2844 replies to this topic

[kevinseven11]

No one has posted the research on uridines vasodilator effects. From what I've read it amplify's the blood vessel dilation from working out but is this effect present even without exercise? (my guess is yes) If so, couldn't this be used for ED too?

[penisbreath]

Sorry, I didn't have the attention span to read through the entire thread, but as someone who suffers from ADD, OCD, depression and sleep problems, I'm definitely interested in trying Uridine ..

Just a couple of questions:

1) Did anyone here who felt worse on DHA as a standalone supplement feel better on the combination? I'm not sure, but I feel like DHA (from neuromins) makes me feel a little more depressed; I also tried a high-DHA fish oil supp. which seemed to increase my anxiety.

If you react badly to taking DHA by itself that is a clear indication that you DON'T NEED OR WANT to take any supplementary DHA. If you had a fatty acid profile analysis lab test carried out you would probably find you are one of those people (like me) who's DHA and EPA levels are both FINE and in fact, taking more is NOT actually a good idea. This is something the majority of people do not realise or understand; you only want to take EPA and DHA IF you need to, and some people DON'T. Too much of anything is bad. If you already have enough you don't want to take more.

This is mostly influenced and determined by a particular person's dietary intake of EPA and DHA, and their particular requirements, over the long-term.

Therefore, I come back to the point that if you react badly to taking DHA by itself that is your body sending you a very clear indication that you DON'T NEED OR WANT to take any supplementary DHA; the same goes for EPA.

TOO MUCH EPA and DHA can induce undesirable side effects including INCREASES in ANXIETY and DEPRESSION and INSOMNIA which you DON'T WANT.

I personally take URIDINE without any DHA and I am finding its effects to be most profound; hence, my advice is that if you don't get along with DHA (like me) then DON'T TAKE IT... i.e. take the URIDINE without any DHA.

Thanks for your reply, ScienceGuy. It's good to know that I can always reap benefits from Uridine sans DHA if need be, as that's something I was curious about.

Are you certain, though, that a poor reaction to DHA is indicative of adequate DHA levels and not due to the fact that supplementing DHA without EPA (or visa versa) might not always be desirable? Specifically, I found that DHA left my mood a little 'flat', whereas high EPA caused anxiety; I've read about others having those same specific reactions, and that taking DHA and EPA together might allow them to balance each other out.

2) I can't tolerate methylfolate either (causes anxiety, agitation); could I get away without supplementing it?

YES.

As per the DHA and EPA, if you react badly to methylfolate that is a very clear indication that you already have more than enough folate since too much folate can induce anxiety, restlessness, agitation and insomnia.

The only other possibility as to why you react badly to methylfolate is that you are overmethylated, in which case you might like to try taking the FOLINIC ACID form of folate instead to determine which is the case; if you still react badly to that then you are not overmethylated, it is definitely the folate that you already have enough of and hence take the URIDINE without any additional folate, since you DON'T NEED IT.

However, if you find you can take the FOLINIC ACID form of folate without reacting badly to it, then its the methylation that you already have enough of, and hence you can take the supplementary folate, but as the FOLINIC ACID form, and avoid the methyl form.

I had a blood test done which showed HIGH histamine levels, suggesting UNDERmethylation. Again, couldn't the reaction to methylfolate just result from increased monoamine synthesis rather than a reaction to methylfolate itself?

[penisbreath]

sorry for totally overthinking this, but just want to clear something up ... i feel you're partly anti-nicotine anyway Mr. Happy, which might be colouring your stance (forgive me if i'm wrong on that point?), but if they do compete for absorption, why wouldn't just dosing at different times fix the issue? i tried reading the study posted in this thread, but didn't really understand it. i suppose i'm trying to have my cake and eat it too, because i hate the idea of giving up on nicotine; it's just too helpful for my condition, even though i use it sporadically. this is a tough decision...

[MrHappy]

Nicotine - yeah.. I'm personally not a fan, but I know it can be effective for some people and I can respect that.

In this case, we've already seen that uridine amplifies some of nicotine's effects and competes with others. In non-ADD people, it's a counterproductive combo.

