208 replies to this topic

[SE102]

I would keep away from antiphycotics at all cost unless your a danger to the public.....They are designed to destroy you, not the delusions. I wouldnt believe to much of what you read on articles on the net. Piracetam is good for most, if you dont feel that its helping you then stop, it so cheap anyway. I would do either drug on its own intially, personally I would have started with the huperzine <100mcg.

False they arent designed to destroy people but bring them back from the brink. I agree though that you shouldnt take one unless you are seriously a threat to yourself or others. They tend to SUUUUCK and can seriously fuck your brain. I've been on several. There are a few that are 'gentle' with your cranium and side effects. One of them is Abilify. I <3 Abilify! It virtually kills the word salad! The only sideffect is weightgain for some (there may be another take a gander on the web) But if youve been in a psychosis for a couple years and you're not a threat and youre pretty under control then take that and it should really take the cognitive suffering out of your mind. It has mine.

I was in a psychosis (not drug caused, but a more biblical madness) for 2 years. It was epic and intense, sometimes ugly and terrible and demented... sometimes extreme quantum awesome etc. And if youre in a psychosis I dont recommend ecstacy, I cannot describe what it does but it entirely changes the paramaters of the psychosis.

[SE102]

So why did this feeling of perfection and connection to reality last 2 weeks and fade away, but the other times I used DXM this lasted a few hours only? Any advice would be appreciated. To the OP, we may have different symptoms and situations, but I believe we will have the same solution. A permanent solution to a temporary problem.

The IV was probably filled with a couple grams of powerful antipsychotics. A friend of a friend tried an herbal blend and buggered out and they gave him injections of abilify and it straightened him out after a couple days. Thats my take on it.

[NR2(x)]

Regarding Saint johns wort, there are many types of NMDA receptor agonists. Some of them are dirty and quite bad for you, examples include DXM.However Dxm is a strong (opiote?) aswell with its known troubles. Wheather a nmda antagonist is bad is mainly determined by the action on individual subtypes of nmdars, that being said, this system does not lend itself to singular/function understanding, its nonlinear, good and bad should only be used unless in the most qualified examples.....

[viscosity]

I find that phosphatidylserine is quite helpful for DXM-related cognitive impairment. Phosphatidylserine serves as a source of L-serine, which is converted to D-serine by serine racemase. D-serine is a stronger co-agonist than glycine and activates the NMDA receptor when agonist glutamate is present (both ligands are required to activate the receptor) . Supplemental glycine, D-alanine (a full agonist at the glycine site like D-serine) or D-cycloserine (a partial agonist) may also help.

Increasing glutamate concentrations won’t work if DXM is still in your system as DXO (a metabolite of DXM) binds better in the presence of glutamate, and it’s a stronger antagonist than DXM!

Dextrorphan, in contrast to dextromethorphan, inhibited [3H]TCP binding more potently in the presence of Mg2+ and L-GLU.

http://www.ncbi.nlm.nih.gov/pubmed/2568580

In addition, I have found Huperzine A and ALCAR to be helpful against persisting anticholinergic effects (DXM is a nicitonic receptor antagonist). I wouldn’t worry too much about Huperzine A’s effect as an NMDA receptor antagonist as I find it to be weaker than memantine (which is weaker than DXM) even at large doses >1000 micrograms.

As a near decade user of dextromethorphan I have gone through somewhere between 400-500 grams of the stuff. While using 1-2 times a week (300-600mg doses) didn’t cause cognitive trouble, daily use at 600-1,000mg sure did. While it was never severe enough to affect my grades, the speech impairment, trouble finding words and spatial acquisition problems weren’t fun. For me they faded completely in 1-2 weeks off DXM, but I know others have experienced impairment lasting months.

Currently I take DXM daily (300mg 3-4x a day) along with 300mg phosphatidylserine and 200mg Huperzine A. I find the phosphatidylserine in particular greatly offsets nasty cognitive issues and allows me to enjoy the meditative dissociation and increased motivation I get from DXM without feeling well, stupid. I have been using DXM in this manner for over 4 months (with only 3 one-day breaks) and do not notice any cognitive impairment besides perhaps a minor increase in typos (hopefully this post is proof of that).

