110 replies to this topic

[goku]

So what's up with this thread?

Which is the best QUALITY res supplement if money is not an issue?

And is it true that res is super easily oxidized?

[mirian]

Longevinex is the only resveratrol supplement proven to activate SIRT1 longevity gene like research-grade resveratrol. Hence, why Dr. Sinclair takes it.

Dr. Sinclair is taking just 5mg per kg making 364 mg for 160lbs right now. I wouldn't go above that for now since he's the expert on it.

Lycopene is a supplement that is also well known to have both a cis and trans form as well. But, resveratrol has shown a big difference being trans form activates SIRT1 and cis form doesn't no huge difference has been shown with lycopene. Lycopene is well known to change forms as well based on light, heat, oxygen as well.

So, for total peace of mind you are activating SIRT1, I'd go with Longevinex which is 100mg for now. Till another competitor wises up. NSI Longevital is only 50mg still.

I sure wish someone came out with a 500mg trans resveratrol LiCap. Again, LiCaps are always legitimate regardless of supplement company since it has to be made by Pfizer personlaly the world's largest pharmaceutical.

Edited by mirian, 17 June 2007 - 06:13 PM.

[proteomist]

No he's not. He quit taking it some time ago to participate in a clinical trial within the company.

Sirtris is testing resveratrol dosages on the order of 5 grams daily in their clinical trials. Tis is ~50-75 mg/kg per day depending on size. Clearly they think they are unlikely to get beneficial effects (or toxic ones for that matter) at lower doses.

Longevinex is the only resveratrol supplement proven to activate SIRT1 longevity gene like research-grade resveratrol. Hence, why Dr. Sinclair takes it.

Dr. Sinclair is taking just 5mg per kg making 364 mg for 160lbs right now. I wouldn't go above that for now since he's the expert on it.

[mirian]

Difference being Sirtris trans resveratrol pills are also emodin-free among other things. Plus, don't have to deal with such small doses like 100mg.

Longevinex has some emodin. But, Longevinex says will eventually have an emodin-free product.

Dr. Sinclair says Resveratrol is just the beginning:

http://www.economist...FTOKEN=51104714

which says:

"Resveratrol, however, is only a starting point. Sirtris Pharmaceuticals, a firm based in Cambridge, Massachusetts, of which Dr Sinclair is a co-founder, has identified a number of synthetic molecules whose effect on yeast is many times more potent than resveratrol's."

Dr. Sinclair may come out with a pill with a synthetic molecule that activates Sir2/SIRT1 many times over what trans resveratrol does!

[proteomist]

Yes, many here have been following this for quite some time now.

"Resveratrol, however, is only a starting point. Sirtris Pharmaceuticals, a firm based in Cambridge, Massachusetts, of which Dr Sinclair is a co-founder, has identified a number of synthetic molecules whose effect on yeast is many times more potent than resveratrol's."

Dr. Sinclair may come out with a pill with a synthetic molecule that activates Sir2/SIRT1 many times over what trans resveratrol does!

[shifter]

I say bugger Resveratrol, too expensive, too iffy and too undecided on what dosage is needed and best. 50mg? 5000mg?

Why is there not a Selegiline bandwagon as low doses of that have quite positive effects on health and lifespan and at 1mg per day its cheap!!!!

[mirian]

If you want a low dose regimen. NOW Pomeratrol has 20mg of trans resveratrol per Vcap with some pomegranate. Which I agree with more than their newer 50mg resveratrol formula with green tea, anyways. 10mg is actually the upper safe amount proven safe for humans to date:

http://ntp.niehs.nih...Resveratrol.pdf

No page ii says that 5mg to 10mg a day of trans Resveratrol appears to be entirely safe.

You have to remember there's not much if any of human studies on resveratrol. Simply making assumptions based on studies from small mammals like mice or rates and quoting a human equavalent dose doesn't cut it for true safety. Humans are different. For example, your dog could have serious complications from consuming Xylitol causing the dogs blood sugar to plummet but for humans is safe except in excess can cause looe stools like vitamin C, magnesium, emodin, etc.

I do agree though that if it makes another mammal live longer. The odds are in favor of it applying also to humans. But, the dosage is critcal. We have yet to find this out. But, I think in the next two years we'll have a better understanding of ideal supplement rage for resveratrol. More isn't always better. Too much selenium promotes diabetes. More than 10mg a day of vitamin B2-Riboflavin accelerates aging of the skin. More than 400IU's daily of even natural vitamin E increases mortality risk.

If I had cancer no doubt I'd be taking probably 2,000mg of trans resveratrol daily. But, because 20mg of melatonin helps with cancer. Doesn't mean someone should supplement with it long term without cancer. Dr Weil indicates that long term supplementation of melatonin reduces the amount your body produces. Should only be used for jet lag for no more than 3 days or perhaps if you have cancer.

Edited by mirian, 18 June 2007 - 08:39 PM.

