2844 replies to this topic

[MrHappy]

I would also be interested in supplying more data. Least I can do. I am not having any major responses to anything, I do have more energy and due to that I think my ultimate issues with motivation are psychological. Bad habits and behaviors. I am not discounting the potential of the supplements I am on just yet, or their potential in the future, I will give it time.

I am planning on getting some blood tests, If Mr Happy or someone else can tell me what I need to ask for, I will go to the Doctors hopefully this week or next week.

Well, hepatic and renal function, blood type, fasting levels of nutrients, levels of histamine would be good.

[MrHappy]

Mmmm.. You'll probably get anxious and 'snarky' from the amplified caffeine effect and the combo will be considerably less effective.

Is this messed up? I always take my zoloft in the evening before bed. Last night I did not take my zoloft. Today I took my uridine after lunch so as not to interfere with my morning coffee. Approximately 4 hours later I am one weepy chick. The story about the hostages freed from Somalia has me crying. The story about the Groupon business owner who lost 10K on the deal had me near tears. Does Uridine tweak the dopamine / serotonin levels? Can it be zoloft withdrawl so soon after missing one dose? I have missed doses before but it usually takes more than 24 hours for the impact to be felt.

Also, I did not take the racetam collection today (and have only been taking in for less than a week anyway) because I want to see how the uridine works without the interference from coffee. As of now - almost but not quite 10 days into this - I am still feeling the brain fog, memory lapses, depression, lethargy and poor verbal fluency. And, as of this afternoon, I am weepy.

Okay, it has been a while since I posted but I ran out of Uridine and I needed to try it without the Zoloft withdrawl and the caffeine interference. Here is one funky thing I noticed almost immediately.... while taking Zoloft but not Uridine I would get what I call a Seratonin Dump between 4 - 5 pm every day. The slightest thing would make me weepy. It was weird. It was like I was having withdrawl only I was still taking Zoloft. Since I reintroduced the Uridine w/o the caffeine, I no longer have the Dump.

I also noticed that 100 mg's makes me bland but 50 mg's does not have that impact and it ends the ceases Seratonin Dump.

Weird?

What about entering DMAE into the picture? Has anyone dabbled with this?

Uridine was amazing for restoring my wife's emotional stability after ceasing Zoloft.
Caffeine is definitely a bad mix for uridine.. I can't touch it all anymore without feeling strung out.

I find too much uridine 'clamps' transient dopamine spikes and you become less vibrant/emotional. It focuses you very much on the task in front of you. Depending on what stress levels are on your plate each day, it can be a very handy thing, sometimes. Most days, you wouldn't want to go overboard. I'm currently dosing 250mg UMP orally, twice a day - everyone has a different sweetspot, though, so finding what that is would be beneficial.

I'm finding ALCAR to be good for memory and despite one of my recent posts, I've already moved on to 100mg alpha-gpc + 500mg ALCAR and I like it a lot.

[MrHappy]

Well I have been, on my regimen for about 2 weeks now which includes Uridine 300mg UMP and Alpha GPC 500mg. I am feeling fairly good, in a subtle way. My diet was probably lacking from a number of key nutrients which has probably helped my mood and my exercise has increased which always makes me feel good. My first week I took the uridine orally and last week I switched to sublingual.

So I cant say that I have seen any life changing effects so far but I am willing to give it a fair go, I will probably report back again in about 2 weeks. I have a feeling I am not getting enough zinc as well so I be taking that shortly and have also considered adding l-glutamine to my regimen to see if that ups the ante.

What are your sleeping patterns like these days?

Edited by MrHappy, 17 February 2012 - 02:40 AM.

[MrHappy]

Just an update: I've been taking Uridine for 5 days in conjunction with Memantine, Magnesium Malate and Bacopa and so far I am not seeing any of the reported by positives effects of uridine. I actually felt better when it wasn't a part of the stack. With memantine, magnesium malate and bacopa, I my anxiety was greatly reduced, less mental fog/fatigue, more confident. Now with the addtion of uridine , it seems to have dampen all the positive effects that i used to get. So, i'm not sure if I should continue taking it and give it more time to see if it'll work or just stop taking it. Should I stop taking the memantine, magnesium and bacopa and just take uridine by itself? What do you guys think? Any input is greatly appreciated.

Perhaps try without memantine for a few days? Also, are you taking any of the other cofactors?

[MrHappy]

it's been 12 days, and it's hard to see if i'm benefiting. i'm think of trying alpha-gpc instead of alcar - could this help?

Can you give us your stack details and sleeping patterns, out of interest?

