42 replies to this topic

[ceridwen]

Hmm high D3 can increase mortality

[Nate-2004]

Hmm high D3 can increase mortality

 

D3 is only toxic beyond 10,000 IU, it's safe up to that point. By high dose I mean 4 to 6,000 IU.

[airplanepeanuts]

It's strange that D3 should work only for some time. Maybe try Vitamin K with it they work together. If you do try all the different kinds because they are very different.

Edited by airplanepeanuts, 19 September 2016 - 11:26 PM.

[Nate-2004]

I started vitamin K recently and no such luck. 

 

I also started higher doses of B6 outside of the complex I normally take, someone hinted on that same reddit thread that it's helping people with ET and so far today that's turning out to be true but we'll see after two weeks which is a solid test since nothing ever lasts that long.

[Mike C]

J Clin Endocrinol Metab. 2013 May;98(5):2160-7. doi: 10.1210/jc.2013-1185. Epub 2013 Mar 26.
Vitamin D levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association.

http://press.endocri...10/jc.2012-1176

Looks like the 600-800 iu reccomended dose is plenty good.
J Clin Endocrinol Metab. 2013 May;98(5):2160-7. doi: 10.1210/jc.2013-1185. Epub 2013 Mar 26.
Vitamin D levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association.

http://press.endocri...10/jc.2012-1176

Looks like the 600-800 iu reccomended dose is plenty good.

[TerryFirmer]

 

Hmm high D3 can increase mortality

 

D3 is only toxic beyond 10,000 IU, it's safe up to that point. By high dose I mean 4 to 6,000 IU.

 

 

I wouldn't be so sure. I took 5,000 IU/day for over ten years (with not a huge amount of sun exposure at latitude 45N) thinking that I couldn't come to any harm. Finally I decided it was time to get a blood test (duh!) and was shocked to find:

 

25-Hydroxy Vitamin D

530 nmol/L where > 250 nmol/L = Possible toxicity

This is equivalent to 210 ng/mL and the widely quoted optimum level is 40-70.

 

I tested my blood calcium level and it was normal, so I seemed to have got away with it. A few months of no vitamin D3 supplements got it down to below 85 ng/mL.

 

Don't be an idiot like I was - get tested!

[pamojja]

With an average intake of 7.000 IU daily for the last 7 years my serum 25(OH)D3 averaged at 61 ng/ml.

 

The highest I ever measured was 84 ng/ml end of 2013 with 7.200 IU/d, and the lowest 27 beginning of 2011 with 6.200 IU/d (after 6 weeks on a Indian beach, go figure..). While intakes varied from 4.800 to 12.000 IU daily.

Regular testing with vitamin D3 is important with intakes in that range.

[Nate-2004]

Again, D3 is really only toxic over 10,000 IU for several months and some sources say higher.

 

http://www.mayoclini...ty/faq-20058108

https://www.ncbi.nlm...les/PMC3191699/

https://www.vitamind...much-vitamin-d/

https://en.wikipedia...ervitaminosis_D

 

A simple Google search resolves all this.

 

 

[lost69]

if you eat no dairies there s no calcium rise (vit d is not toxic it just makes high calcium absorption from food)

 

calcium is normal even if vitd25oh>4000ng/ml...i had it, there s a protocol to use vit d for autoimmnuity and boost immunity at the same time and it works but checking all food to avoid dairies is hard when you travel.....there is a network of trained doctors on this for MS and autoiimune diseases and more than 35.000 people have been treated to put these diseases in to remission for more than 11 years

 

this said such high levels of vit d and doses of vit d from 10.000 to 400.000iu per day requires trained doctors supervision and is only to treat MS and autoimmunity

 

 

 

Edited by lost69, 30 November 2016 - 12:41 AM.

[RWhigham]

if you eat no dairies there s no calcium rise (vit d is not toxic it just makes high calcium absorption from food)

 

calcium is normal even if vitd25oh>4000ng/ml...i had it, there s a protocol to use vit d for autoimmnuity and boost immunity at the same time and it works but checking all food to avoid dairies is hard when you travel.....there is a network of trained doctors on this for MS and autoiimune diseases and more than 35.000 people have been treated to put these diseases in to remission for more than 11 years

 

this said such high levels of vit d and doses of vit d from 10.000 to 400.000iu per day requires trained doctors supervision and is only to treat MS and autoimmunity

 

1) Vitamin D can cause a deficiency in vitamin K2.