I have introduced another daily user to phosphatidylserine as well and she finds it helps with speech impairment and memory. She takes 300-600mg of DXM and 500mg ps daily.

Disclaimer: Daily use of DXM has caused problems for many and obviously impairment will subside quicker if you stop taking DXM.

[Mindweaver]

You are insane for taking it daily in that manner, absolutely insane. But for a healthy person who has lasting cognitive impairment from DXM, would others agree that this is a good suggestion?

[viscosity]

You are insane for taking it daily in that manner, absolutely insane.

I can't say I recommend it.

A friend of mine took 1200-2000+ mg of DXM daily (or near daily) for over 6 months who said it took 8-9 months for impairment to go away. He didn't split up those doses either.

I have an article about glycine & glycine agonists that has information on glycine, D-alanine, D-serine, D-cycloserine and milacemide. Download link for PDF (it's too big to attach even as a zip):
http://www.box.net/shared/5ke72kecj4

[Spectre]

I find that phosphatidylserine is quite helpful for DXM-related cognitive impairment. Phosphatidylserine serves as a source of L-serine, which is converted to D-serine by serine racemase. D-serine is a stronger co-agonist than glycine and activates the NMDA receptor when agonist glutamate is present (both ligands are required to activate the receptor) . Supplemental glycine, D-alanine (a full agonist at the glycine site like D-serine) or D-cycloserine (a partial agonist) may also help.

Increasing glutamate concentrations won’t work if DXM is still in your system as DXO (a metabolite of DXM) binds better in the presence of glutamate, and it’s a stronger antagonist than DXM!

Dextrorphan, in contrast to dextromethorphan, inhibited [3H]TCP binding more potently in the presence of Mg2+ and L-GLU.

http://www.ncbi.nlm.nih.gov/pubmed/2568580

In addition, I have found Huperzine A and ALCAR to be helpful against persisting anticholinergic effects (DXM is a nicitonic receptor antagonist). I wouldn’t worry too much about Huperzine A’s effect as an NMDA receptor antagonist as I find it to be weaker than memantine (which is weaker than DXM) even at large doses >1000 micrograms.

As a near decade user of dextromethorphan I have gone through somewhere between 400-500 grams of the stuff. While using 1-2 times a week (300-600mg doses) didn’t cause cognitive trouble, daily use at 600-1,000mg sure did. While it was never severe enough to affect my grades, the speech impairment, trouble finding words and spatial acquisition problems weren’t fun. For me they faded completely in 1-2 weeks off DXM, but I know others have experienced impairment lasting months.

Currently I take DXM daily (300mg 3-4x a day) along with 300mg phosphatidylserine and 200mg Huperzine A. I find the phosphatidylserine in particular greatly offsets nasty cognitive issues and allows me to enjoy the meditative dissociation and increased motivation I get from DXM without feeling well, stupid. I have been using DXM in this manner for over 4 months (with only 3 one-day breaks) and do not notice any cognitive impairment besides perhaps a minor increase in typos (hopefully this post is proof of that).

I have introduced another daily user to phosphatidylserine as well and she finds it helps with speech impairment and memory. She takes 300-600mg of DXM and 500mg ps daily.

Disclaimer: Daily use of DXM has caused problems for many and obviously impairment will subside quicker if you stop taking DXM.

Man that's crazy lol..I would never touch DXM again, even if I was on a bunch of nootropics that would limit the damage from the drug..I get sick just thinking about it really lol.

My package of ALCAR and St. John's Wort arrived today, I took the ALCAR this morning and afternoon (1g 2x) and have already noticed effects from it..my overall thinking capacity seems to have heightened, and my sense of logic has seemed to increase as well..I feel more connected with my thoughts and all-around better, I'm pretty sure this isn't a placebo effect either The ALCAR powder is extremely acidic but doesn't taste bad.

