What are some drug or supplements that tigthen the LES spincter? I tried baclofen, and I don't think that helped much. My doctor won't prescribe a prokinetic, he says there's too many side effects like tardive dyskinesia, etc. I just started taking glutamine as i read it could tighten it. I also tried 6MG of melatonin, and ashwaganda but they did nothing. Anymore options?
Background: I have treatment resistant GERD, and I've tried all acid reducers, and every supplement, but i am certain it's a sphincter issue, rather that an acid one. That's why I'm not interested in acid reducer right now, just things to tighten the sphincter. I don't have a hiatial hernia, and also no hy pylori.