2) A deficiency in vitamin K2 will cause calcified arteries and increase mortality.

 

Regarding Nate's  "A quick search of pubmed" - Did he review all 50,000 vitamin-D studies? Obviously not.

A person can find pages and pages of references to support whichever view they like. So yes, vitamin D is controversial.

It might be better to look at the experiences of long time users.

 

I took 8,000 IU of D3 daily for about 25 years along with 90 mcg daily of MK7. My Agatston coronary artery calcium (CAC) score a year ago was 8 giving a calculated 10-yr heart attack risk of 3%. Based on my age it would be 10% with no other risk factors. I have the aorta diameter of a teen ager, no carotid plaque, and BP 105/65, so it would appear that my arteries were not damaged by D3 taken with K2.

 

I was disappointed in my CAC score of 8. 90% at my age are higher but nearly 10% are less. So I greatly increased my vitamin K. I also upped my D3 to 10,000 IU daily because 8,000 IU daily was no longer working as well as it used to. My recent plasma level after 10,000 IU for a year was 82.9 ng/ml.  

Edited by RWhigham, 27 March 2017 - 05:11 PM.

[pamojja]

I took 8,000 IU of D3 daily for about 25 years along with 90 mcg daily of MK7.

 

Surprised to hear that vitamin K2-mk7 was already commercially available in 1991.
 

[RWhigham]

 

I took 8,000 IU of D3 daily for about 25 years along with 90 mcg daily of MK7.

 

Surprised to hear that vitamin K2-mk7 was already commercially available in 1991.
 

 

 

I started taking MK7 when it was first introduced by Jarrow Formulas. I cannot say for sure what year that was.

Jarrow was the only brand I could find at the time. It was not common.

 

As best I can recall, I started 8000 IU of D3 about 25 years ago and added the MK7 a bit later.

[lost69]

 

if you eat no dairies there s no calcium rise (vit d is not toxic it just makes high calcium absorption from food)

 

calcium is normal even if vitd25oh>4000ng/ml...i had it, there s a protocol to use vit d for autoimmnuity and boost immunity at the same time and it works but checking all food to avoid dairies is hard when you travel.....there is a network of trained doctors on this for MS and autoiimune diseases and more than 35.000 people have been treated to put these diseases in to remission for more than 11 years

 

this said such high levels of vit d and doses of vit d from 10.000 to 400.000iu per day requires trained doctors supervision and is only to treat MS and autoimmunity

 

1) Vitamin D can cause a deficiency in vitamin K2.

2) A deficiency in vitamin K2 will cause calcified arteries and increase mortality.

 

Regarding Nate's  "A quick search of pubmed" - Did he review all 50,000 vitamin-D studies? Obviously not.

A person can find pages and pages of references to support whichever view they like. So yes, vitamin D is controversial.

It might be better to look at the experiences of long time users.

 

I took 8,000 IU of D3 daily for about 25 years along with 90 mcg daily of MK7. My Agatston coronary artery calcium (CAC) score a year ago was 8 giving a calculated 10-yr heart attack risk of 3%. Based on my age it would be 10% with no other risk factors. I have the aorta diameter of a teen ager, no carotid plaque, and BP 105/65, so it would appear that my arteries were not damaged by D3 taken with K2.

 

I was disappointed in my CAC score of 8. 90% at my age are higher but nearly 10% are less. So I greatly increased my vitamin K. I also upped my D3 to 10,000 IU daily because 8,000 IU daily was no longer working as well as it used to. My recent plasma level after 10,000 IU for a year was 82.9 ng/ml.  

 

 

good to hear about your experience, i also take about 10.000iu of d3 now and lifeextension super K k1 1500mcg,k2 mk4 1000mcg and mk7 200mcg, i also add mk4 45mg but not every day because too expensive.i researcher on vit k filed indicated about 200-400mcg of mk7 as best dose although there s no good studies to confirm this yet but best be on the higher dosage than low since mk7 and mk4 have no sides

MK4 has studies made in japan on osteoporosis prevention and liver cancer prevention too