2208 replies to this topic

[megatron]

Would it be possible to split a 10 ml vial by taking 5 ml with one syringe and 5 ml with other and leaving the second 5ml syringe in a plastic bag in the fridge over night and injecting it the next day?

That's what I just said.

[FDA Approved]

Would it be possible to split a 10 ml vial by taking 5 ml with one syringe and 5 ml with other and leaving the second 5ml syringe in a plastic bag in the fridge over night and injecting it the next day?

That's what I just said.

Oh yes, I don't know how I've missed your post, thanks.

Anyway I ordered everything, also got myself 3 types of needles (25g 1'', 23g 1.25'', 22g 1.5;''), hopefuly I should receive those stuff and the cerebrolysin by monday so I can start with the start of the week.

[Mr Matsubayashi]

I have found that my ventrogluteal area and legs require less penetration than my dorsogluteal area. Its nice not having to stick the entire needle length in. The method of poking around the injection site for a location with less sensation has been a massive help, thanks Joe Black. I will complete the cambridge science test on my second "off" day this weekend. This is my first week in and I think I am feeling a difference, it's hard to tell because the placebo factor of this medication is huge;

Its Expensive
It needs to be injected
The science shows promise
The anecdotal evidence on this forum shows that its meant to work....... 77% of the time (haha)

Furthermore the guideline is that maximum benefit is achieved when you push yourself hard, maybe I always had this spare capacity in me? Perhaps the biggest test of this drugs effectiveness will be when the cycle ends and I try to maintain the same levels of productivity.

My biggest hurdle in the last few days has been performing the injection, if you get your biggest hurdle out of the way at 7am each morning perhaps that's the recipe for having an awesome day?

In any case, I feel awesome.

[Plasticperson]

deff got flu symptoms during cycle. most noticeably lung congestion.

[sunshinefrost]

I have found that my ventrogluteal area and legs require less penetration than my dorsogluteal area. Its nice not having to stick the entire needle length in. The method of poking around the injection site for a location with less sensation has been a massive help, thanks Joe Black. I will complete the cambridge science test on my second "off" day this weekend. This is my first week in and I think I am feeling a difference, it's hard to tell because the placebo factor of this medication is huge;

Its Expensive
It needs to be injected
The science shows promise
The anecdotal evidence on this forum shows that its meant to work....... 77% of the time (haha)

Furthermore the guideline is that maximum benefit is achieved when you push yourself hard, maybe I always had this spare capacity in me? Perhaps the biggest test of this drugs effectiveness will be when the cycle ends and I try to maintain the same levels of productivity.

My biggest hurdle in the last few days has been performing the injection, if you get your biggest hurdle out of the way at 7am each morning perhaps that's the recipe for having an awesome day?

In any case, I feel awesome.

How many days exactly had it been ? 10?

[megatron]

Does Cerebrolysin increase logical reason and/or creativity?

[zilla1126]

Does Cerebrolysin increase logical reason and/or creativity?

I'm not sure that there have been any studies on this specific aspect. But I've found that cerebrolysin has stimulated my ability to order things from overseas locations and has helped me get over my fear of jamming large gauge needles into my body. So, there's that.

Seriously though, it seems to make whatever you have work better. And the amount of improvement seems to track with how much damage you have to repair.

Edited by zilla1126, 16 January 2013 - 05:43 PM.

[friable vitreous carapace]

4. IM injection seem unecessary to me. Subqutaneous injection into belly fat is now the standard for insulin, peptides and testosterone. I suspect that the IM injection requirement is just an artifact of some medical community effort to protet their own jobs by recommending the default postion that everything must be injected IM. Please comment on what the origin and logic behind the IM injection requirement is for this stuff. Note: I know how to IM inject into the ventrogluteal muscle, I have done is dozens of times, but it is a huge hassle compared to Sub Q injection. Poking holes daily into the same muscle is a health concern IMO.