[howtodisappear]

Well I have been, on my regimen for about 2 weeks now which includes Uridine 300mg UMP and Alpha GPC 500mg. I am feeling fairly good, in a subtle way. My diet was probably lacking from a number of key nutrients which has probably helped my mood and my exercise has increased which always makes me feel good. My first week I took the uridine orally and last week I switched to sublingual.

So I cant say that I have seen any life changing effects so far but I am willing to give it a fair go, I will probably report back again in about 2 weeks. I have a feeling I am not getting enough zinc as well so I be taking that shortly and have also considered adding l-glutamine to my regimen to see if that ups the ante.

What are your sleeping patterns like these days?

I think I am not in the best position to be monitored for positive effects at this point. I have spoken to you before about my issues with motivation and these are being exacerbated by my situation. I am just finishing some studies, not working. I spend long unproductive hours in front of the computer, and sleep regularly in the sense i got to bed around 2am every morning but I don't have a real schedule.

As mentioned, I am feeling like there is a subtle effect which led me to make the conclusion that my procrastination has a behavioral/psychological basis but I believe I will be able to see and utilise the benefits much more once I am in a job and with regular routine. The more you do the more you want to do, so to speak.

And when you say blood type for the test, do you man A B O etc?

[csrpj]

it's been 12 days, and it's hard to see if i'm benefiting. i'm think of trying alpha-gpc instead of alcar - could this help?

Can you give us your stack details and sleeping patterns, out of interest?

morning empty stomach:
- 500mg ALCAR

after breakfast:
- TAU 75mg
- Fish oil: EPA/DHA 1230mg/822
- vitamin e: http://www.iherb.com...20-Softgels/205
- all b vitamins

others:
- zinc/magnesium at night, zoloft 75mg in the afternoon

sleep patters suck with several days in the week sleep deprived, but this existed before the uridine stack.

[Jr Cauton]

Just an update: I've been taking Uridine for 5 days in conjunction with Memantine, Magnesium Malate and Bacopa and so far I am not seeing any of the reported by positives effects of uridine. I actually felt better when it wasn't a part of the stack. With memantine, magnesium malate and bacopa, I my anxiety was greatly reduced, less mental fog/fatigue, more confident. Now with the addtion of uridine , it seems to have dampen all the positive effects that i used to get. So, i'm not sure if I should continue taking it and give it more time to see if it'll work or just stop taking it. Should I stop taking the memantine, magnesium and bacopa and just take uridine by itself? What do you guys think? Any input is greatly appreciated.

Perhaps try without memantine for a few days? Also, are you taking any of the other cofactors?

I think I am going to do just that. I'm taking cod liver oil as DHA source. Thanks for the tip.

[Reformed-Redan]

Just wanted to drop in that supplementing DHA with choline will also get similar results if not as substantial as with uridine. Just the minor detail in the study:

The scientists found that the gerbils given choline with UMP and/or DHA showed cognitive improvements in tasks thought to be relevant to gerbils, such as navigating mazes.

So, load up on the DHA.

Edited by redan, 17 February 2012 - 04:45 AM.

[Reformed-Redan]

Summary of everything on this topic and more, here:
http://www.perpetual...nhancement.html

[MrHappy]

Great link! Read this, for how much extra benefit uridine is to that mix:
http://wurtmanlab.mi...ic/pdf/1037.pdf

[MrHappy]

Csrpj and howtodisappear - I think your sleeping patterns have a lot to do with this.

My sleeping patterns the last few weeks has been atrocious and I have been suffering. Been managing to get to bed <11pm for 3 days and I am nearly my happy, functional self again.

Sleep is when your brain repairs and processes short term memory into longterm. Sleep is the ultimate nootropic.

Edited by MrHappy, 17 February 2012 - 05:55 AM.

[choqueiro]

Could uridine decreased libido?? Does any uridine user is experimenting a decrease in libido??

Thanks

[MrHappy]

I think alpha-gpc could cause decreased libido.

[howtodisappear]

Csrpj and howtodisappear - I think your sleeping patterns have a lot to do with this.

My sleeping patterns the last few weeks has been atrocious and I have been suffering. Been managing to get to bed <11pm for 3 days and I am nearly my happy, functional self again.

Sleep is when your brain repairs and processes short term memory into longterm. Sleep is the ultimate nootropic.

I always feel like my body is on that 25 hour clock they talk about. Naturally a late night person. I just need a reason to get up, which I don't have at the moment.

Could uridine decreased libido?? Does any uridine user is experimenting a decrease in libido??

Thanks

It might be my other supplements but at this point time the reverse is true for me.

[JChief]

I think alpha-gpc could cause decreased libido.

yet many report citicoline increases it!

[MrHappy]

Exactly why I think uridine is not the culprit (CDP breaking down to uridine + choline).

