63 replies to this topic

[Logic]

Thanks Lynx for the lead on covalzin.

It seems that covalzin is the brand name for the cat version of Kremezin. Kremezin is a spherical activated charcoal supplement that strongly adsorbs Dietary Advanced Glycation Endproducts and Uremic Toxins.

http://morelife.org/...s/kremezin.html

As such it seems like a good suppliment to add to one's anti aging regimn, but one wonders about it absorbing benificial suppliments/nutrients etc.
I did a quick search to try and find out what makes it different to standard activated charcoal without luck.
I think this stuff may deserve its own thread?

[hmm]

If this is out of line I apologize and stand fully willing to delete these words. I don't know if 2 oz freshly squeezed lemon juice stirred into 2 oz. virgin olive oil qualifies as a supplement, and don't know if the OP is interested in alleviating kidney stones. But this mixture put an end to about 7 years of torture done to me by a calcium oxalate stone.
The mixture shut down pain I was having following a lithotripsy 2 or 3 years ago, but x-rays showed two pieces of the broken stone remaining. Pain and bleeding returned a few months ago, became so acute in the middle of one January night that I stumbled out of bed and mixed up the oil and juice, drank it down, and almost immediately felt better. Drank that mixture daily for a week, and just last month the latest CAT scan results showed no stones remaining!

[stephen_b]

hmm, I think your comment is fine.

For kidney supps, I'd +1 the silymarin. I'd imagine that K2 (mk4 might be better, but I'd probably take both) would be helpful.

[albedo]

Just resurrecting this thread up as I think it includes good information and in the eventually someone has more to add...

 

I am interested to what proactively we can do. It is hard seeing function degrading with one of the main risk factors: age. This also adds to the SENS case and seeing aging as a disease, IMHO, as treatments when you start to see degradation are quite limited and not reversing the problem.

 

LEF has a nice new section on kidney health which includes several of the recommendations made in this thread, such vitamin D, coenzyme Q10, N-acetyl L-cysteine (NAC), keeping an alkalizing diet of Mediterranean style. I also wondered about nicotinamide riboside (NR) as hypothesized here which generated an interesting reply by Prophets. Also watch very carefully the usage of NSAIDs e.g. as listed here, lower your blood pressure, keep being hydrated, watch glucose and try reducing glycation.

[albedo]

Interesting on supplements to watch:

 

Gabardi S, Munz K, Ulbricht C. A review of dietary supplement-induced renal dysfunction. Clin J Am Soc Nephrol. 2007;2(4):757-65.

https://www.ncbi.nlm...pubmed/17699493

 

 supplements - kidneys.PNG   92.91KB   5 downloads

 

Also: https://health.cleve...idneys-healthy/

 

(edit: add links)

Edited by albedo, 11 August 2017 - 10:31 PM.

[albedo]

Keeping kidney healthy. I find this subject is not discussed very much on LC and extremely important:

• Keep your blood pressure at the target set by your health care provider. For most people, the blood pressure target is less than 140/90 mm Hg. This can delay or prevent kidney failure.
• If you have diabetes, control your blood glucose level.
• Keep your cholesterol levels in the target range.
• Take medicines the way your provider tells you to. (Important! Certain blood pressure medicines called ACE inhibitors and ARBs may protect your kidneys. Ask your health care provider for more information.)
• Cut back on salt. Aim for less than 2,300 milligrams of sodium each day.
• Choose foods that are healthy for your heart: fresh fruits, fresh or frozen vegetables, whole grains, and low-fat dairy foods.
• Limit your alcohol intake.
• Be more physically active.
• Lose weight if you are overweight.
• If you smoke, take steps to quit. Cigarette smoking can make kidney damage worse.

https://www.niddk.ni...ys-healthy.aspx

 

 

[albedo]

Good source of information in particular on the protective role of soy foods and soy-based nutrients:

 

McGraw NJ, Krul ES, Grunz-Borgmann E, Parrish AR. Soy-based renoprotection. World Journal of Nephrology. 2016;5(3):233-257. doi:10.5527/wjn.v5.i3.233.

