2844 replies to this topic

[csrpj]

Csprj - maybe the SSRI is masking effects. Keep us posted.

maybe. but then your wife, for example, started feeling great on uridine while also on zoloft before tapering off....

in any case i'll wait 10 days on the regimen before coming here with a report.

also, i forgot to mention, i'm taking 18.8mg dhea and 29.6mg pregnenolone split in three doses during the day (as prescribed by doctor for adrenal insufficiency) as part of a 12-week recovery program. i would assume small doses of these substances wouldn't affect the uridine, but who knows...

i'm curious to see how you do switching A-GPC for ALCAR. i wonder actually if i'd get more out of it by switching to A-GPC from ALCAR (even though what i'm doing now is recommended here for depressive disorders).

[MrHappy]

Actually, my wife started on uridine some time after giving up zoloft. Zoloft withdrawal was not pleasant - she didn't taper off properly and messed herself up a bit. Uridine sorted out the issues very well!

ALCAR - so far I've had a feeling like hot flushes, but people around me have flu, so I'm not jumping to any conclusions.. Mentally - good so far, but too early to comment.

[Jr Cauton]

Is it ok to take TAU with memantine?

[MrHappy]

Looks synergistic. Memantine is a NMDA blocker.

[Jr Cauton]

Sweet :-). Thanks.

[nupi]

lucky.pierre - see how you go, I find that without DHA, it's somewhat less effective, but certainly still very helpful.

thanks, i'll give it a shot. do you know if uridine is safe to combine with an irreversible maoi?

It would look to be safe, but especially with MAOA-I I would nonetheless be very very careful

[owtsgmi]

Is it ok to take TAU with memantine?

I have found that memantine potentiates the uridine. I think it reverses the tolerance or "resets" the uridine. I need to take much less uridine the next day after I take the memantine, because I experience hypertension-like effects (feels like too much stimulation). My intake of memantine is quite low (about 1mg every 4 days or so). If I take too much, I become a total doofus.

Also, to respond to other posts concerning the time of day to take the uridine, I take my uridine / DHA / ALCAR / Vitamin E stack in the morning before work.

[Jr Cauton]

owtsgm - how much uridine do you take? I take 10mg memantine daily split in two doses, so how much uridine do you should I take? I ordered the TAU btw. TIA.

[owtsgmi]

owtsgm - how much uridine do you take? I take 10mg memantine daily split in two doses, so how much uridine do you should I take? I ordered the TAU btw. TIA.

My uridine is in powdered form. The container has a 250mg scoop in it. I currently take only about 1/2 scoop each morning. When I started it though, I took about 4 times that daily spread out into two 12 hour doses. I just lower the dose if I feel like I am getting too much of a dopaminergic response. Eventually, you will settle on a comfortable amount. I find that I can tolerate less uridine on the days I take memantine. As i was saying, the reason I take the memantine is that I feel it resets or cleanses the dopamine response. I chop that 10mg pill up in no less than 8 pieces - and then take that only every 4 days or so. But, I hear higher doses of memantine works wonders for others on these forums. YMMV!

Oh, and review the thread for posts from MrHappy and others who describe the conversion rate between uridine and tau. I can't recall off-hand but I think it has been established to some certainty (qualitatively).

Edited by owtsgmi, 12 February 2012 - 09:10 AM.

[rg8032]

[...]
Oh, and review the thread for posts from MrHappy and others who describe the conversion rate between uridine and tau. I can't recall off-hand but I think it has been established to some certainty (qualitatively).

Establishing a quantity qualitatively is definitively uncertain. Just saying.

[owtsgmi]

so no effect on serotonin as far as you're aware?

I think it potentiates serotonin. I was taking a lot of 5htp with the uridine and I was getting what I now am pretty sure was serotonin syndrome-like effects (e.g. I was stable on the 5htp dosage for years). The effects I felt were pounding heart, jitters, insomnia. I had to keep tapering down the uridine from my initial dose of 250mg x 2 to about 150mg x 1. I am in the process of trying to dump the 5htp all together (today is my first day i will take none - hopefully). It's 2pm and I've already taken uridine 150mg x 3. It seems to be compensating nicely for the 5htp, although I am getting a tiny amount of foggyness.

