208 replies to this topic

[Spectre]

Werkshop, naloxone has absolutely changed everything for me. When I speak, I'm much more articulate and coherent, and everyone around me has noticed a tremendous change in how I act. I would say that it's gotten me to act much more "mature", at least in the way I act towards other people and the way I communicate with them. I notice things other people don't, I tend to think much faster than people around me, and all-around just seem much more "on-point" than before. I wouldn't say I'm arrogant, but I'm a lot more logical and think things through much quicker than the people I talk to, and I have a very hard time dealing with other people that aren't on my level (my patience wears very thin while I take this stuff)..I went from a person that was going insane and couldn't think rationally, to someone who thinks almost too rationally now..but I absolutely love it! My motor skills have improved tremendously, I react much quicker than before, and I feel a lot more in control of situations, it's completely killed any sense of anxiety that I previously had. I'm not overstating when I say that this WILL change your life..you will feel capable of anything, and your mental problems will disappear after you try this.

You can order naltrexone on alldaychemist, I'm trying to obtain a legitimate prescription from a psychiatrist, but my next appointment isn't until the end of the month. The tablets on the site are 50mg, and come in packs of 10. I'm ordering 3 packs, and will be dividing each tablet into 8 doses each, so it'll last me for 240 doses. You don't need a high dose of this stuff to cure OCD and depersonalization. The price is more than worth it, you'll be getting your life and sanity back. It's literally a miracle drug, and I feel better now than ever before. You'll feel vigilant, intelligent, with an improved memory, less anxiety and depression, just all around better. Take my word on it.

-What do you think it would do if a normal person took naloxone/naltrexone (nootropic value)? Would they get extra mental clarity + speed of thinking?
-Do you feel a noticable difference between using nalaxone vs naltrexone?
- Also, this is from wikipedia: " Naloxone is a μ-opioid receptor competitive antagonist, and its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms". Did you experience any withdrawls or anything like that? It would make sense if withdrawls do happen when you first start taking naloxone because of upregulation happening just like the side effects of memantine when you first start taking it and you get brainfog.
- How long do the effects last for? Do you have to redose every hour/day/weeek?
- Since your blocking opioid receptors (antagonism), wouldn't they upregulate and become more sensitive which could possibly make you super sensitive to opiates or something?
- Wouldn't it be better to use nalorphine instead since it is longer acting than naloxone? Although it is a mu-antagonist and kappa agonist, wouldn't that be counterproductive since you said kappa-receptor antagonism is what treated your derealization?
- You also seem to be talking about naloxone and naltrexone, what is the difference between them (pros/cons) in your experience? I think since naltrexone has a higher affinity for k-receptors (antagonism), it should be more effective than naloxone.

Well from what other people who have used naltrexone have reported, it's caused an increase in alertness, energy, memory, and mood..I can definitely attest to the fact that naloxone has done that for me, I haven't tried naltrexone yet but I just ordered some, it should arrive sometime this or next week. Naloxone has a very short half-life (1-1.5 hours), while naltrexone has a 4 hour half life..so redosing on naloxone is necessary every few hours for me to keep the effects active. I can only assume that naltrexone will be even more effective for me since it's longer lasting and has a higher affinity to the k-opioid receptors than naloxone.

From what I've researched, it more than likely will cause hypersensitivity for opiates in me in the long run, but I have no problem with that..I don't plan on using opiates again, naloxone completely blocks the normal drug-seeking behavior that is hardwired into my brain. The idea of getting high or altered doesn't even occur to me while "under the influence" of naloxone..and it's given me the ability to focus on tasks at hand and increase my ability to pay attention better than anything else I've ever taken. I'm actually cutting out all stimulants and depressants, including caffeine..I get all the energy and focus I need from simply blocking my kappa-receptors..it produces such a remarkable and profound effect in my ability to think, I seriously don't understand why this drug isn't being used as a main-line treatment for OCD, ADHD, depression, and anxiety. It effectively destroys all of those at once, it's a miracle!!

[Gamerzneed]

From what I've researched, it more than likely will cause hypersensitivity for opiates in me in the long run, but I have no problem with that..I don't plan on using opiates again, naloxone completely blocks the normal drug-seeking behavior that is hardwired into my brain. The idea of getting high or altered doesn't even occur to me while "under the influence" of naloxone..and it's given me the ability to focus on tasks at hand and increase my ability to pay attention better than anything else I've ever taken. I'm actually cutting out all stimulants and depressants, including caffeine..I get all the energy and focus I need from simply blocking my kappa-receptors..it produces such a remarkable and profound effect in my ability to think, I seriously don't understand why this drug isn't being used as a main-line treatment for OCD, ADHD, depression, and anxiety. It effectively destroys all of those at once, it's a miracle!!

