69 replies to this topic

[rwac]

I've been using Meth blue again but this time without the Ubiquinol and it's working great again! Somehow, these two together interfere ...

Question for you. How long after you stopped the ubiquinol did the MB start working again ?
I'm wondering whether CoQ10 interferes with MB within the mitochondria, or while being transported to the mitochondria.

I hope the DEA isn't monitoring us...

You could always use your super-navigator powers to edit it and replace it with "MB", make it less ...troublesome.

Edited by rwac, 08 August 2009 - 05:08 AM.

[AgeVivo]

(a quick google did only show E133 and E131 as color additives for curacao).

Yup, I don't think Methylene blue is even an allowed food-dye.

a) Methylene blue is sold in Belgium pharmacies.

b) googling for "methylene blue curacao" (in English) leads to quite few pages revealing the information, either in forum discussions or google's cache but not in the new version of the web pages. I imagine that methylene blue is not used anymore and that the blue-curacao selling companies asked to correct the information, smthg like that.
If you google "methylene bleu curacao" (in Fench) you will see that pages written in French still say it:

example1: http://www.plaisirdo....php?recordID=5
"tout le monde connaît le Cointreau ou le Grand Marnier. La couleur bleue est obtenue en ajoutant à ce mélange d'oranges, d'eau-de-vie et de sucre du bleu de méthylène."
(translation: everyone knows Cointreau or Grand Marnier. The blue color is obtained by adding methylene blue to this mix of oranges, brandy and sugar)

example2: http://fr.wikipedia....eu_de_méthylène
"Le bleu de méthylène (...) est utilisé pour colorer le Curaçao et certaines variétés de Gin."
(methylene blue is used to color curacao and some sorts of gin)

Edited by AgeVivo, 08 August 2009 - 07:55 AM.

[Lufega]

I've been using Meth blue again but this time without the Ubiquinol and it's working great again! Somehow, these two together interfere ...

Question for you. How long after you stopped the ubiquinol did the MB start working again ?
I'm wondering whether CoQ10 interferes with MB within the mitochondria, or while being transported to the mitochondria.

I hope the DEA isn't monitoring us...

You could always use your super-navigator powers to edit it and replace it with "MB", make it less ...troublesome.

I say it took a couple weeks. I just noticed it this as I was doing some last minute cramming for exams.

[rwac]

a) Methylene blue is sold in Belgium pharmacies.

b) googling for "methylene blue curacao" (in English) leads to quite few pages revealing the information, either in forum discussions or google's cache but not in the new version of the web pages. I imagine that methylene blue is not used anymore and that the blue-curacao selling companies asked to correct the information, smthg like that.
If you google "methylene bleu curacao" (in Fench) you will see that pages written in French still say it:

example1: http://www.plaisirdo....php?recordID=5
"tout le monde connaît le Cointreau ou le Grand Marnier. La couleur bleue est obtenue en ajoutant à ce mélange d'oranges, d'eau-de-vie et de sucre du bleu de méthylène."
(translation: everyone knows Cointreau or Grand Marnier. The blue color is obtained by adding methylene blue to this mix of oranges, brandy and sugar)

example2: http://fr.wikipedia....eu_de_méthylène
"Le bleu de méthylène (...) est utilisé pour colorer le Curaçao et certaines variétés de Gin."
(methylene blue is used to color curacao and some sorts of gin)

In that case, I think you would get less easily drunk on curaçao and have less of a hangover than most alcohol.
Excess NADH is produced by metabolizing alcohol, and MB will increase NAD+/NADH ratio.

[AgeVivo]

Test whether methylene blue prevents you from getting drunk...

[rwac]

Test whether methylene blue prevents you from getting drunk...

A good friend of mine was in town recently. I was taking MB at the time.
I managed to drink twice as much as I normally drink, and I was still ok after.
(6 drinks, but I'm a lightweight)

Of course, the other possibility is that me and my liver are in better shape than the last time I drank alcohol, which is probably also true.

Disclaimer: Highly Anecdotal.

Edited by rwac, 08 August 2009 - 03:40 PM.

[rwac]

Hmm, anyone here used Idebenone?

How does the effect compare to MB ?

[GoodFellas]

What's the side effects (both long term and short term) from taking MB?

[rwac]

What's the side effects (both long term and short term) from taking MB?

MB is used therapeutically at much higher doses (1000 times what we're using = a few 10s of mg), without significant side effects.
At higher concentrations, MB is pro-oxidant, as well as being a MAOI, potentially suppresses insulin release, etc.

However, these concentrations are unlikely to be reached at the mcg doses we're using.

I would expect potential short term side effects to be similar to idebenone, perhaps.
Long term side effects ? Probably none, but we don't know.

The following link should have the side effects of the therapeutic dosages.
http://www.drugs.com...ylene-blue.html

Edited by rwac, 08 August 2009 - 06:23 PM.

[nameless]

For those using this, have you considered going with the prescription version instead? No concerns about contamination using a medication meant for fish/aquariums?

Some of the reactions mentioned do sound somewhat placebo-like (and please don't be offended by that). I consider a placebo reaction a possibly valid benefit even if that is the case.