Edited by owtsgmi, 13 February 2012 - 09:57 PM.

[howtodisappear]

Well I have been, on my regimen for about 2 weeks now which includes Uridine 300mg UMP and Alpha GPC 500mg. I am feeling fairly good, in a subtle way. My diet was probably lacking from a number of key nutrients which has probably helped my mood and my exercise has increased which always makes me feel good. My first week I took the uridine orally and last week I switched to sublingual.

So I cant say that I have seen any life changing effects so far but I am willing to give it a fair go, I will probably report back again in about 2 weeks. I have a feeling I am not getting enough zinc as well so I be taking that shortly and have also considered adding l-glutamine to my regimen to see if that ups the ante.

[trismatic]

I received my uridine today. I ordered a powder form from Blissful Supplements UK. It had around 1000 positive feedbacks in eBay.

I took 250mg sublingually and after half an hour, I feel lightheadedness - although in a good way. I didn't receive the same effect from 1000mg of LEF RNA, which I've been using for 3 weeks daily. I'm going to take all the cofactors and report after ten days.

PS I thought it would taste worse. It has the effect of salivation though when taken sublingually haha

Edited by trismatic, 14 February 2012 - 10:07 AM.

[MrHappy]

I decided to open my 1Kg bag of UMP from China today.. haven't had time to get another CoA for it and decided to guinea pig myself.
Tasted right, smelt right. If I don't post any more comments, avenge death.

PS. Does anyone want to help me create http://ratemynoot.com ? The longecity project post is here: http://www.longecity...tical-database/

[MrHappy]

Also, it's been a week on ALCAR.
My comments: I like it. Different subtle 'feeling' - somewhat more crisp thinking. I'll keep going for another week, as is, then I'm going to try mixing 50-100mg a-gpc + 500mg ALCAR.

[riloal]

How are you doing on the memantine and uridine combo? Thanks

[nito]

i hope that in my quest to become like the guy from limitless i end up becoming brainless. Lol i'mn addicted to spending, i need a wife that can take care of my money. Any single lady here who has nootropic passion but finance skills? You know where i'm at!

[Zippy123]

Mmmm.. You'll probably get anxious and 'snarky' from the amplified caffeine effect and the combo will be considerably less effective.

Is this messed up? I always take my zoloft in the evening before bed. Last night I did not take my zoloft. Today I took my uridine after lunch so as not to interfere with my morning coffee. Approximately 4 hours later I am one weepy chick. The story about the hostages freed from Somalia has me crying. The story about the Groupon business owner who lost 10K on the deal had me near tears. Does Uridine tweak the dopamine / serotonin levels? Can it be zoloft withdrawl so soon after missing one dose? I have missed doses before but it usually takes more than 24 hours for the impact to be felt.

Also, I did not take the racetam collection today (and have only been taking in for less than a week anyway) because I want to see how the uridine works without the interference from coffee. As of now - almost but not quite 10 days into this - I am still feeling the brain fog, memory lapses, depression, lethargy and poor verbal fluency. And, as of this afternoon, I am weepy.

Okay, it has been a while since I posted but I ran out of Uridine and I needed to try it without the Zoloft withdrawl and the caffeine interference. Here is one funky thing I noticed almost immediately.... while taking Zoloft but not Uridine I would get what I call a Seratonin Dump between 4 - 5 pm every day. The slightest thing would make me weepy. It was weird. It was like I was having withdrawl only I was still taking Zoloft. Since I reintroduced the Uridine w/o the caffeine, I no longer have the Dump.

I also noticed that 100 mg's makes me bland but 50 mg's does not have that impact and it ends the ceases Seratonin Dump.

Weird?

What about entering DMAE into the picture? Has anyone dabbled with this?

[Zippy123]

Mmmm.. You'll probably get anxious and 'snarky' from the amplified caffeine effect and the combo will be considerably less effective.