I am curious to know if it is still required or rather, if it can be substituted by uridine, for ADD.

[JChief]

Happy perhaps you could chime in here. I am reading above in this thread something about over/under methylation regarding folate? Anxiety is something I sure what to avoid. Hmmm well I just started a much expanded supplement regimen for a variety for reasons. Fertility was one of them as we are planning to have kids soon. But I wonder if any of these things will compete with uridine? What I've added recently in addition to ALCAR, EPA/DHA and multivitamin are (Perque/AOR products primarily): RALA, NAC, folate 5-MTHF, Arginine, Maca, Myo-Inositol, Lecithin, Deer Antler Velvet, Tongkat Ali 1:200, Vit D, Curcumin, Astaxanthin, Melatonin before bed when I work overnight shifts, a product containing Silymarin, Glutathione, Selenium, CoQ10, L-methionine, Vit E, creatine, coconut oil, lots of green tea as main source of fluids... anyway I am noticing great mood thus far, no anxiety, and great workouts. I tried to cover a lot of bases with this regimen. Raise glutathione, for brain health, antioxidant support, exercise etc.

[choqueiro]

Hi MrHappy.

So, if I take 500 mg. daily in two dosages of 250 mg. (one in the morning and another in the evening) should I also take in the evening 500 mg. more of Alpha GPC + 2 capsules more of fishoil or it is enough taking the Alpha GPC + fishoil + multivitamin + Vitamin E once daily after taking the uridine in the morning?? I mean, I have to double the quantities of the rest of the susbtances of the stack if I take the double quantitie of Uridine (500 mg)??

Thanks

[MrHappy]

JChief - looks fine to me!
This link below is a really good read on methylation - histamine levels are suggested as a way to check methylation:
http://www.enzymestu...methylation.htm

Choqueiro - you don't need to double everything else.

Edited by MrHappy, 13 January 2012 - 09:05 AM.

[Justchill]

OK the Uridine powder has come in... (I'm from Belgium)
Going to cycle off supps for 1 week and after that start with it (now on piracetam + NALT). Stuff tastes a bit salty! How long does it have to stay under the tongue?
I keep taking my 3 g's of fish oil and get my choline from... eggs! (very healthy)

Cheers, have a nice weekend - will report in 2 weeks

[MrHappy]

sorry for totally overthinking this, but just want to clear something up ... i feel you're partly anti-nicotine anyway Mr. Happy, which might be colouring your stance (forgive me if i'm wrong on that point?), but if they do compete for absorption, why wouldn't just dosing at different times fix the issue? i tried reading the study posted in this thread, but didn't really understand it. i suppose i'm trying to have my cake and eat it too, because i hate the idea of giving up on nicotine; it's just too helpful for my condition, even though i use it sporadically. this is a tough decision...

Did you see this earlier in the thread?
http://www.sciencedi...074742703000248

Edited by MrHappy, 13 January 2012 - 07:44 PM.

[MrHappy]

HI All,

Can someone please help me?

My Uridine arrived today. I purchased the Cardiovascular Research brand from capusled from Pure Formula. This is my anticpated stack:

1) Uridine (25 mg capsules)
2) Fish Oil 1000 = Life's Abundance
3) Multivitamin = Dr. Whitakers Forward Nutrition - contains more fish oil as well as vitamin e among others
4) CoQ10 = Jarrow's
5) B-Right = Jarrow's (I am B deficient)
6) Vitamin D3 = Jarrow's (I am D deficient)
7) Pycnogenol = Whole Foods Brand (I am smart deficient)
8) Rhodiola 200 mg's = Natures Way
9) ALCAR = Jarrow's
10) Zoloft = 150 mg's

I take the Rhodiola and ALCAR first thing in the am. After 30 minutes I eat breakfast and take the rest of the stack minus the Zoloft. The Zoloft I take before bed. Do I need to add anything else? I think I get enough B but do I need extra E? I eat a lot of eggs so can I go without the choline? I presently take GET SMART which has Piracetam and Antiracetam in it and I don't suffer any headaches.

I ordered some Piracetam and Antiracetam which also arrived today but I will wait a few weeks before I add that in.