I just took some St. John's Wort powder about 10 minutes ago, and the taste was absolutely unbearable..I might as well have choked down some dirt, I honestly can't see myself finishing off 100 grams of this stuff with ease..I feel like this was a waste of money, but I'll wait and see how it affects me.

[Mindweaver]

Ashwagandha is great, and after 4 days I'm already getting itches (supposed to indicate growing nerve endings). I wake up every morning feeling clearer, and have distinctly clear memory-dreams when I sleep, where I'm placed lucidly in a memory of something I hadn't remembered before dreaming about it. Really interesting, like my brain's rebuilding lost/damaged connections. In addition my Lion's Mane has arrived. Just took both, will update on progress after 2 weeks of Ash.and 1 week of Lion's Mane.

[Spectre]

Ashwagandha is great, and after 4 days I'm already getting itches (supposed to indicate growing nerve endings). I wake up every morning feeling clearer, and have distinctly clear memory-dreams when I sleep, where I'm placed lucidly in a memory of something I hadn't remembered before dreaming about it. Really interesting, like my brain's rebuilding lost/damaged connections. In addition my Lion's Mane has arrived. Just took both, will update on progress after 2 weeks of Ash.and 1 week of Lion's Mane.

Awesome man, I'm glad this is working out for you I wish I could get my hands on some Lion's Mane but I have no clue where to go for that (and I'd like to get an extract/powder/capsules of it, not the actual mushroom). I would also like to try out some Ashwagandha at a decent dose, not the small dose I get from Mentat (which I think puts me in a semi-manic state of mind, I tend to get agitated shortly after taking Mentat now for some reason).

[Mindweaver]

Weird @ the Mentat thing. I buy the Ashwagandha from Vitamin Shoppe, and the Lion's Mane I bought from Full Spectrum. See the Lion's Mane thread (here: http://www.imminst.o...ic=37707&st=120) because on the last page I was given better sources for the product, as I got the mushroom powder in a capsule but apparently the root extract is more potent and has another NGF related compound in it.

[chrono]

Mentat has the most ingredients of anything I've come across. Intriguing stuff.

Ashwagandha is great, and after 4 days I'm already getting itches (supposed to indicate growing nerve endings). I wake up every morning feeling clearer, and have distinctly clear memory-dreams when I sleep, where I'm placed lucidly in a memory of something I hadn't remembered before dreaming about it.

That's great to hear! I'm curious, where does it itch? You may have mentioned it already in another thread, but what ashwagandha product are you using?

[Mindweaver]

All over my body, sometimes on my leg, arms, back, it's almost uncontrollable lol.. At first I was wondering if I was allergic to something I ate, then I remembered the itching aspect of Ashw. I'm taking the Vitamin Shoppe brand.

[bobman]

All over my body, sometimes on my leg, arms, back, it's almost uncontrollable lol.. At first I was wondering if I was allergic to something I ate, then I remembered the itching aspect of Ashw. I'm taking the Vitamin Shoppe brand.

That's very odd. I wouldn't rule out an allergy. The only time you should feel itching is if you had peripheral nerve damage and you were re-enervating the area.

That being said, the lion's mane mice study did show itching. Hey everyone is different. Ashwagandha is great stuff, so it'd be a shame if you were allergic. How much are you taking? Any rashes or other reactivity?

[Animal]

You are insane for taking it daily in that manner, absolutely insane. But for a healthy person who has lasting cognitive impairment from DXM, would others agree that this is a good suggestion?

He's a drug addict, that's fairly clear from his utter abuse of the substance. I would expect rapid cognitive decline as he ages, talk to him again in a few years and you can be sure he'll have a different perspective, if he's still capable of typing that is.

The addiction is self reinforcing in that the cognitive deficits can appear negated while you are under the influence of the substance. Thus you begin to believe the delusion that you somehow need the DXM to function, that it is an integral part of your psyche or some other spiritual bullshit. Whatever it takes to justify the continued abuse to yourself.

If you're depressed or suffering motivation issues there are far more appropriate substances without the deleterious effects of DXM.