 

"...Potential mechanism(s) of soy-based renoprotection. Soy protein has been shown to have effects on the cardiovascular system, as well as direct renal effects, that improve renal function. The actual components of soy that mediate these effects are unclear; but some data suggest a contribution of soy isoflavones, including genistein. Lowering of blood pressure may occur via decreased angiotensin-converting enzyme levels. In addition, soy improves the lipid profile, putatively via a decrease in lipogenic pathways demonstrated in animal models (e.g., FAS and transcription factor SREBP-1). The anti-inflammatory effects of soy may occur systemically, or within the kidney; animal studies have shown decreased NF-κB, TNF-α and IL-6 expression. Soy protein decreases renal fibrosis, possibly via a reduction in TGF-β signaling. There is also data suggesting that soy improves oxidant defense mechanisms in the kidney. Targets shown in italics have only been demonstrated in animal models..."

[albedo]

http://www.longecity...on/#entry826582

[bluemoon]

The about.nr site has a fairly new NR study added: Elysium has started a human trial with 24 participants who have accute kidney injury. Doses of BASIS at 250 mg NR / 50 mg pterostilbine twice a day as well as 2x, 3x and 4x that dose as well as a placebo are used. The study ends September 2018.

 

https://clinicaltria...e&draw=1&rank=9

 

 

[albedo]

The about.nr site has a fairly new NR study added: Elysium has started a human trial with 24 participants who have accute kidney injury. Doses of BASIS at 250 mg NR / 50 mg pterostilbine twice a day as well as 2x, 3x and 4x that dose as well as a placebo are used. The study ends September 2018.

 

https://clinicaltria...e&draw=1&rank=9

 

Yes, Bluemoon. Tks for that link. It is quite known NAD+ increase by different paths ("amidated" (e.g. NR, NMN, NAM) or "deamidated" (e.g. NA) or "de novo synthesis" from tryptophan) could potentially be beneficial to kidney health, a key feature of kidney dysfunction being the SIRT1 and SIRT3 loss of activity due to aging.  It has been studied for example in AKI (Acute Kidney Injury) in ischemia/reperfusion and also in the kidneys mesangial cell hypertrophy.

 

From the researchers (e.g. Auwerx) very much involved in studying the NAD+ metabolism see:

 

Katsyuba E, Auwerx J. Modulating NAD(+) metabolism, from bench to bedside. EMBO J. 2017

http://onlinelibrary....201797135/full

 

and Dr. Katsyuba's PhD thesis:

https://infoscience....h/record/230346

[MikeDC]

NAD+ precursor NMN protect against AKD.

 

https://www.ncbi.nlm...pubmed/28246130

 

 

[Multivitz]

Like all parts of the body the kidneys can regenerate well. The herbs and their extracts have had good success helping a failing organ.
Adrenal function is paramount as it provides the growth factors that allow correct growth of many structures. Having identified parasite presence, protective measures should be made, then an introduction to key minerals and their companion nutrients should be made. If fancey therapies are to be invested in, one should exhaust the possibility that malnutrition is not to blame, but we all know most of the time it is.
Iodine and boron are key players in everything. Hope this helped.

[MikeDC]

There is a post on NR personal experience thread. It is a repost of a message on yahoo CdXC board.
A 73 year old doctor said his creatinine dropped from 1.4 to 1.1 after 4 months of using Niagen at doses 500mg to 1000mg per day.

[Heisok]

Mike, I have a lack of knowledge about how a Creatinine level going from 1.4 to 1.1 actually proves a Kidney benefit. Are there other tests which if looked at with Creatinine levels confirm.  I would love to put a possible Kidney risk off the table for me.

 

In the first 2 years of using NR, my Creatinine went from .88 (12/2014) to .75  low if the range in the lab report is correct.  (10/2016) No test in last 11 months. Maybe I should request one. I have average muscles. (Yes, I have been using NR that long 

 

"Creatinine-based measurements of kidney function, however, may be limited as a tool to estimate either the rate of kidney function change in the elderly or the effects of age, sex and race. Since creatinine is a breakdown product of muscle, serum creatinine levels are directly associated with muscle mass. Muscle mass is lower in older persons, women and whites on average, which complicates the interpretation of creatinine changes over time. Equations to estimate GFR from creatinine make the inherent assumption that the effects of age, sex and race on the creatinine-GFR relationship are constant over time. Cystatin C is an alternative serum marker of kidney function that appears less biased for measuring kidney function in the elderly. Prior studies using cystatin C in older persons demonstrated its greater prognostic ability compared with creatinine or creatinine-based estimated GFR (eGFR) for predicting adverse outcomes [2,3,4,5,6,7]. Yet, no study has evaluated changes in kidney function over time using cystatin C, or compared such changes with estimates based on creatinine."

