2844 replies to this topic

[MrHappy]

Since Uridine could increase chances of mental (schizophrenia) problems, should this be restricted from younger people?

I'd say the opposite is more likely, given what it does to BPD. I'd like to see a study performed on it.

[Logic]

Since Uridine could increase chances of mental (schizophrenia) problems, should this be restricted from younger people?

I think all you need to o is make sure you get enough B3.
http://www.doctoryou...cinreviews.html

"...their son was so unmanageably violent that he was kicked out of the asylum and sent to live with them. On a good day, his Mom and Dad somehow got him to take 3,000 milligrams of niacin and 10,000 mg of vitamin C. Formally a hyperactive insomniac, he responded by sleeping for 18 hours the first night and becoming surprisingly normal within days. It was an astounding improvement..."

[1thoughtMaze1]

thats 42 pages with mostly random comments.

can someone summirize this. is there 1 supplement that contains all 3 ingredients or do you need them seperately and combine ?
if so, which supplements do you recomend one buys to combine ?

I think a sticky comment injected at position 1 may help here.

<ctrlcopy> & <ctrlpaste>
Morning:

300mg UMP, orally
GOOD multi vitamin, that includes the RDI of b group and trace minerals
500IU of mixed vitamin E
250mg choline
A large dose of fish oil with >700mg DHA + >300mg EPA (other forms available if you are vegetarian)
-optional, but (personally) recommended - 10mg noopept



Evening:

300mg UMP, orally
250mg choline
-optional, but (personally) recommended - 10mg noopept


Start there and re-evaluate after 1-2 weeks.

A good supplier is http://superiornutraceuticals.com - but I'd avoid their 'uridine enhanced' product, as I think it's imbalanced on the B vitamins and will probably lead to temporary mild tinnitus. (Any nootropic can, as the bloodflow and nervous system changes, but that one's avoidable!)

Hey Mr, I noticed you started noopept. Can you give some feed back on how that has fit in, postive or negative effects? too soon maybe

[celiac]

Mr. Happy,

It seems like you've jumped around a bit on the amount you recommend per day and whether to use UMP orally or sublingually (for someone just beginning and wanting to experiment).

Is your final recommendation 300mg twice a day orally? I just began using UMP on Monday - roughly 150mg twice a day sublingually.

One brief note - I eat eggs for choline, but do not take any of the other recommended supplements. Personally I believe with my generally healthy diet I should be fine in terms of trace minerals, B vitamins, vitamin E, and omega-3s (I eat only grass-fed meat, as well as consume fish on occasion - note, I was recently taking Carlson's Cod Liver Oil). If I would add anything, it would be Cod Liver Oil for omega-3s, but that isn't really an option right now. Would you care to comment on this as well?

This is a great thread. Took me a week to read through! I appreciate your hard work in staying on top of it! I think I speak for many of the lurkers on here when I say Thanks!

[sparkk51]

I don't feel enough from uridine to justify daily use at 1 dollar/gram

In bulk UMP is less than 50¢ per day at the standard 250mg dose sublingual. I can't think of anything you can buy cheaper than that....not even a bottle of water.

I can. Like, daily doses of five other mid-cost supplements or noots.

This stuff is bloody expensive, as supplements go. If it profoundly improves your life it might well be worth it, but I don't feel nearly as much from 50 cents worth of daily UMP as I do from the average 50 cents worth of stuff in my stack.

Matter of lifestyle, I guess. Buying 50¢ bottles of water seems insane to me, too.

Has anyone noticed any significant difference when adding gpc choline to the mix? I am currently unsure of uridine's effects, but have been feeling a little less stimulated than before. Could uridine supplementation without choline be depleting my choline stores perhaps? Could I be dropping in acetylcholine?

I've tried and never noticed a significant difference. What UMP noticably does for me hasn't been contingent on any of the cofactors except possibly the B9 and B12 that comes mixed with the powder.

It's theoretically possible though, if it's causing more of the choline that reaches your brain to be used towards phosphatidylcholine.

I'd sooner look elsewhere, though. Do you use any daily dopaminergics to reach your usual level of stimulation? If so, uridine could be normalizing you downward, and you could consider taking it at night instead.

Thanks for the reply. Do some people take this supplement at morning and evening? If so, at 300 mg each interval?

Along with Uridine, I am taking ALCAR, a multivitamin, L-glutamine, Vitamin D, Venlafaxine (150 mg), Fish Oil, and Guanfacine (2 mg morning & 1 mg evening).

