2844 replies to this topic

[kevinseven11]

Uridine and phosphatidylserine works well for me

[howtodisappear]

I have been the on Uridine UMP for the last 3 months with co-factors and haven't really felt anything noticeable I am generally pretty positive and healthy besides my chronic procrastination. As a suggestion by Mr Happy earlier on I have just bought some Tyrosine. I am taking a rough teaspoon in the morning on an empty stomach with Uridine and vitamin b-complex.

Maybe I am already feeling good and so the gains for me aren't going to be as pronounced, I will be debating about purchasing some more but it looks so good on paper and maybe there are other benefits I am just not physically aware of that I am still not sure I want to give up on it.

[Reformed-Redan]

Co-supplementation with DHA is ultra important.

[Baten]

I bought a new 25g uridine monophosphate tub from Superior Neutraceuticals, and I noticed it looked quite different from last time.
The first tub of uridine looked like it was filled with sugar, it looked almost exactly like sugar: a bit grainy.
This newer batch looks much more powdery, like a mixture of flour and sugar. It also looks noticeable more white.
Hope what I bought is actual uridine :/ ... thankfully it still is water soluble.
It's probably just sourced from somewhere else, but I still find it weird that raw powders from different sources look this different.

Edited by Baten, 27 March 2012 - 08:24 AM.

[choqueiro]

Well, I´m going to give a last opportunity to Uridine. So I´m going to buy L-tyrosine, but I have doubts. It would be better to buy L-Tyrosine or L-Phenylanine??

Thanks

[nito]

it would be nice if we had a poll to see responders vs non responders.

[Psionic]

Co-supplementation with DHA is ultra important.

What if I supplement with pure EPA only? I found that DHA causes in me some depressive and depersonalization symptoms, not to mention worse muscle regeneration.. maybe only bad quality fish oil, but EPA works really great for me, can it have some synergy with uridine?

[Junk Master]

New here, but longtime lurker.

Thanks to MrHappy's suggestion I began Uridine and Flax/Krill oil about 3 months ago. I also use Mthylene Blue at approx. 3 mg per day in divided doses, two weeks on and two weeks off.

I've been very pleased with the dopamine modulating effects. My baseline happiness is significantly improved, and my moods are generally more stable. Again, subjectively, I just feel my brain function has been "balanced" and "healthier."

The only downside has been the noticeable decline in hypomania, and a lack of pleasure coffee and the occasional 1/8 square of nicotine patch I use while working.

I'm currently dosing mid-morning, using a double dose of UMP sublingually, has anyone experimented with mega-dosing? What does "too much" Uridine feel like.

Also, I've been trying to find the optimal time to dose and the few times I've tried in the evening I felt better than normal the next day, however, I do feel the slight energizing effect of uridine made it harder to sleep. Does anyone else dose at night?

Thanks to all the psychonauts here for continuing to push the envelope here in a way conventional mental health medicine does not.

[Blink]

Also, I've been trying to find the optimal time to dose and the few times I've tried in the evening I felt better than normal the next day, however, I do feel the slight energizing effect of uridine made it harder to sleep. Does anyone else dose at night?

This is similar to what I've experienced. I had been taking uridine (once a day, morning) and gotu kola (twice a day, morning and evening) daily for 2 weeks. Then I skipped the uridine one day and felt absolutely great, almost euphoric, during the first half of that day.

Currently I'm not taking any supplements at all and I've experienced some problems during this break. I don't know if it's because of the absence of gotu kola or uridine, but I have a hard time falling a sleep at night and during the days I look tired and sick even tho I feel ok. It's been a week now and I still have these problems but I think it's getting a little better.

Edited by Blink, 31 March 2012 - 09:19 AM.

[kevinseven11]

Infections can maintain for weeks. ^
Anyways no where on here have I seen that saturated fats are required for neuronal growth as well. Saturated fats must be included with this regime. I guess most people assume that the typical person will have plenty of this sourced but I know a lot of you on this website want to stay healthy, so perhaps not.
Currently Im at..

Uridine TAU 100mg
Fish Oil
Olive Oil
Phosphatidylserine 300mg (Sometimes 600mg)

This stack is BETTER than piracetam. It honestly reminds me of taking 5mg of adderall without the toxic effects/ come down.

Edited by kevinseven11, 01 April 2012 - 08:13 PM.

[choqueiro]

Hi kevinseven11.

I' m not having success with uridine and cofactors.

What do you think about adding l-tyrosine to the stack??