[viscosity]

If you're depressed or suffering motivation issues there are far more appropriate substances without the deleterious effects of DXM.

Actually I'm a she, but no I'm not depressed. I have motivation and behavioral issues that DXM seems to fix and currently take it as self medication. I am well aware of the risks of maintaining such a lifestyle, but ultimately it is my choice.

I have been on other prescription medications for ADHD in the past (methylphenidate, dextroamphetamine, atomoxetine and memantine). Stimulants were okay, but tended to get me locked into things too much and I have to admit that I still like DXM better. It's really a shame I didn't find memantine as effective for motivation though; it's a weaker antagonist and better suited to daily use imo.

As far as combating impairment goes, I have also tried piracetam on a break from DXM but it never did anything for me personally although I have heard others say it's helpful. I would like to start taking ALCAR again when funds permit.

There is more information on co-agonists in "Glycine Site Agonists of the NMDA Receptor: A Review". The article is too big for me to attach, but I can send you it if you like. It has more information about glycine, D-serine, D-alanine and D-cycloserine.

Something interesting from the article:

Some evidence suggest that glycine may convert some of the antagonist-preferring binding sites into agonist-preferring sites. The functional significance of these findings is that glycine may be converting physiologically less responsive NMDA receptors (antagonist-preferring binding sites) into highly responsive receptors (agonist-preferring sites)

I think the glycine site is an interesting target for treatment of lingering problems.

[Spectre]

If you're depressed or suffering motivation issues there are far more appropriate substances without the deleterious effects of DXM.

Actually I'm a she, but no I'm not depressed. I have motivation and behavioral issues that DXM seems to fix and currently take it as self medication. I am well aware of the risks of maintaining such a lifestyle, but ultimately it is my choice.

I have been on other prescription medications for ADHD in the past (methylphenidate, dextroamphetamine, atomoxetine and memantine). Stimulants were okay, but tended to get me locked into things too much and I have to admit that I still like DXM better. It's really a shame I didn't find memantine as effective for motivation though; it's a weaker antagonist and better suited to daily use imo.

As far as combating impairment goes, I have also tried piracetam on a break from DXM but it never did anything for me personally although I have heard others say it's helpful. I would like to start taking ALCAR again when funds permit.

There is more information on co-agonists in "Glycine Site Agonists of the NMDA Receptor: A Review". The article is too big for me to attach, but I can send you it if you like. It has more information about glycine, D-serine, D-alanine and D-cycloserine.

Something interesting from the article:

Some evidence suggest that glycine may convert some of the antagonist-preferring binding sites into agonist-preferring sites. The functional significance of these findings is that glycine may be converting physiologically less responsive NMDA receptors (antagonist-preferring binding sites) into highly responsive receptors (agonist-preferring sites)

I think the glycine site is an interesting target for treatment of lingering problems.

I am definitely interested in obtaining more information about Glycine. Would DMG or TMG (dimethyl & trimethyl glycine) be a better choice to take instead? The closest thing I've taken to any of those is SAMe, which I may take a break from for a little while to see how it affects me. (It feels as though SAMe counteracts some of the other supplements I take for cognition, I seemed a lot more alert than normal yesterday, and I didn't take SAMe in the morning like I usually do, I would think it would have the opposite effect).

[viscosity]

Would DMG or TMG (dimethyl & trimethyl glycine) be a better choice to take instead?

I can't find anything about them interacting with the NMDA receptor directly although in the body TMG is converted to DMG which is then converted to glycine. So I guess they would serve as a source of glycine.

Edited by viscosity, 30 June 2010 - 11:12 PM.

[Spectre]

Bump.

Does anyone know if Salvia Divinorum or DXM can causes seizures in the brain? I was doing some research on deja vu and how they are frequently related to "temporal lobe epilepsy"..could my deja vu experiences that lasted for almost 2 years be attributed to this? Or is it more than likely NMDA receptor damage? The thought of having brain seizures scares the crap out of me, but I would like to know the cause of this. (A few months ago, after taking about 2 grams of phenylethylamine, I had spiking blood pressure and felt a very intense deja vu experience for about 10 minutes). Over those 2 years, I would feel random bouts of deja vu that felt extremely paranormal..and it all started after smoking Salvia Divinorum (but was noticed a lot more after taking DXM). Thanks.