Is this messed up? I always take my zoloft in the evening before bed. Last night I did not take my zoloft. Today I took my uridine after lunch so as not to interfere with my morning coffee. Approximately 4 hours later I am one weepy chick. The story about the hostages freed from Somalia has me crying. The story about the Groupon business owner who lost 10K on the deal had me near tears. Does Uridine tweak the dopamine / serotonin levels? Can it be zoloft withdrawl so soon after missing one dose? I have missed doses before but it usually takes more than 24 hours for the impact to be felt.

Also, I did not take the racetam collection today (and have only been taking in for less than a week anyway) because I want to see how the uridine works without the interference from coffee. As of now - almost but not quite 10 days into this - I am still feeling the brain fog, memory lapses, depression, lethargy and poor verbal fluency. And, as of this afternoon, I am weepy.

Okay, it has been a while since I posted but I ran out of Uridine and I needed to try it without the Zoloft withdrawl and the caffeine interference. Here is one funky thing I noticed almost immediately.... while taking Zoloft but not Uridine I would get what I call a Seratonin Dump between 4 - 5 pm every day. The slightest thing would make me weepy. It was weird. It was like I was having withdrawl only I was still taking Zoloft. Since I reintroduced the Uridine w/o the caffeine, I no longer have the Dump.

I also noticed that 100 mg's makes me bland but 50 mg's does not have that impact and it ends the ceases Seratonin Dump.

Weird?

What about entering DMAE into the picture? Has anyone dabbled with this?

OH, I also want to add, the Uridine has allowed me to reduce my Zoloft from 100 Mg's to 50 Mg's but it hasn't done much for memory recall, verbal fluency and overall DOH! that I experience cognitively - hence my inquiry about adding DMAE

[Zippy123]

Hey.

My eight day taking Uridine + DHA + Multivitamin + Vitamin E. Unfortunately I can´t report anything positive. All my symptoms (depression, anxiety, memory issues, brain fog, etc.) continue there and I have not experimented any improve. In fact yesterday my symptoms got worse. I was playing a football match in the afternoon (I took the Uridine stack in the morning) and I felt really brain fogged (I don´t know if it has any relationship but the true is that I felt really horrible).

I´m start thinking that I´m one of those "non responders" to any nootropic. Since I began taking nootropics I have tried with no positive results: piracetam, alpha gpc, alcar, ginkgo, gotu kola, bacopa and now this combo (uridine + dha + mutlivitamin + vitamin E).

MrHappy suggested for those that we suffer from depression to avoid Alpha GPC the first days. After one week taking the combo without choline maybe today I should begin with Alpha GPC. Even though, all those new threads in the forum, talking about Choline side effects and the inconveniences of this substance for those with depression or OCD, do not offer me any confidence and I think that maybe Alpha GPC is going to harm instead of improve the Uridine combo.

Today I´m going to order LEF Magnesium L-Threonate. It´s my last attempt with nootropics. If it does not work, maybe I´ll have to satrt thinking in live "permanently" with brain fog, memory issues, anxiety, depression, etc.

Have you tried DMAE? I don't know much about it other than it has been strongly touted as a repair source for cognitive challenges - such as brain fog and memory. I took one capsule tonight for thr first time and while at first I experienced a slight headache followed by some fatigue I feel great now. I actually feel it is working. Mind you, this is the first time i have dabbled with it so who knows what tomorrow will bring.

[Zippy123]

You're very welcome. JChief is the guy with the awesome 'drug-person' avatar.

Everyone here deserves credit though, as without all the self-testing, contributions and feedback, this kind of knowledge-building just wouldn't be possible. Longecity is such a great community!

Next item that definitely needs group help:
What are the reasons for slow or non-responders? Genetics? Dose? Hepatic / renal function? Sleep? Other supplements / medication?

While blood and hepatic tests would be extremely useful, maybe with more data we could correlate some factors and solve this. Would people be willing to share some more info, if I drafted a template?