- Does it have any negative effects on sleep for you? The alertness you say it gives might interfere with sleep although you probably can just wait out the effects if it's a problem.
- Does it have any rebound effect that is worse than baseline after wearing off?

Edited by Gamerzneed, 18 March 2012 - 09:07 PM.

[Spectre]

From what I've researched, it more than likely will cause hypersensitivity for opiates in me in the long run, but I have no problem with that..I don't plan on using opiates again, naloxone completely blocks the normal drug-seeking behavior that is hardwired into my brain. The idea of getting high or altered doesn't even occur to me while "under the influence" of naloxone..and it's given me the ability to focus on tasks at hand and increase my ability to pay attention better than anything else I've ever taken. I'm actually cutting out all stimulants and depressants, including caffeine..I get all the energy and focus I need from simply blocking my kappa-receptors..it produces such a remarkable and profound effect in my ability to think, I seriously don't understand why this drug isn't being used as a main-line treatment for OCD, ADHD, depression, and anxiety. It effectively destroys all of those at once, it's a miracle!!

- Does it have any negative effects on sleep for you? The alertness you say it gives might interfere with sleep although you probably can just wait out the effects if it's a problem.
- Does it have any rebound effect that is worse than baseline after wearing off?

I haven't noticed any negative effects on sleep, but it will keep me awake if I take a dose too late during the day or anytime at night. I fare better if I take it in the morning or early afternoon. I don't see any rebound effects at this point, but I've been taking it every day since I started (only about 10 days into it). I think that over time, the naloxone is rewiring my brain chemistry, so if anything I should start seeing more positive effects later on down the road.

[Werkshop]

Hey man.

Found this video, and thought it would help someone understand a little more about Naltrexone.

<iframe width="420" height="315" src="http://www.youtube.c...ed/xr-n8jMLenU" frameborder="0" allowfullscreen></iframe>

Also, watch with your re-dosing. Naltrexone is know to cause liver damage if used in excess or continuously.

[strider]

Let me know how it goes. I too am curious about the nootropic potential.

[Gamerzneed]

About low-dose naltrexone therapy, apparently there's a lot more to naltrexone usage than just blocking opioid effects. I've also read several experiences on the internet from people who have used it for years with no problems using low dose naltrexone (4.5mg/day-ish). Since it activates an immune response from increasing the amount of endorphins it helps with a lot of diseases that are correlated with problems with immunity like autoimmune disease, crohn's disease, multiple sclerosis, etc. My main question though is, if it increases the amount of endorphins you have, won't you feel physically good? I know that steroid users often experience increase in confidence due to the sense of well being that testosterone induces and am wondering if increase in endorphins might have similar effects. If this is the case then this could have some potential as an anti-depressant or anti-anxiety or something like that.

[Spectre]

About low-dose naltrexone therapy, apparently there's a lot more to naltrexone usage than just blocking opioid effects. I've also read several experiences on the internet from people who have used it for years with no problems using low dose naltrexone (4.5mg/day-ish). Since it activates an immune response from increasing the amount of endorphins it helps with a lot of diseases that are correlated with problems with immunity like autoimmune disease, crohn's disease, multiple sclerosis, etc. My main question though is, if it increases the amount of endorphins you have, won't you feel physically good? I know that steroid users often experience increase in confidence due to the sense of well being that testosterone induces and am wondering if increase in endorphins might have similar effects. If this is the case then this could have some potential as an anti-depressant or anti-anxiety or something like that.

Oh definitely, I feel just all-around better after I take the suboxone, but I feel that I'm building a tolerance to it now (I'm going to take it 5 on/2 off every week from now on). Naltrexone apparently increases testosterone levels in males through LH (luteinizing hormone), but I'm not sure the exact mechanism of action in that regard. I do feel a lot more confident on it though, my ability to get anything done is exponentially increased, and it cuts out my anxiety completely. I feel very motivated and structured mentally, I can actually focus in on one task and get it done without getting distracted by anything else. I see a very bright light for kappa blockers in the near future, as I believe they can completely revolutionize the psychiatric drug industry for ADHD, OCD, and depression. It'll probably be touted as the new "speed", but without the negative effects associated with stimulants. I feel way more energy on this than I've ever gotten from a stimulant before, just on point and motivated to get everything done. It's a great feeling that I've never gotten from anything else before.

[Gamerzneed]

It's probably the extra endorphin rush that has built up from opiate receptor antagonism. And you said suboxone tolerance? Suboxone is buprenorphine and naloxone. I thought you couldn't get tolerant to substances that antagonize your receptors like naloxone/naltrexone, although I'm not sure about buprenorphine.

