38 replies to this topic

[athrahasis]

I wasn't referring to the mushrooms but Baker's Yeast extract of 1,3/1,6. the baker's yeast derived molecule outweighs the mushroom extract based on the jana study

Interesting. Are there any longitudinal studies on use as well that you know of.?.. Epicor seems to be pretty safe generally from my cursory look a year back. Bakers yeast of course has been consumed for a long time, but this is pretty concentrated even if GRAS. The other potential factor is how the body adjusts to it typically. Does it, for example need to be cycled in order to remain effective like an adaptogen?

I am not entirely sure about oregano oil's interaction and contraindications other than its potential anti-hypertensive effects. I did a search on oregano oil and warfarin/blood thinners awhile back and but nothing turned up.

My mom made the decision to experiment since her condition is both chronic and at times very daunting... in terms of getting effective antibiotics. The lack of a cohesive medical strategy when it comes to auto-immune conditions, esp organ killing ones like systemic Lupus is primarily our issue. It's been a bloody seesaw of upping steroids to dampen immune response (along with blood thinner to mitigate the associated vasculitis) then pick up infection then take antibiotics and lower steroids and then back again. Everytime a little harder. She's relatively young, just making 60, so it's been barely ok. As she ages this will, I assume become more difficult, aside from the proliferating super bugs. That said, it's been a battle to try anything with the medical oversight being ok with non medical approaches. My mom still listens to her doctors, esp specialists. They are very hesitant to let her try anything that may affect INR. But non of them will do the homework to tell us why it's dangerous.

Edited by athrahasis, 10 January 2010 - 12:05 AM.

[sentrysnipe]

I wasn't referring to the mushrooms but Baker's Yeast extract of 1,3/1,6. the baker's yeast derived molecule outweighs the mushroom extract based on the jana study

Interesting. Are there any longitudinal studies on use as well that you know of.?.. Epicor seems to be pretty safe generally from my cursory look a year back. Bakers yeast of course has been consumed for a long time, but this is pretty concentrated even if GRAS. The other potential factor is how the body adjusts to it typically. Does it, for example need to be cycled in order to remain effective like an adaptogen?

I am not entirely sure about oregano oil's interaction and contraindications other than its potential anti-hypertensive effects. I did a search on oregano oil and warfarin/blood thinners awhile back and but nothing turned up.

My mom made the decision to experiment since her condition is both chronic and at times very daunting... in terms of getting effective antibiotics. The lack of a cohesive medical strategy when it comes to auto-immune conditions, esp organ killing ones like systemic Lupus is primarily our issue. It's been a bloody seesaw of upping steroids to dampen immune response (along with blood thinner to mitigate the associated vasculitis) then pick up infection then take antibiotics and lower steroids and then back again. Everytime a little harder. She's relatively young, just making 60, so it's been barely ok. As she ages this will, I assume become more difficult, aside from the proliferating super bugs. That said, it's been a battle to try anything with the medical oversight being ok with non medical approaches. My mom still listens to her doctors, esp specialists. They are very hesitant to let her try anything that may affect INR. But non of them will do the homework to tell us why it's dangerous.

Re: Glucan, Glucan, "Bakers Yeast extract from Saccharomyces cerevisiae" is GRAS 21CFR170.30 http://www.accessdat...ces/802459A.PDF http://www.lifesourc...ucts.safety.cfm . It was used in treating Anthrax both prophylactically (pre-infection as preventive measure) and clinically: http://www.ana-jana....s/JANAVol52.pdf. The concentrated glucan itself is a complex carb / polysaccharide, similar to Metamucil/psyllium and Oats, which consequently has hypocholesterimic effects and delays glucose uptake. this has been used in Japan for a long time now esp. as an adjuvant supp to cancer treatment. It does not require cycling but it needs to be taken for a long time. The glucans attach to the complement receptors on the neutrophils' cell membranes at around Day 5 (Wellmune is the commercial brand of Glucan by Biothera. Based on my research, Transfer Point's Glucan-300 also uses Biothera's raw materials since their apparent triumphant lawsuit against other companies using a similar method of extraction):



Day 1 - glucans are ingested by the intestinal macrophages, Day 3 - glucans in spleen macrophages broken down to smaller fragments, Day 5 - the glucans are attached to the neutrophils priming them for chemotaxis and other antibody activities.