I also remember Rwac and Lufega commenting on maybe having Lyme/tick/viral diseases in various threads here. Perhaps it is having some positive benefits with killing bacteria or viruses?

[100YearsToGo]

When I hear Angina, I think chest pain. I guess that's not what you're talking about.

oh wrong word, i meant sore throat, or tonsillitis
I hope there is still an old bottle at my parent's place, if so when i go there in a few weeks i'll give the references (and pictures). It was not concentrated enough to have blue pee.

Btw i know that blue curacao (alcoholic drink) also contains methylene blue. i don't think that at small doses it makes impressive effects

Hey man. Incredible. I live on Curacao (the caribbean) and you told me something I didn't know! Going to buy me a bottle!

Edited by 100YearsToGo, 08 August 2009 - 07:03 PM.

[rwac]

For those using this, have you considered going with the prescription version instead? No concerns about contamination using a medication meant for fish/aquariums?

Some of the reactions mentioned do sound somewhat placebo-like (and please don't be offended by that). I consider a placebo reaction a possibly valid benefit even if that is the case.

I also remember Rwac and Lufega commenting on maybe having Lyme/tick/viral diseases in various threads here. Perhaps it is having some positive benefits with killing bacteria or viruses?

The problem is that we're talking about dosages of a few mcg. The prescription version uses dosages of a few 10s of mg (30, 60 mg).

A. MB is antimicrobial, so unlikely to be any contamination in the bottle.
B. MB is meant for fish which are quite sensitive to contaminants, so it's probably good.
Additionally we're diluting it with water, so contaminants will be diluted too.

[rwac]

Hey man. Incredible. I live on Curacao (the caribbean) and you told me something I didn't know! Going to buy me a bottle!

Read the rest of the thread. Curacao may no longer use MB as a dye.

[100YearsToGo]

Hey man. Incredible. I live on Curacao (the caribbean) and you told me something I didn't know! Going to buy me a bottle!

Read the rest of the thread. Curacao may no longer use MB as a dye.

Well yes trying to find out if it is really the case. Not a lot of references. Can always call the factory. Its 10 blocks away. And yes I know it has to be diluted isn certain rang to be effective. Nevertheless it would be nice to know if it contains MB.

[GoodFellas]

Should a 20 year old use it?

Also, what's really the disadvantages with using it?

[AgeVivo]

Should a 20 year old use it?

Also, what's really the disadvantages with using it?

for now, there is no particular proved reason to use methylene blue in normal conditions

but it was showed to improve human skin cell-lifespan, probably by enhancing mitochondrial respiration, and there are arguments towards life extension in mice.

we are searching for a few more volonteers to have a few mice at home (in 2 cages bought in your nearest petstore, placed on the top of your kitchen cupboards) so that we see if it extends their lifespan. if you are interested, PM me.

[rwac]

Should a 20 year old use it?

Also, what's really the disadvantages with using it?

It's a nice metabolic boost and a nootropic.
One disadvantage is that it needs to be dosed multiple times a day.

Don't know of any major disadvantage as yet.
Also you might not be done growing at 20. The effects of MB on growth are as yet unknown.

Edited by rwac, 08 August 2009 - 08:31 PM.

[GoodFellas]

I'll wait till I'm 22. My growth plates are closed, but I still don't have my chest hair, so I'm not completely done with puberty.

[AgeVivo]

It's a nice metabolic boost and a nootropic.

It is reported to improve locomotion in rodents (detailed elsewhere in imminst); but being a 'metabolic boost and a nootropic' seems unproven to me.

One disadvantage is that it needs to be dosed multiple times a day.

Don't know of any major disadvantage as yet.
Also you might not be done growing at 20. The effects of MB on growth are as yet unknown.

The NTP toxicity test studies (freely available online; i posted previously about it on imminst) at small doses (but we are talking of very low doses anyway) did not show any particular side effects on growth or whatever, nor long term effect (they did not test it on aging: such studies are too often stopped when the animals start to get old).

[rwac]

It is reported to improve locomotion in rodents (detailed elsewhere in imminst); but being a 'metabolic boost and a nootropic' seems unproven to me.

Just anecdotal evidence. But people can test it themselves easily.
For one, I'm pretty sure I can tell when something is having an effect.
I built an entire regimen based on that and the things I chose to take have been borne out by the theory.
I only figured out why something helped much later ...

The NTP toxicity test studies (freely available online; i posted previously about it on imminst) at small doses (but we are talking of very low doses anyway) did not show any particular side effects on growth or whatever, nor long term effect (they did not test it on aging: such studies are too often stopped when the animals start to get old).

That study completely slipped my mind for some reason.
I'll go back and read it.

Edited by rwac, 08 August 2009 - 09:56 PM.

[AgeVivo]

i myself need to re-read the NTP study carefully

For one, I'm pretty sure I can tell when something is having an effect.
I built an entire regimen based on that and the things I chose to take have been borne out by the theory.
I only figured out why something helped much later ...

i must say that on the whole your posts regularly looked quite coherent and pertinent to me, but that i am reluctant to such messages: unless one personnally knows the author of such posts, one never knows if the person writting the post has some financial interest or is able to feel things right, or has some strange reactions to many things, etc.