I do not know if any of these are giving me higher dopamine.

Edited by sparkk51, 02 August 2012 - 10:29 PM.

[mrak1979]

Great thread guys! I have a simple question and don't know if it was answered before, but does Uridine need to be cycled on/off?

thx.

Edited by mrak1979, 03 August 2012 - 01:48 AM.

[dear mrclock]

thats 42 pages with mostly random comments.

can someone summirize this. is there 1 supplement that contains all 3 ingredients or do you need them seperately and combine ?
if so, which supplements do you recomend one buys to combine ?

I think a sticky comment injected at position 1 may help here.

&
Morning:

300mg UMP, orally
GOOD multi vitamin, that includes the RDI of b group and trace minerals
500IU of mixed vitamin E
250mg choline
A large dose of fish oil with >700mg DHA + >300mg EPA (other forms available if you are vegetarian)
-optional, but (personally) recommended - 10mg noopept



Evening:

300mg UMP, orally
250mg choline
-optional, but (personally) recommended - 10mg noopept


Start there and re-evaluate after 1-2 weeks.

A good supplier is http://superiornutraceuticals.com - but I'd avoid their 'uridine enhanced' product, as I think it's imbalanced on the B vitamins and will probably lead to temporary mild tinnitus. (Any nootropic can, as the bloodflow and nervous system changes, but that one's avoidable!)

just curious where do you get your uridine then ? i assume brewer yeast's RNA/DNA ingredient on the lable contains it ? but still, its too heavy for me, is there uridine supplement all by itself that is made by reputable company and people can recomend it ??

Please re-read the comment you just quoted.

so this is the best ?
Uridine-5'-Monophosphate disodium 25 Grams




dunno why its in grams. kind of difficult to dose properly. is it synthetic or of natural source if you know ??

[MrHappy]

thats 42 pages with mostly random comments.

can someone summirize this. is there 1 supplement that contains all 3 ingredients or do you need them seperately and combine ?
if so, which supplements do you recomend one buys to combine ?

I think a sticky comment injected at position 1 may help here.

&
Morning:

300mg UMP, orally
GOOD multi vitamin, that includes the RDI of b group and trace minerals
500IU of mixed vitamin E
250mg choline
A large dose of fish oil with >700mg DHA + >300mg EPA (other forms available if you are vegetarian)
-optional, but (personally) recommended - 10mg noopept



Evening:

300mg UMP, orally
250mg choline
-optional, but (personally) recommended - 10mg noopept


Start there and re-evaluate after 1-2 weeks.

A good supplier is http://superiornutraceuticals.com - but I'd avoid their 'uridine enhanced' product, as I think it's imbalanced on the B vitamins and will probably lead to temporary mild tinnitus. (Any nootropic can, as the bloodflow and nervous system changes, but that one's avoidable!)

Hey Mr, I noticed you started noopept. Can you give some feed back on how that has fit in, postive or negative effects? too soon maybe

Fits well. More focus, memory, etc. Haven't seen any bad effects. Causes temporary sobriety after drinking, I've found.

[MrHappy]

Mr. Happy,

It seems like you've jumped around a bit on the amount you recommend per day and whether to use UMP orally or sublingually (for someone just beginning and wanting to experiment).

Is your final recommendation 300mg twice a day orally? I just began using UMP on Monday - roughly 150mg twice a day sublingually.

One brief note - I eat eggs for choline, but do not take any of the other recommended supplements. Personally I believe with my generally healthy diet I should be fine in terms of trace minerals, B vitamins, vitamin E, and omega-3s (I eat only grass-fed meat, as well as consume fish on occasion - note, I was recently taking Carlson's Cod Liver Oil). If I would add anything, it would be Cod Liver Oil for omega-3s, but that isn't really an option right now. Would you care to comment on this as well?

This is a great thread. Took me a week to read through! I appreciate your hard work in staying on top of it! I think I speak for many of the lurkers on here when I say Thanks!

I think it's a good starting point. You can make adjustments from there as needed. I'd still supplement the B's, E and omega-3.

[MrHappy]

I don't feel enough from uridine to justify daily use at 1 dollar/gram

In bulk UMP is less than 50 per day at the standard 250mg dose sublingual. I can't think of anything you can buy cheaper than that....not even a bottle of water.

I can. Like, daily doses of five other mid-cost supplements or noots.

This stuff is bloody expensive, as supplements go. If it profoundly improves your life it might well be worth it, but I don't feel nearly as much from 50 cents worth of daily UMP as I do from the average 50 cents worth of stuff in my stack.