I would

[howtodisappear]

I would also be interested in supplying more data. Least I can do. I am not having any major responses to anything, I do have more energy and due to that I think my ultimate issues with motivation are psychological. Bad habits and behaviors. I am not discounting the potential of the supplements I am on just yet, or their potential in the future, I will give it time.

I am planning on getting some blood tests, If Mr Happy or someone else can tell me what I need to ask for, I will go to the Doctors hopefully this week or next week.

[csrpj]

it's been 12 days, and it's hard to see if i'm benefiting. i'm think of trying alpha-gpc instead of alcar - could this help?

Edited by csrpj, 16 February 2012 - 06:23 AM.

[manic_racetam]

I decided to open my 1Kg bag of UMP from China today.. haven't had time to get another CoA for it and decided to guinea pig myself.
Tasted right, smelt right. If I don't post any more comments, avenge death.

PS. Does anyone want to help me create http://ratemynoot.com ? The longecity project post is here: http://www.longecity...tical-database/

nice initial design

[Jr Cauton]

Just an update: I've been taking Uridine for 5 days in conjunction with Memantine, Magnesium Malate and Bacopa and so far I am not seeing any of the reported by positives effects of uridine. I actually felt better when it wasn't a part of the stack. With memantine, magnesium malate and bacopa, I my anxiety was greatly reduced, less mental fog/fatigue, more confident. Now with the addtion of uridine , it seems to have dampen all the positive effects that i used to get. So, i'm not sure if I should continue taking it and give it more time to see if it'll work or just stop taking it. Should I stop taking the memantine, magnesium and bacopa and just take uridine by itself? What do you guys think? Any input is greatly appreciated.

[owtsgmi]

That's hard to say. It seems like there are some people that really respond to memantine (e.g., confidence, clear head, etc.) and others that get just the opposite effects from memantine. I am one of the latter. I get tremendous brain fog, impaired cognitive function and disassociation with memantine. It does, however, have a place in my stack since it resets tolerance to some of my other supplements. To me it is sort of like a necessary evil. I endure many hours of brain fog in order to get back the positive effects of my other supplements for 3-4 days.

It seems like there are two camps on the memantine. Those who respond really well and those who respond negatively. Since you and I are in different camps, I don't know if it makes sense for me to offer advice. All I can say is that for me uridine started working immediately and is the best addition to my stack in two years (after piracetam). I have been able to totally stop taking heavy 5Htp and light rasagaline due to the uridine. I am currently eyeing other supplements that I may be able to jettison also (piracetam??). Hopefully, you'll be able to find a way to make uridine work for you.

Edited by owtsgmi, 16 February 2012 - 07:24 PM.

[nito]

does memantine go well with an ssri, lets say lexapro?

[Gamerzneed]

That's hard to say. It seems like there are some people that really respond to memantine (e.g., confidence, clear head, etc.) and others that get just the opposite effects from memantine. I am one of the latter. I get tremendous brain fog, impaired cognitive function and disassociation with memantine. It does, however, have a place in my stack since it resets tolerance to some of my other supplements. To me it is sort of like a necessary evil. I endure many hours of brain fog in order to get back the positive effects of my other supplements for 3-4 days.

It seems like there are two camps on the memantine. Those who respond really well and those who respond negatively. Since you and I are in different camps, I don't know if it makes sense for me to offer advice. All I can say is that for me uridine started working immediately and is the best addition to my stack in two years (after piracetam). I have been able to totally stop taking heavy 5Htp and light rasagaline due to the uridine. I am currently eyeing other supplements that I may be able to jettison also (piracetam??). Hopefully, you'll be able to find a way to make uridine work for you.

I've read in other forums that memantine requires an adaptation period before all the brain fog goes away. Memantine antagonizes the NMDA receptors which causes brainfog but then the NMDA receptors upregulate/sensitize or something like that and then mental cognition is supposed to actually enhance. Search through mind & muscle forums for a lot more specific info. I don't know if this also is of any relevance but when a lot of the mind & muscle forum users were posting on using memantine with amphetamine (for tolerance prevention), they said that during the adaptation phase amphetamine was pretty useless and didn't work, so maybe after the adaptation phase you could keep taking memantine for reset of tolerance for your supplements while still keeping taking them. Hope this helped.

