14 replies to this topic

[Thorsten3]

Does anyone have any experience taking this amino acid?
I'm not interested in taking DPLA or L-Phenylalanine as I have come to the conclusion that my Dopamine/Serotonin balance isn't something to be messed with. I get plenty of protein in my diet and if anything need to eat more food rich in tryptophan to probably balance this up more as I am always feeling like my mind is buzzing/racing. I also think I have too much norepinephrine after reading about some of the side effects on the internet that can be attributed to this.
I took DPLA for patches recently, more in a experimental sense really but really enjoyed the antidepressant qualities it gave. I have tried L-Phenylalanine in comparison and it's obviously a different effect. I'm more interested in the pure form of D-Phenylalanine really due to its effect in blocking enkephalinase in the brain. This would I gather increase endorphin levels in the brain but I'm just wondering the impact this would have. Like everything in life I suppose the initial high would wear off after prolonged use and you would soon get used to the effects? Would this in future effect the production of endorphins in the brain? I suppose Deprenyl has a similar effect really hence I was quite close to purchasing some but then decided not to as one thing I don't want to screw around with is my dopamine. I've read articles about how it lowerss dopamine production due to all that lovely free dopamine floating around which obviously is worrying if you become immune to the beneficial effects. Certainly is a worry long term. Could this concept be aplied to D-Phenylalanine? It inhibits enkephalinase so would this effect endorphin production? What impact would this have?
Anyway this is just a general question really. I'm a bit confused as there doesn't appear to be any threads on D-Phenylalanine which I would of thought would have interested people as it involves the most heavenly feeling neurotransmitters known to the human race I would have thought?

[Chaos Theory]

Could you be more specific about what exactly you were worried about with Deprenyl use? I'm just curious if there is some info out there showing specific hazards of using it intermittently.

[Thorsten3]

I don't really know anything hazardous of using deprenyl intermittently no. I don't have any experience taking it at all so wouldn't be the best person to ask really for any personal experiences with this. I've just read on various threads where people who have taken it for a period of time (usually daily) and thought it was amazing (which it probably is for a while), then the effects tapered off which I'm guessing happens because your brain realizes it has too much dopamine and this results in down regulating its dopamine production. So this would tie in with all the personal experiences I have read on here where people take it for a while and think its great, the effects lessen, even out, diminish and then they end up feeling worse than before.
So I suppose anything that effects the production of dopamine in a negative way is not a good thing generally. I think there are lots of threads on here about this. Using very intermitently for nootropic purposes would be fine though I would think. Depends on how much you take and how often. Me personally at 27 would probably take 1ml twice weekly maximum. But then would I feel any benefits to even bother? I suppose if you had real low dopamine this could make an impact to your life. Hence the reason I have decided not to purchase deprenyl as I don't think I need it really.

[Chaos Theory]

1mg once to twice weekly is about what I take. I'm also using bupropion at the moment. I can definitely feel 1mg, and I could even before the bupropion. Taken for a few consecutive days it leaves me feeling a bit manic. Seems like it leaves me a bit unstable really, I've been trying to avoid it but some days when I'm feeling a bit low I still take it.

[4eva]

I used DLPA and D-PA over tyrosine because of a problem with endorphins and enkalphalins.

But you don't mention a problem with pain. Tyrosine would cause me to experience pain or muscle tension in my neck and shoulders. That is what endorphins and enkalphalins do for me - help with pain issues.

If your objective is to treat depression or increase catecholamines then I don't think you need to pay more money for D-PA. (Pure D-PA can be more expensive and not as widely available as DLPA or tyrosine.)

You will need other nutrients to get the benefits of amino acids. B6 and some other B vitamins are important, besides some other things. Sufficient copper is also needed for dopamine.

I think high NE may be about an over active sympathetic nervous system. Everyone can be dominant in either sympathetic (SNS) or parasympathetic (PNS) nervous system; but some nutrients, if in excess, can make that imbalance worse.

High copper can cause high calcium. Calcium for one thing stimulates the SNS. Zinc and copper are not always properly balanced in most people.

To take these nutrients and hope for success you would need to have different lab tests done from time to time.

[Thorsten3]

Many years on...

It's always amusing reading your old posts when the world seemed so simple (i.e, if I increase dopamine...blah..blah, lol), but I've recently become interested in D-Phenylalanine again. I never got around to buying any, 4 years back. I have been taking DL-Phenylalnine again, on and off, and have noticed how amazing it is for helping me with pain. I go to the gym three times a week and I am usually completely fucked after a session. Pain will indeed be present. But now, on DL Phenylalanine, I am pain free - despite the intensity that I work at. Pretty impressive! I've tried many anti-inflammatory compounds to try and treat the issue of pain with joints, etc, and have been left dissapointed again and again. Even high strength Curcumin was a dissapointment. An SSRI (all of which are highly anti-inflammatory - look on pubmed), is the only compound that has ever treated the symptons of this issue, for me. But of course, SSRIs suck ass (even in low dosages), so I won't be taking them for anything (I prefer a life, thanks).

With DLPA, I know tolerance builds to the mood enhancing effects of the dopaminergic side of it, but I wonder if D-Phenylalanine can be taken more frequently?

Anyone use it?

Edited by Thorsten2, 03 February 2013 - 04:43 PM.

[panhedonic]

I'm also very interested in the effects of DLPA, specially in combination with Selegiline, of which I take 5mg a day.

