602 replies to this topic

[hav]

I'm tired, confused and so disappointed that I can't just get someone to say how great Product B is and that yes it will help me look younger and stop my joint pain....

to me, all that anybody is willing to say is that it made their eyesight a little better and they can now run a bit faster... this kind of stuff doesn't matter to me, is that all telomere lengthening does? make super healthy people a little bit healthier? because i just want to be able to get out of my CHAIR, and walk across the room without huge pain... am i barking up the wrong tree?

oh i have been diagnosed with Chronic Fatigue Syndrome and Fibromyalgia, and no, there's no help anywhere for that, i try to control it a bit by diet....

Note sure what in this thread gave you the idea that Product B might help with your problems. Although it does have a little Resveratrol in it, I wouldn't expect either the amount or the combination of ingredients in Product B to affect your joint pain either way. My own experience as someone with arthritis is that Resveratrol alone had no impact on my pain levels. But Resveratrol in the 250 mg range and higher mitigated my joint pain but only when taken together with D3 and either Luteolin or Quercetin. Recently, I ran out of Resveratrol and replaced it in my stack with Polydatin which is very similar and my joint pain returned at a level similar to what you describe. After 6 weeks I restocked with a new stack of Resveratrol, Polydatin, and Luteolin and voila, the joint pain subsided again. Just keep in mind that reactions differ and my arthritis is not as sever as your ailments, but I'm convinced in my case that Resveratrol can help with simple joint pain when combined with D3 and Luteolin. Perhaps Broduct B would help too if one combined enough of it with D3 and Luteolin.

Note that I also take C60. I don't have the impression that it has any impact either way on my joint pain. For the severity of the problems you describe, however, I would recommend you investigate DMSO instead. Here is a thread I saw on it recently.

Howard

Edited by hav, 27 August 2012 - 04:18 AM.

[niner]

oh i have been diagnosed with Chronic Fatigue Syndrome and Fibromyalgia, and no, there's no help anywhere for that, i try to control it a bit by diet....

Elaine, There's a growing body of evidence that mitochondrial dysfunction and oxidative stress are involved in FM. That probably applies to CFS as well. Do you have headaches, by any chance? I seriously doubt that telomerase inducers are going to do anything for you, though it's conceivable that some of the ingredients in Product B will help for reasons unrelated to telomeres. There are, however, a number of things that you could try which would address the mitochondria/oxidative stress issues.

These include:

C60-olive oil, 2-5 mg/day
Ubiquinol, 100-200 mg/day or Ubiquinone, 100 mg, three times/day
Acetyl L-Carnitine, 500-1000 mg twice a day. (this is often called ALCAR)
Resveratrol 500 mg/day
Methylene Blue, 60 mg three times/day
PQQ (not sure of dosage)

Personally, I would try the C60-oo, which is available from two sources on the net, one in the US and one in the EU. I'd get Ubiquinol and ALCAR from Swanson, and start with those three. There have been some reports that ubiquinone takes up to a couple months to have an effect; ubiquinol may be faster.

[Louis]

The patent goes on to list many other telomerase activating compounds identified in the Sierra Sciences RT-PCR screen. The combination of many of these other natural componds comprise much of the remaing 50% of product B by weight:

[0026] Follow-on testing of additional samples was undertaken using the same methodology. Hits were obtained on samples containing by horny goat weed (Epimedium sagittatum), Grape Seed (Vitis vinifera), Turmeric (Curcuma longa), Bacopa (Bacopa monnieri), Pomegranate (Punica granatum), DL-alpha lipoic acid, Asian ginseng, (Panax ginseng), Green Tea, White Tea, Black Tea (Camellia sinensis), Acacia (Acacia nilotica), Plantain (Plantago major), L-glutathione, Velvet Bean (Mucuna pruriens), Hawthorn (root) (Crataegus pinnatifida), Quercetin, Boswellia, (Boswellia serrata), Maca (Lepidium meyenii), Hawthorn (fruit) (Crataegus pinnatifida), Resveratrol, Harada (Terminalia chebula), Shilajit, Chia (Salvia hispanica), N-Curcusorb (trade name for version of Turmeric), Polygonum Cuspidatum (trans resveratrol), pterostibene, (a synthetic form of resveratrol developed by ChronaDex Company), Tumipure (trade name for Turmeric ingredient by Naturex Company).

