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Please Help...Nootropics for Nerve Regeneration?


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#1 joezee88

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Posted 09 February 2010 - 01:00 AM


I'm new here and really need some advice. I am suffering from Bell's Palsy. Bell's is a very insidious ailment - the 7th cranial nerve goes dead causing paralysis on one side of the face, in my case, the right side. Other than some prednisone (to combat inflammation around the nerve) when you are first stricken, there is no treatment...you just wait for the nerve to regenerate. I have been waiting 10 weeks and have had only minimal improvement. I have considered taking several drugs but I am hesitant because it is such an unusual ailment that I don't know how the drugs will affect it and I don't want to do anything that could potentially cause a problem. Over the past few years, before being stricken with Bell's, I have experimented with Piracetam and Lucidril and, to a lesser degree, Hydergine. In fact, I had been taking Piracetam and Lucidril fairly regularly for a few months before the onset of the illness. I stopped taking them when the illness started because I was worried about conflicts with the prednisone and other drugs I was given (antibiotics for a sinus infection and valium to fight off the terror that comes from being disfigured). The nootropics always worked pretty well for me. I tend to be very scattered and unfocused and they helped with that. My questions are: Is there any real reason to believe that nootropics can help with nerve regeneration and, if so, which ones would be best? Is there any reason to believe that nootropics could have a negative effect on my condition? Does anyone know of any other readily available supplements other than nootropics that might help? Any advice would be greatly appreciated. Thanks.

Joe

#2 The Likud Is Behind It

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Posted 09 February 2010 - 05:39 AM

Stimulating NGF should do the trick. http://www.imminst.o...NGF-t37707.html

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#3 tekd

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Posted 14 February 2010 - 05:46 AM

Well the good news is that nerves outside of the brain regenerate much more easily than nerves inside. The thing about damaged nerves though is that when they're healing you'll basically experience what you're currently experience-very little noticeable improvement.

Think of your nerves like an electrical wire-if you cut it in half, the thing won't work until the two disconnected ends are completely back together. So basically until the damaged portions of your nerves have finished healing and fixed the bad connection you won't really feel like you're healing even though you probably are.
If I were you I'd probably take some Acetyl-L-Carnitine, which has been shown to help nerve regeneration in several kinds of nerve damage, but most of the research has been from diabetes (mostly because diabetes is a major cause of nerve problems). This sometimes comes formulated with added alpha lipoic acid which is also helpful in controlling damage to nerves from free radicals generated by the inflammatory process (research has shown it can be helpful for nerve damage in diabetes).

Since most of the damage in diabetes is due to an inflammatory type process it may be likely that this is the best combination to use in your situation as well.

There does appear to be at least one study where they basically tested acetyl-l-carnitine on facial nerve paralysis and it did help-which makes perfect sense given it's role in speeding up nerve regeneration.
http://grande.nal.us...p;therow=610500

I will warn you though again, that since nerve healing is one of those processes where it's often an "all or nothing" deal with whether the signals are getting through correctly or not, that even though taking these will likely speed up how long it takes for you to heal, your subjective feelings of whether it's healing or not may not change very much. Personally I would stick to these two things (Acetyl-L-Carnitine and Alpha Lipoic Acid) and not add much other stuff since sometimes things you figure might help can have unexpected consequences. In all honesty sometimes I see people suggesting things for a particular effect without thinking too much about side effects from long-term usage of some of these things-there's a LOT of stuff that I've considered regularly taking but eventually ruled out as just too much of a question mark for long term safety.

If you want other suggestions for stuff that actually has good evidence of having helped, I'd try to find a neurologist who currently also works at an academic institution and is involved in research about this kind of stuff-they tend to know more about unconventional solutions that have actually been shown to work. A neurologist who isn't as involved in current research would be somewhat less likely to tell you to try stuff like this.

The only other stuff I can think of off the top of my head that may help you heal up in general would probably be getting your blood levels of Vitamin D measured to see if you're low (you probably are) and if so then supplementing with 2000-4000 IUs/day until your levels are back up (alternately some doctors will just tell you to take a larger amount once a week) since it's associated with helping to control inflammation and very recently shown to help prevent some kind of neuronal damage that can cause schizophrenia. It is possible to OD on vitamin D (although not very common) so it is prudent to have your blood levels checked on occasion to see how they are. I would probably also take a fish oil pill daily so long as you're not having any surgery or dental work done (it can cause you to bleed more than usual), since it has been shown to help with nerve damage as well by controlling the involved inflammation.
You'll notice that a lot of what I'm recommending works largely by controlling the inflammation in and around your nerves-this is because the problem isn't that your nerves don't want to or are incapable of healing, it's that inflammatory processes basically undo a good chunk of any attempt to heal and continue to do damage so controlling nerve-level inflammation is good. This does *not* mean that you should start popping random anti-inflammatories! You want stuff that'll be more helpful at the nerve level that won't cause side effects that may negate benefits.