[viscosity]

DXM has actually been used to treat seizures although there is of course individual variance in response as two patients in the study experienced increased seizure frequency.
http://www.ncbi.nlm....pubmed/10702964

My boyfriend who has epilepsy takes DXM occasionally and has not had any problems while on it. He also takes the medication Keppra (Levetiracetam) which interestingly enough blocks the same N-type calcium channels as DXM.

Coricidin on the other hand has been implicated in seizures as the Chlorpheniramine maleate in it can lower the seizure threshold.

[bobman]

I would recommend something light like 50micrograms a day for the first week, if you notice any side effects stop and either try again at a lower dose or dont resume taking. I have heard of effects at this dosage but many people are taking far higher doses, work your way slowly up as and where you feel needed, I personally wouldnt use over 500mcg.
Get as much exercise as you can as well and get those antioxidants

You might be right because 400mg was really stimulating to me when I first took it. I'd say no more than 100mg then, so amend that 200. It's crazy stuff when you first take it at 400mg, your heart races, it's quite emotionally intense, you become more sensitive to emotions.

[Mindweaver]

All over my body, sometimes on my leg, arms, back, it's almost uncontrollable lol.. At first I was wondering if I was allergic to something I ate, then I remembered the itching aspect of Ashw. I'm taking the Vitamin Shoppe brand.

That's very odd. I wouldn't rule out an allergy. The only time you should feel itching is if you had peripheral nerve damage and you were re-enervating the area.

That being said, the lion's mane mice study did show itching. Hey everyone is different. Ashwagandha is great stuff, so it'd be a shame if you were allergic. How much are you taking? Any rashes or other reactivity?

Nope no rashes, just crazy dreams and a little mental fatigue for the first 5 minutes upon waking, pretty much intense being-tiredness. I take one serving size/capsule of Ash and LM before bed. Still taking 1 ALCAR, 1 Piracetam and 1 Choline source in the morning but that is what I've minimized my dose too. I've been feeling so good lately, everything is 100x more lucid than a month ago, and my memory is ridiculously good. ALCAR is a miracle supplement, this is NO bullshit and no placebo. Long-term memory, short-term memory storage and recall are unbelievable. For example, I've used my credit card multiple times on the internet and had to type out the number for orders and whatnot... I'd say 10 times in the last few months. Before ALCAR and Piracetam, I never remembered the numbers because I didn't have to/didn't pay attention. Now I still didn't have to/didn't pay too much attention, but after ordering LM and another product online, I've got my card memorized.. by looking at it TWICE. And that's just the minimal effects I've gotten, ALCAR seriously has repaired SOMETHING in my brain. I've only been on it two weeks too at a steady dose.. can't wait to see 2 months' progress. My mental imagery has somehow become extremely powerful as well, I don't know how ALCAR effects that but this product is highly recommended.

[bobman]

All over my body, sometimes on my leg, arms, back, it's almost uncontrollable lol.. At first I was wondering if I was allergic to something I ate, then I remembered the itching aspect of Ashw. I'm taking the Vitamin Shoppe brand.

That's very odd. I wouldn't rule out an allergy. The only time you should feel itching is if you had peripheral nerve damage and you were re-enervating the area.

That being said, the lion's mane mice study did show itching. Hey everyone is different. Ashwagandha is great stuff, so it'd be a shame if you were allergic. How much are you taking? Any rashes or other reactivity?