My thoughts exactly! I have a bunch of cere sitting around here. A couple of months ago I gave it a couple of goes injecting IM but my technique was poor, twice my leg was totally numb for days afterwards. I gave up after 2 ampoules...

I had a look around and found the following info/similar on some dodgy Chinese vendor/trade sites:

Dosage commonly used in adults 10-30mL diluted slow infusion of 60 to 120 minutes in 5% glucose or normal saline 250mL drop finished each course of injections of 10-20 times, depending on the illness. Minor cases or high-dose medication after to maintain the effects, the available intramuscular, subcutaneous or intravenous injection, each 1-5mL, subcutaneous injection of no more than 2mL / time, no more than 5mL / intramuscular, intravenous injection of no more than 10mL / use 10-20 times, after 2-3 times per week can be repeated several treatment until clinical performance no longer improved.

Of course, subQ's bound to be the least efficient injectable ROA - a complete waste of the drug perhaps, even. However, with more reasonably-priced cerebrolysin now becoming available - I'm gonna give it a try...

update: 2ml injected into belly fat using insulin needle - after 30 minutes I seem to be feeling something... a little mental stimulation/arousal. Placebo? Or perhaps cere synergises with some of the other stuff I'm on (gerovital, noopept, piracetam, c60-oo, etc..). Of course, with such combinations, contraindications are perhaps more likely...fingers crossed...

Edited by friable vitreous carapace, 16 January 2013 - 06:51 PM.

[megatron]

Holy shit I can't wait for Cerebrolysin to arrive! Does anybody know how long I can store the ampoules at room temperature?

[CognitionCoefficient]

I remind folks that the Dual N-Back protocol is an easy way to test their gains vis-a-vis working memory (and potentially fluid intelligence). Even unblinded quantitative results under repeatable conditions are valuable, under these circumstances.

The least I would ask of some of you with prior N-Back training is that you post your results post-Cerebrolysin use (i.e. more than one week) with at least one week of dosed DNB data to contrast your results.

Negative / Neutral results are valuable, so do not shy away from posting unremarkable results if that's what you find.

[zilla1126]

I remind folks that the Dual N-Back protocol is an easy way to test their gains vis-a-vis working memory (and potentially fluid intelligence). Even unblinded quantitative results under repeatable conditions are valuable, under these circumstances.

The least I would ask of some of you with prior N-Back training is that you post your results post-Cerebrolysin use (i.e. more than one week) with at least one week of dosed DNB data to contrast your results.

Negative / Neutral results are valuable, so do not shy away from posting unremarkable results if that's what you find.

Someone else (or maybe it was you) mentioned this or other benchmarks to do before and afters with. FYI, I will not be doing them because my mental functioning fluctuates on a daily / hour by hour basis even in the best of times due to the multitude of issues I deal with.

So, this would be of limited use for me (or anyone trying to get something from the results) unless I performed many such tests prior to starting CB - which I did not.

I suspect that the results for most people would perhaps be similarly less than repeatable.

Of course that does not make it any less desirable to know how people do before and after . . .

[megatron]

I remind folks that the Dual N-Back protocol is an easy way to test their gains vis-a-vis working memory (and potentially fluid intelligence). Even unblinded quantitative results under repeatable conditions are valuable, under these circumstances.

The least I would ask of some of you with prior N-Back training is that you post your results post-Cerebrolysin use (i.e. more than one week) with at least one week of dosed DNB data to contrast your results.

Negative / Neutral results are valuable, so do not shy away from posting unremarkable results if that's what you find.

Will definitely do that when my Cerebrolysin arrives next week. It should be easy to see if the DNB pattern is being broken, since I've been doing it for such a long time. Also my progress is currently at a standstill.

[CognitionCoefficient]

I remind folks that the Dual N-Back protocol is an easy way to test their gains vis-a-vis working memory (and potentially fluid intelligence). Even unblinded quantitative results under repeatable conditions are valuable, under these circumstances.

The least I would ask of some of you with prior N-Back training is that you post your results post-Cerebrolysin use (i.e. more than one week) with at least one week of dosed DNB data to contrast your results.

