http://www.springerlink.com/content/n2664kv787l642lr/ less euphoria, same psycosis
http://www.drugs.com...645-1477-0.html Probably dampens stimulatory effects
http://ajp.psychiatr...tract/131/7/820 Abstract only, but it looks like they pretty much oppose each other completely
2 minutes on google scholar searching "amphetamine and lithium interactions".
I appreciate the references, but I too found those on PubMed. The problem is that they used lithium carbonate at therapeutic levels used to treat bipolar patients - so probably in the 450mg-1200mg/day range - which I don't think is even in the same ballpark as taking 5mg supplemental lithium orotate or aspartate. A slingshot and a bazooka, at their most basic levels, both perform basically the same function - just on very magnitudes. This doesn't mean that one should expect a handheld slingshot to pack the same punch as a bazooka, or vice-versa.
As I understand lithium, lower doses tend to have a mildly sedative effect, while higher doses can be much more stimulatory. So if high and low doses have opposite effects, would a low dose of Li Orotate have an opposite effect to that of the higher dose Li Carbonate/d-amp combo in the studies Delta Gamma linked above? Or is the spectrum of Lithium's sedative/stimulatory modalities self-contained, (that is to say) independent of its interaction with other drugs?
I can't find many published studies on lithium orotate, and none directly relevant to my specific question. I know a fair amount amount about amphetamines but very little about lithium, so I'm kind of groping around in the dark here at a theoretical loss as to what interaction the low-dose Lithium Orotate/30mg Adderall XR combo would have.
From what I know of Li Orotate's neuroprotective/neuroregenerative effects, it seems to cover similar grounds as Memantine on the NMDA-antagonism front, but also provides a host of other cognitive and life extension benefits. Given that Memantine, a powerful NMDA antagonist, induces pretty nasty brain fog (which lasted almost a month for me, despite a strict dosing/titration schedule) and IMO seemed to blunt the effects of d-amp, it seems reasonable to infer that Li Orotate - also an apparently strong NMDA antagonist - could be a potentially viable alternative to Memantine, at least as a poor man's substitute, and possibly even a superior alternative in some respects.
Is that hypothesis reasonable enough to warrant testing? And by testing, I mean on myself. What do you guys think? Does anyone know of any potential danger with this combo? I'm fairly confident that they are perfectly safe, but as I said I'm a Lithium virgin and any advice or anecdotal accounts on the substance would be appreciated.
I'm very curious about this combo and am probably going to pick up some Li Orotate at the natural pharmacy tomorrow to test it out with my XR and Dex in the evening. Will post my result later in the week after.
Now back to midterm prep. Grrrhhhhhhhh....
Nootropics are far more interesting than school, which feels ironic somehow....
Edited by J. Galt, 07 March 2011 - 10:55 AM.