[kevinseven11]

I agree to trying L-tyrosine, but I feel like its possible to achieve too high of a level of dopamine. My dopamine already appears high so I didn't need it. Also note to try 100mg TAU sublingualy

[Junk Master]

Why do you say your dopamine appears high?

Also, I just switched my Uridine dosing schedule to evenings and am having fantastic results with improved mood in the morning. It's the way to go for me.

[kevinseven11]

High Drive, satisfied life, and uridine works great.
Junk master, Do you experience improved dreams by taking it in evenings?

Edited by kevinseven11, 04 April 2012 - 12:19 AM.

[Junk Master]

Funny you should mention dreams kevinseven11, the last few nights I've had exceedingly vivid dreams. I have sleep apnea, so at times I have vivid dreams when sleep deprived but I haven't been especially sleep deprived lately, so I'm inclined to attribute them to the change in Uridine dosing time.

[MrHappy]

Well, I'm back!

Can't report much as new, other than 3 more (very) positive responses for age-related cognitive decline.

[Junk Master]

I'd like to hear some subjective reports of how Uridine interacts with caffeine, and low dose nicotine. Also, Uridine and Methylene Blue.

So far, I'm still not sure if it's best to dose in the morning, split the dose twice a day, dose in mid-afternoon, or dose at night.

I have had a couple very positive experience with feeling great the day after dosing at night, but I've had a couple nights where I felt Uridine might have contributed to very vivid dreams that left me almost exhausted the next morning.

As a note, I do have sleep apnea, so I'm not sure how that might have contributed to feeling exhausted as I'm currently waiting for a new CPAP machine.

[MrHappy]

I found that uridine+ fixed the brain fog & mood issues I was left with after rapidly stopping methylene blue following about 6 weeks of MB testing.

Caffeine+uridine - I found that I would get very irritable from even 1 cup of coffee, which normally happens if I have too much caffeine. It looks like they access some of the same receptors. There is a paper further back in the thread that talks about interaction with AMPA and NMDA signaling.

[mpe]

Mr Happy,

Does the Uridine have any effect on blood pressure ? I ask because i have high blood pressure and have to give up my coffee addiction and now have a problem with brain fog.

[medievil]

Mr happy; very impressed with the efford you put in this thread; keep up the good work.

[Junk Master]

Definitely keep up the good work.

In my experience, Uridine definitely makes me want less coffee. I find myself not finishing a big morning cup, versus drinking two.

What I wonder is how it effects the top end of pleasure, since it modulates dopamine. For example, Uridine and cocaine? Uridine and adderall?

Methylene Blue still fascinates me on so many levels. I have no problem taking 3 mg a day and stopping. Nothing. But the other day I took 1 mg with a small dose of Phenibut and felt like I'd taken 10 mg of valium.

So much to learn...thanks again, and I'm shocked uridine isn't commonly used for brain injury recovery in conjunction with fish oil and vitamin B.

[MrHappy]

Mpe, uridine has some substantial cardio benefits. It seems to be a decent neural vasodilator, as well.

I'd give it a go and see how your brain fog fares. I suspect it'd be quite useful for you.

[choqueiro]

Hi Mr. Happy.

I´ve been several months on uridine + cofactors without any benefit. My daily regime was:

a) Uridine UMP: 250 mg
b) Alpha GPC: 500 mg (2 capsules)
c) DHA: 1800 mg DHA and 360 mg EPA (2 capsules)
d) Multivitamin AOR Ortho Core: (6 capsules)
e) Vitamin E AOR: (1 capsule)

Recently I have opened a thread (http://www.longecity...-and-brain-fog/) to try to find a solution to my problems. So I´m going to start a new regime with: Piracetam + Centropehenoxine and following the advices of "JChief" I´m going to give another try to uridine.

Three questions:

1) Any problem taking Piracetam + Centro + Uridine + cofactors??

2) JChief suggests to take TAU instead of UMP variety?? What do you think about it??

3) I was taking 250 mg. daily of UMP Uridine. Should I take more??

[Psionic]

Hi Mr. Happy.

I´ve been several months on uridine + cofactors without any benefit.

It seems that I benefit with uridine alone without supplementing with dha. Maybe you have to have some brain deficit in order to get noticeable benefits but for me it means that I can keep prolonged focus on normaly boring tasks/activities and do them without distracting thoughts.. Seems like the longer I take it the better improvements I do..