[tdmonster99]

I share very similar symptoms with Spectre, actually I think I replied in this thread. I am currently dealing with derealization caused by DMT and have treated it with varying success. I have used LDN and regular dose Naltrexone with mixed results. I definitely experienced a reduction in anxiety and maybe DR visuals but it did increase depressive symptoms. Spectre, if suboxone is working for you, stick with it. Naltrexone has a weaker affinity for the kappa opioid compared to Suboxone/Buprenorphine. But who knows, hopefully your experience will be better.

Any more updates, Spectre? My psychiatrist is very willing to prescribe medications that could possibly help with DP/DR but buprenorphine might be a stretch. I'm thinking about ordering online. Any one have any experiences with ordering buprenorphine online? The strong KOR antagonism is what im after and naltrexone gets a little messy with its affinity for Mu and Delta Opioid receptors. Also, the research chem JDTic might hold some value since it has a strong affinity just for the Kappa Opioid Receptor and neither Mu nor Delta. But there is too little human data to give me any comfort in trying this substance. I found a source, anyone willing to try it?

[Orajel]

About low-dose naltrexone therapy, apparently there's a lot more to naltrexone usage than just blocking opioid effects. I've also read several experiences on the internet from people who have used it for years with no problems using low dose naltrexone (4.5mg/day-ish). Since it activates an immune response from increasing the amount of endorphins it helps with a lot of diseases that are correlated with problems with immunity like autoimmune disease, crohn's disease, multiple sclerosis, etc. My main question though is, if it increases the amount of endorphins you have, won't you feel physically good? I know that steroid users often experience increase in confidence due to the sense of well being that testosterone induces and am wondering if increase in endorphins might have similar effects. If this is the case then this could have some potential as an anti-depressant or anti-anxiety or something like that.

Oh definitely, I feel just all-around better after I take the suboxone, but I feel that I'm building a tolerance to it now (I'm going to take it 5 on/2 off every week from now on). Naltrexone apparently increases testosterone levels in males through LH (luteinizing hormone), but I'm not sure the exact mechanism of action in that regard. I do feel a lot more confident on it though, my ability to get anything done is exponentially increased, and it cuts out my anxiety completely. I feel very motivated and structured mentally, I can actually focus in on one task and get it done without getting distracted by anything else. I see a very bright light for kappa blockers in the near future, as I believe they can completely revolutionize the psychiatric drug industry for ADHD, OCD, and depression. It'll probably be touted as the new "speed", but without the negative effects associated with stimulants. I feel way more energy on this than I've ever gotten from a stimulant before, just on point and motivated to get everything done. It's a great feeling that I've never gotten from anything else before.

Of course you feel good, soboxone is a very powerful opiate coupled with an opiate blocker, and you will build tolerance. You feel good in part because you are getting high off

[Orajel]

About low-dose naltrexone therapy, apparently there's a lot more to naltrexone usage than just blocking opioid effects. I've also read several experiences on the internet from people who have used it for years with no problems using low dose naltrexone (4.5mg/day-ish). Since it activates an immune response from increasing the amount of endorphins it helps with a lot of diseases that are correlated with problems with immunity like autoimmune disease, crohn's disease, multiple sclerosis, etc. My main question though is, if it increases the amount of endorphins you have, won't you feel physically good? I know that steroid users often experience increase in confidence due to the sense of well being that testosterone induces and am wondering if increase in endorphins might have similar effects. If this is the case then this could have some potential as an anti-depressant or anti-anxiety or something like that.

Oh definitely, I feel just all-around better after I take the suboxone, but I feel that I'm building a tolerance to it now (I'm going to take it 5 on/2 off every week from now on). Naltrexone apparently increases testosterone levels in males through LH (luteinizing hormone), but I'm not sure the exact mechanism of action in that regard. I do feel a lot more confident on it though, my ability to get anything done is exponentially increased, and it cuts out my anxiety completely. I feel very motivated and structured mentally, I can actually focus in on one task and get it done without getting distracted by anything else. I see a very bright light for kappa blockers in the near future, as I believe they can completely revolutionize the psychiatric drug industry for ADHD, OCD, and depression. It'll probably be touted as the new "speed", but without the negative effects associated with stimulants. I feel way more energy on this than I've ever gotten from a stimulant before, just on point and motivated to get everything done. It's a great feeling that I've never gotten from anything else before.

Of course you feel good, suboxone is a very powerful opiate coupled with an opiate blocker, and you will build tolerance. You feel good in part because you are getting high off of the opiate in suboxone. Realize that it's not all "rebound effect."

That's why suboxone is given to people suffering from opiate withdrawals, it's the same logic used when giving benzodiazepines to people suffering from alcohol withdrawal.

