How will you get lifespan if you don't have healthspan first? That is my first question. Give an 80 year old with major health issues a telomerase activator and I guarantee you he will be more likely to get cancer than a healthy 30 year old also given a telomerase activator. I think multiple supplements should be the basis to improve healthspan and then give a telomerase activator to actually achieve a longer lifespan. I have been taking most of the items on that list for several years now plus much more they left out. As I pointed out in the NAC,vit. C thread I would like to see some more supplements added to see if the effect can be extended namely curcumin,resveratrol and carnosine. I believe those three would work better than garlic,ginkgo,aspirin and ginger. The other carotenoids are very important also. Alpha carotene has been found to decrease all-cause mortality in humans by 40% at the highest intakes. That was an 18 year study also. I don't know of any other single substance/supplement that has showed the same efficacy. They also left out the other tocopherols. Gamma tocopherol may be more important than Alpha but all of them should be given.
And it was said above that the supplements should be narrowed down to find the most important ones. I don't think 1 or 2 or 5 of them are the ones giving the effects. Unfortunately our pharmaceutical industries "1 drug, 1 disease" mentality won't work to cure the most difficult diseases of aging nor aging itself. Human beings require many substances to sustain life and it will take several things to delay/cure aging. Here is the alpha carotene study.
Arch Intern Med. 2010 Nov 22. [Epub ahead of print]
Serum {alpha}-Carotene Concentrations and Risk of Death Among US Adults: The Third National Health and Nutrition Examination Survey Follow-up Study.
Li C, Ford ES, Zhao G, Balluz LS, Giles WH, Liu S.
Office of Surveillance, Epidemiology, and Laboratory Services (Drs Li and Balluz), and Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion (Drs Ford, Zhao, and Giles), Centers for Disease Control and Prevention, Atlanta, Georgia; and Departments of Epidemiology and Medicine, University of California at Los Angeles (Dr Liu).
Abstract
BACKGROUND: Much research has been conducted relating total carotenoids-and β-carotene in particular-to risk of cancer and cardiovascular disease (CVD). Limited data are emerging to implicate the important role of α-carotene in the development of CVD or cancer.
METHODS: We assessed the direct relationship between α-carotene concentrations and risk of death among 15 318 US adults 20 years and older who participated in the Third National Health and Nutrition Examination Survey Follow-up Study. We used Cox proportional hazard regression analyses to estimate the relative risk for death from all causes and selected causes associated with serum α-carotene concentrations.
RESULTS: Compared with participants with serum α-carotene concentrations of 0 to 1 μg/dL (to convert to micromoles per liter, multiply by 0.01863), those with higher serum levels had a lower risk of death from all causes (P < .001 for linear trend): the relative risk for death was 0.77 (95% confidence interval, 0.68-0.87) among those with α-carotene concentrations of 2 to 3 μg/dL, 0.73 (0.65-0.83) among those with concentrations of 4 to 5 μg/dL, 0.66 (0.55-0.79) among those with concentrations of 6 to 8 μg/dL, and 0.61 (0.51-0.73) among those with concentrations of 9 μg/dL or higher after adjustment for potential confounding variables. We also found significant associations between serum α-carotene concentrations and risk of death from CVD (P = .007), cancer (P = .02), and all other causes (P < .001). The association between serum α-carotene concentrations and risk of death from all causes was significant in most subgroups stratified by demographic characteristics, lifestyle habits, and health risk factors.
CONCLUSIONS: Serum α-carotene concentrations were inversely associated with risk of death from all causes, CVD, cancer, and all other causes. These findings support increasing fruit and vegetable consumption as a means of preventing premature death.
Edited by JKDC, 21 December 2010 - 01:08 AM.
LongeCity