Edited by AgeVivo, 08 August 2009 - 11:40 PM.

[rwac]

i must say that on the whole your posts regularly looked quite coherent and pertinent to me, but that i am reluctant to such messages: unless one personnally knows the author of such posts, one never knows if the person writting the post has some financial interest or is able to feel things right, or has some strange reactions to many things, etc.

That's right. No proof as such, and my personal experience is about as much I can give you.
You can try it yourself or not as you choose.

[abelard lindsay]

I've been taking Methylene Blue for a few weeks now. It's great! Gives me tons of energy and has a good mood and nootropic effect. I mix 4 eye dropper drops into 750ml of San Pelligrino and take sips of it throughout the day. I can confirm, anecdotally, that it is a powerful anti-fungal and anti-bacterial as well.

disclaimer: personal results, your mileage may vary, etc. Basically, if you are not aware of and accept the risks of experimenting with non-mainstream supplements stick to what you can buy at Vitamin Shoppe.

Edited by abelard lindsay, 09 August 2009 - 06:06 PM.

[tunt01]

I've been taking Methylene Blue for a few weeks now. It's great! Gives me tons of energy and has a good mood and nootropic effect. I mix 4 eye dropper drops into 750ml of San Pelligrino and take sips of it throughout the day. I can confirm, anecdotally, that it is a powerful anti-fungal and anti-bacterial as well.

disclaimer: personal results, your mileage may vary, etc. Basically, if you are not aware of and accept the risks of experimenting with non-mainstream supplements stick to what you can buy at Vitamin Shoppe.

do you take anything else that effects your mitochondria? resveratrol, lipoic acid, alcar?

thx


i'd be curious to hear any other Mito-combinations people are experimenting with and any logic behind them...

[abelard lindsay]

I've been taking Methylene Blue for a few weeks now. It's great! Gives me tons of energy and has a good mood and nootropic effect. I mix 4 eye dropper drops into 750ml of San Pelligrino and take sips of it throughout the day. I can confirm, anecdotally, that it is a powerful anti-fungal and anti-bacterial as well.

disclaimer: personal results, your mileage may vary, etc. Basically, if you are not aware of and accept the risks of experimenting with non-mainstream supplements stick to what you can buy at Vitamin Shoppe.

do you take anything else that effects your mitochondria? resveratrol, lipoic acid, alcar?

thx


i'd be curious to hear any other Mito-combinations people are experimenting with and any logic behind them...

I take Alcar/ALA daily. I can feel the MB all by itself though.

Edited by abelard lindsay, 09 August 2009 - 07:43 PM.

[stephen_b]

I mix 4 eye dropper drops

Four drops of the 2.3% Kordon solution, or of something else? I'm not feeling too much from 60 mcg twice daily.

Edited by stephen_b, 10 August 2009 - 12:04 AM.

[rwac]

Four drops of the 2.3% Kordon solution, or of something else. I'm not feeling too much from 60 mcg twice daily.

Ubiquinol might interfere with MB.
Perhaps the stronger effects of MB come from replacing CoQ10 (bit similar to idebenone), and CoQ10 intake interferes with it.

Lufega had MB effects return after about 2 weeks of stopping ubiquinol.
I'm going to try the same.

You could also reduce MB dosage to 1 mcg, and try that ...

[abelard lindsay]

I mix 4 eye dropper drops

Four drops of the 2.3% Kordon solution, or of something else? I'm not feeling too much from 60 mcg twice daily.

Yes this is the Kordon 2.3% solution. I take 4 large eye dropper drops in a 750ml San Peligrino that I sip throughout the day. For those of you who want to experiment, since this thing is not exactly marketed for human consumption, I'd make sure before taking any that it has no smell and only an extremely mild, barely perceptible taste and start out with only 1 drop in a very large solution to make sure there's no contamination in your batch. Also, if you take too much you'll start to get a mild headache and your pee will temporarily turn green or blue. There's definitely a point at which the effects become less beneficial. Also be careful in handling this stuff because even just a tiny amount of it will permanently stain just about anything bright blue and even stain resistant stuff like porcelain sinks will take a lot of scrubbing to get the stains off.

I have skin problems and I recently bathed in highly diluted MB (10 drops in a bathtub) and it helped quite a bit. Make sure it's very diluted if you try this, otherwise you'll stain the tub and it will take you hours to scrub it off.

[sdxl]

Can't you just use a reducing agent like ascorbic acid to transform the methylene blue to the colorless leucomethylene blue to prevent/treat staining?

[rwac]

Can't you just use a reducing agent like ascorbic acid to transform the methylene blue to the colorless leucomethylene blue to prevent/treat staining?

I think ascorbic acid needs to be in an acidic solution to work as a reducing agent.
Glucose (or corn syrup) should work too, in a basic solution.

Additionally shaking it would reintroduce oxygen into the solution, re-oxidizing it into methylene blue.
Leucomethylene blue is probably not super-stable in air ....

Edited by rwac, 23 August 2009 - 02:41 AM.