Best of luck. And to be honest while all this stuff will probably help speed up your healing time the good news is that you'll probably eventually heal even if you didn't take any of this stuff-so hang in there.

Edited by tekd, 14 February 2010 - 05:55 AM.


#4 JasRonq

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Posted 14 February 2010 - 05:05 PM

Along the same lines I would add Lion's Mane mushroom as something to combine with that acetyl-l-carnitine for higher nerve growth factor and also any anti-oxidants. Vitamins C E are important here, ALA is great too, as mentioned, and Acetyl-L-carnosine. Carnosine protects nerves from free radicals and is itself an anti-oxidant so it would also help control the inflammation damage. Acetyl-L-carnosine Basically anything that can reduce the inflammation at the site, reduce free-radical damage to the nerve from the inflamation process, or ingrease the growth rate of the nerve should help your recovery time.

As always and especially in your situation, your mileage may vary and do your own research. This is just an internet forum.

#5 JLL

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Posted 14 February 2010 - 07:45 PM

In memory-deficient mice with neuronal atrophy and synaptic loss in the brain, withanolide A – an extract of ashwagandha – induced significant regeneration of nerve fibers and dendrites, as well as a reconstruction of pre- and postsynapses in the neurons (link). Treatment with the extract resulted in a reversal of the memory deficit. Two other extracts, withanoside IV and withanoside VI, appear to have similar effects (link). Ashwagandha or its extracts could thus be used to reconstruct neuronal networks.


Ashwagandha as a Nootropic

#6 Jacovis

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Posted 21 February 2010 - 04:07 AM

I am suffering from Bell's Palsy.


Not a supplement but you should definitely try the Lip Trainer Patakara®.
The 'Rehabilitation purpose - Green color' one, which is the one mentioned on the below quote, along with the 'Bottle Lip Trainer Patakara®' can be bought from here: http://www.liptrainer.com/shop/buy.htm .

Here is more on the various versions of this product along with the various resistance strengths: http://www.actwell.biz/pepi.html

You should incorporate the trainer into your daily routine - while 4 times a day sounds difficult, you could always use it when washing the dishes, ironing, cooking, etc for example. And the Bottle Lip Trainer could be used everytime you take a drink...

Regular dedication to using a product like this, along with supplements like those mentioned above, should yield results for your problem...


http://www.liptraine...m/main/bell.htm
Bell's palsy (Facial nerves palsy)

It is said that if a patient with Bell's palsy "does not get cured within 3 weeks of the appearance of the disease, he never recovers". It can be said from the conclusion that when lip myofunctional therapy is applied with Lip Trainer Patakara®, though slight illness can be easily remedied, a little more time is required for serious illnesses.

The points to be noted when doing lip-stretching by Lip Trainer Patakara® for facial nerve disorders are as follows.
For facial nerve disorders, sustaining a light power for 20 minutes continuously at one time gives a good result. At the same time, when you intake water, the stretching which was aimed at as target can be done by using the 'Bottle Lip Trainer' on the illness side. In about 2 ~ 4 weeks from starting such stretching, along with the restoration of the muscles of the atrophied healthy side, the ridge line of the nose on the paralyzed side was stretched and turned. I was also surprised at the change in the patient at first, but think of it as the first signs of the effect. In addition, after a lapse of about 4 weeks, the shape of the nose becomes straight. A male patient will be satisfied with this level of cure; a woman will not be satisfied with this. If one is associated with it a little more, the balance will improve further and a good result will be obtained.

I think that the use of rehabilitation type(softest hardness) is good for rehabilitation. First of all, hold still the device for rehabilitation in the mouth and then add the load as described below. At this time, keep the device balanced and open the paralyzed side which cannot be closed and though it becomes an "Inclined shape" when the healthy side is closed, this state is Ok at the beginning. Gradually, it will be possible to close the Lip Trainer Patakara® horizontally in 4 weeks time, so there is no need to hurry.


http://www.liptraine...estimonials.htm
House wife with bell's palsy from Malaysia

Sent: Wednesday, November 09, 2005 12:08 AM

Subject: Bell's palsy
Name: M (female)
Country: MYS
Occupation: homemaker
Subject: bells palsy


Message: i bought the lip trainer three months ago. My bells palsy is 95% recovered after using the lip trainer. Thanks to the lip trainer patakara. And i would like to enquire, if i want to continue maintaining to use the lip trainer, wat colour should i buy for the next lip trainer? I am currently using the green color one. Glad to hear from u soon. Thank You.



#7 jazzcat

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Posted 21 February 2010 - 05:57 AM

Have you researched vitamin B12 injections for this? I think this may be worth looking in to. In Canada and some other countries you can get B12 ampules for injection at any pharmacy without a prescription. And this is something you can learn to do yourself or have your doctor's nurse do it for you. But the cost of B12 injections can be pretty reasonable if you do it yourself.