Edit: when narcan alone is given to people suffering from opiate withdrawal, or people who have overdosed on opiates, they do not feel good.

Edited by Orajel, 24 March 2012 - 10:11 AM.

[gamesguru]

Also check out the "causes" section.
http://en.wikipedia....dence#Treatment

[Orajel]

http://en.wikipedia....ioid_dependence

Check out the "recreational use" section as well.

As with any powerful opiate, I would have to counteract a previous post and say that if supoxone is working for you, that's not surprising and stop taking it if you want to avoid dependence.

Edited by Orajel, 24 March 2012 - 09:12 PM.

[ConquerYourFear]

Thank you very much, Spectre. I'm going to take your word for it and give it a shot. $16.80 is NOTHING in comparison to my sanity, and I'll also follow your tips on dividing doses. If this works for me, you can guarantee you won't ever hear the end of my gratitude, and you'll have yourself a new internet best friend.

I'm curious about the proposed questions from Gamerzneed as well. I'd especially like to know if this is a permanent correction, or if this is something I'm going to need to keep taking for life.

EDIT: I just found out about an anti-epileptic medicine that's supposed to reverse the effects of ketamine (a dissociative, like DXM).

Here's a clip of some information about it:

“Our own clinical experience has been that many patients referred to our clinic have been on an SSRI for prolonged periods with little or no impact on their symptoms, and this has led us to investigate other potential pharmacotherapies, in particular the anticonvulsant lamotrigine. Lamotrigine acts at the presynaptic membrane to reduce the release of glutamate, and it has been shown to reverse depersonalisation-related phenomena induced by the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine in healthy individuals (Anand et al, 2000). In the absence of large-scale randomised controlled trials, and in the presence of conflicting published data (see below), the efficacy of lamotrigine (whether as monotherapy or in conjunction with an SSRI) is not yet firmly established, but it is often our first-line treatment for the condition.”

Any thoughts?

That snippet seems promising, any thoughts? Also, I'd also like to know if the previously mentioned supplement has to be taken daily or if it can be taken a 'few' times to induce positive permanent changes.

[Killword]

Thank you very much, Spectre. I'm going to take your word for it and give it a shot. $16.80 is NOTHING in comparison to my sanity, and I'll also follow your tips on dividing doses. If this works for me, you can guarantee you won't ever hear the end of my gratitude, and you'll have yourself a new internet best friend.

I'm curious about the proposed questions from Gamerzneed as well. I'd especially like to know if this is a permanent correction, or if this is something I'm going to need to keep taking for life.

EDIT: I just found out about an anti-epileptic medicine that's supposed to reverse the effects of ketamine (a dissociative, like DXM).

Here's a clip of some information about it:

"Our own clinical experience has been that many patients referred to our clinic have been on an SSRI for prolonged periods with little or no impact on their symptoms, and this has led us to investigate other potential pharmacotherapies, in particular the anticonvulsant lamotrigine. Lamotrigine acts at the presynaptic membrane to reduce the release of glutamate, and it has been shown to reverse depersonalisation-related phenomena induced by the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine in healthy individuals (Anand et al, 2000). In the absence of large-scale randomised controlled trials, and in the presence of conflicting published data (see below), the efficacy of lamotrigine (whether as monotherapy or in conjunction with an SSRI) is not yet firmly established, but it is often our first-line treatment for the condition."

Any thoughts?

That snippet seems promising, any thoughts? Also, I'd also like to know if the previously mentioned supplement has to be taken daily or if it can be taken a 'few' times to induce positive permanent changes.

I have completely aborted a dissociative trip with low dose lamotrigine. I am not sure how it would effect functioning afterward though. I had it left over from when I was taking it as an antidepressant. It worked pretty well for that with very few adverse effects.

[Neveragain]

One day about 7 months ago, after being up whole night, I bought a bottle of cough syrup which contained 1050mg of DXM. I extracted it carefully (Lets assume purity of my extraction was 80%, that leaves me at 15-17mg/kg), drank grapefruit juice to potentiate the effect (which I guess didn't really have any effects since I drank it nearly same time than DXM, or?). I drank this nasty stuff with ½ beer (should protect against brain damage, they said..) and gone to my bed.

Trip started with some extremely vivid CEVs. After that I had my most realistic hallucination ever, I was casually chatting with my mother in a different room of my house. Soon I realized I was still lying in my bed and still coming up on DXM. I started to freak out a little, worrying where things are going to since I already got so intense hallucinations. I don't remember did I get any intense hallucinations after this, I remember some random looping CEVs and very high BPM.

