Hell yeah!
lol. What's the "hawthorn berry/cissus quadrangularis/enbosarm" part of the stack for?
Posted 14 September 2013 - 02:59 AM
Hell yeah!
Posted 14 September 2013 - 11:09 AM
Edited by nuc, 14 September 2013 - 11:14 AM.
Posted 14 September 2013 - 11:13 AM
Posted 14 September 2013 - 07:26 PM
Can Zembrin be taken in the evening without sleep issues?
Has anyone tried any alternative ways of ingesting Zembrin e.g smoking or insufflating? I know this can be done with Kanna.
Posted 14 September 2013 - 08:07 PM
Can Zembrin be taken in the evening without sleep issues?
Has anyone tried any alternative ways of ingesting Zembrin e.g smoking or insufflating? I know this can be done with Kanna.
Why'd you want to? It's absorbed perfectly from the capsules. The study indicating its' PDE4 inhibition also used the same product.
Myself I discontinued Zembrin use because of the Serotonergic effect and subsequently elevated prolactin. This also lead to elevations in estrogen. Made me feel way too silly.
Posted 14 September 2013 - 08:27 PM
Edited by darejz00, 14 September 2013 - 08:43 PM.
Posted 14 September 2013 - 10:16 PM
Edited by chung_pao, 14 September 2013 - 10:21 PM.
Posted 15 September 2013 - 01:59 AM
Different transcription elements have been proposed to play a role in the regulation ofacetylcholinesterase (AChE) in muscle and neuron, and cyclic adenosine 3',5'-monophosphate (cAMP)-dependent pathway is one of them
...
These results support the involvement of a cAMP-dependent pathway in regulating the expression of human AChE.
Edited by abelard lindsay, 15 September 2013 - 02:29 AM.
Posted 15 September 2013 - 02:28 AM
Very cool Abelard! So glad you're experimenting with this. What did you decide about forskolin with TULIP?I think I found another clue to the Acetylcholinesterase (AChE) / cAMP relationship
http://www.ncbi.nlm....pubmed/10869820Different transcription elements have been proposed to play a role in the regulation ofacetylcholinesterase (AChE) in muscle and neuron, and cyclic adenosine 3',5'-monophosphate (cAMP)-dependent pathway is one of them
...
These results support the involvement of a cAMP-dependent pathway in regulating the exp<b></b>ression of human AChE.
So more or less the theory is is that, cAMP, through activation of some transcriptional factor (CREB perhaps) is upregulating AChE. CREB we know increases transcription of proteins in the cell supporting Long Term Potentiation (LTP) through epigenetic activity, which should be good for cognition, but it also helps to increase transcription of AChE in the package so it would help to keep AChE under control with AChE inhibitors or more choline in order to avoid getting sleepy.
I took the Tulip,Uridine, and CILTEP stack today all together and boy was I sleepy even with a good amount of acetyl-l-carnitine until I took a galantamine. Now my brain seems to be firing on all cylinders again.
And.... I just scored 22 on odd-one-out and 32 on grammatical reasoning on cambridgebrainsciences
Posted 15 September 2013 - 02:50 AM
Very cool Abelard! So glad you're experimenting with this. What did you decide about forskolin with TULIP?
This was shown to arise from AChE promoter activation, mediated by activation of the transcription factor Elk-1.
We show here that cAMP can activate the transcription factor Elk-1 and induce neuronal differentiation of PC12 cells via its activation of the MAP kinase cascade
Edited by abelard lindsay, 15 September 2013 - 03:09 AM.
Posted 15 September 2013 - 03:19 AM
Any further thoughts on this bit of my query?Just double checking though with abelard's latest update including ALCAR in the morning with the stack, does this mean Phenylalanine is still required? I'm cool either way, just want to do the right thing.
Posted 15 September 2013 - 04:20 AM
Any further thoughts on this bit of my query?Just double checking though with abelard's latest update including ALCAR in the morning with the stack, does this mean Phenylalanine is still required? I'm cool either way, just want to do the right thing.
I'm also taking the PAGG stack and Cissus Quadrangularis, both promoted by Tim Ferriss for fat loss. Seeing he's a big fan of Abelard's artichoke and forksolin stack I'm guessing there must be no issues.
Thanks again all!
Posted 15 September 2013 - 04:28 AM
Very cool Abelard! So glad you're experimenting with this. What did you decide about forskolin with TULIP?
