Many health supplements like Curcumin and Resveratrol are damaged by the stomach acid, or destroyed by the liver if they make it that far. For this reason, people spend big bucks on huge doses that probably damage the liver and still don't get serum levels that high.
Why not take these supplements rectally? Dissolve them in warm butter, and then cool the butter into a hard suppository. Once at colon temperature, the butter will have the consistency of water and spread out for good absorption surface area. Therapudic doses will be reached at least for the first pass, after which the liver will destroy them. Maybe the first pass will be enough to reach all the cells.
My question, though, is if humans have never had high serum resveratrol levels, then how do we know it is safe to get what we want? Maybe the reason the supplements are legal is because FDA assumes people will take them orally, which is known to have poor bioavailabilty. Would you like to be a guinea pig and get the higher serum levels? I'm tempted to buy some 98% and give it a go, but want some feedback first. I thought of injecting it, but it is not water soluble, and injecting it would mean it absolutely better be safe or I could really mess myself up.
I would like to see some scientists give resveratrol suppositories to mice, and see if the mice actually live longer. Previous studies used a high fat diet to attempt to increase oral bioavailability, and found they lived longer than a the high fat controls, but not longer than a healthy diet.
Edited by CCS, 05 July 2011 - 06:23 AM.