There's 3rd party confirmation that pterostilbene does in fact activate telomerase.

Bryant Villeponteau and his company LifeCode, who formulate and sell Stem Cell 100, make the same claim on their webpage:
http://www.lifecoderx.com/telomeres/

Quoting from this webpage:
Stem Cell 100 increases telomerase activity in stem cells via the resveratrol analog pterostilbene, which is a major active component in Stem Cell 100. ... We have verified that pterostilbene is indeed active in stimulating telomerase.

This product B patent has multiple errors/typos: The company that makes pterostilbene is ChromaDex with an "m" (not n). And as most people on here know, pterostilbene is a natural molecule that can be found in many fruits/vegetables, e.g. blueberries. It would only be classified as "synthetic" in the sense that the ChromaDex version may be synthesized to save cost, rather than naturally extracted. But I have no idea whether Chromadex synthesizes or extracts it.

[Louis]

Your post history shows that you didnt even visit the threads that have to do with much else, or items that may help deal with your illnesses.

I suggest to search around and be informed before buying anything else.
In my book Product B will not cure your illness.

Louis,
will you back up my last statement, or do you believe it will cure her illnesses?
You are the expert on Product B, so let Elaine know what you think.

A

Circle me: https://profiles.goo...236572014252197

I agree, I would be very surprised if it helped very much.

But if it were me, I'd give it a try. I'm continually surprised with the stories I'm hearing about TA-65, product B, and this new product about to hit the market T-Activator 100. This field is still in its infancy: nobody really knows what telomerase will cure yet, if anything. I think it's worth it to try any of these 3 products. My only experience so far has been with prodB. If you do try the B, I'd suggest the regular 4/day dose for the first few weeks, and if all goes well, gradually work your way up to 10/day, which is where I've personally had the best results.

Obviously inform your doctor what you're doing, and stop if you have any negative side effects. Be careful if you take medication because the herbs in product B induce/suppress various pathways in the cytochrome P450 system. They can cause you to metabolize more or less of the medication, e.g. the way grapefruit juice suppresses a cytochrome P450 pathway shared by many medications. Take the dosage up VERY slowly if you're on any serious medications. Same warning applies to most supplements -- most are also metabolized in the liver through various cytochrome P450 pathways that are shared with medications. Introduce them slowly.

I don't think T-Activator 100 has been made available to the general public yet, but I've heard the company is run by a former TA-65 exec. You folks probably know more than I do about it. Bill Andrews has been talking about in the last few months, and supposedly he has added it to his regimen along with the TA-65 + prodB he was already taking. He's probably taking more telomerase activating compounds at once than anyone on the planet right now.

Edited by Louis, 28 August 2012 - 01:38 AM.

[Telo]

I hope it will be possible soon to buy Product B in more than a few countries.

Btw, when should we expect to hear any results from the human trials?

[niner]

I don't think T-Activator 100 has been made available to the general public yet, but I've heard the company is run by a former TA-65 exec. You folks probably know more than I do about it.

First I've heard of it, but I don't follow this kind of thing closely. Google turns up the company behind it; the incipient web page prominently features a quote from some "anti-aging doctor" whose qualifications include the claim that he is a "visionary".

[Turnbuckle]

I don't think T-Activator 100 has been made available to the general public yet, but I've heard the company is run by a former TA-65 exec. You folks probably know more than I do about it.

First I've heard of it, but I don't follow this kind of thing closely. Google turns up the company behind it; the incipient web page prominently features a quote from some "anti-aging doctor" whose qualifications include the claim that he is a "visionary".