My opinion is that forskolin just magnifies and prolongs CREB transcription of genes in the mitochondria which is where TULIP increases activity. This is a good thing but the increased ACHe transcription in the nucleus has to be counteracted to avoid sleepiness. I suspect sleepiness shouldn't happen with TULIP alone as, unless I overlooked something, ACHE isn't produced in the mitochondria.
I found a interesting paper on ACHe transcription. It is mediated by ELK-1
http://www.ncbi.nlm....pubmed/15258260
This was shown to arise from AChE promoter activation, mediated by activation of the transcription factor Elk-1.
ELK-1 is activated by cAMP
http://www.ncbi.nlm..../pubmed/9094716
We show here that cAMP can activate the transcription factor Elk-1 and induce neuronal differentiation of PC12 cells via its activation of the MAP kinase cascade
Edited by Potent, 15 September 2013 - 04:28 AM.
Posted 15 September 2013 - 06:48 AM
I noticed anxiety while on phe, very apreciable. I have not taken phe today and I feel totallly awesome. This LTP seems amazing to me. It has the contra of being detrimental to working-memory (only while on it) . But long term it's obviously good for short-term memory. I had a strong experience yesterday. I experienced a kiind of déjà vus in which I basically recovered all my entire long long term memory. This stack (with or without ALCAR) does wonders. I got a lot of energy and pre-disposition to almost everything. I have started to recover one sensation from my childhood but I don't know how to explain it. A kind of coherence and fullfiling. I also notice a good motivational, physical, and moodly enhancement. Sometimes it makes anxiety high but only while you use it. It may be even better in language improving than Cerebrolysin. I have been fluent and spontaneous, It may be due in part to ALCAR but ciltep cummulates over the time, I'm getting more and more LTP and that is changing all things drastically. I have to say I love it and that it takes lots of energy and mood cycles are accelerated (you pass your day running mentally and knowing how to orientate goals,actions and words. I also believe I'm bettter lying now hahaha (this is curious thing) . I seem to just being able to move on despite what's happening.Any further thoughts on this bit of my query?Just double checking though with abelard's latest update including ALCAR in the morning with the stack, does this mean Phenylalanine is still required? I'm cool either way, just want to do the right thing.
I'm also taking the PAGG stack and Cissus Quadrangularis, both promoted by Tim Ferriss for fat loss. Seeing he's a big fan of Abelard's artichoke and forksolin stack I'm guessing there must be no issues.
Thanks again all!
The stack is experimental, and as with all nootropic stacks, needs to be tweaked to personal preference. I've enjoyed CILTEP with Phe, but noticed that Phe was anxiogenic in certain circumstances. So now I CILTEP without Phe.
Bottom line is basic CILTEP stack = 5 mg Forskolin, 600 mg Artichoke. Those two are required. Caffeine also seems essential to me. Tweak to your preference, ALCAR, Phe, NAC, Zembrin, anything else can be added based on how you feel. Hope that helps.
Posted 17 September 2013 - 10:25 AM
Posted 17 September 2013 - 11:54 PM
Posted 19 September 2013 - 11:58 AM
Posted 19 September 2013 - 04:13 PM
Creatine should be very beneficial for cognition and general protection of your precious dopamine neurons, if you're deficient.
When I first started dosing creatine, it was like a 10-15% boost in intelligence and an even bigger effect on muscular performance.
If you're deficient, it'll benefit you whether or not you take CILTEP.
Judd Crane: Yeah. For me, bacopa didn't offer a lot of benefits. It gave me very lucid dreams though! (even when taken 5h before bed)
*I've also been experimenting a bit with this stack and have found a sustainable program that has incredible effects.
I've taken CILTEP for at least 6 months now, and this "prescription" has produced the best results so far:
1) At wake up: 10 mg Active Forskolin extract, 1x500mg Artichoke extract, 50 mg Modafinil.
ALCAR and caffeine are optional. I also take a very short cold shower after dosing the above, because of the immediate alertness it provides.
2) Before bed: 3-5 whole eggs, 15g saturated dairy-fat (from butter or cheese; pref grass-fed).
Both elements are essential. Especially the fats before bed. They are what enable Modafinil to be included in the stack, regularly.
If I don't eat those exact foods before going to sleep when using Modafinil, I'm guaranteed wake up with a grinding migraine.
The addition of modafinil potentiates the stack due to many different, even unknown mechanisms. My hypothesis is secondary dopamine-reuptake and release, among other things.