Then I woke up and realized that I had passed out. I was still tripping pretty hard and looked at the clock, I was 6-9 hours into the trip. I felt absolute shit and searched my stash to find anything to stop the trip, with bad results.. I'm wondering did I pass out because of DXM or just because I was extremely tired? I think I maybe tried to sleep to get over the bad trip. I have no memories of that time, just like when you go to sleep very drunk and wake up with horrible hangover thinking "wtf just happened"..

Next few days I had horrible depersonalization/-realization. I looked in the mirror and had no idea who I was looking at. Nearly all my memories were gone, also my short-term memory. I had also those common problems with speaking and vocabulary. Thinking now, some of these were probably caused by DXM hangover, which I didn't even realize to think about because I never before had gotten it.

I was sure my life was over which worsened my depression. Being 21 and thinking you permafried your brain isn't very fun..

Now I'm nearly back to myself, maybe 95%, it took about 3 months for my memory to start working OK and I remember more and more things every day. Depersonalization/-realization are pretty much gone, popping up sometimes. I think I was fairly psychotic for the first month, but nobody noticed that so I don't know was I really so messed up.

Problems I still have:
- Mood swings
- Sometimes I feel like I'm going insane + insane thinking (which I realize is insane)
- I feel like my brain isn't functioning at 100%, like a part would be disabled
- DP/DR (pretty rare and mild)
Will add more when/if I remember..

Some info which may help to know what receptors I fucked up:
- Sleep deprivation helps
- While having a very bad hangover I can see very clear CEVs (4 years of LSD made this for me, but it was only about 10% of what it is now)
- I feel more sane when I have a little hangover
- I start to feel worse if I'm about 10 days without drinking
- Sometimes I feel fucked up after drinking, like there would be some changes on some receptors, drinking again fixes this
- My feelings were pretty much gone for a few months (thankfully they are nearly 100% back)
- 25I-NBOMe (5HT2A full agonist) makes me feel 100% myself but there's still that feel some part of my brain would be disabled
- Not really related but just saying: I took an IQ test and it's still the same than before this fuck up

My current supplements:
- Nicotine (Must have or I feel shit, I don't know if it helps some of my receptors or is it just withdrawal..)
- SAMe 400mg (Used for about 10 days and I'm feeling a lot more sane and stable. Depression is starting to disappear, increasing dose soon)
- Ashwagandha (Very good for all problems)
- B-vitamins & other basic stuff
- Exercise & non-gluten diet

I will soon order some supplements mentioned in this thread, I hope they will bring me back to 100%. I guess most of my problems are only in my head, but there is indeed some brain damage done. I currently think my NMDA receptors are damaged since alcohol & nicotine both help with my problems and both have effects on NMDA, but then there's also 25I-NBOMe, why it helps the best?

Sorry for messy post, I'm very tired and I get very anxious when I think back to the day my life "ended". Any help will be greatly appreciated, especially I would like to know what receptors I fucked up since my own knowledge on this subject is very limited. After my brain is working again, I can fully focus on my psychological problems.

Thanks for reading.

Edited by Neveragain, 31 March 2013 - 06:15 AM.

[Werkshop]

One day about 7 months ago, after being up whole night, I bought a bottle of cough syrup which contained 1050mg of DXM. I extracted it carefully (Lets assume purity of my extraction was 80%, that leaves me at 15-17mg/kg), drank grapefruit juice to potentiate the effect (which I guess didn't really have any effects since I drank it nearly same time than DXM, or?). I drank this nasty stuff with ½ beer (should protect against brain damage, they said..) and gone to my bed.

Trip started with some extremely vivid CEVs. After that I had my most realistic hallucination ever, I was casually chatting with my mother in a different room of my house. Soon I realized I was still lying in my bed and still coming up on DXM. I started to freak out a little, worrying where things are going to since I already got so intense hallucinations. I don't remember did I get any intense hallucinations after this, I remember some random looping CEVs and very high BPM.

Then I woke up and realized that I had passed out. I was still tripping pretty hard and looked at the clock, I was 6-9 hours into the trip. I felt absolute shit and searched my stash to find anything to stop the trip, with bad results.. I'm wondering did I pass out because of DXM or just because I was extremely tired? I think I maybe tried to sleep to get over the bad trip. I have no memories of that time, just like when you go to sleep very drunk and wake up with horrible hangover thinking "wtf just happened"..

Next few days I had horrible depersonalization/-realization. I looked in the mirror and had no idea who I was looking at. Nearly all my memories were gone, also my short-term memory. I had also those common problems with speaking and vocabulary. Thinking now, some of these were probably caused by DXM hangover, which I didn't even realize to think about because I never before had gotten it.

I was sure my life was over which worsened my depression. Being 21 and thinking you permafried your brain isn't very fun..