A plastic surgeon trained at Mount Sinai with 21 patents to his credit, he's not just some crank.

[niner]

A plastic surgeon trained at Mount Sinai with 21 patents to his credit, he's not just some crank.

Not a crank, but he appears to go where the money is. (Pla$tic $urgery, Patent$) There's money in the telomerase activation story.

[Turnbuckle]

A plastic surgeon trained at Mount Sinai with 21 patents to his credit, he's not just some crank.

Not a crank, but he appears to go where the money is. (Pla$tic $urgery, Patent$) There's money in the telomerase activation story.

You're right about the money. He's also a founding partner at Griffin Capital Group, and that's a good thing. People like that tend to have a grasp of what is real.

[Louis]

I don't think T-Activator 100 has been made available to the general public yet, but I've heard the company is run by a former TA-65 exec. You folks probably know more than I do about it.

First I've heard of it, but I don't follow this kind of thing closely. Google turns up the company behind it; the incipient web page prominently features a quote from some "anti-aging doctor" whose qualifications include the claim that he is a "visionary".

I believe the former TA Sciences employee who started the company is named David Cross. The company is called Telomere Biosciences.

In his latest talk(s), Bill Andrews is saying that there are now 3 products on the market that activate telomerase, and he's calling T-Activator 100 the third. That's what's peaked my interest here. Until recently, he's only vouched for TA-65 and Product B. Now he seems to be giving his blessing on this third product as well.

If anyone knows more about it, please post!

[niner]

A plastic surgeon trained at Mount Sinai with 21 patents to his credit, he's not just some crank.

Not a crank, but he appears to go where the money is. (Pla$tic $urgery, Patent$) There's money in the telomerase activation story.

You're right about the money. He's also a founding partner at Griffin Capital Group, and that's a good thing. People like that tend to have a grasp of what is real.

If this was about bricks, mortar, cash flow, or ROI, I'd agree. But it's about the awesomely complex field of biology, which he would only have skimmed the surface of during his medical education. He is more and more seeming like a guy who smells money in this telomere story. There is no shortage of people who have bought the telomere story and are anxious to buy a product, any product, that promises them longer telomeres.

[hav]

There's 3rd party confirmation that pterostilbene does in fact activate telomerase.

Bryant Villeponteau and his company LifeCode, who formulate and sell Stem Cell 100, make the same claim on their webpage:
http://www.lifecoderx.com/telomeres/

Quoting from this webpage:
Stem Cell 100 increases telomerase activity in stem cells via the resveratrol analog pterostilbene, which is a major active component in Stem Cell 100. ... We have verified that pterostilbene is indeed active in stimulating telomerase.

I don't know. I looked at their page and found 10 study references and none of them applied to pterostilbene. The closest they come is this statement with references related to resveratrol:

Resveratrol has been shown to activate telomerase in human adult stem cells in independent studies^8,9,10

...

8. Uchiumi F, Watanabe T, Hasegawa S, Hoshi T, Higami Y, Tanuma S. The effect of resveratrol on the werner syndrome RecQ helicase gene and telomerase activity. Curr Aging Sci. Feb 2011;4(1):1-7.
9. Xia L, Wang XX, Hu XS, et al. Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Br J Pharmacol. Oct 2008;155(3):387-394.
10. Pearce VP, Sherrell J, Lou Z, Kopelovich L, Wright WE, Shay JW. Immortalization of epithelial progenitor cells mediated by resveratrol. Oncogene. Apr 10 2008;27(17):2365-2374.

In reference #8, the study involved dousing the cells in a 10 μM solution of Rsv with peak telomerase activity after 16 hours. Problematical is that the cells they used were human cervical carcinoma (HeLa S3) cancer cells. Not exactly a good cite for a resveratrol or pterostilbene vendor.