[Gorthaur]

I've been using D-Phenylalanine for two weeks now in doses of 1-2 g per day. It's actually very effective at blocking pain - it's roughly as strong as 400 mg of ibuprofen, except it lasts all day or more. I bought it hoping for a mood increase, but it's not very effective in that regard. I have yet to try going for a jog, though - perhaps it'll produce a great runner's high? I can definitely see it being helpful for chronic pain.

I've also used DLPA in conjunction with selegiline with horrible results. I started out with 1 mg sublingual selegiline and 50 mg (yes, just 50 mg) of DLPA and developed an excruciating headache for several hours, presumably from high blood pressure. This combo has a very small margin for error. I've seen recommendations that it's best to start with 10 mg of DLPA or PEA and work up from there.

[Thorsten3]

I only take DLPA on gym days (three days a week).

I tried D-Phen and didn't notice much. I'll have to do some more experimenting with it. Perhaps the dopaminergic side to DLPA plays a role in its pain killing effects. Or perhaps i need to try D-Phen more to actually gauge whether it has efficacy.

[Thorsten3]

I've been using D-Phenylalanine for two weeks now in doses of 1-2 g per day. It's actually very effective at blocking pain - it's roughly as strong as 400 mg of ibuprofen, except it lasts all day or more. I bought it hoping for a mood increase, but it's not very effective in that regard. I have yet to try going for a jog, though - perhaps it'll produce a great runner's high? I can definitely see it being helpful for chronic pain.

I've also used DLPA in conjunction with selegiline with horrible results. I started out with 1 mg sublingual selegiline and 50 mg (yes, just 50 mg) of DLPA and developed an excruciating headache for several hours, presumably from high blood pressure. This combo has a very small margin for error. I've seen recommendations that it's best to start with 10 mg of DLPA or PEA and work up from there.

Interesting. Please feel free to keep me posted on whether you notice any tolerance developing to the effects of D-Phen. I wonder if the beneficial effects would just persist for you?

I have stopped taking both DLPA and D-Phen at the moment as I am just taking a complete break from supplements for a while (although still plugging DLPA three times a week for my gym sessions with continuing success).

So far, I have only tried D-Phen the once, and like yourself, didn't notice any psychoactive effects. The dopaminergic side to DLPA appears to be mostly responsible for the potent mood boost I get, although I have only tried D-Phen once as I say. But then, DLPA defintely feels much different to tyrosine or L-Phenylalanine, to me. So the endorphin aspect of it plays a part for sure.

When I do take DLPA, by the way, I crush the tablet in my mouth until it becomes a paste, then leave it in there swirling around (especially under my tongue). I find the sublingual method to work for DLPA as there is definitely faster onset. It would be the first thing I do when I wake up in the morning. Leave it in there for 20mins, then swallow. I notice the effects within 20mins, which then persist for the rest of the day. DLPA is slightly anxiogenic, though. That appears to be the only drawback. But it isn't anything disabling and can be offset by taking 5HTP along with it.

Edited by Thorsten2, 18 February 2013 - 09:56 AM.

[Thorsten3]

double post

Edited by Thorsten2, 18 February 2013 - 09:56 AM.

[Ultravioletbllc]

I'm about too start a month trial of d-pa 250-500 mgs daily for thirty days (I'm also taking a pretty complex stack that includes deprenyl and (-)-BPAP ) I'm really excited about the potential for opioid like mood and motivational effects can be induced with the Mao inhibition from deprenyl The catecholamine activity enhancement of bpap and the Pro monoamine transporter modulation effects of Luteolin , will report back , btw in the meantime I'll continue on with DLPA at 500 mgs daily n deprenyl in split doses w/o deprenyl I take it TID at a dose of roughly 1.5 grams I also have PTSD and suffer from anxiety and attacks however DLPA and dopaminergics in general do not induce anxiousness in myself

[panhedonic]

Where do you buy your luteolin and BPAP? I take Selegiline and DLPA, I'm interested in understanding and maybe following your stack.

[Ultravioletbllc]

The bpap is complicated but as for the luteolin the same seller has two quantities in bulk right now on e-bay

[eon]

is euphoria directly linked to having confidence?

 

I could use more confidence level to a point where ANYTHING life throws at me (negatives) means almost nothing. Right now I have a lot going on. I'm going back to school, going to work, and trying to keep a social life as well but it's usually the social part where you have to deal with shitty people who try to bring me down, either intentional or not (could be how I "took it" as well). But at the end of the day, there are those types of people who just can't be happy for me. I need something that will not bring me down emotionally due to what people said as this ruins my day. I want to be bulletproof to say the least. 

 

I am on an amphetamine called Vyvanse at 50 mg. I think I may need to up it to 70 mg (max dose) or perhaps switch to Desoxyn (meth). I just need that confidence level at high levels, not to a point of becoming overconfident/egotistical/delusional/etc.  Just something that shuts off the background noise (people that want to disappoint me for being focus on my self and or trying to sabotage my attempt at achieving something they could only dream of, academically, socially, etc.)

 

I do feel confident on Vyvanse but I think it fizzles in and out. Also, I think people notice my confidence level to a point that it becomes envied IMO that sometimes people want to see you down (in my mind) due to my confidence level. I guess what I'm looking for is something that does not break my spirits no matter what people think or say about me. I guess what I'm looking for is that endorphins that I read about regarding D-phenylalanine? The dopamine and norepinephrine that Vyvanse releases is great for confidence, but I think my problem here is that it goes in and out and not as stable. I would assume something that induces euphoria like D-phenylalanine would be a great addition? I know L-phenylalanine is more of an appetite suppressant and I'm assuming DLPA is both a euphoriant and an appetite suppressant.

Edited by eon, 05 July 2015 - 09:12 AM.