Now I'm nearly back to myself, maybe 95%, it took about 3 months for my memory to start working OK and I remember more and more things every day. Depersonalization/-realization are pretty much gone, popping up sometimes. I think I was fairly psychotic for the first month, but nobody noticed that so I don't know was I really so messed up.

Problems I still have:
- Mood swings
- Sometimes I feel like I'm going insane + insane thinking (which I realize is insane)
- I feel like my brain isn't functioning at 100%, like a part would be disabled
- DP/DR (pretty rare and mild)
Will add more when/if I remember..

Some info which may help to know what receptors I fucked up:
- Sleep deprivation helps
- While having a very bad hangover I can see very clear CEVs (4 years of LSD made this for me, but it was only about 10% of what it is now)
- I feel more sane when I have a little hangover
- I start to feel worse if I'm about 10 days without drinking
- Sometimes I feel fucked up after drinking, like there would be some changes on some receptors, drinking again fixes this
- My feelings were pretty much gone for a few months (thankfully they are nearly 100% back)
- 25I-NBOMe (5HT2A full agonist) makes me feel 100% myself but there's still that feel some part of my brain would be disabled
- Not really related but just saying: I took an IQ test and it's still the same than before this fuck up

My current supplements:
- Nicotine (Must have or I feel shit, I don't know if it helps some of my receptors or is it just withdrawal..)
- SAMe 400mg (Used for about 10 days and I'm feeling a lot more sane and stable. Depression is starting to disappear, increasing dose soon)
- Ashwagandha (Very good for all problems)
- B-vitamins & other basic stuff
- Exercise & non-gluten diet

I will soon order some supplements mentioned in this thread, I hope they will bring me back to 100%. I guess most of my problems are only in my head, but there is indeed some brain damage done. I currently think my NMDA receptors are damaged since alcohol & nicotine both help with my problems and both have effects on NMDA, but then there's also 25I-NBOMe, why it helps the best?

Sorry for messy post, I'm very tired and I get very anxious when I think back to the day my life "ended". Any help will be greatly appreciated, especially I would like to know what receptors I fucked up since my own knowledge on this subject is very limited. After my brain is working again, I can fully focus on my psychological problems.

Thanks for reading.

Great post and welcome to the community.

I'm still suffering the problems mentioned previously, but my old self is shining through more and more day-by-day.

Oddly enough, alcohol also makes me feel alive again. It makes me feel like my old self, but once sober I return back to my gloomy, unfunny, anxious self. Wish I knew the reason why. Oh, and sleep deprivation does this too. If I go a day or two without sleep, I suddenly become energetic, happy, funny, confident, etc. I wish the feeling would last forever.

Hopefully someday we'll discover a way to make those feelings stay. Keep us updated!

Oh, and I suppose I should use this post as an update of my own.

I tried Naltrexone with little to no success. I used piracetam for awhile, and I felt that it may have been helping me along with a slight increase in memory and vocabulary skills, but nothing extreme, so I stopped that. I take regular vitamins with an extra B-complex, folic acid, vitamin C, fish oil, and an occasional B-12 after a long night of drinking.

I've tried a few nootropics, and am currently taking some right now.

I'm taking:
Noopept 10-30mg estimated 3 times a day, with a break on the weekends
Alpha GPC 600mg once a day
Huperzine A 200mcg 1-2 times a day (is this too much? Each pill is 200mcg.)
Vinpocetine 10 mg 1-2 times a day
Occasional scullcap for anxiety 425 mg

So far this stack has done pretty well for me. Unfortunately I kinda started taking them all at the same time, so I can't contribute effects to individual supplements/noots, but my memory is getting sharper, and everything just seems kind of brighter. I can understand things easier, and the scullcap helps a bit for anxiety. Helps me spcialize a little better (without the need for alcohol). Alcohol, however, is the best cure (or rather most effective cure) so far to treat my anxiety and allow me to have amazing conversations with my friends. It honestly hurts, because I slowly see myself relying on alcohol to function in life, but I know this will only impair me further.

Other things to note:
Smoking cannabis now makes me very anxious and paranoid, wheras it used to make me funny, happy, giggly, stress-free, etc. This could also have a relation to my synthetic cannabinoid abuse, but it seems DXM may have also played a role in it.

As noted before, alcohol and sleep deprivation both bring me back to my old self. Would really like to know the reason for this.

Sorry for the messy post. I'm a bit scatterbrained anymore, and I find it hard to focus on one topic. Any help or insight is much appreciated. Please don't let this thread die. There are so many that need help desperately here. Hopefully someone can come along with some more solutions.