 

https://www.ncbi.nlm...les/PMC2820322/

Edited by Heisok, 29 September 2017 - 12:11 AM.

[MikeDC]

He said his number has been between 1.3 and 1.8 for many many years and it changed quickly to 1.1 in 4 months.

A better test might be urine Microalbuminuria Test. My wife's creatinine number is within normal range, but she has microalbuminuria for many years. So this test is more sensitive. Her number improved after 9 months of 250mg NR. I am hoping the next test will be in normal range.

[Heisok]

Thanks Mike, that helps.

[albedo]

From the study Heisok posted above it looks like eGFR (estimated Glomerular Filtration Rate) based on Cystatin C is a much better predictor of disease and mortality than eGFR based on Creatinine. It would be extremely interesting to provide data if and how eGFR (Cystatin C) changed with a specific supplementation, e.g. NR.

edit: link

Edited by albedo, 29 December 2017 - 09:37 AM.

[Blueflash]

https://examine.com/...s-membranaceus/

[MikeDC]

From the study Heisok posted above it looks like eGFR (estimated Glomerular Filtration Rate) based on Cystatin C is a much better predictor of disease and mortality than eGFR based on Creatinine. It would be extremely interesting to provide data if and how eGFR (Cystatin C) changed with a specific supplementation, e.g. NR.
edit: link

You got it. A poster posted this on CDXC yahoo board.

CharlesH2 days ago
I am 70+ had stage 3 kidney disease, but after taking Niagen for almost 3 months now blood test shows GFR 66...no more kidney disease. I didn't even know that was possib

[albedo]

 

From the study Heisok posted above it looks like eGFR (estimated Glomerular Filtration Rate) based on Cystatin C is a much better predictor of disease and mortality than eGFR based on Creatinine. It would be extremely interesting to provide data if and how eGFR (Cystatin C) changed with a specific supplementation, e.g. NR.
edit: link

You got it. A poster posted this on CDXC yahoo board.

CharlesH2 days ago
I am 70+ had stage 3 kidney disease, but after taking Niagen for almost 3 months now blood test shows GFR 66...no more kidney disease. I didn't even know that was possib

 

Thank you. From that post (here) it looks to me he is using eGFR (Creatinine) and not eGFR (Cystatin C) as he is quoting only Creatinine (at 1.09). Maybe you can ask CharlesH directly as I am pretty sure the "Mike" in that thread's reply is you. I see he is taking 125 mg/day of NR. Should you pop up into a study I would be very interested to know though I understand NAD+ precursors as NR are beneficial in kidney diseases such as AKI as I reported here.

[MikeDC]

From the study Heisok posted above it looks like eGFR (estimated Glomerular Filtration Rate) based on Cystatin C is a much better predictor of disease and mortality than eGFR based on Creatinine. It would be extremely interesting to provide data if and how eGFR (Cystatin C) changed with a specific supplementation, e.g. NR.
edit: link

You got it. A poster posted this on CDXC yahoo board.

CharlesH2 days ago
I am 70+ had stage 3 kidney disease, but after taking Niagen for almost 3 months now blood test shows GFR 66...no more kidney disease. I didn't even know that was possib

Thank you. From that post (here) it looks to me he is using eGFR (Creatinine) and not eGFR (Cystatin C) as he is quoting only Creatinine (at 1.09). Maybe you can ask CharlesH directly as I am pretty sure the "Mike" in that thread's reply is you. I see he is taking 125 mg/day of NR. Should you pop up into a study I would be very interested to know though I understand NAD+ precursors as NR are beneficial in kidney diseases such as AKI as I reported here.

His quote is GFR 66 which I think he meant eGFR. He mentioned creatinine only when asked. Not sure there are two eGFR.

[albedo]

Yes there are many methods to estimate the GFR. E.g. see:

https://www.kidney.o...toz/content/gfr

https://www.kidney.o.../gfr_calculator

[Rocket]

Yes there are many methods to estimate the GFR. E.g. see:

https://www.kidney.o...toz/content/gfr

https://www.kidney.o.../gfr_calculator

 

eGFR should take into account bodyweight or else muscular people can measure as having kidney disease.
 