Negative / Neutral results are valuable, so do not shy away from posting unremarkable results if that's what you find.

Will definitely do that when my Cerebrolysin arrives next week. It should be easy to see if the DNB pattern is being broken, since I've been doing it for such a long time. Also my progress is currently at a standstill.

If you've reached your current plateau, it's probably the ideal time to test the effect of Cerebrolysin after a period of adjust (read: one week of dosing before training).

I'm glad to read that you're amenable to this, myself and untold many lurkers will be grateful for your contribution.

Edited by CognitionCoefficient, 16 January 2013 - 07:54 PM.

[CognitionCoefficient]

I remind folks that the Dual N-Back protocol is an easy way to test their gains vis-a-vis working memory (and potentially fluid intelligence). Even unblinded quantitative results under repeatable conditions are valuable, under these circumstances.

The least I would ask of some of you with prior N-Back training is that you post your results post-Cerebrolysin use (i.e. more than one week) with at least one week of dosed DNB data to contrast your results.

Negative / Neutral results are valuable, so do not shy away from posting unremarkable results if that's what you find.

Someone else (or maybe it was you) mentioned this or other benchmarks to do before and afters with. FYI, I will not be doing them because my mental functioning fluctuates on a daily / hour by hour basis even in the best of times due to the multitude of issues I deal with.

So, this would be of limited use for me (or anyone trying to get something from the results) unless I performed many such tests prior to starting CB - which I did not.

I suspect that the results for most people would perhaps be similarly less than repeatable.

Of course that does not make it any less desirable to know how people do before and after . . .

Day-to-day fluctuations are normal, if you've ever wondered if your experience is an outlier, it's not.

In all likelihood, those most eager to benefit from Cerebrolysin have some form of deficit or area of weakness they'd like to improve. Your results may prove more representative for this group, if these fluctuations are larger in magnitude or more frequent.

If you ever change your mind, there are a great many of us who will appreciate your contribution.

[OpaqueMind]

Has anyone here suffered from psychotropic drug induced cognitive decline and if so have you found cerebrolysin effective at reversing it at all? I'm aware of its potential efficacy at treating other types of brain damage and was wondering if the general situation and therefore treatments for one might be translatable to the other. Thanks

[Raza]

I remind folks that the Dual N-Back protocol is an easy way to test their gains vis-a-vis working memory (and potentially fluid intelligence). Even unblinded quantitative results under repeatable conditions are valuable, under these circumstances.

The least I would ask of some of you with prior N-Back training is that you post your results post-Cerebrolysin use (i.e. more than one week) with at least one week of dosed DNB data to contrast your results.

Negative / Neutral results are valuable, so do not shy away from posting unremarkable results if that's what you find.

Considering Cerebrolysin is a neurotrophic, I think it's more likely that practing Dual-N-Back on it causes working memory increases than that it measures improvements that were already available in the background before starting the game.

Which only makes it more important to do these tests, for the user as well as the curious audience.

[megatron]

I remind folks that the Dual N-Back protocol is an easy way to test their gains vis-a-vis working memory (and potentially fluid intelligence). Even unblinded quantitative results under repeatable conditions are valuable, under these circumstances.

The least I would ask of some of you with prior N-Back training is that you post your results post-Cerebrolysin use (i.e. more than one week) with at least one week of dosed DNB data to contrast your results.

Negative / Neutral results are valuable, so do not shy away from posting unremarkable results if that's what you find.

Considering Cerebrolysin is a neurotrophic, I think it's more likely that practing Dual-N-Back on it causes working memory increases than that it measures improvements that were already available in the background before starting the game.

Which only makes it more important to do these tests, for the user as well as the curious audience.

I totally agree. The likeliness of suddenly getting increased working memory is probably little or none. I'm not sure, but to me it sounds like Cerebrolysin only works on things you do. If you are a math fanatic, and start taking Cerebrolysin it's probably more likely you get better at logical thinking, compared to doing very limited math.

