9 replies to this topic

[sugarstack]

http://www.springerl...872518P0550.pdf - Better on reference Memory on rat.
http://jcp.sagepub.c...stract/25/4/291 - Pharmacokinetics of oral pramiracetam in normal volunteers
http://linkinghub.el...167494394005427 - Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers
http://www.neurology...stract/41/4/570 - Nootropic drugs in Alzheimer's disease
http://www3.intersci...l...=1&SRETRY=0 - Some neurochemical properties of pramiracetam (CI-879), a new cognition-enhancing agent
http://www.springerl...07kr7t6uh97260/ - Arousal deficit shown in aged rat's quantitative EEG and ameliorative action of pramiracetam compared to piracetam
http://md1.csa.com/p...p;setcookie=yes - Safety of pramiracetam.
http://grande.nal.us...p;therow=217281 - Reversal of scopolamine-induced alterations of choline transport across the blood-brain barrier by the nootropics piracetam and pramiracetam.
http://www.sciencedi...823dcb1516cfcef - The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake
http://www.ncbi.nlm..../pubmed/3035858 - Effects of nootropic drugs on brain cholinergic and dopaminergic transmission
http://linkinghub.el...167494396869068 - Memory training and drug therapy act differently on memory and metamemory functioning: evidence from a pilot study

Edit: http://www.sciencedi...14311d0a63cc4ee - In search of the mechanism of action of the nootropics: New insights and potential clinical implications

Edited by sugarstack, 26 April 2010 - 12:48 AM.

[Guacamolium]

http://www.springerl...872518P0550.pdf - Better on reference Memory on rat.
http://jcp.sagepub.c...stract/25/4/291 - Pharmacokinetics of oral pramiracetam in normal volunteers
http://linkinghub.el...167494394005427 - Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers
http://www.neurology...stract/41/4/570 - Nootropic drugs in Alzheimer's disease
http://www3.intersci...l...=1&SRETRY=0 - Some neurochemical properties of pramiracetam (CI-879), a new cognition-enhancing agent
http://www.springerl...07kr7t6uh97260/ - Arousal deficit shown in aged rat's quantitative EEG and ameliorative action of pramiracetam compared to piracetam
http://md1.csa.com/p...p;setcookie=yes - Safety of pramiracetam.
http://grande.nal.us...p;therow=217281 - Reversal of scopolamine-induced alterations of choline transport across the blood-brain barrier by the nootropics piracetam and pramiracetam.
http://www.sciencedi...823dcb1516cfcef - The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake
http://www.ncbi.nlm..../pubmed/3035858 - Effects of nootropic drugs on brain cholinergic and dopaminergic transmission
http://linkinghub.el...167494396869068 - Memory training and drug therapy act differently on memory and metamemory functioning: evidence from a pilot study

Edit: http://www.sciencedi...14311d0a63cc4ee - In search of the mechanism of action of the nootropics: New insights and potential clinical implications

Pramiracetam is not that great given its elusive evaqsiveness and grandiose status of the rams. It is like piracetam but WAY intense and unfocused, for me. Throw your chops, the dogs of kibbles and bits may come a running. It's a grey-area racetam and it helps who it does and what not. It definitely is not the epitome of the racetaqm class.

[LabRat84]

Thanks for posting these.

There's no evidence that pramiracetam works better than piracetam or aniracetam, just that it's effective at a lower dose, and that the half-life is longer than aniracetam. I respond to 1.6 mg of piracetam or 750mg of aniracetam, but I haven't really felt much from 600mg pramiracetam. I personally can't justify the higher cost.

Edited by LabRat84, 26 April 2010 - 06:50 AM.

[outsider]

Thanks for posting these.

There's no evidence that pramiracetam works better than piracetam or aniracetam, just that it's effective at a lower dose, and that the half-life is longer than aniracetam. I respond to 1.6 mg of piracetam or 750mg of aniracetam, but I haven't really felt much from 600mg pramiracetam. I personally can't justify the higher cost.

You don't necesserily have to "feel" something to experience cognitive improvement. A smart person doesn't feel nothing about logic or knowledge, he just knows the answer.

[LabRat84]

Thanks for posting these.

There's no evidence that pramiracetam works better than piracetam or aniracetam, just that it's effective at a lower dose, and that the half-life is longer than aniracetam. I respond to 1.6 mg of piracetam or 750mg of aniracetam, but I haven't really felt much from 600mg pramiracetam. I personally can't justify the higher cost.

You don't necesserily have to "feel" something to experience cognitive improvement. A smart person doesn't feel nothing about logic or knowledge, he just knows the answer.

I can feel aniracetam and piracetam though.

[potofgold23]

So in the study located here http://md1.csa.com/p...p;setcookie=yes what exactly were the adverse effects?

[sugarstack]

So in the study located here http://md1.csa.com/p...p;setcookie=yes what exactly were the adverse effects?

Pramiracetam was evaluated in open-label and controlled, double-blind studies involving 112 normal volunteers and 336 patients with primary degenerative dementia, Alzheimer's disease, or benign senescent forgetfulness. Pramiracetam was given in single doses up to 1,600 mg and in multiple doses of 75 to 1,500 mg/day for four to nine weeks. No drug-related changes were seen in blood pressure, heart rate, electroencephalograms, electrocardiograms, or clinical laboratory values. In controlled studies adverse experiences occurred in 25%, 15%, and 17% of patients treated with pramiracetam 75, 150, 300 mg/day, respectively, and in 17% of those treated with placebo. The safety of pramiracetam was clearly demonstrated in these studies.

[potofgold23]

So in the study located here http://md1.csa.com/p...p;setcookie=yes what exactly were the adverse effects?

Pramiracetam was evaluated in open-label and controlled, double-blind studies involving 112 normal volunteers and 336 patients with primary degenerative dementia, Alzheimer's disease, or benign senescent forgetfulness. Pramiracetam was given in single doses up to 1,600 mg and in multiple doses of 75 to 1,500 mg/day for four to nine weeks. No drug-related changes were seen in blood pressure, heart rate, electroencephalograms, electrocardiograms, or clinical laboratory values. In controlled studies adverse experiences occurred in 25%, 15%, and 17% of patients treated with pramiracetam 75, 150, 300 mg/day, respectively, and in 17% of those treated with placebo. The safety of pramiracetam was clearly demonstrated in these studies.

Right, I was just curious what the adverse effects experiences that occured in 25%, 15%, and 17% were.

[Tukotih Doji]

Thanks for posting these.

There's no evidence that pramiracetam works better than piracetam or aniracetam, just that it's effective at a lower dose, and that the half-life is longer than aniracetam. I respond to 1.6 mg of piracetam or 750mg of aniracetam, but I haven't really felt much from 600mg pramiracetam. I personally can't justify the higher cost.

You don't necesserily have to "feel" something to experience cognitive improvement. A smart person doesn't feel nothing about logic or knowledge, he just knows the answer.

I can feel aniracetam and piracetam though.

Same here, I feel a significant improvement in focus with Aniracetam. No doubt. (I have ADD, if it matters)
I've not tried Pramiracetam. But I'd be greatly amazed if it had any other great differences apart from the dose.

[Orajel]

Piracetam treatment was without effect on HACU, but induced significant increase of HVA in the striatum leaving striatal DA concentration unchanged. On the contrary, pyritinol, pramiracetam and oxiracetam increased HACU, but did not change striatal DA and HVA levels.

Any idea what this means?