i think there was this one thing called nervonic acid that was found to repair myelin and is found in mustard powder
http://www.longecity...uper-nootropic/http://greatmasticat...-did-it-go.htmlhttp://biosingularit...elin-formation/ (protein Par-3)
At a basic level, our nervous system is like a collection of wires that transmit electrical signals encoding our thoughts, feelings, and actions, both conscious and unconscious. The connections in our brain are formed by neurons that extend to each other and to muscles long wires called axons. Just as an electrical wire needs insulation, our axons require an insulating sheath (myelin) that helps to propagate the electrical signal and maximize the efficiency and velocity of these signals in our brain and body. It is this property (myelination) that facilitates the long-distance communication in our nervous system across junctions called synapses, such that a thought can result in the movement of a finger or a toe. Diseases and injury that compromise the integrity of myelin such as multiple sclerosis, or peripheral neuropathies, have dramatic consequences like paralysis, uncoordinated movements, and neuropathic pain. More specifically, the study showed that a protein called Par-3 is at the base of the myelination process. This protein becomes localized to one side of the myelin-forming cells called Schwann cell, upon contact with the axon that is to be myelinated. Par-3 acts as a sort of molecular scaffold to set-up an “organizing centre”, which brings together key proteins essential for myelination, in particular a receptor for a molecule secreted by the neurons. The scientists found that when they disrupted this organizing centre, cells could not form myelin normally. Importantly, their discovery demonstrates that Schwann cells need to become polarized so that they know which side of the cell is in contact with the axon so that they can initiate wrapping and bring essential molecules to this critical interface. These studies open the way to new research, which should help to identify other components that are recruited at the organizing centre set-up by Par-3. Importantly, in conditions such as multiple sclerosis or after injury, it is believed that Schwann cells could be used to re-myelinate axons. But so far this approach has proved to be relatively inefficient. Therefore, these experiments bring about the possibility that manipulating the Par-3 pathway in Schwann cells might allow for more efficient re-myelination of damaged or diseased nerves.
also this may be relevant:
http://www.genengnew...erape/81245731/A technique for generating pure populations of mouse oligodendrocyte progenitor cells (OPCs) that can differentiate into myelin-producing cells both in vivo and in vivo is reported by scientists at Case Western Reserve University School of Medicine and Stanford University School of Medicine. The method involves directing the differentiation of pluripotent mouse epiblast stem cells (EpiSCs) through defined developmental transitions, which, the team claims, results in the rapid and efficient production of highly expandable populations of mouse OPCs.
http://www.ncbi.nlm....pubmed/21913336Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation and differentiation.
Edited by Ampa-omega, 29 December 2011 - 10:41 PM.