[Mr Matsubayashi]

I have found that my ventrogluteal area and legs require less penetration than my dorsogluteal area. Its nice not having to stick the entire needle length in. The method of poking around the injection site for a location with less sensation has been a massive help, thanks Joe Black. I will complete the cambridge science test on my second "off" day this weekend. This is my first week in and I think I am feeling a difference, it's hard to tell because the placebo factor of this medication is huge;

Its Expensive
It needs to be injected
The science shows promise
The anecdotal evidence on this forum shows that its meant to work....... 77% of the time (haha)

Furthermore the guideline is that maximum benefit is achieved when you push yourself hard, maybe I always had this spare capacity in me? Perhaps the biggest test of this drugs effectiveness will be when the cycle ends and I try to maintain the same levels of productivity.

My biggest hurdle in the last few days has been performing the injection, if you get your biggest hurdle out of the way at 7am each morning perhaps that's the recipe for having an awesome day?

In any case, I feel awesome.

How many days exactly had it been ? 10?

Did my 5th 10ml injection this morning, a total of 51ml's has been injected.

[FDA Approved]

What do you cap off the full njection with when you are leaving it in the fridge for later?

Edited by FDA Approved, 17 January 2013 - 01:21 PM.

[Mr Matsubayashi]

Just drug tested myself, came back clean.

[megatron]

What do you cap off the full njection with when you are leaving it in the fridge for later?

Shouldn't it be stored at room temperature?

[JohnD60]

What do you cap off the full njection with when you are leaving it in the fridge for later?

My experience with #25 and #29 needles is that if you pull in a small air bubble they do not leak, have not used cerebrolysin, the viscosity might be different. Don't see any reason why one would use a bigger diameter than #25. One could always tape the needle upside down to a vertical surface.

[friable vitreous carapace]

Holy shit, Cerebrolysin has been around since 1973! Check out this sweet review of the literature:
https://wiseyoung.wo...2009/02/10/271/

Animal studies turned the tide of skepticism. In the early 1980’s, the work of Wenzel, et al. [84] showing changes in neuronal synapses and Windisch & Poiswanger [85] reporting dose-related effects of cerebrolysin on cerebral metabolism suggested that the hydroxylate was doing something to the brain. Cerebrolysin also appeared to affect brain phospholipids [88] and may even have some effects of the immune system [89]. By the 1990’s, several groups reported remarkable effects of cerebrolysin on hippocampal lesions, preventing degeneration and atrophy of cholinergic neurons [91] and amnesia [92, 93], In 1995, Boado [96] showed that cerebrolysin remarkably upregulates the glucose transporter in the blood brain barrier, through a specific mechanism involving stabilization of the GLUT1 mRNA and associated not only with increase in GLUT1 protein but also increased glucose transport across the blood-brain-barrier [100].

Many clinical trials have now reported that cerebrolysin is an effective and safe therapy for many neurological disorders, ranging from stroke to Alzheimer’s disease. The drug’s primary effect seems to be on hippocampal function. Some studies suggest that cerebrolysin may be modestly neuroprotective in stroke and facilitates recovery from stroke. The side effects of the drug seem to be negligible. There are efforts underway to develop an oral version of the drug but the vast majority of the studies involve daily intravenous injections. The apparently broad spectrum of neuroprotective and neuroreparative effects of the drug both in the acute and chronic phases of brain injury suggest that this drug should be useful for both acute and chronic stroke and traumatic brain injury. Several studies suggest that the drug stabilizes excitability of the brain and can reduce hyperkinetic syndromes associated with neuroleptic drugs used for Parkinson’s disease. It may also be useful for preventing progressive deterioration in Parkinson’s disease although no clinical trial has addressed this issue yet.