I don't think reference #10 is very good for them either. According to the full-text it used Li–Fraumeni syndrome breast cells with mutated P53 genes making them highly likely to develop cancer. And observed it happen after dousing cells in a 10 μM solution of resveratrol for 24 hours, via telomerase activation. On a brighter note the abstract states, "Resveratrol results in immortalization of mixed progenitor cells with mutant p53, but not human epithelial cells with wild type p53." There is also mention that progesterone nullifies observed resveratrol telomerase activation even in cells with mutant P53.

I think reference #9 is probably their strongest. According to its full-text, mononuclear cells were isolated from the blood of healthy male and female humans. White blood cells, I think. These were doused in concentration of resveratrol ranging from 10 to 100 μM for 24 hours. Minimal telomere elongation was observed at 10 μM with peak elongation at 50 μM. Cell death from toxicity was observed at 100 μM.

Of course the strength of these studies for any conclusions regarding telomerase activation by ingesting resveratrol is limited by the liklihood of achieving the concentrations tested with inside a living being. I think the only thing pterostilbene adds is that it might remain in the blood stream a little longer than taking resveratrol alone, making it similar to polydatin.

Howard

[PhilZulli]

Hello everyone. I have good answers for you on the subject of Product B™.

I've just joined Longecity because I found this thread on Product B™ and want to shed light on the subject. I just introduced myself in the Longecity Community forum, but will repeat it here to save you guys a couple of clicks.

I've been a natural health advocate for 30 years. I've been inside the nutrition industry as a corporate executive and as an industry consultant. I've build and managed several national field organizations, and I've trained hundreds of thousands of people how to make simple changes to improve their health and longevity through lectures and tele-conferences. And it has been my pleasure to touch so many lives in such a profound way.

I'm here at this forum now because I have been inside on the Product B™ project with Isagenix since 2010. I believe that Product B™ will change the game next year when the two prestigious clinical studies are completed and published. I found Longecity while keeping up on views regarding telemere science as it relates to health and aging.

The information here on Product B™ is incomplete at best. I am available to answer any questions to the best of my ability, and I look forward to learning new ideas and perspectives from the good people here.

Someone please start us off by asking a question and letting me know who is still interested in this subject.

[AdamI]

ok, Phil got 2 questions:
Will Product B have a complete list of what it contains and the amount in the future? And if not why...
second, some have said that Isagenix have some kind of close relationship to Sierra. And that Isagenix will get every new ingriedent that activate Telomerase if Sierra finds any in there research?

[Andey]

Hello everyone. I have good answers for you on the subject of Product B™.

Someone please start us off by asking a question and letting me know who is still interested in this subject.

Hi, Phil )

What is the main component in Product B ? And what dosage ? ))

[PhilZulli]

Thanks for the questions, guys. A good starting point and it gives me a chance to address many of the questions and statements I've seen here. So this first answer will be long but hopefully interesting to you all.

First, let me be clear that I do not speak for Isagenix, Sierra Sciences, or Dr. Andrews. But I have been with the project and followed it closely. I've been on many conference calls with Dr. Andrews and our leadership, and I've worked with the Isagenix Compliance Dept on a TV News story about Product B™ and was quoted in that story. I will tell you what I know. And for full disclosure, it's no secret that I am a distributor for Isagenix and I want to see as many people as possible using our nutritional systems with Product B™. The results are greater than anything I've ever seen or experienced.

Adaml and Andey both asked about the ingredients. I'll give you the current list of ingredients but first some explanation is needed. This will cover a lot of the questions I've seen on this forum.

Product B™ was formulated by one of the top Master Formulators in the world, John Anderson. John build a billion dollar nutritional supplement contract manufacturing business in the 80's and 90's. Before the Internet gave us connectivity with peoples all around the planet, John traveled to places and cultures with high levels of health and longevity to explore their unique foods and lifestyles. He discovered and began importing valuable nutritional substances and learned very private processing methods. John co-founded Isagenix in 2002 in order to bring his premium formulations to the marketplace to create real, state-of-the art results for people.