Btw, adaptation phase for memantine in most users was about 1 week using 10 or 20mg and then the brain fog went away after that. You also have to use it consistantly, like everyday or else your NMDA receptors won't adapt.

Edited by Gamerzneed, 16 February 2012 - 11:56 PM.

[owtsgmi]

That's hard to say. It seems like there are some people that really respond to memantine (e.g., confidence, clear head, etc.) and others that get just the opposite effects from memantine. I am one of the latter. I get tremendous brain fog, impaired cognitive function and disassociation with memantine. It does, however, have a place in my stack since it resets tolerance to some of my other supplements. To me it is sort of like a necessary evil. I endure many hours of brain fog in order to get back the positive effects of my other supplements for 3-4 days.

It seems like there are two camps on the memantine. Those who respond really well and those who respond negatively. Since you and I are in different camps, I don't know if it makes sense for me to offer advice. All I can say is that for me uridine started working immediately and is the best addition to my stack in two years (after piracetam). I have been able to totally stop taking heavy 5Htp and light rasagaline due to the uridine. I am currently eyeing other supplements that I may be able to jettison also (piracetam??). Hopefully, you'll be able to find a way to make uridine work for you.

I've read in other forums that memantine requires an adaptation period before all the brain fog goes away. Memantine antagonizes the NMDA receptors which causes brainfog but then the NMDA receptors upregulate/sensitize or something like that and then mental cognition is supposed to actually enhance. Search through mind & muscle forums for a lot more specific info. I don't know if this also is of any relevance but when a lot of the mind & muscle forum users were posting on using memantine with amphetamine (for tolerance prevention), they said that during the adaptation phase amphetamine was pretty useless and didn't work, so maybe after the adaptation phase you could keep taking memantine for reset of tolerance for your supplements while still keeping taking them. Hope this helped.

Btw, adaptation phase for memantine in most users was about 1 week using 10 or 20mg and then the brain fog went away after that. You also have to use it consistantly, like everyday or else your NMDA receptors won't adapt.

Interesting. I have read accounts of the adaption phase, but I also read accounts of people induring weeks of use and never getting rid of the fog. I cannot do this since I really need to think at my job (engineer). At one point, though, I was taking about 1mg memantine every other day with a small amount of rasagaline. I did this for about 6 months and at this extremely low dose I pretty much avoided the fog. It really kept the rasagaline potent. Now, I am off the rasagaline and am not taking the memantine every other day. I am taking uridine now and I find that I need the memantine now every 4 days or so to "reset" the uridine (fixes the classic edginess, hyper-vigilance feeling). But, I think it gives me some brain fog now because my NMDA receptors essentially are starting over each time. The good news is I can go down to grains of the memantine and still seem to get the reset effect and not get too much brain fog. I am still experimenting with this so I don't have good answers yet. I am also took a Mg Threonate today instead of my usual Mg Citrate and am experiencing a bit more fog than usual.

[MrHappy]

You're very welcome. JChief is the guy with the awesome 'drug-person' avatar.

Everyone here deserves credit though, as without all the self-testing, contributions and feedback, this kind of knowledge-building just wouldn't be possible. Longecity is such a great community!

Next item that definitely needs group help:
What are the reasons for slow or non-responders? Genetics? Dose? Hepatic / renal function? Sleep? Other supplements / medication?

While blood and hepatic tests would be extremely useful, maybe with more data we could correlate some factors and solve this. Would people be willing to share some more info, if I drafted a template?

I would

Excellent! Well for you and anyone else who wants to contribute, I'm building the database on http://ratemynoot.com and it's coming along nicely. The idea will be that you can input your combo/doses/other factors and over the period of up to a year, indicate how effective it is and a number of criteria of how you are feeling. People can then perform statistical analysis on the data to find common strengths and weaknesses.

If anyone else develops databases/websites and wants in on the project, let me know!

Edited by MrHappy, 17 February 2012 - 02:46 AM.