when authorities or whoever analyzed it. http://www.longecity...120#entry357117

Edited by Nume, 09 December 2013 - 03:29 PM.

[spookytooth]

I would gladly get a perscription.
But the chances are low.

Because I have to go from Doc to Doc, to find one who is willed to perscribe it to me.
It would need several weeks or more.

The docs where i´ve been are very conservative -.-

Do You believe or know that nootropic.eu is not trustworthly ?

I believe they are trustworthy. As a matter of fact my first order of Cerebrolysin came from them. What I meant was that if you have a prescription Cerebrolysin is a little cheaper.

[Flex]

@ Nume, thanks for the interresting link
@ spookytooth, thanks anyway for the tip

[SLR2009]

Thanks guys,

I will buy it from nootropic.eu. What quantity do I need to purchase if I need it for 1 month?

[formergenius]

@SLR:

If I'm going to take 10 ML 5 days a week for 1 month then how many vials do I need to purchase?

10ml x 5 days x 4 weeks = 200ml.
200ml / 10ml = 20 ampules
20 ampules / 5 ampules = 4 boxes.
You'll need 8 boxes if you're getting 5ml ampules, but that would be more expensive I think.

9th set of injections today.. Nothing noticed yet, though one of my legs is getting a bit sore. Maybe cause I tend to shake whilst injecting, which I can imagine damages more muscle tissue. That aside, I was wondering whether someone could elaborate on the differences between MoA's of Cere and NSI-189, and how likely the chance is that should Cere not work for someone, that NSI-189 will?

edit: perhaps that question should best be discussed here though (forgot I made a topic on that...).

Edited by formergenius, 10 December 2013 - 07:49 PM.

[SLR2009]

Hi formergenius,

Thank you very much for the info . Where did you purchase Cerebrolysin from?

Don't give up hope that Cerebrolysin or something else in the near future will help you.

I've heard great things about HBOT (Hyperbaric Oxygen Chamber) in repairing brain injuries. I am considering this as another option. Too bad it's not covered by insurance at the moment.

They've been working on ways to reverse brain damage for years which means I'm hopeful that new treatments will be here soon. My thinking is that if they can reverse the brain damage from people who have Multiple Sclerosis then the same would help us and millions of other people.

I've been researching Dr. Ricardo Heredia’s who is located in Chapala, Mexico and he uses Cerebrolysin to treat people with many neurological disorders. Anyone go there and have the treatment done at his office?

Edited by SLR2009, 10 December 2013 - 08:47 PM.

[formergenius]

Bought mine from nootropic.eu. Nothing to indicate it's illegitimate, though I'd be more confident to say that once it starts working. Good communication too. I'll keep HBOT in mind, but I'm not a fan of going to hospitals. Rather just buy a tank of oxygen and huff away.

Edited by formergenius, 10 December 2013 - 09:10 PM.

[SLR2009]

Anyone purchase from drugscase.net?

[SLR2009]

If I was to drive to Canada what pharmacy's could I get Cerebrolysim from? I need 20, 10 ML Vials, would I need a doctor's prescription?

[formergenius]

So I concluded my trial prematurely (after 2 weeks/100ml) due to discovering that Cere is primarily synaptogenic, whereas NSI-189 is neurogenic. (correct me if I'm wrong) Given that I expect to have NSI in a few weeks, it would make more sense to grow new neurons before adding new synapses. I.E. I'm saving 100ml for after, or (intermittently) during my NSI trial. That, and my legs were getting sore from all the poking.

That said, I have not noticed any benefits whatsoever from Cerebrolysin thus far, and I'm hoping that NSI will exert more substantial effects.
In the meantime I'm trying the Mr. Happy stack with some additions for 2 weeks. In any case, I'll report back here once or if I use Cere again.

P.S. Don't let my experience scare you from trying it. My personal case is also a bit... unique, so chances are it would help others.

Edited by formergenius, 15 December 2013 - 01:18 AM.

[Flex]

@ formergenius
Regarding the reversal of cocaine changes( at least some)

I read that acetylcysteine reverses the impairment of glutamte transport.

And methionin (an aminoacid) reverses the hypometylation in the pfc, allbeit huge doses are needed ( 10 grams a day for min. 1 Week) and huge ammounts of b Vitamins are needed to prevent an excess of homocysteine.

Furthermore certain histone deacetylase blocker( afaik group 2) do reverse some epigenetic changes

Please correct me if im wrong

Altough its Off-topic i just want to complete my post( sry for the long post):

There are several HDAC targets, who interfere with the changes who are induced by Cocaine:

HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner
http://www.ncbi.nlm....pubmed/23297220

Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation.
http://www.ncbi.nlm....pubmed/23475113
Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.
http://www.ncbi.nlm....pubmed/22243750


The HDAC 3 Inhibitors who I could find so far is Amitriptyline (in a Concetration about 15-30 muM)
and Curcumin ( I dont know about its potency)

Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation
...can inhibit the expression of class I HDACs (HDAC1, HDAC3, and HDAC8)...
http://www.ncbi.nlm....pubmed/15842781

The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases
Full Text @:
http://www.google.de....57967247,d.Yms

This is important regarding Amtriplyines safety, because it can be Neurotoxic like some other Tricyclic Antidepressants( e.g. Clomipramine):
http://www.ncbi.nlm....pubmed/21120605
Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity.
http://www.ncbi.nlm....pubmed/19263520

Further Antidepressants and Mood stabilisers who affect mitochondrial function:
http://www.ncbi.nlm....pubmed/20588251
http://www.ncbi.nlm....pubmed/11230808
http://www.ncbi.nlm..../pubmed/2931948

And further Informations about what Up/Down regulates which HDAC:
Neuroprotective Effects of Psychotropic Drugs in Huntington’s Disease
PDF downloadable @:
http://www.google.de....57967247,d.Yms

[lourdaud]

Don't forget sodium butyrate!

[Flex]

Sry forgot it completly.

I´ve searched allready for a HDAC5 Inhibitor and found only Vorinostat (10.000 Dollar for 120 Capsules )

Sodium butyrate is an Inhibitor too, but I dont know the potency:
..Butyrate inhibits most HDAC except class III HDAC and class II HDAC6 and -10..
Inhibition of Histone Deacetylase Activity by Butyrate
http://jn.nutrition....33/7/2485S.full

But the effect seems complicated:

...Effects of NaBut on extinction were more complex, with a low-dose (0.3 g/kg) facilitating extinction and a high dose (1.2 g/kg) weakening extinction..
Inhibition of histone deacetylase activity by butyrate.
http://www.ncbi.nlm....pubmed/12840228

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