John met Dr. Bill Andrews in 2010. As most of you know, Dr. Andrews discovered human telomerase in 1997 and he has developed and patented technologies that allowed him to identify and quantify substances that activated telomerase in human cells. No one else is able to do what Dr. Andrews can do. But he kept hitting a dead end. He tested over 300,000 chemicals to find an effective telomerase activator. It took him years. After all his efforts, he was able to find just over 300 chemicals that had some level of activity, he calls those "hits", but they were all too toxic to be used in the living body. The most powerful of these too-toxic-to-use chemicals became his control sample. And he began to look more seriously for a natural botanical solution. That is how he met John Anderson.

I refer to it as a match made in Heaven. Dr. Andrews knew what to look for and how to identify and quantify "hits". John knew where to look and, through his proprientary methods, how to optimize activity.

The first hits came quickly and an early formulation of Product B™ was made available to a limited group of people. Results were great, although that first version was still pretty weak. John built a new dream lab in Arizona for Product B™ development and he and Dr. Andrews are continually testing substances and continually improving the formula. In August 2011, a stronger version was released to the marketplace. And over the last year, the formula has been made many times stronger as new "hits" are discovered. We released Version 3 this past August 2012.

Many people ask how Product B™ compares to TA-65 and other products that claim to activate telomerase. The bandwagon is getting pretty full! Dr. Andrews has stated that his early attempt at a consumer product in 2005, TA-65, is a weak telomerase activator; he called it a weak telomerase inducer. He has tested others and my last information is that there is one other product that gives a "hit". But both of those products give a small percentage of the activity of his control sample; remember that is too-toxic-to-use chemical that gave the greatest "hit" during his years of testing before meeting John Anderson. The big news in August was that the new 3rd generation Product B™ surpasses the activity of that control sample. Dr. Andrews was ecstatic at that news, by the way. He thought it would be years before John was able to formulate a product to surpass the control.

One last point that you guys have been discussing. Dr. Andrews business relationship is with John Anderson, not Isagenix, and Dr. Andrews technology is exclusive to John as far as nutritional supplements is concerned. For these reasons and many more, Product B™ is considered by the top experts who know the details to be at least 10 years ahead of the competition. It is obviously a very exciting time for us, and when the clinical studies are published next year and we are able to openly discuss lab results, it's a whole new ball game in the field of health and wellness!

Now, to finally answer the ingredients question

Here is the current list of ingredients. As I mentioned, it is being updated batch to batch as new, better "hits' are discovered. Isagenix doesn't mind spending money to continually improve their products. But this is where it is right now.

[Andey]

Thanks for the questions, guys. A good starting point and it gives me a chance to address many of the questions and statements I've seen here. So this first answer will be long but hopefully interesting to you all.


Here is the current list of ingredients. As I mentioned, it is being updated batch to batch as new, better "hits' are discovered. Isagenix doesn't mind spending money to continually improve their products. But this is where it is right now.

Thank you for such comprehensive answer )
I am on your side and hope Product B is excellent not least because it much more affordable then TA-65, but honestly - your answer on ingredients are marketing like answer )

If you want to drunk you can drink some less then percent alcohol yogurt, a beer, a wine or... vodka )
And there are no sense on mixing them together. First it would be a mess, second - there is no sense in mixing if vodka works the best on this purpose )
So anyone can assume that there are one or couple main ingridients on Product B and others are for marketing reasons )
I understand that my question was too straight and no way you could answer on this as is, but your answer is not a answer on my question ))

Edited by Andey, 18 October 2012 - 07:49 PM.

[zorba990]

Just speaking for myself - it is highly unlikely I will take something that has such an extensive list of herbs under a 'proprietary blend' designation. Just to mention two reasons, Resveratrol without the emodin content listed and velvet bean containing who knows how much L-Dopa.

