2844 replies to this topic

[MrHappy]

I've bought this a few times:
http://item.mobilewe...Id=310336119467

Hopefully the link works on normal browsers...

[MrHappy]

Uridine increases levels of phosphocreatine:
http://www.purebodyb...ine-supplements

[1thoughtMaze1]

Hey Mr, I was skimming through some of this threat, miles long, and came across you saying something like 500ml of tomato juice = 600 mg of uridine... Something about going the natural path... Are you surree?

[Hebbeh]

From page 2.......

Actually, that may not be the correct conversion for tomatoes after all.. It'll depend on the water content.

1kg of tomatoes (dry weight) = 1g uridine.
(according to -sigh- wikipedia)

And from page 4......

Well, I mentioned earlier in the thread that anyone concerned about it should stick to food sources.

Everything on this site is experimental - that's why we are here. Trying new things with the benefit of discussion/debate with intelligent people is much better than taking a shot in the dark yourself.

I think spirulina, at 5%, is pretty efficient. 5g = 250mg of uridine. The normal serving size is 3g, so looks like a really good source. Oddly enough, as a small child, I used to chew on spirulina like candy. Might explain some of my more useful gifts in life.
http://nutritiondata...products/2765/2

Tomatoes, while being a source of uridine, at .1%, are not a great source - they are typically 95% water, so the amount you'd have to eat is unrealistic. They are a good source of folate, but no B12.
http://nutritiondata...products/2682/2

Brewer's Yeast, is good at 3%, but I'm not comfortable ingesting 10g of yeast every day. Sounds like a yeast infection in the making. Perhaps if it was cooked/dead. High folate as well.
http://nutritiondata...products/5129/2

Lef has an isolated RNA supplement, which would be useful, but no B vitamins or supporting nutrients.

None of those nutrient data sheets mention uridine, which is pretty poor work for USDA supplied data. Here's some info:
http://en.m.wikipedia.org/wiki/Uridine
http://www.pnas.org/.../10123.full.pdf

Again, I mention that the probability of being completely folate deficient outside the petri dish or controlled animal studies that are deliberately kept folate deficient, is pretty low.

However, since this combination of nutrients is shown to uprate neurogenesis, your body is going to be needing more folate than it normally uses, anyway. If you are not obtaining uridine from food sources, why not follow nature's ratios and supplement accordingly? It's not exceeding RDA, in any case.

You really need to read the whole thread rather than asking for cliff notes on what has already been discussed and unnecessarily clutter the thread further.

[MrHappy]

1thoughtmaze - no, it won't work, I corrected that later - turned out it was dry weight. Tomato juice is like >95% water. UMP is the way to go.

[Lufega]

I have no idea how I missed this thread (thanks to rwac and Mrhappy for the plug in the myopia thread). I recently started sniffing cinnamon oil to boost cognitive function. While it does increase alertness it also makes me feel scatterbrained and unable to focus on any one thing. Bleh. Uridine sounds like what I need to get me studying again. I have a big test I've been putting off for a year now. I also experienced depression when using any cholinergics. Heck, even using pantothenic acid >500 mg (which increases acetylcholine via Acetyl Coa) makes me feel depressed. UMP it is..

[MrHappy]

Apparently people are also rubbing it into their skin these days:
http://www.aminocare...sun-lotion.html

Localised transdermal absorption, I guess? Repairs damaged DNA.. Hmm. I like the name 'celligent', though.

[MrHappy]

Reishi: natural source of uridine, used for longevity and treatment of a number of conditions. Very interesting
http://www.encognitive.com/node/15714

[ODAN]

Hello again MrHappy ! I would like to know if you have a preferred Uridine sublingual brand ? Could you give me an idea of how much I should take, and when, in regard of the nootropics I'll be taking ?

Here's the list of nootropics I intend to use with it. I'll post my topic about it that way I don't spam the place with my stuff http://www.longecity...__gopid__492510

Thanks a lot MrHappy. What you're doing here is AWESOME.

[MrHappy]

Hi ODAN,

I bought some from here originally:
http://www.ebay.com/...s-/310336119467

Here's an online store in France, so faster shipping than from USA. More expensive, though..
http://www.eurofitne...=2076&cust_id=0

Otherwise
http://www.sndonline...cp-p-15116.html
http://www.naturalwe...qertdswwo5g.php

Just google 'ecological formulas uridine monophosphate'

I'd try around 200-300mg UMP sublingually, for ADD or 100mg TAU, orally. I've looked at the rest of your intended stack and that looks fine.

Edited by MrHappy, 23 December 2011 - 12:41 PM.

[MrHappy]

Uridine + vitamin E as a radioprotective agent:
http://www.faqs.org/...app/20110183021

[MrHappy]

Uridine for treating tobacco / nicotine dependance:
http://www.freepaten...06/0217344.html

[ODAN]

Awesome, thanks ! Since most of what you sent me is the Ecological Formula brand of Uridine, which is the monophosphate UMP kind, and each capsule is 300mg, then I should just open one capsule and take it sublingualy.

Saying it again to make sure, I'd rather avoid beignner's mistakes, ahahah. Thanks again !

[Hebbeh]

That's what I do. Tip your head back and twist the capsule open as you dump it under your tongue. Actually I preferred the bulk uridine though and am going to go that route again. The caps have fillers and flow agents in them and doesn't seem to absorb quite as nicely.