Nope no rashes, just crazy dreams and a little mental fatigue for the first 5 minutes upon waking, pretty much intense being-tiredness. I take one serving size/capsule of Ash and LM before bed. Still taking 1 ALCAR, 1 Piracetam and 1 Choline source in the morning but that is what I've minimized my dose too. I've been feeling so good lately, everything is 100x more lucid than a month ago, and my memory is ridiculously good. ALCAR is a miracle supplement, this is NO bullshit and no placebo. Long-term memory, short-term memory storage and recall are unbelievable. For example, I've used my credit card multiple times on the internet and had to type out the number for orders and whatnot... I'd say 10 times in the last few months. Before ALCAR and Piracetam, I never remembered the numbers because I didn't have to/didn't pay attention. Now I still didn't have to/didn't pay too much attention, but after ordering LM and another product online, I've got my card memorized.. by looking at it TWICE. And that's just the minimal effects I've gotten, ALCAR seriously has repaired SOMETHING in my brain. I've only been on it two weeks too at a steady dose.. can't wait to see 2 months' progress. My mental imagery has somehow become extremely powerful as well, I don't know how ALCAR effects that but this product is highly recommended.

I don't believe you could possibly feel the repair happening in real time. In my case I notice once in a while that something just "clicks" that hadn't before, especially with memories that were lost during my medication use, or occasionally I'll just notice that my depth of insight, or free-association, is a step up from what it was before that moment. At those moments I think to myself that the relevant neurons now have dendrites connected further out than previously, or that enough new connections were formed to allow increased long-distance synaptic coherence.

However some of these substances increase cognition in other ways, and I think the effects you notice from piracetam and alcar are from that, rather than from the physical re-wiring that is also occurring concurrently. You'll have awesome progress if you're noticing this just 2 weeks out. The coolest thing is that I notice my brain works more efficiently post-aniracetam & alcar use. My washout is significant as well, about 1 year since last aniracetam & alcar use. I say aniracetam, but I switched it up with piracetam for a few months last summer (good also). I used nootropics for about 1.5 years altogether, more or less consistently. The hyper-acute memory (especially visualized memory, something akin to eidetic) more or less stays, although you have to force yourself to focus more as you aren't as "primed" if that makes sense. While on aniracetam I was always "primed", now I need to force that state, but it becomes second nature.

Edited by bobmann, 05 July 2010 - 07:10 PM.

[viscosity]

Does anyone know if Salvia Divinorum or DXM can causes seizures in the brain?

DXM has actually been used to treat seizures although there is of course individual variance in response as two patients in the study experienced increased seizure frequency (I'd link to the study but it sometimes takes days for my posts to get through the moderation queue when I use a link).

My boyfriend who has epilepsy takes DXM occasionally and has not had any problems while on it. He takes the medication Keppra (Levetiracetam) which interestingly enough blocks the same N-type calcium channels as DXM (DXM blocks L-type calcium channels as well). Levetiracetam as the name suggests is also in the racetam class of drugs.

Coricidin (Chlorpheniramine maleate + DXM) on the other hand has been implicated in seizures as Chlorpheniramine maleate seems to lower the seizure threshold.

[aLurker]

Does anyone know if Salvia Divinorum or DXM can causes seizures in the brain?

DXM has actually been used to treat seizures although there is of course individual variance in response as two patients in the study experienced increased seizure frequency (I'd link to the study but it sometimes takes days for my posts to get through the moderation queue when I use a link).

My boyfriend who has epilepsy takes DXM occasionally and has not had any problems while on it. He takes the medication Keppra (Levetiracetam) which interestingly enough blocks the same N-type calcium channels as DXM (DXM blocks L-type calcium channels as well). Levetiracetam as the name suggests is also in the racetam class of drugs.

Coricidin (Chlorpheniramine maleate + DXM) on the other hand has been implicated in seizures as Chlorpheniramine maleate seems to lower the seizure threshold.

Bacopa also seems good against epilepsy and has neuroprotective properties.

Bacopa monnieri and Bacoside-A for ameliorating epilepsy associated behavioral deficits.

Mathew J, Paul J, Nandhu MS, Paulose CS.

Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India.
Abstract

Bacopa monnieri is an outstanding nervine tonic used for raising the mental performance. It helps in concentration, comprehension, recall and alertness, Brahmi is particularly beneficial as it aids in categorizing information in brain and its subsequent expression. Bacopa is also called as a natural antioxidant which may give details its neuroprotective role seen in the memory centers of the brain. Epilepsy is neuronal disorder characterized by learning, cognitive and memory impairments. The present review summarizes information concerning botany, chemistry and beneficial effect of Bacopa monnieri on epilepsy associated behavioral deficits.