[MEMOREX]

I currently taking 250mg - 300mg UMP
500mg AphaGPC
460mg DHA
345mg EPA

When I take this in the morning, I have serious fatigue at work.Fatigue is one of the problems I am trying to get rid off.
When I take it at 6pm in the evening, the fatigue is not so bad the following day.
When I took it at night time, I had quite an enjoyable sleep with vivid dream but a terrible day the following morning at work with serious fatigue.

In addition to the above I am taking, B-Complex, Mg & K,,Himalaya MindCare ,Ashwagandha and StressCare,3g Spirulina, Quercetin,, 25mg Zn, 200mcg Sn,

My mains problems are brain fog, Fatigue, Balance and Coordination problem,Memory and Recall problem.,Running nose and itchy eyes, PE,panic attack, sweatiness,
When I do have fatigue at work, I get quite irritable and when speaking the words just doesn't comes out right, Also I noticed when I do have fatigue there is a "kicking like" movement in my right leg,just for a split second.I don't have fatigue at home.
Also I can't seem to pass my driving test because I keep missing the road signs.

Previously, i have taken 800mcg Metafolin and for a minute my brain was working fine,with a disappearance of most of the symptoms but this didn't last for long.

Now thinking of trying TAU and L-Tyrosine.

[JChief]

2) JChief suggests to take TAU instead of UMP variety?? What do you think about it??

JChiefs actually suggested using TAU if UMP was taken orally but since you indicated later on it was taken sublingually I am now advocating it to only to try something different if you wish. I have had good results with TAU but that doesn't mean you will.

I also wanted to point out on this thread that there sure seems like theres something to the whole caffeine and uridine connection because only after did someone else mention did I realize that all too often I will not finish a cup of coffee whereas before I started uridine I could consume several cups over a work shift. Out of habit I might go get some coffee but I rarely will feel the need to finish the cup. I don't really know the reason behind it.

[owtsgmi]

Mr Happy,

Does the Uridine have any effect on blood pressure ? I ask because i have high blood pressure and have to give up my coffee addiction and now have a problem with brain fog.

I'd like to know if anyone else has experienced higher blood pressure with uridine. My bp is high (135/90) and I don't know if this is partially a result of the uridine supplementation I have been taking for the last 3 months. I started daily bp checks about a month ago because I kept getting tension-like feelings when I took too much uridine. I remember my bp being quite good only a year or so ago, but I don't have any data between that reading and the current ones. My gut feeling is that uridine has something to do with the bp rise but have no proof of that. I may stop for a bit and see if it goes down. Also, I definitely noticed I can tolerate much less caffiene than before. The caffiene and uridine seen to act almost exactly the same in the tension-type feelings when i take too much.

[Junk Master]

I take a boat load of piracetam, basically 6 teaspoons a day-- roughly 12-16 grams, been adding some centro lately (hate the taste), and have had no problems with uridine 25-500 sublingually a day.

I didn't like the above when mixed with one of those over the counter green tea weigh loss extracts. Too much caffeine plus some weird chills, stomach pains.

My BP has been high lately as well, though. Hmm. Anyone else notice a rise in BP with Uridine?

[Psionic]

My mains problems are brain fog, Fatigue, Balance and Coordination problem,Memory and Recall problem.,Running nose and itchy eyes, PE,panic attack, sweatiness,
When I do have fatigue at work, I get quite irritable and when speaking the words just doesn't comes out right, Also I noticed when I do have fatigue there is a "kicking like" movement in my right leg,just for a split second.I don't have fatigue at home.
Also I can't seem to pass my driving test because I keep missing the road signs.

Please do not look only into this brain issues which can be just the top of the whole problem.. your root cause can be somewhere else.. I would look into traditional chinese medicine and also watch carefully the food you eat. Most of the problems you describe have people today just because of the bad food they eat.. Improving brain health can be only short term solution..

Edited by Vojtech Mejzlik, 17 April 2012 - 07:46 AM.

[MrHappy]

Memorex - while what you describe could be an intolerance to alpha-gpc (try without it for a few days), if it's not, I'd look at potential liver issues.

I think your problems could revolve around CCK-4 or possibly CCK-8 production and while uridine addresses that, if it turns out you do have liver issues, you're better off dealing with it directly.
http://en.m.wikipedi...Cholecystokinin

Things that work on repairing liver issues: L-taurine, silymarin, B6.

There could be other, more serious, causes of liver damage. It'd be worth getting a blood test and liver function test (although it can often report as fine even when it is not). Again, try removing alpha-gpc for a few days first.