I have depression and ADHD and will gladly report my experiences back. Thank you in advance for your help. Be well - Z

I think you're OK for choline, with both eggs and ALCAR.

I can't locate the vitamin E content of the Dr. Whittaker's product. Do you have an ingredient list?

[Lufega]

I added Quercetin to my Uridine/fish oil combo and this seems to prolong the effect quite nicely. Quercetin alone, has a noticeable effect on cognitive function in some people so I figured this might combine well with Uridine. I'm only using 25 mg TAU and each dose is still very noticeable. In fact, it brings down the mind-racing, stimulant effect of an ephedrine/caffeine/iodine/tea morning overkill I'm using.

[ScienceGuy]

Sorry, I didn't have the attention span to read through the entire thread, but as someone who suffers from ADD, OCD, depression and sleep problems, I'm definitely interested in trying Uridine ..

Just a couple of questions:

1) Did anyone here who felt worse on DHA as a standalone supplement feel better on the combination? I'm not sure, but I feel like DHA (from neuromins) makes me feel a little more depressed; I also tried a high-DHA fish oil supp. which seemed to increase my anxiety.

If you react badly to taking DHA by itself that is a clear indication that you DON'T NEED OR WANT to take any supplementary DHA. If you had a fatty acid profile analysis lab test carried out you would probably find you are one of those people (like me) who's DHA and EPA levels are both FINE and in fact, taking more is NOT actually a good idea. This is something the majority of people do not realise or understand; you only want to take EPA and DHA IF you need to, and some people DON'T. Too much of anything is bad. If you already have enough you don't want to take more.

This is mostly influenced and determined by a particular person's dietary intake of EPA and DHA, and their particular requirements, over the long-term.

Therefore, I come back to the point that if you react badly to taking DHA by itself that is your body sending you a very clear indication that you DON'T NEED OR WANT to take any supplementary DHA; the same goes for EPA.

TOO MUCH EPA and DHA can induce undesirable side effects including INCREASES in ANXIETY and DEPRESSION and INSOMNIA which you DON'T WANT.

I personally take URIDINE without any DHA and I am finding its effects to be most profound; hence, my advice is that if you don't get along with DHA (like me) then DON'T TAKE IT... i.e. take the URIDINE without any DHA.

Thanks for your reply, ScienceGuy. It's good to know that I can always reap benefits from Uridine sans DHA if need be, as that's something I was curious about.

Are you certain, though, that a poor reaction to DHA is indicative of adequate DHA levels and not due to the fact that supplementing DHA without EPA (or visa versa) might not always be desirable? Specifically, I found that DHA left my mood a little 'flat', whereas high EPA caused anxiety; I've read about others having those same specific reactions, and that taking DHA and EPA together might allow them to balance each other out.

2) I can't tolerate methylfolate either (causes anxiety, agitation); could I get away without supplementing it?

YES.

As per the DHA and EPA, if you react badly to methylfolate that is a very clear indication that you already have more than enough folate since too much folate can induce anxiety, restlessness, agitation and insomnia.

The only other possibility as to why you react badly to methylfolate is that you are overmethylated, in which case you might like to try taking the FOLINIC ACID form of folate instead to determine which is the case; if you still react badly to that then you are not overmethylated, it is definitely the folate that you already have enough of and hence take the URIDINE without any additional folate, since you DON'T NEED IT.

However, if you find you can take the FOLINIC ACID form of folate without reacting badly to it, then its the methylation that you already have enough of, and hence you can take the supplementary folate, but as the FOLINIC ACID form, and avoid the methyl form.

I had a blood test done which showed HIGH histamine levels, suggesting UNDERmethylation. Again, couldn't the reaction to methylfolate just result from increased monoamine synthesis rather than a reaction to methylfolate itself?

"Doctor, Doctor, It hurts when I do this"

Doctor: "Then don't do that!"

[Zippy123]

HI All,

Can someone please help me?