Yeast beta-Glucan Amplifies Phagocyte Killing of iC3b-Opsonized Tumor Cells via Complement Receptor 3-Syk-Phosphatidylinositol 3-Kinase Pathway
http://www.jimmunol..../177/3/1661.pdf

http://www.jimmunol....ull/177/12/8667
β-Glucan Is a Fungal Determinant for Adhesion-Dependent Human Neutrophil Functions



The first clip shows a visual MoA and the second features Paul Clayton who was Senior Scientific Advisor to the UK Committee on the Safety of Medicines

You may want to take time reading the links I included in my previous post, along with the Biothera and Wellmune websites.

Oregano oil is widely used in the Middle East and Israel, iirc. The one research I read was from an Israeli MD I think.

[athrahasis]

sentrysnipe,

Fanstastic write up, I really appreciate it.

I'll read though the attached studies this week. So the Epicor may have been a bad choice then, but the general idea is solid. The ability to attack something like anthrax is pretty impressive, prima facie. I wonder if a B-G cannot ultimately be modified to targeted antibiotic level [short term] efficacy. Maybe with a little genetic engineering? Also, is the jury in whether it is best against aerobic or anaerobic strains? I forget whether Anthrax is aerobic, probably right?

I'll do some testing with the Oragano oil and my own INR. It's not going to be comparable to my Mothers values but I will do it on a fasting day and see what it does for a couple of days and then we may introduce it as well.

BTW, what are your thoughts if any on the use of pre/pro biotics aside from replenishing antibiotic damaged gut bacteria. In terms of disrupting bacteria communication systemically?

I was really taken aback by Bonnie Bassler talk on TED that I linked someplace. The consequences are massive, if communications of attacking bacteria can be even somewhatdisrupted with friendly probiotics at high loading. If we can theoretically assess the actual molecules used in the general channel, and have a simple gut bacteria broadcast that widely- I wonder how much disease can be routinely avoided...

[Matt]

Im looking for a reliable brand of Beta glucan to buy, I used to get AOR but they discontinued their maitake D supplement :-( And for a reasonable price! (in the UK).

[athrahasis]

Matt,

Per sentrysnope, something like this?

[sentrysnipe]

Well good news. I found a cost-effective (very) yeast glucan.

BulkActives sells 70% 1,3/1,6 yeast glucan for 30,000mg for 10$

http://www.bulkactiv.../betaglucan.htm
http://www.bulkactiv...etaglucan70.pdf

"DISCLAIMER: Products sold by BulkActives are not intended to be used as nutritional supplements."

However, it was discussed in his forum and he made mention that the products they sell are nutritional grade:

We buy our actives from manufacturers and when they are shipped out they are nutritional grade. In fact, our manufacturers supply mainly to companies who make nutritional supplements.
However, once the products arrive at our business they become technical grade, because we do not operate from a FDA approved, sterile, food grade facility.
This does not mean we are not hygienic, the opposite in fact. We are extremely careful when handling and packing the bags (masks, gloves, coats, alcohol etc.). However, we still sell them as technical grade only.

Either have her mix it with water and her favorite cream, apply it topically and use a dermaroller for an effective transdermal administration to the bloodstream; or take it orally.

Matt,

Per sentrysnope, something like this?

Yep. Get the 500mg. Give your mom a single dose of 1000-1500mg first thing in the morning, empty stomach 30 mins before first meal. That brand is Biothera's. The "WGP" label is registered to have at least 75% 1,3/1,6 glucans.

Edited by sentrysnipe, 18 January 2010 - 03:14 AM.

[kurdishfella]

its good be be ready with vitamins etc so your immune system is strong in case of covid infection (or anything at all longevity etc)  so there the least amount of damage when it leaves or nothing at all and ofc higher likelyhood so that you survive. some stress is good for immune system but not deficiencies. 

Edited by kurdishfella, 07 February 2021 - 12:34 AM.

[kurdishfella]

We have infections etc in our body at all times just that its so small that it doesnt affect you until it breaks out bigger when your unhealthy or somth

[kurdishfella]

Don't inject in the same place you are infected otherwise you might lose a lot of the substance before it gets absorbed.