The resultant effects are very distinguishable however: The bulletproof confidence of a fighter-pilot, as close to perfect recall of studied information, and a focus that's annoyingly persistent. It makes studying ridiculously easy and fun. The confidence part is also completely absurd, perceived as a complete absence of negative emotion and self-consciousness.
But still... I won't be using the Modafinil addition daily. The effects are too mind-altering and puts you in almost a 12 hour trance where you can't "zoom out" and actually consider what you need to do. Very robotic, but awesome for the purposes of this stack: To promote LTP and memorize information.
Edited by raincheck, 19 September 2013 - 04:38 PM.
Posted 19 September 2013 - 08:37 PM
I've been reading and following this thread since the beginning and appreciate the community contributing useful data into the thread. I've been using Ciltep in different variations, this one Chung Pao posted did not have any effect on me whatsoever. I am curious, was the recommended forskolin dosage based on the 95% Cbolic extract ? Are you skipping breakfast and insuling spiking stimulus?
Here is my current stack I do not take it regularly....
- 2x450 mg Now Artichoke Extract.
- 4mg of Forskolin Better Body Sports 95% pure C-Bolic capsules
- 500mg Phenylalanine
- 1/2 dose B-Vitamin Complex (life source naturals Coenzymated B-complex, contains NADH, P5p and many other essentials)
- 900-1000 mg ALCAR (primaforce)
- 1g Creatine HCI
- 350 - 500mg Bulk N-Acetyl L-Tyrosine (occasionally to boost my energy when my brain gets saturated.)
I workout using HIIT with body weight work outs and feel no positive effects from this stack. However after more steady (but not regular) dosing I notice definite increased LTP. I am a student and work at a retail cellphone store.
...
Just wanted to post my results as testimony and drive more conversation, I hope to get some feedback as well.
Thanks!
Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability.
The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced.
Edited by abelard lindsay, 20 September 2013 - 05:14 AM.
Posted 20 September 2013 - 02:52 AM
Posted 20 September 2013 - 03:50 AM
That looks pretty good but just to clear up any confusion:
The Better Body Sports Forskolin caps contain 25mg of forskolin and a couple hundred mg of inert filler. So, if you emptied a capsule out and got 500mg of material for example, to get 5mg you would weigh out 4/25 of that or 80mg of that material.
LTP, which CILTEP is theorized to work on, is downstream from NMDA/AMPA signalling which occurs in the synaptic cleft. It could be possible, in theory, that non response to CILTEP could be due to a deficiency in signalling in general in the synaptic cleft.
Magnesium-L-Threonate has shown some clinical evidence in being able to aid in the development this synaptic signalling mechanism.
http://www.ncbi.nlm....pubmed/20152124Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability.
The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced.
Posted 20 September 2013 - 05:20 AM
Yeah I used 4/25 to match my 4mg recommendation on the first post but didn't change the earlier term to 4mg. Thanks for pointing that out.I am honored that you replied to my post! I am not following your math, did you mean to say 5/25 or 100 mg of total C-Bolic material?
I only recently switched to C-Bolic from Soloray so its no wonder why I haven't felt noticeable effects. I'll start with the recommended 4 mg dosing procedure as you outlined in the first page of this thread and see how it goes.
I was taking Magnesium Theonate for sometime but I didn't understand the effects fully. There was a huge digression into Magnesium supplementation and the importance of Magnesium Theonate and its BBB crossing abilities were washed out.
Again appreciate the input,
Edited by abelard lindsay, 20 September 2013 - 05:31 AM.
Posted 20 September 2013 - 06:30 PM
Posted 20 September 2013 - 09:14 PM
Edited by xsiv1, 20 September 2013 - 09:18 PM.
Posted 21 September 2013 - 05:33 PM
Posted 21 September 2013 - 06:11 PM
Posted 21 September 2013 - 10:37 PM
Edited by acrunchyfrog, 21 September 2013 - 11:00 PM.
Posted 22 September 2013 - 03:25 AM
A couple of questions: Would L-carnitine l-tartrate also work well in the stead of ALCAR? And further, I see people using galantamine to reset if they crash. Anyone using Huperizine A for the same effect? And finally, is anyone using DLPA with this stack?
Edited by abelard lindsay, 22 September 2013 - 03:28 AM.
Posted 22 September 2013 - 05:02 AM
Posted 22 September 2013 - 08:48 AM
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