Edited by aLurker, 05 July 2010 - 09:17 PM.

[viscosity]

Other glycine site agonists that may be of interest

Beta-Alanine - endogenous glycine agonist, more selective than taurine
L-Alanine - glycine receptor agonist, more potent than D-Alanine
L-Proline - glycine receptor agonist
L-Serine - endogenous glycine receptor agonist, weaker than D-serine but can be converted by serine racemase.
Taurine - non-selective, endogenous glycine receptor partial agonist
Hypotaurine - non-selective endogenous glycine receptor agonist

Agonist potency according to wikipedia (I don't have access to the reference used):
glycine >> Beta-alanine > taurine >> alanine, L-serine > proline

[Spectre]

Bump.

Does anyone know if Salvia Divinorum or DXM can causes seizures in the brain? I was doing some research on deja vu and how they are frequently related to "temporal lobe epilepsy"..could my deja vu experiences that lasted for almost 2 years be attributed to this? Or is it more than likely NMDA receptor damage? The thought of having brain seizures scares the crap out of me, but I would like to know the cause of this. (A few months ago, after taking about 2 grams of phenylethylamine, I had spiking blood pressure and felt a very intense deja vu experience for about 10 minutes). Over those 2 years, I would feel random bouts of deja vu that felt extremely paranormal..and it all started after smoking Salvia Divinorum (but was noticed a lot more after taking DXM). Thanks.

Bump...

[viscosity]

Here's a link to the study on epilepsy and DXM:
http://www.ncbi.nlm....pubmed/10702964

[bobman]

Bump.

Does anyone know if Salvia Divinorum or DXM can causes seizures in the brain? I was doing some research on deja vu and how they are frequently related to "temporal lobe epilepsy"..could my deja vu experiences that lasted for almost 2 years be attributed to this? Or is it more than likely NMDA receptor damage? The thought of having brain seizures scares the crap out of me, but I would like to know the cause of this. (A few months ago, after taking about 2 grams of phenylethylamine, I had spiking blood pressure and felt a very intense deja vu experience for about 10 minutes). Over those 2 years, I would feel random bouts of deja vu that felt extremely paranormal..and it all started after smoking Salvia Divinorum (but was noticed a lot more after taking DXM). Thanks.

Bump...

The answer is yes. DXM withdrawal can cause massive rebound extracellular glutamte spikes leading to kindling and seizures. Every NMDA antagonist carries this risk. I'm not familiar with Salvia's mode of action.

[Spectre]

Bump.

Does anyone know if Salvia Divinorum or DXM can causes seizures in the brain? I was doing some research on deja vu and how they are frequently related to "temporal lobe epilepsy"..could my deja vu experiences that lasted for almost 2 years be attributed to this? Or is it more than likely NMDA receptor damage? The thought of having brain seizures scares the crap out of me, but I would like to know the cause of this. (A few months ago, after taking about 2 grams of phenylethylamine, I had spiking blood pressure and felt a very intense deja vu experience for about 10 minutes). Over those 2 years, I would feel random bouts of deja vu that felt extremely paranormal..and it all started after smoking Salvia Divinorum (but was noticed a lot more after taking DXM). Thanks.

Bump...

The answer is yes. DXM withdrawal can cause massive rebound extracellular glutamte spikes leading to kindling and seizures. Every NMDA antagonist carries this risk. I'm not familiar with Salvia's mode of action.

Massive rebound extracellular glutamate spikes? I've never heard of this..how long can these effects last? (Months to even years after cessation of use?). And if that's the case, what can prevent or cure this? I've noticed improvements since using Piracetam and ALCAR, but I still do get minor occurrences of deja vu (which may seem normal to some people, but I'd prefer to never obtain that feeling again). Thank you for the information.

[Mindweaver]

Spectre, how's your progress?