[curious_sle]

- your link is broken
- it's 10mg/kg/day

[Anthony_Loera]

If you want a low dose regimen. NOW Pomeratrol has 20mg of trans resveratrol per Vcap with some pomegranate. Which I agree with more than their newer 50mg resveratrol formula with green tea, anyways. 10mg is actually the upper safe amount proven safe for humans to date: http://ntp.niehs.nih...Resveratrol.pdf

Mirian please read the following:

http://www.revgeneti...vailability.pdf

It appears low doses of resveratrol is easily tossed out of your system. Why would Dr Sinclair be testing 2.5-5 grams of a resveratrol formulation if he didnt believe a low dose may not be suitable?

Anthony

[mirian]

Ok, I read I just emailed people that did the study see if I get a reply. I want to get down to the bottom of this.

[texxsonn]

I am very suspicious of Longevinex. I ordered 30 days supply and guess what? Not only did I get the Longevinex but I also received an order of "Dual action Cleanse" which I did NOT order. I sent the Dual Action Cleanse back. I called and talked to a rep at Longevinex and they say that they have no affiliation with Dual Action Cleanse. Coincidence? Not sure at this point but I am very suspicious. Both products came from California. Has anyone else has this happen? Best wishes to all!

[tintinet]

They send me random "sample" type amounts of other supplements fairly regularly. Once, they did attempt to charge me, but I stomped on that noise.

[dannov]

I have viewed a few studies that basically show Resveratrol to be very stable and not easily degraded.

[geo12the]

Seems like there has been a lot of talk regarding bioavailbilty and the amount of resveratrol you need to take to reap any benefits. The way I tend to think about is that you may not need a huge amount of this stuff in your system to have a beneficial effect:

Anyone who has taken LSD can attest to the fact that ingesting a very miniscule amount of a compound can produce profound effects.

Resveratrol has pretty significant effects when fed to mice. I could be wrong, and if so someone please correct me, but from what I’ve read there is no reason to believe that resveratrol is inherently more bioavailble in mice than humans.

Something is responsible for the “French paradox” and resveratrol is a good candidate for playing a role. I would be willing to bet if you took the resveratrol out of wine the “French paradox” would disappear. The concentration of resveratrol in wine is not that high.

As for Longevinex, as I’ve stated before on this forum I don’t like the inclusion of IP6 in the formulation, it’s not something I want to take on a daily basis, so I take RevGenetics pills instead.

George

[Anthony_Loera]

The company has done Biomol testing, independent US lab tests, and is cheaper per gram, offers not only 50% but also 99% trans-resveratrol.
Look at the price watch list, it states who has done SIRT1 testing:

http://www.imminst.o...tch-t15059.html

A

Edited by Mind, 18 April 2008 - 11:08 PM.

[Mind]

Thanks Anthony for bringing this old thread back to life (so I can close it down). A lot has changed in the Resv industry since it was started and there are a lot of providers. There are many threads here at Imminst which discuss aspects of resveratrol. As you know we try to keep a lid on marketing and commercial spam in the forums because it is annoying, but also because there are sponsors at Imminst. This is the type of thread that is a magnet for heated controversy and viral marketing (for and against) and thus I am closing it. Much more fruitful and enlightening discussions about bio-availability, the newest SIRT1 activation news, etc... can be found in the resveratrol forum.

[Mind]

I am rolling the dice by opening this thread up again. I don't have a horse in the resveratrol race. I don't use the supplement often (very infrequently in fact) but when I have, I tried Revegenetics and Longevinex.

Anyway, just wanted to hear what people had to say about this research result. Longevinex improved endothelial function. Legit result? Nothing to crow about? Already known? I doubt the brand would matter.

[hav]

Interesting product. Had to look up the ingredients to find out what it's all about. http://www.longevine...lementfacts.php ... Mostly D3 with 100 mg micronized resvertrol plus quercetin. Thought it was odd however that the research cited focuses mostly on the resveratrol Nitric Oxide connection because I have poor leg circulation myself and supplement additionally with Gotu Kola and L-Arginine for more evident relief. I used to take a Resveratrol / Quercetin mix but had occasional leg cramping issues... have had much better success with Resveratrol / Luteolin which goes well with 2000 IU D3.

Howard

Edited by hav, 06 December 2011 - 11:02 PM.

[Forever21]

Oh hey guys. How are you doing with Longevenix if you're on this supplement?

[Harkijn]

Oh hey guys. How are you doing with Longevenix if you're on this supplement?

Same question here. Taking a look at the starting date of this thread, I think there may be some longtime users of Longevinex or RSV plain. Is one of the early posters still using Longevinex and looking a lot younger than his peers?

I ask this because Bill Sardi still claims to sell you the Fountain of Youth and says he receives emails from satisfied customers:

http://www.resveratr...1470/#more-1470

[brosci]

Giving this thread a little bump -- I'm curious if there's any concern over the EGCG in Longevinex.  I also eat a ketogenic diet, which I've read can "profoundly" deplete liver stores of glutathione, somewhat mimicking acetaminophen toxicity -- https://www.ncbi.nlm...les/PMC3102314/

 

If I drink green tea regularly and have longevinex during my daily morning fast, am I setting myself up for potential liver toxicity issues from this EGCG stack?