My Uridine arrived today. I purchased the Cardiovascular Research brand from capusled from Pure Formula. This is my anticpated stack:

1) Uridine (25 mg capsules)
2) Fish Oil 1000 = Life's Abundance
3) Multivitamin = Dr. Whitakers Forward Nutrition - contains more fish oil as well as vitamin e among others
4) CoQ10 = Jarrow's
5) B-Right = Jarrow's (I am B deficient)
6) Vitamin D3 = Jarrow's (I am D deficient)
7) Pycnogenol = Whole Foods Brand (I am smart deficient)
8) Rhodiola 200 mg's = Natures Way
9) ALCAR = Jarrow's
10) Zoloft = 150 mg's

I take the Rhodiola and ALCAR first thing in the am. After 30 minutes I eat breakfast and take the rest of the stack minus the Zoloft. The Zoloft I take before bed. Do I need to add anything else? I think I get enough B but do I need extra E? I eat a lot of eggs so can I go without the choline? I presently take GET SMART which has Piracetam and Antiracetam in it and I don't suffer any headaches.

I ordered some Piracetam and Antiracetam which also arrived today but I will wait a few weeks before I add that in.

I have depression and ADHD and will gladly report my experiences back. Thank you in advance for your help. Be well - Z

I think you're OK for choline, with both eggs and ALCAR.

I can't locate the vitamin E content of the Dr. Whittaker's product. Do you have an ingredient list?

Hi Mr. Happy,

Thank you for your response.

The Forward Plus Multi Contains:

Vit A = 7500 iu
Vit C = 500 mg
Vit D = 400 iu
Vit E = 150 iu
Thiamine = 25 mg
Riboflavin = 25 mg
Niacin = 50 mg
Vit B6 = 38 mg
Folic Acid = 400 mcg
Vit B 12 = 75 mcg
Biotin = 150 mcg
Pantothenic Acid = 25 mg
Silica = 13 mg
Delta Tocopherol = 10 mg
Mixed Tocotrienols = 5 mg
Trace Mineral Complex = 5 mg
Calcium = 500 mg
Iodine from kelp = 75 mcg
Magnesium = 250 mg
Zinc = 15 mg
Selenium = 100 mcg
Copper = 1 mg
Maganese = 5 mg
Chromium = 100 mcg
Molybdenum = 65 mcg
Potassium = 57 mg
Choline = 100 mg
Citrus Bioflavonoid Complex = 125 mg
Gamma Tocophernol = 30 mg
Rutin = 25 mg
Para-aminobenzoic acid = 25 mg
Inositol = 20 mg
Alpha Lipoic Acid = 15 mg

This multi is taken two times a day.

Today I took 9 of the 25 mg Uridine capsules in the am and then another nine in the afternoon. Total of 500 mg's. Is this too much?

Thank you again and be well!

[MrHappy]

The multi is fine.

You are taking too much TAU though - 100mg/day is plenty. That extra will probably just end up as bile...

[trance]

OK the Uridine powder has come in... (I'm from Belgium)
Going to cycle off supps for 1 week and after that start with it (now on piracetam + NALT). Stuff tastes a bit salty! How long does it have to stay under the tongue?
I keep taking my 3 g's of fish oil and get my choline from... eggs! (very healthy)

Cheers, have a nice weekend - will report in 2 weeks

If you place the uridine under your tongue, it will usually takes 3-5 minutes to disappear. It does have a mild salty taste.

I've also found if you rinse your mouth out with mouthwash (or probably any other alcohol based drink for that matter) before placing the uridine under your tongue, the uridine will be completely gone in about 30 seconds. It is far more dissolvable in the small amount of alcohol left over from the mouthwash than plain saliva.

I'm not sure that it enhances the buccal absorption, but if you are in a hurry for it to dissolve or don't like the taste, there you go ...

[nupi]

Going to cycle off supps for 1 week and after that start with it (now on piracetam + NALT). Stuff tastes a bit salty! How long does it have to stay under the tongue?

Got mine too. Wondering how long it has to stay under my tongue? 30s? 60s?

[MrHappy]

Until it dissolves.

Could be up to 5 minutes, sometimes..

[nupi]

Well it dissolves quite quickly when it comes in contact with any saliva? Do we have any idea of its bioavailability sublingually vs straight oral consumption

[nito]

damn been up for 35h on uridine, CDP choline, fish oil, multi, b complex, and 600 modafinil. I just started hallucinating. I even go in and out of hallucunation a s i am writing this. Oh i forgot, smoked pot during this time too,, lol.