An impressive array of clinical trials support beneficial effects of cerebrolysin on Alzheimer’s disease, beginning with Ruther, et al. [42] with 120 patients in 1994 and Rainer, et al. [43] with 645 patients in 1997. In 1999, Roshchina, et al. [47], Bae, et al. [48], and Ruther, et al. [50] confirmed these results. The effects of the cerebrolysin are not only statistically but also clinically significant [54]. The cerebrolysin responder rate on global clinical impression scale was 64.5% compared to 41.4% in placebo treated patients [52]. Several clinical trials also showed a clear dose-response [58] and several animal studies [6] are suggesting that the active ingredient is in the peptide fraction and not the amino acid fraction of cerebrolysin. People with genetic causes of the disease appear to be more responsive to cerebrolysin [56]. More interesting, the drug effects appear to last many months or even years after treatment has stopped [52, 53, 55]. This long-lasting effects suggest that cerebrolysin is not merely improving the balance of neurotransmitters or increasing the excitability of neurons, although EEG studies suggest that changes of excitability do occur with cerebrolysin treatment. Thus, it seems that cerebrolysin may be stimulating repair or perhaps even neuronal replacement in the brain. One interesting possibility is the cerebrolysin may be stimulating stem cells in the brain and repair processes that we do not understand.

Some clinical evidence suggest that cerebrolysin may be beneficial for other neurological conditions, including extrapyramidal hyperkinesis associated with neuroleptic therapy [38-40], with acute [65, 66] and chronic [28, 30, 31] stroke, diabetic neuropathy [67], Rett syndrome [71], vascular dementia [72], brain trauma [73, 74], organic mental disorders [77], multiple sclerosis [78], anti-aging [79], ischemic encephalopathy [80], and other neurodegenerative disorders [75, 76], Little data is available concerning the effect of the drug on spinal cord injury. Only one recent study is available regarding cerebrolysin therapy of a rat spinal cord compression model and it suggests a modest effect of the drug compared to another antioxidant. More studies are needed to ascertain the benefits of cerebrolysin for both acute and chronic spinal cord injury.

I apologise in case the above is a repost. It's been a while since I read the earlier pages in this thread.

I'm becoming pretty sure it is active via subQ administration - I dosed at teatime yesterday, slept for an hour and a half only last night, after staying awake all night studying the previous night. By rights I should be completely shattered by now - I feel fine. Slight flu-like symptoms, certainly an aching chest. I'm a heavy smoker, and today, the cigarettes seemed to feel harsher on my lungs than usual. Some transitory immunogenic response, perhaps.

Edited by friable vitreous carapace, 17 January 2013 - 11:01 PM.

[Xenix]

Can someone please provide instructions and a list of equipment required for IV injection? I can only seem to find directions and advice for IM injection. My CRB arrived today and I would very much prefer to use it in the most effective way as it is very expensive. I understand it is a more risky route but I am in a pretty desperate position. Thanks.

[figure9]

For those that find a 3 inch 18 gauge needle intimidating, I would like to point out that, depending on the viscosity of the preparation (water vs oil base), a much thinner 1/2 insulin syringe can reach muscle tissue in areas where the dermal layers are thin (deltoid, biceps, triceps, pecs, etc) with minimal discomfort.

Note: This is just anecdotal, and is not to be misconstrued as medical advice. Please conduct research responsibly.

That being said, this is a very interesting compound. I'd be interested to see how it compares to Selank.

Edited by figure9, 20 January 2013 - 04:47 AM.

[Kimo]

For those that find a 3 inch 18 gauge needle intimidating, I would like to point out that, depending on the viscosity of the preparation (water vs oil base), a much thinner 1/2 insulin syringe can reach muscle tissue in areas where the dermal layers are thin (deltoid, biceps, triceps, pecs, etc) with minimal discomfort.

Note: This is just anecdotal, and is not to be misconstrued as medical advice. Please conduct research responsibly.

That being said, this is a very interesting compound. I'd be interested to see how it compares to Selank.