I'm sure people that take few/no supplements can achieve a notable increase in vitality from taking blends of herbs already known to have positive effects in addition to ones that contain known stimulants like ginseng and velvet bean. So having lots of anecdotal positive experiences is certainly achievable this way. I consume many of the listed ingredients, like tea and raspberries for many reasons. Others are specific medicines, like hawthorne, that might be contraindicated for certain people and certain conditions.

When Product B has the depth of studies that Epitalon has and is shown to be as effective (or more) then I'll certainly be listening. UNtil then it's just another MLM product as far as I'm concerned. But good luck and good health!

[Andey]

When Product B has the depth of studies that Epitalon has and is shown to be as effective (or more) then I'll certainly be listening. UNtil then it's just another MLM product as far as I'm concerned. But good luck and good health!

I live in russian speaken enviroment and here in Ukraine and Russia where a lot of peptides studies are from they have a reputation of 'fake science'. For me it is rather a risky story )

[zorba990]

When Product B has the depth of studies that Epitalon has and is shown to be as effective (or more) then I'll certainly be listening. UNtil then it's just another MLM product as far as I'm concerned. But good luck and good health!

I live in russian speaken enviroment and here in Ukraine and Russia where a lot of peptides studies are from they have a reputation of 'fake science'. For me it is rather a risky story )

That's a pretty bold statement. You are saying the volume of Russian peer-reviewed studies on pubmed are fake?

[PhilZulli]

Thanks for your replies, Andey and Zorba990. I really want to answer your questions. My smile above is because your objections sound like mine 2 years ago. Extraordinary claims require extraordinary evidence and the idea that we can help cells to express telomerase is extraordinary, and is a game changer. So I'll do my best to address your concerns.

Andey - I think it's easy to understand that many companies are trying to duplicate Product B™, so the specifics on dosages of particular ingredients are proprientary. The question in not what's in it; the question is does it work. And Dr. Andrews is by far the leading scientist is the field, with over 43 patents that says he is able to determine if it works. And he says it does. So do Product B™ users.

Your point is well-taken about "extra" ingredients. Two answers - first, the active ingredients in Product B™ require a strong antioxidant base to have an effect on telomeres. My understanding is that without that base, a body would use Product B™ as a super-antioxidant instead of using it to support telomeres. So there are additional antioxidant ingredients. The second thing is that John Anderson knows very well how to prevent discovery of his proprietary 'magic'.

And you're right, my answers will have a tend to have a marketing flavor; I am a marketer and natural health advocate, not a scientist.

Zorba990 - The people I was referring to who added Product B™ and report remarkable results were all using our very complete Isagenix nutritional programs. If you're interested, you should have a look at the unbelievably comprehensive list of ingredients in our programs. Highest quality, theraputic-grade in many instances, working with the top people like Dr. Bill Judy. We use his maximum CoQ10 ingredient with 800% better absorbtion for example. We use the highest grade of undenatured New Zealand whey protein and lots of it. And high-quality resveratrol was part of what these people were taking before adding Product B™.

Different people have different levels of proof, and my goal is not to twist your arm or "sell" you. But there are many misconceptions here that I want to shed some light on. Product B™ is the real thing.

[PhilZulli]

After a few more posts, I will be allowed by this forum to post links.

Isagenix has an information website for Product B™ and telomere science, and also a health blog witth great info. We also have a podcast blog with hundreds of hours of audio; interviews with doctors and industry experts discussing our products, formulations, and results. We have just completed a very impressive weight-loss study and preliminary results are available. The juicy details will be discusses when peer-review is complete and that study is published. We expect that to happen in January.

When I hear us dumped into the category of "MLM companies", I want to clarify that. Some companies that share profits with happy product users through tracked referrals are actually good!

Isagenix is extremely well-respected and as far as taking the science seriously, Isagenix employs over 25 full-time scientists who function is to make sure that our products are safe and effective and represent the very best science available. When a new ingredient, study, manufacturing process, etc is verified as improving what we have, Isagenix will implement it. They are very snotty about being the best. <grin>

Edited by PhilZulli, 18 October 2012 - 08:32 PM.

