You would expect this from a supplement that actually increase brain GABA. Tinnitus is caused by excess Long Term Potention which is covered by the inhibitory effects of GABA. Also Nician will help somewhat
Using my experience with tinnitus as a subjective but empirical base for reason, I would tend to agree with the above poster. I had tinnitus in my early twenties, had a stretch of 7-8 years where it disappeared, and had it return the other morning after the first time I did a Nootropic (a small amount of aniracetam without a choline source). My experience strongly speaks to tinnitus having a basis in deeper brain neurotransmitter/neurohormone chemistry. If it were just an issue of vasodilation, my tinnitus wouldn't have stayed away all of those years.
Also, a feeling of short patience and anxiety was extremely strong the following day. Almost to the point where I felt my long ago beaten OCD (16 years ago) creep back, ever so slightly. This also speaks to strong GABA receptor interaction. Without pontificating on how it interacts (I have my theory, which also gels as to why racetams seem to re-sensitize receptors to GABA agonists), my experience would indicate that a small amount of a racetam can have a large effect on the brain, which will be evident if you are sensitive to your own physiology or have had various neurological issues.
Remember that its a widely held principle that the strongest and most effective medicines are poisons taken in very small doses. I'm not saying that anything discussed here is a poison, but rather that if something is effective, it tends to be the most effective, in terms of long term prophylaxis, at very small doses. In my experience, anything that has been extremely effective for me is much less effective in larger doses.
Perhaps the very small dose of aniracetam that I took was responsible for my acute reaction (other than the anxiety and tinnitus, which could have been due to the omission of a choline source or a gaba agonist to help ease the neurochemical adjustment, it seemed to have some positive effect. Especially in terms of sex hormones, or possibly acetylcholines action on sexual function).
Another recent example is my taking 5 mg of arginine alpha-ketogluterate recently, which almost immediately cleared up a case of epiditmytus that I had for the past 5 months, and that a 10 day round of extremely strong and expensive antibiotics couldn't clear up. I hadn't even taken the arginine for that purpose, not knowing anything about arginines role in inflammation, but rather to try it as a weight lifting supplement. I found it useless for the latter purpose, and was dissapointed int he purchase until my inflammatory condition ameliorated within three days, as well as another inflammatory condition that I won't discuss here, for the sake of decorum, but which was intimately tied in to the epiditmytus in terms of when the inflammatory pain would appear. Judging from my past experience, the arginine would not have had such a strong long term positive effect if it had been taken in a larger dose. It actually may have had the opposite effect, and made the inflammation worse. Arginines role in the Urea cycle, and the potential for inflammatory disease in relation to that cycle, can serve as a model to further explain my experience. (BTW, Im not very physiologically knowledgeable, at least compared to many on this board, but have looked at a methylation map. I can't debate anyone on the above observations.)
Edited by golgi1, 22 October 2010 - 05:17 PM.
