3 replies to this topic

[rwac]

A form of vitamin B1 [structural formula below] that is sold as a supplement increases stamina in rats, write Japanese researchers in Nutrition Research. Rats that are given allithiamine are capable of swimming for longer.



...
The researchers gave their lab rats for five days either nothing, 50 mg thiamine/kg bodyweight or 50 mg allithiamine/kg bodyweight. Then they tied a weight to the animals’ tail and made them swim in water. The researchers recorded how long the animals were able to keep swimming. The results are shown below. Thiamine did not have a statistically significant effect, but allithiamine did.









...

In the blood, brains, muscles, heart, liver and kidneys of the rats that had been given allithiamine, the concentration of thiamine triphosphate had increased considerably.

http://www.ergo-log....lithiamine.html
http://www.ncbi.nlm..../pubmed/8815395

[Lufega]

If only it didn't taste so darn disgusting going down. I still have come transdermal cream though.

[VespeneGas]

Effects of thiamine supplementation on exercise-induced fatigueMasashige Suzuki¹ and Yoshinori Itokawa²


Abstract: High-dose thiamine (vitamin B₁) supplementation (100 mg/day) may be helpful in preventing or accelerating recovery from exercise-induced fatigue. Sixteen volunteer male athletes volunteer, 8 with a blood thiamine level of 40 ng/ml or more (normal thiamine group) and 8 with levels below that level (low thiamine group) were selected as subjects. They exercised on a bicycle ergometer and the effects of thiamine supplementation were compared with placebo. Blood thiamine level markedly increased following supplementation of thiamine for 3 days before exercise. Exercise-induced changes in hemodynamic parameters and cardiopulmonary function indicated the onset of fatigue. Thiamine supplementation significantly suppressed the increase in blood glucose in the normal thiamine group and significantly decreased the number of complaints shortly after exercise in the subjective fatigue assessment of 30 items.

[VespeneGas]

Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats

Satoshi Nozakiacd, Hiroshi Mizumaace, Masaaki Tanakaabc, Guanghua Jinacf, Tsuyoshi Taharaace, Kei Mizunoacd, Masanori Yamatoacf, Kaori Okuyamaacf, Asami Eguchiacf, Kouji Akimotog, Takahito Kitayoshig, Noriko Mochizuki-Odah, Yosky Kataokaacf, Yasuyoshi Watanabeacd
Received 26 August 2009; received in revised form 3 October 2009; accepted 12 October 2009.


Abstract
Impaired energy metabolism is considered a possible cause of fatigue. The thiamine derivative, thiamine tetrahydrofurfuryl disulfide (TTFD), is prescribed and is also an over-the-counter drug for the attenuation of fatigue. It is readily absorbed from the intestinal tract and converted into thiamine pyrophosphate (TPP), which plays an important role as a cofactor for enzymes of metabolic pathways involved in the production of adenosine triphosphate (ATP). We postulated that TTFD has an anti-fatigue effect by improving energy metabolism during physical-fatigue loading. Here, we initially used the forced swimming test to determine whether daily TTFD or thiamine for 5 days has anti-fatigue effects on weight-loaded rats. The swimming duration of TTFD-, but not of thiamine-treated rats, was significantly longer than that of control rats (P < .05). Based on these findings, we examined changes in the levels of thiamine and its phosphate esters in various organs and the effect of TTFD on ATP levels in skeletal muscle after forced swimming, to determine the cellular mechanisms of the anti-fatigue effect of TTFD. Daily TTFD resulted in a characteristic distribution of thiamine and its phosphate esters in rat skeletal muscle, liver, kidney, heart, brain, and plasma. Furthermore, daily TTFD attenuated the decrease in ATP content in the skeletal muscle caused by forced swimming with a weight load for a defined period (150 s). These results indicate that TTFD exerts anti-fatigue effects by improving energy metabolism during physical fatigue.

Edit: formatting

Edited by VespeneGas, 24 December 2009 - 11:00 PM.