Of course you would probably need to supplement (orally) some other vitamins as well (other B vitamins particularly).

I think it's always good to try different things, different approaches that compliment each other, for any serious problem.

Edited by jazzcat, 21 February 2010 - 05:58 AM.


#8 joezee88

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Posted 04 March 2010 - 02:44 AM

Thanks everyone. I appreciate your input on this. I have started taking several supplements as a result of your answers and based on my own research. I currently take B12 Methylcobalamin (lozenges under the tongue) plus another B Complex, Aceytl L Carnitine, Phosphatadyl Choline, Vitamin C, Fish Oil, Ginseng and L Lysine. The only nootropic I am taking is Centrophenoxene. I have been noticing some improvement, including movement in the corner of my mouth...which, until recently had been 100% paralyzed on that side. I went to the doctor today and he felt that I was definitely improving.

Here's another question if anyone feels like discussing this further:

Bell's Palsy is believed to be caused by a herpes virus that attacks the 7th cranial nerve. I read about some research that suggests that the amino acid arginine can cause the virus to grow. I also read that arginine pyroglutamate is very similar in structure to Piracetam which I have used on and off for years and that I had been taking regularly when I was stricken with the Bell's Palsy. Is it possible that the Piracetam strengthened the virus and lead to the illness?

#9 Rhcan09

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Posted 04 March 2010 - 02:49 AM

Not sure if this has been mentioned - but take a look into Lion's Mane

#10 Lauren

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Posted 04 March 2010 - 04:27 AM

Hi Joe,

I'm actually relatively new here myself, or at least I haven't been on for quite some time. I am so sorry to hear about your Bell's palsy. You actually sound like you are incredibly lucid and articulate. You sound amazing, in fact. Listen, I wish that I had more knowledge of neurological conditions such as Bell's palsy, but I *do* really want to help you in some way. Do you regularly go to a neurologist? I'm sorry if this is not much help, but if ever you need support, please feel free to message me at any time. I'm always around (hugs)

Yours,

Lauren




I'm new here and really need some advice. I am suffering from Bell's Palsy. Bell's is a very insidious ailment - the 7th cranial nerve goes dead causing paralysis on one side of the face, in my case, the right side. Other than some prednisone (to combat inflammation around the nerve) when you are first stricken, there is no treatment...you just wait for the nerve to regenerate. I have been waiting 10 weeks and have had only minimal improvement. I have considered taking several drugs but I am hesitant because it is such an unusual ailment that I don't know how the drugs will affect it and I don't want to do anything that could potentially cause a problem. Over the past few years, before being stricken with Bell's, I have experimented with Piracetam and Lucidril and, to a lesser degree, Hydergine. In fact, I had been taking Piracetam and Lucidril fairly regularly for a few months before the onset of the illness. I stopped taking them when the illness started because I was worried about conflicts with the prednisone and other drugs I was given (antibiotics for a sinus infection and valium to fight off the terror that comes from being disfigured). The nootropics always worked pretty well for me. I tend to be very scattered and unfocused and they helped with that. My questions are: Is there any real reason to believe that nootropics can help with nerve regeneration and, if so, which ones would be best? Is there any reason to believe that nootropics could have a negative effect on my condition? Does anyone know of any other readily available supplements other than nootropics that might help? Any advice would be greatly appreciated. Thanks.

Joe


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#11 Lauren

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Posted 04 March 2010 - 04:30 AM

Here's another question if anyone feels like discussing this further:

Bell's Palsy is believed to be caused by a herpes virus that attacks the 7th cranial nerve. I read about some research that suggests that the amino acid arginine can cause the virus to grow. I also read that arginine pyroglutamate is very similar in structure to Piracetam which I have used on and off for years and that I had been taking regularly when I was stricken with the Bell's Palsy. Is it possible that the Piracetam strengthened the virus and lead to the illness?[/quote]


It's very possible - in fact, I think you've pinpointed its etiological origin exactly. Is there any possibility that you can discuss this with your neurologist or any other physician?

Edited by Lauren, 04 March 2010 - 04:35 AM.


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#12 What'sAllThisThen

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Posted 07 March 2010 - 05:26 AM

Bell's Palsy is believed to be caused by a herpes virus that attacks the 7th cranial nerve. I read about some research that suggests that the amino acid arginine can cause the virus to grow. I also read that arginine pyroglutamate is very similar in structure to Piracetam which I have used on and off for years and that I had been taking regularly when I was stricken with the Bell's Palsy. Is it possible that the Piracetam strengthened the virus and lead to the illness?


Hmmmm, is that right? I know Arginine can promote the herpes virus, but didn't know piracetam was similar. I've got a cold sore right now and I wonder if it's from the piracetam. I only get one cold sore a year and this is around the same time I got one last year, so it could just be a coincidence, but it has me wondering now.




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