[boylan]

Phil,

Can you elaborate on this statement? "Results were great, although that first version was still pretty weak."

What results?

[Andey]

When Product B has the depth of studies that Epitalon has and is shown to be as effective (or more) then I'll certainly be listening. UNtil then it's just another MLM product as far as I'm concerned. But good luck and good health!

I live in russian speaken enviroment and here in Ukraine and Russia where a lot of peptides studies are from they have a reputation of 'fake science'. For me it is rather a risky story )

That's a pretty bold statement. You are saying the volume of Russian peer-reviewed studies on pubmed are fake?

May be I have used wrong words (or been too strong). Majority of info I read in russian have some criticism on author and idea. I summarise it for me as scientific community in Russia and Ukraine are not so shure in peptides as many people on this forum. It is enough to uncertain me on this matter )

Anyway sorry for been offtopic in this thread.

Edited by Andey, 18 October 2012 - 08:28 PM.

[zorba990]

After a few more posts, I will be allowed by this forum to post links.

Isagenix has an information website for Product B™ and telomere science, and also a health blog witth great info. We also have a podcast blog with hundreds of hours of audio; interviews with doctors and industry experts discussing our products, formulations, and results. We have just completed a very impressive weight-loss study and preliminary results are available. The juicy details will be discusses when peer-review is complete and that study is published. We expect that to happen in January.

When I hear us dumped into the category of "MLM companies", I want to clarify that. Some companies that share profits with happy product users through tracked referrals are actually good! Isagenix is extremely well-respected and as far as taking the science seriously, Isagenix employs over 25 full-time scientists who function is to make sure that our products are safe and effective and represent the very best science available. When a new ingredient, study, manufacturing process, etc is verified as improving what we have, Isagenix will implement it. They are very snotty about being the best. <grin>

Sounds like every other MLM I've ever heard of. I take New Zealand Whey Isolate, it's readily available on iHerb and through protein factory. But many experts, like Will Brink, feel its overkill as far as going for purity. Publish results, as in proof of telomere elongation, through reputable journals with independent peer-review and there will be plenty of sales for the product.

Take the other route, publish internally or only self-sponsored, no study duplication by outside scientists, run it as a MLM and you'll be relegated to the snake oil isle for lot of people. There is science and there is hype. Science is repeatable. Hype repeats but with the 'latest and greatest' thing. If you don't want competition then go into the pharmaceutical industry. Supplements will always have competition and drive the price down to something affordable for most people. And THIS is the 'good thing'.

[Andey]

Andey - I think it's easy to understand that many companies are trying to duplicate Product B™, so the specifics on dosages of particular ingredients are proprientary. The question in not what's in it; the question is does it work. And Dr. Andrews is by far the leading scientist is the field, with over 43 patents that says he is able to determine if it works. And he says it does. So do Product B™ users.

Your point is well-taken about "extra" ingredients. Two answers - first, the active ingredients in Product B™ require a strong antioxidant base to have an effect on telomeres. My understanding is that without that base, a body would use Product B™ as a super-antioxidant instead of using it to support telomeres. So there are additional antioxidant ingredients. The second thing is that John Anderson knows very well how to prevent discovery of his proprietary 'magic'.

And you're right, my answers will have a tend to have a marketing flavor; I am a marketer and natural health advocate, not a scientist.

Pretty honest and open answer ) Also it is a very important mention about need in antioxidative support.
Thanks )


P.S. English is a foreign language for me and I could look rude sometimes - but mostly it because I am very limited in vocabulary )

[PhilZulli]

Boylan, we have been asked not to go into much detail on results until the studies are published. I can say that generally, people report a real boost in stamina and vitality. Changes in skin tone, appearance, and hair thickness are sometimes reported as "dramatic". There are some reports of hair color going dark again but I haven't seen that commonly yet. Many people tell me that their doctors are very surprised by the improvement in their blood tests.