[MrHappy]

I normally use bulk powder. At the moment I am testing TAU, while on holidays. 100mg TAU is pretty strong, but UMP works out a lot cheaper, sublingually.

Edited by MrHappy, 23 December 2011 - 06:03 PM.

[ODAN]

Ah, but how does one "dose" the powder ? The only dose spoon I find are for Whey protein to work out, or for gunpowder ahahah


So you guys use the bulk powder from Ebay then ? So do you recommend me this one ?

[MrHappy]

That's the one I've been using. It comes with a 250mg scoop.

[Hebbeh]

I weighed the uridine and a level scoop is exactly 250 mg on the money. A heaping scoop was closer to 300 mg which is what I was using.

[ODAN]

Fantastic guys, thanks. Then it's one scoop under the tongue and done ! Ahahah

Then, I'll get the bulk powder. Thanks guys

[1thoughtMaze1]

Hey Hebbeh.. Nice name by the way... Why don't you just stop posting all together and stop cluttering this thread.. Sound good to you... Alllll righty thann

[Hebbeh]

Hey Hebbeh.. Nice name by the way... Why don't you just stop posting all together and stop cluttering this thread.. Sound good to you... Alllll righty thann

It's called contributing... which I did,,,and you're welcome...and what have you contributed?

[1thoughtMaze1]

I don't feel like you're contributed at all.. Matter of fact you wasted my time.. Nice name by the way, and why you saying you're welcome? Did you see me say thanks? Why don't you read the entire post so you know what you're talking about. What's that? Can't concentrate for that long? Ohh poor Hebabh...

[Hebbeh]

I don't feel like you're contributed at all.. Matter of fact you wasted my time.. Nice name by the way, and why you saying you're welcome? Did you see me say thanks? Why don't you read the entire post so you know what you're talking about. What's that? Can't concentrate for that long? Ohh poor Hebabh...

Everybody is impressed with your demonstrable tact and intelligence. Merry Christmas!

[1thoughtMaze1]

Good come back, why you saying merry Christmas? You don't even celebrate it haha

[spider]

Gentlemen! This won't make MrHappy very happy.

[MrHappy]

ಠ_ಠ

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[Hebbeh]

ಠ_à²

Why the long face? You're on Holiday for crying out loud!!!

[MrHappy]

It has been an amazing holiday, so far!

[choqueiro]

Hi MrHappy.

So here I am. I am going to follow your recommendations. It sounds really good this stack!!!

After reading these threads I must say that for me the clue it´s Uridine. I´ve been taking DHA and GPC (choline) in the past with no positive results (I also take Alcar and vitamins B without any positive result), so maybe uridine it´s a must to have benefits.

It´s curious because Uridine is not very popular, few brands commercialize it and it doesn´t seem to be a nootropic product (it seems more a cardiovascular supplement). But the studies are there and perhaps it´s the "clue".

Even though this stack sounds promising MrHappy, I have some doubts.

JChief in the thread: http://www.longecity...r-dha-vitamins/ says that "Ecological Formulas is the only brand I've found that offers both TAU and UMP varieties in capsule form". I don´t understand very well. Are two varieties of uridine?? Which one is more important?? Both??

I also have doubts with the DHA supplement. Right now I´m taking a E-EPA 650 mg. (90 % pure EPA). It is said that EPA is better for depression than DHA. I´m currently taking this supplement: http://www.biovita.f...s&lang=en&id=21. Before taking this supplement I try another omega 3 supplement that contains only DHA. This was the product: http://www.farmaciarubio.es/en/algatrium/525-algatrium-plus-in-pearls-180-capsules.html. We are talking about an omega product that contains only DHA. So I don´t know if there is any reason to take DHA. The studies with uridine were done with DHA I think. Taking DHA instead of EPA it´s a must?? Should I take DHA only?? EPA only?? DHA + EPA??

About choline I don´t know if it would be better to take Alpha GPC or Choline CDP. What dou you think??

In this thread you talk only about Choline + Uridine + DHA but JChief talks in his thread (see: http://www.longecity...r-dha-vitamins/) about other things as: Alcar and vitamins. I don´t know if this is a must. My experiences with Alcar were inconclusive but I think that it raises my anxiety. According to the vitamins supplementation recently I suffer a niacin flush after takign only one pill of b complex from Jarrow Formulas (something very strange because it was the first time taht I take a b supplement and I only take one pill).

I would like to start quickly with this regime MrHappy, so tell me what is your current regime, with specification of quantities and brands if it is possible.

Thanks so much and Merry Christmas.

[MrHappy]

OK, it has been a number of pages, so it probably is time for a recap/update anyway.

According to the various literature, you want both EPA and DHA, a cholinergic, a tocopherol, methylation cofactors, uridine, minerals.

So, morning dose:
200-300mg UMP, sublingually OR 75-100 TAU, orally
500mg a-gpc - substitute with alcar or cdp-choline, as preferred
400-600mg EPA
1500-2000mg DHA
1000IU+ vitamin E

400mcg folate
1mg b12 (yes, that is intentionally high, feel free not to megadose if you have objections)
RDA of zinc, calcium, magnesium, b1,2,3,6... A good multi should cover most of these.

If you are treating depression or anything dopamine related, feel free to delay adding the cholinergic for a week or 2, but you may not notice any issues at that dose of uridine, anyway.