Although I haven't had any libido problems as such, mind you, my wife is rather amazing , I have noticed an increased libido when I swapped from alpha-gpc to ALCAR for a week. So far that's still the same on 100mg alpha-gpc + 500mg ALCAR, too. Unless maybe it's just that ALCAR increases my libido? <chuckle>

[irving]

I have been taking uridine (TAU form 50mg, together with alcar and fish oil) daily for a week. Unfortunately the only thing I felt from day 1 was headache and dizzy. So I decided to stop it. I don't know if it will make any difference if I switch to UMP form. Or maybe I should just give up and move on to other stuffs.

[MrHappy]

Try introducing the components 1 at a time, per day, that way you can identify any problems.

[user1]

Where do UK people get their uridine from?

I saw one person gets this stuff: http://www.blissfuls...dine/4559869796

[user1]

Can someone answer a question I have...

If uridine raises acetylcholine, isn't this bad for Parkinson's? With Parkinson's, don't you want to lower acetylcholine?

I read through the entire thread but could not find an answer ... maybe I missed it.

Apologies if there is an obvious answer - I am new to nootropics, still learning

[MrHappy]

Choline is normally antidopaminergic, however as uridine acts as a potent dopamine modulator, it's not an issue. Alpha-gpc and CDP-choline actually increase dopamine levels in the striatum. See the links I included in the reply to your PM for more details, or look around page 7 of this thread.

[csrpj]

has anybody tried uridine with CDP-choline as their choline source?

[MrHappy]

Hebbeh, I believe.

[Hebbeh]

I use 250 mg of CDP bid and a TBSP of lecithin per day. I also use 500 mg of ALC bid with the CDP. I also use 500 mg oral resveratrol and 500 mg sublingual resveratrol in the morning with my first dose CDP, ALC, the lecithin, fish oil and the uridine. I also use 5 grams standard fish oil spread through the day. I was using that regimen long before uridine. I use 250-300 mg UMP sublingual and 100 mg TAU in the morning with my first dose of CDP, ALC, resveratrol, 2g fish oil and the lecithin (on an empty stomach). I just got back late last night from driving 1600+ miles in 2 days....and used additional sublingual UMP later in the day during the drive which would definitely bring me back to baseline and shake the "fogginess" of driving fatigue. Uridine has been exceptional in lifting my "brain fog" and mental fatigue and restoring a clear mind with clear unhindered concentration...it has turned back the clock on my 54 yo brain and allows the clear minded concentration that I remember from my youth. It brought me back to baseline....but I don't think it will elevate you much above your potential baseline....but I'm more than happy and excited about feeling my mental youth again.

[MrHappy]

http://www.faqs.org/...p/20110257109#b
Patent application title: USE OF DRUGS THAT ACTIVATE P2Y RECEPTORS TO ENHANCE SYNAPTOGENESIS (Wurtman, et al.)

The present invention encompasses compositions and methods that activate P2Y receptors for the increased production of new synapses in the central nervous system. The formulations of the invention may be administered to a healthy subject or to a subject in need thereof to restore synapses.

Looks like adding ATP to the mix further stimulates P2Y receptors, increasing synaptogenesis.

[Hologram]

Hey, Mr.Happy as you can guess I have a few more questions. The stack is working pretty good so far, some noticeable anti-depressant effects, but what I'm wondering about is the blood thinning.
Vitamin E and the fish oil, I take are both blood thinners, I was thinking about adding Ginkgo Biloba(maybe overrated, I know but I'd like to try it). But that also is a blood thinner and I'm starting to worry about mini bleeds in the brain as well as other complications. What are your thoughts on this?

Also, it's probably ideal to take this in the morning but my current schedule doesn't allow for the lengthy sublingual administration(how long is that supposed to take anyway?). Does it really matter, if I take them later in the night?

[owtsgmi]

Mr. Happy - Can you also update us on your uridine stack (e.g., how much you are taking daily, adjuncts, etc.)? Any tolerance issues? Also, how did you fare with the powder from China?

[MrHappy]

Cerberus - I don't think there are any issues at these doses. Adding ginkgo on a sporadic schedule shouldn't cause any issues - I'd take bacopa & brahmi once or twice a week.

[MrHappy]

Owtsgmi - my current stack:
250-300mg UMP, morning & night
500mg ALCAR, morning and night
100mg alpha-gpc, morning
1 berocca, morning
500IU vitamin E, morning
4x flaxseed oil capsules, morning
2x grape-seed extract, morning
.. and the occasional random vitamin/mineral/supplement, as needed.

It's been nearly 6 months now. No tolerance, side-effects or issues observed - I've tried changing the stack and removing components. I've tried ceasing all supplements for a week (I didn't like it.) I've played around with doses and now ALCAR/alpha-gpc mixes - I'm still feeling good and my current stack is working very well for me.