[MrHappy]

Why are you avoiding sleep?

[MrHappy]

Nupi - no supporting literature, but it feels like 7x-10x, subjectively - at least from my experiences.. Anyone else have a take on it?

[nupi]

Not sure I feel anything so far - what should the Uridine feel like?

[Zippy123]

The multi is fine.

You are taking too much TAU though - 100mg/day is plenty. That extra will probably just end up as bile...

Hi Mr. Happy,

Okay, great to know, thank you. I will continue with 100 mg a day (maybe 2 x a day) and will report back on my experiences. I am so hopeful and excited. Thank you!

Be well

[trance]

Not sure I feel anything so far - what should the Uridine feel like?

I've been taking it for the last three weeks -- 250mg scoop uridine under the tongue each morning when I wake up, and 75mg TAU in the evening. I had/have already been taking all the support supplements related in this chain as part of my daily regime.

I can say after three weeks, that I don't feel anything noticably different ...

[MrHappy]

Uridine - it's more about what you don't feel anymore.

The unwanted stuff fades away, leaving you feeling happy and balanced. The feeling of wellbeing is basically a return to your 'normal' state. It's gentle, definitely not normally like a stimulant eg. coffee. It gradually builds up and after a week or so, you just feel 'good' and unimpeded. Your ability to recall gets better. Your ability to sleep gets better. Problem solving becomes quick and painless. Things don't stress you out anywhere near as much. Everything just works.

The effects that are typically observed quite quickly are being clear-headed, even in the face of sleep debt and in the larger doses, your focus improves.

Of course, the more obvious effects can be masked or missed by stimulants and drugs / medications. YMMV.

You haven't been at it long, but if you have any concerns, give me a list of everything that you are taking / doing and I'll cast an eye over it.

[MrHappy]

Trance - lose the evening TAU dose and see how you go. Too much can also be an issue..

[Hologram]

I have a few questions, Should this regimen be cycled? I'm one of those who really don't want to grow a tolerance to noots. I was thinking of using for 5 days then taking the weekend off. Secondly how much vitamin B, C and E do you really need to make this work?

[MrHappy]

No tolerance observed so far (nearly 4 months?) and because of the way it works, it actually can fix tolerance problems caused by other substances.
Additionally, taking a break on a weekend isn't an issue, either way.

RDA of vitamin B group, C suggested. 500IU+ of vitamin E is recommended, which is above one governing body's RDA, however quite normal according to others. Tolerable upper limit in humans, before side-effects is 1500IU, according to various sources.

I'd probably suggest most people starting out with UMP/TAU don't go too overboard. There seems to be somewhat different effects at different doses. If you find you are too 'focused', try just taking a 200-300mg dose of UMP / 50-75mg TAU, once per day for a while and see how you go from there.

[Lufega]

Uridine - it's more about what you don't feel anymore.

The unwanted stuff fades away, leaving you feeling happy and balanced. The feeling of wellbeing is basically a return to your 'normal' state. It's gentle, definitely not normally like a stimulant eg. coffee. It gradually builds up and after a week or so, you just feel 'good' and unimpeded. Your ability to recall gets better. Your ability to sleep gets better. Problem solving becomes quick and painless. Things don't stress you out anywhere near as much. Everything just works.

For me, it's been exactly how he said it even while I'm taking it with stimulants. I convinced my mom and siblings to take it. My mom says she doesn't feel any different but I noticed she's not bitching as much anymore and she now sings every morning. I don't know who that lady is anymore !

[elovefire]

This was posted earlier in the post:

http://www.vrp.com/b...s-and-dendrites

just read all 21 pages n I love this stack. Im going to try n follow mr happy recommendation.

My reason for this post is mainly regarding the link I add. *Should Acetyl carnitine Acetyl carnitine arginate be added to this stack;and maybe Gotu kola.* any opinions, experiences, dosages, etc..

And too add: I am going to also try Methyl blue with this.
a.* any opinions, experiences, dosages, etc..