[MikeDC]

Since he used GFR, I would assume it was really bad to indicate stage 3 kidney disease.

https://www.davita.c...-disease/e/4749

Edited by MikeDC, 30 December 2017 - 09:18 PM.

[Rocket]

Since he used GFR, I would assume it was really bad to indicate stage 3 kidney disease.

https://www.davita.c...-disease/e/4749

 

eGFR can also be affected by having high protein meals even the day before the blood test. It can also be affected by physical activity. My own doctor told me he thought I had kidney disease based on eGFR, totally ignoring the fact that I weigh over 210 and lifted weights 4 days a week and eat 200 grams of protein a day. When using eGFR based on age and body weight, the numbers came out fine. When tested for cystatin c, I was just fine.

 

Its called "estimated" GFR for a reason.... No one should be trying to shuck and jive NR on people based on an anonymous post from someone who doesn't understand the dynamics of calculating eGFR.

 

I saw a 4 or 5 point improvement in eGFR in bloodwork I ordered on myself after Dasatanib + Q. An n=1 data point doesn't prove anything but I've read that they want to test D on people with failing kidneys.

Edited by Rocket, 31 December 2017 - 12:33 AM.

[MikeDC]

Since he used GFR, I would assume it was really bad to indicate stage 3 kidney disease.

https://www.davita.c...-disease/e/4749

eGFR can also be affected by having high protein meals even the day before the blood test. It can also be affected by physical activity. My own doctor told me he thought I had kidney disease based on eGFR, totally ignoring the fact that I weigh over 210 and lifted weights 4 days a week and eat 200 grams of protein a day. When using eGFR based on age and body weight, the numbers came out fine. When tested for cystatin c, I was just fine.

Its called "estimated" GFR for a reason.... No one should be trying to shuck and jive NR on people based on an anonymous post from someone who doesn't understand the dynamics of calculating eGFR.

I saw a 4 or 5 point improvement in eGFR in bloodwork I ordered on myself after Dasatanib + Q. An n=1 data point doesn't prove anything but I've read that they want to test D on people with failing kidneys.

I understand your point. I still believe his result is valid to a degree. We can say that his kidney function improved. This has been demonstrated in mice already. NAD+ metabolism is evolutionary conserved across all mammals. All human studies of NR has validated previous mice studies. Two years in a row, my wife’s doctor was surprised that her kidney function improved without taking the drugs he prescribed to prevent further damage.

Edited by MikeDC, 31 December 2017 - 01:08 AM.

[albedo]

 

Yes there are many methods to estimate the GFR. E.g. see:

https://www.kidney.o...toz/content/gfr

https://www.kidney.o.../gfr_calculator

 

eGFR should take into account bodyweight or else muscular people can measure as having kidney disease.
 

 

I use what the lab provides (with the BSA-Body Surface Correction) in mL/min/1.73m2. When also testing the Cystatin C (vs. only the Creatinine) the lab uses the Cystatin C based formula given in the links I provided above. In there you can also remove the BSA correction, enter your height and weight and get the result in mL/min for the different formulas.

 

Moreover I look at both the eGFR and kidney damage indication e.g. provided by the spot urine ACR (Albumine to Creatinine ratio) so you can determine the G stage of disease from the table in: https://renal.org/in...ide/ckd-stages/

 

When interpreting the eGFR I found useful to keep in mind several recommendation, in particular checking trends rather than only absolute vales, e.g. see:

https://renal.org/in...ide/about-egfr/

 

HAPPY NEW YEAR to all!

Edited by albedo, 02 January 2018 - 09:18 AM.

[albedo]

A case for L-ergothioneine and Vitamin D:

 

l-Ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids

http://www.clinicaln...(03)00108-0/pdf

 

Vitamin D and Kidney Disease

http://cjasn.asnjour...t/3/5/1555.full

 

Someone come up with a formulation:

http://www.ergo4heal...lth-supplements

[hav]

You might also consider ip6. Just make sure you take it on a totally empty stomach with a lot of water and as far apart as possible from any metal (including calcium) supplements you might take.

 

Howard

[Kris111]

 When using eGFR based on age and body weight, the numbers came out fine. When tested for cystatin c, I was just fine.

 

 

 

How do I know if my GFR testing was for cystatin c?  It just says GFR.  Also, you mention "based on age and body weight".  Is that something I can apply manually in some kind of an equation to my GFR value?