I can validate some of that with my own results. There are additional details about my personal story that I can't fully discuss in order to be compliant with regulatory guidlines. I can say that I have spent the last 5 years working through a serious illness and experienced agressive "growths" in my lower abdomen and I was very, very ill. I chose a natural health path instead of chemical or radiation therapies and I am past those issues now. I am still repairing my digestive system and my energy and stamina levels. I was on Isagenix for complete nutritional support during those years and when I added Product B™ it was a night and day difference in the way I felt and my ability to work and live more normally again. I make no claim that Isagenix or Product B™ "cured or mitigated" my illness, but I believe that when you feed your body in an optimal way and assist in removing impurities, your body has incredible self-healing capabilities that we are just beginning to tap into. Product B™ seems to feed the body in way I have never seen before, and I have been seriously chasing these ideas for almost 30 years.

[Andey]

Phil, another question )
What is the planned target or declarated effect of ProductB ? Telomerase length is a measurable thing so it would be correct to measure effectiveness of product by this way..or no ?
Telomerases can be longered to some extend or just slow or stops shortening process ? Can it reach initial lenght same as at birth time ? )
Also - obviously product B dosage was calculated for some average person - what weight it suggests ?

[PhilZulli]

Andey, as one of the largest health and wellness companies, Isagenix responsibly bases its claims and representations on the best available science, and on FTC and FDA regulations. It most areas that Isagenix products address, like weight-loss and energy and performance, the regulatory guidelines are clear. But in the brand new area of telomerase activators the regulatory agencies have not issues compliance guidelines. As a result, what we can say at this point in time is limited.

We promote Product B™ as a telomere support product. When you add the back story of Dr. Bill Andrews and his patented technologies and his findings on what the ingredients in Product B™ affect human cells, the story gets clearer. But it won't be fully clear until the two clinical studies are completed.

With that said, I'll do my best to answer your questions, Andey. Dr. Bill Andrews has had a good long-term releationship with Dr. Maria Blasko. Dr. Blasko is the Director of the Spanish National Cancer Research Center in Madrid, and she is the founder and developer of Life Length™, which is regarded as the most accurate telomere length testing available. Dr. Blasko is working with Dr. Andrews and Isagenix to measure telomere length of Product B™ users as a part of the clinicals underway.

Your question about the upper possiblities of restoring telomere length as still theoretical, but on everyone's mind. One thing I will mention is to be aware of the difference between slowing the pre-mature shortening of telomeres and funamentally affecting telomere length. Common sense approaches to health, things like not smoking, regular activity and exercise, eating right, reducing exposure to toxins, etc, these things are now known to prevent the premature shortening on telomeres. But being able to fundamentally affect telomere length means affecting telomerase in cells, and according the Dr. Andrews, who has the patented technology to identify and quantify telomerase activation, the ingredients in Product B™ produce a significantly stronger effect than anything else he has tested, and his lab has so far tested over 300,000 substances, including the consumer products claiming to activate telomerase.

As to dosage/weight, Product B™ is formulated to produce the best results in the greatest amount of people. Many of us are using double and triple the recommended amount, but most people are using it according to label directions with great satisfaction.

[Mind]

The only proof I need to see is if Product B lengthens telomeres or at least stops them from deteriorating. Otherwise the ingredients list reads like a typical dietary/supplement regimen of the average Longecity poster. Most of the herbs, vitamins, nutrients are already in most people's diets. IMO, a proprietary blend might increase the effectiveness of the product....slightly...but I seriously doubt someone in good health already would "feel" much less get much objective health boost from these ingredients. The ingredients have been known, ingested, studied, and sold, known for decades if not centuries (in some cases). If they lengthened telomeres and/or were SUPER health/rejuvenation substances, we would have known a long time before now.

That being said, if clinical trials show an objective health boost for people, it is probably something I would try. The ingredients, individually, have been known for being "good" for some aspects of health.