Thanks for reading,
Alex

[Psionic]

Oddly enough, alcohol also makes me feel alive again. It makes me feel like my old self, but once sober I return back to my gloomy, unfunny, anxious self. Wish I knew the reason why. Oh, and sleep deprivation does this too. If I go a day or two without sleep, I suddenly become energetic, happy, funny, confident, etc. I wish the feeling would last forever.

Sleep deprivation is known to lift depression in more than 60% depressed patients. Even a few minutes of sleep can bring depression back due to activation of mesolimbic system.

Neuroscience researchers from Tufts University have found that our star-shaped brain cells, called astrocytes, may be responsible for the rapid improvement in mood in depressed patients after acute sleep deprivation. This in vivo study, published in the current issue of Translational Psychiatry, identified how astrocytes regulate a neurotransmitter involved in sleep. The researchers report that the findings may help lead to the development of effective and fast-acting drugs to treat depression, particularly in psychiatric emergencies.

http://www.scienceda...30123093725.htm


Alcohol alters sleep and also affect GABA/NMDA so it can be more complicated.. but being on hangover allow me to be more creative/insightful and be 100% of my self so you got third person with same qualities

Edited by Psionic, 03 April 2013 - 02:25 PM.

[Werkshop]

Wow. Crazy enough as it is, I was just reading articles on what you wrote exactly. I'm going on a no-sleep binge attempt and will record results. I'm on hour 22 right now, and I'm already past the first sleepy stage (for lack of a better term). Could there be a correlation between alcohol's effects on NMDA and DXM's? I'm no neuroscientist, but I do know that DXM is a NDMA antagonist.

With a third person feeling the same way, I'm sure there must be more. I may just be going out on a limb here, but was anyone out here sleep deprived for a long time prior to DXM abuse? I was, but after continued abuse (2 bottles of Robitussin every night), I started going to bed early and got on a regular sleep schedule. In fact, after a while, the only thing I WOULD do is chug the bottles, go home, put on some headphones, and fall asleep listening to techno (sounds like a blast, right?). Perhaps sleep has a larger effect on our mental issues than DXM abuse itself... Any thoughts?

[Werkshop]

My first sleep deprivation trial failed (passed out), and I'm one one again. I've been up for approximately 32 hours now and minus the obvious bit of lethargy here and there, I feel great, mentally. I don't have any anxiety, depression, and I can converse a lot better. Also, since I'm a bit goofy, I seem to be funnier and I'm making people laugh like crazy. I'm very quick-witted and creative. I've already written a short essay and I've started on two new songs, that sound actually pretty good.

In all honesty, this is the greatest I've felt in a long time. I called my grandma up just for a chat (she's battling leukemia, and she likes to have someone to talk to, but I'm normally too anxious to talk to her. Yeah, that doesn't make me feel the greatest...) I'm a bit scatterbrained, because I'm not used to this sleeplessness like I used to be, but I believe if I deprived myself of sleep more often, it would help lift my mood and bring me back to my old self.

Any thoughts?

Oh, and if you're interested in my writing abilities while sleep deprived, here's the short writing:

Vita Est Orbis
Alex Werkmeister

You ever have one of those days where you sit there and try to think of something you want to do, but nothing comes to mind? Where you just want to sit there and do nothing. You don't even want to sleep or watch TV. You just want to do nothing. You're not suicidal, but you don't even want to be alive.

Every day I feel like this. No motivation. No emotion. No sense of being "here," or even wanting to be, for that matter. It's like a constant haze of apathy. It becomes overwhelming sometimes. No overwhelming as in stressful or depressing. Overwhelming as in just--plain frustrating. It's to the point where I will run a million ideas through my head trying to find something that would be fun, productive, or just enjoyable in some way, shape, or form, but the motivation to do any of those things just isn't there. It never seems to be.

Every now and then, I'll get a spark of--motivation, I guess you could call it, and I'll pick up my guitar for an hour or so and just create. Once it's started, it's hard to stop. Mostly because I know that as soon as I do, I'll fall back into my nest of carelessness. Not the nice type of carelessness you'd obtain from meditation or smoking a joint. Carelessness to the point of someone setting fire to my house, and I could just sit there and let myself become engulfed in flames. The pain would be excruciating for a bit, but after a few moments... death.