18 gadge for a IM injection is a harpoon and would be excessive short of someone with leather hide like skin and a 3 inch needle would only be approreate in the morbidly obbese. Insulin syringes are far too fragle and risk the chance of breaking off in your which would leave you in world of hurt, 25 gadge is the absolute smallest period for IM injections

[figure9]

For those that find a 3 inch 18 gauge needle intimidating, I would like to point out that, depending on the viscosity of the preparation (water vs oil base), a much thinner 1/2 insulin syringe can reach muscle tissue in areas where the dermal layers are thin (deltoid, biceps, triceps, pecs, etc) with minimal discomfort.

Note: This is just anecdotal, and is not to be misconstrued as medical advice. Please conduct research responsibly.

That being said, this is a very interesting compound. I'd be interested to see how it compares to Selank.

18 gadge for a IM injection is a harpoon and would be excessive short of someone with leather hide like skin and a 3 inch needle would only be approreate in the morbidly obbese. Insulin syringes are far too fragle and risk the chance of breaking off in your which would leave you in world of hurt, 25 gadge is the absolute smallest period for IM injections

Fair enough, but IMHO, I could only see a huge risk in using a 27 or even 29 gauge insulin pin on those with body-builder body types or unusually high muscle density.

18g 2.5-3in pins aren't uncommon for injecting a week's worth of "playgoodbaseballosterone" into the glutes.

[stablemind]

Any updates from those currently on a cycle? I check this thread everyday and I'm planning on seeing a doctor in Taiwan to get a Cerebrolysin script.

[JohnD60]

I'm becoming pretty sure it is active via subQ administration - I dosed at teatime yesterday, slept for an hour and a half only last night, after staying awake all night studying the previous night. By rights I should be completely shattered by now - I feel fine. Slight flu-like symptoms, certainly an aching chest. I'm a heavy smoker, and today, the cigarettes seemed to feel harsher on my lungs than usual. Some transitory immunogenic response, perhaps.

Are you saying that you are currently injecting Cerebrolysin subQ, and that you are experiencing the expected positive effects? If I buy this I am only going to inject subQ, I will not inject 5+ml IM daily.

[friable vitreous carapace]

I'm becoming pretty sure it is active via subQ administration - I dosed at teatime yesterday, slept for an hour and a half only last night, after staying awake all night studying the previous night. By rights I should be completely shattered by now - I feel fine. Slight flu-like symptoms, certainly an aching chest. I'm a heavy smoker, and today, the cigarettes seemed to feel harsher on my lungs than usual. Some transitory immunogenic response, perhaps.

Are you saying that you are currently injecting Cerebrolysin subQ, and that you are experiencing the expected positive effects? If I buy this I am only going to inject subQ, I will not inject 5+ml IM daily.

Well, yes - in that I’m on my third day of dosing 2ml subQ, and I plan to continue this for the next month..

In all honesty, it’s difficult to say if I’m really feeling the expected positive effects at the moment, but since I’m not suffering from any acute brain trauma or under heavy stress, the effects were expected to be rather subtle, at least at first.

All I can say for certain is that I have been functioning very well on very little sleep for the past few days - which is a new feeling for me - and I *think* I might be experiencing an improvement in mental clarity. A strange thing I noticed yesterday - when reading, I seem to be finding myself unconsciously trying to work out the meanings of technical/scientific words from their Greek/Latin roots, rather than looking them up.

I’ve had issues with my memory, attention span, syntactic and lexical processing, etc. for a couple of years now, following an extended period as a functional alcoholic, with periods of multi-gram binges on neurotoxic stimulants such as 4-MMC. I’m at college at the moment, studying a fairly intensive course, and racetams have helped greatly with my studies, but only for the duration of their effects. (i.e. when they wear off, I’m back to my usual drug-addled self). I’m hopeful that following this course of Cerebrolysin will enable me to work & think clearly *without* the help of piracetam+choline+caffeine, etc.

At the moment I am still finding it very difficult to grasp new concepts at school and my motivation to study/revise hasn’t been affected at all. I’ll update if I notice any changes to my mental state/the quality of my school work...