Death is very intriguing I see it as a bitter sweet release from this everyday, mundane routine I've fallen into. It's not just me, either. Take a moment, and observe your life. Take a good, hard look at it. What's it's blossomed into for you. What do you do? Every day you wake up, get ready, go to work or school, do your duties, have fun, go to sleep, and repeat. No matter what you do to add excitement or variance into your life, it will always find a way to repeat itself. History repeats itself, work repeats itself, parting repeats itself, your TV program repeats itself. You will hear the same song over and over again on the radio, you'll watch the same movies multiple times, you'll eat the same food, and you'll go to the same places. Over and over. Again and again. And at the end of all this--this cycle of repetition--you will die. And the circle of life with start anew. If you had children, you will pass this routine down to them, and they too will fall into a very similar pattern. And their children. And their children's children. This is one of my greatest realizations I've ever come across in my short time on this planet, which also follows a strict pattern of circles, rotation, and repetition. Vita Est Orbis--life is circles.

[Keynes]

I am very much interested in hearing an update from this, as our stories are similar (although I did ketamine and not DXM). Dissociatives are incredibly dirty drugs. I'll try and get a prescription for naltrexone (which also might help my possible ADD).

[Endymion]

I am very much interested in hearing an update from this, as our stories are similar (although I did ketamine and not DXM). Dissociatives are incredibly dirty drugs. I'll try and get a prescription for naltrexone (which also might help my possible ADD).

Just to clarify for anyone reading the thread...
As Orajel pointed out, the perceived benefits that Spectre was getting from suboxone (naloxone + buprenorphine) were from the buprenorphine, which is an opiate. Suboxone is used in harm-reduction drug replacement as a long-acting substitute for heroin and other abused opiates.

Suboxone is taken sublingually and the naloxone component is NOT absorbed, only the opiate (buprenorphine) is. Naloxone is only active when given intravenously.
So why is it included in the formulation? It is there to prevent addicts injecting suboxone to get a greater rush from the opiate (buprenorphine). If they were to crush up suboxone and inject it they would cause very unpleasant opiate withdrawal symptoms due to the action of naloxone.
I don't imagine the positive effects of buprenorphine are sustainable, as tolerance will develop.

Nevertheless, naltrexone is a very interesting drug and is worth a shot for depersonalization/derealisation-like symptoms.
Good luck.

[Keynes]

I am very much interested in hearing an update from this, as our stories are similar (although I did ketamine and not DXM). Dissociatives are incredibly dirty drugs. I'll try and get a prescription for naltrexone (which also might help my possible ADD).

Just to clarify for anyone reading the thread...
As Orajel pointed out, the perceived benefits that Spectre was getting from suboxone (naloxone + buprenorphine) were from the buprenorphine, which is an opiate. Suboxone is used in harm-reduction drug replacement as a long-acting substitute for heroin and other abused opiates.

Suboxone is taken sublingually and the naloxone component is NOT absorbed, only the opiate (buprenorphine) is. Naloxone is only active when given intravenously.
So why is it included in the formulation? It is there to prevent addicts injecting suboxone to get a greater rush from the opiate (buprenorphine). If they were to crush up suboxone and inject it they would cause very unpleasant opiate withdrawal symptoms due to the action of naloxone.
I don't imagine the positive effects of buprenorphine are sustainable, as tolerance will develop.

Nevertheless, naltrexone is a very interesting drug and is worth a shot for depersonalization/derealisation-like symptoms.
Good luck.

Thank you for clearing that up! Great explanation, and I agree with the sustainability issue concerning chronic opiate usage.

Since naltrexone is off label use for dp (everything is though) I made my doctor really uncomfortable asking for it (he started stammering). I guess I'd have to fake alcohol dependence to get near it, which is a shame.

[Endymion]

Thank you.
It's a shame he reacted that way. So he wouldn't prescribe it? Maybe try a different doctor.

[Ark]

Suboxone is junk, soon as someone is on that stuff for a month or longer they won't be able to stop with ease.

You guys need ibogaine. FTW

[tolerant]

Is DXM-induced psychosis dose-dependant? Can ketamine result in psychosis too?

[Flex]

Yes to both.

Just type Your question in Google and You will find an abstract like this:

http://www.ncbi.nlm....pubmed/11557159

 

They are stronger NMDA antagonists than magnesium or Berberine & etc.

I would rather be concerned about the Brain damage.

Btw: afaik adrenergic a2 antagonist( so probably THC/Cannabis too) and adrenergics could increase the damage of NMDA blockers

[tolerant]

This is interesting, because I was trying to self-medicate with ketamine at sub-recreational doses. The first time I took it, I was fine, although showed no response. The second time I took it, it was a larger and more concentrated dose, but I had also taken clonidine 12 hours prior and my blood pressure was still low. This time it made me feel worse in terms of depression/anxiety and just overall. This was more than a week ago now and I still haven't recovered fully from that experience.

[boroda]

I know it's an old topic but I can't resist saying... 4 DXM trips @400mg caused a damage and memory problems? I don't believe that. Those doses are tiny.

 

4 trips @1200mg could cause noticeable damage. But not @400mg.