Matter of lifestyle, I guess. Buying 50 bottles of water seems insane to me, too.

Has anyone noticed any significant difference when adding gpc choline to the mix? I am currently unsure of uridine's effects, but have been feeling a little less stimulated than before. Could uridine supplementation without choline be depleting my choline stores perhaps? Could I be dropping in acetylcholine?

I've tried and never noticed a significant difference. What UMP noticably does for me hasn't been contingent on any of the cofactors except possibly the B9 and B12 that comes mixed with the powder.

It's theoretically possible though, if it's causing more of the choline that reaches your brain to be used towards phosphatidylcholine.

I'd sooner look elsewhere, though. Do you use any daily dopaminergics to reach your usual level of stimulation? If so, uridine could be normalizing you downward, and you could consider taking it at night instead.

Thanks for the reply. Do some people take this supplement at morning and evening? If so, at 300 mg each interval?

Along with Uridine, I am taking ALCAR, a multivitamin, L-glutamine, Vitamin D, Venlafaxine (150 mg), Fish Oil, and Guanfacine (2 mg morning & 1 mg evening).

I do not know if any of these are giving me higher dopamine.

Yes, but try taking less, if you are finding yourself less vibrant and too focused.

[MrHappy]

Great thread guys! I have a simple question and don't know if it was answered before, but does Uridine need to be cycled on/off?

thx.

Try 3 months on, 1 or 2 weeks off.

Depends on your response/reason for supplementing, too.

[MrHappy]

thats 42 pages with mostly random comments.

can someone summirize this. is there 1 supplement that contains all 3 ingredients or do you need them seperately and combine ?
if so, which supplements do you recomend one buys to combine ?

I think a sticky comment injected at position 1 may help here.

&
Morning:

300mg UMP, orally
GOOD multi vitamin, that includes the RDI of b group and trace minerals
500IU of mixed vitamin E
250mg choline
A large dose of fish oil with >700mg DHA + >300mg EPA (other forms available if you are vegetarian)
-optional, but (personally) recommended - 10mg noopept



Evening:

300mg UMP, orally
250mg choline
-optional, but (personally) recommended - 10mg noopept


Start there and re-evaluate after 1-2 weeks.

A good supplier is http://superiornutraceuticals.com - but I'd avoid their 'uridine enhanced' product, as I think it's imbalanced on the B vitamins and will probably lead to temporary mild tinnitus. (Any nootropic can, as the bloodflow and nervous system changes, but that one's avoidable!)

just curious where do you get your uridine then ? i assume brewer yeast's RNA/DNA ingredient on the lable contains it ? but still, its too heavy for me, is there uridine supplement all by itself that is made by reputable company and people can recomend it ??

Please re-read the comment you just quoted.

so this is the best ?
Uridine-5'-Monophosphate disodium 25 Grams




dunno why its in grams. kind of difficult to dose properly. is it synthetic or of natural source if you know ??

Yes. Likely synthetic, but ask one of the chemists on here. Dosing is easy - it comes with a 350mg scoop.

[mrak1979]

Mr. Happy, I'm taking for focus and dopamine enhancement (general wellbeing). 300mg oral daily. Cycle 3months or am I okay without cycling?

Edited by mrak1979, 03 August 2012 - 06:31 PM.

[Hebbeh]

Been using UMP sublingual for 9 months with no breaks and I still experience the same positive effects now that I did 9 months ago. Absolutely no tolerence to date.

[dear mrclock]

im not keen to trying uridine if its some synthetic shit. and update me what was UMP again ?

[Brainfart]

Can I use Lovaza in place of the DHA/EPA?

Just ordered my UMP also. I'm psyched!

I am also using Cognitex from Life Extension for the time being...

[dear mrclock]

i was wondering, i saw supplements stating RNA/DNA and i avoided them before cuz i thought thats weird use for supplement but now im realizing what it means is, it contains uridine in natural form. is this good idea to get one of those and give it a try ??

im trying to get anything that i can directly with cash. i have no use for the website you cited because i dont have ability to buy things online and i cannot pay for them with cc.

Edited by dear mrclock, 03 August 2012 - 08:42 PM.

[X_Danny_X]

I can't feel anything with this stack until I added the CRAZE supplement. So far now my head is working and my brain is thinking. I was wondering, if you dont feel anything, that doesn't mean that it is not working?

Edited by X_Danny_X, 03 August 2012 - 09:05 PM.

[sparkk51]

im not keen to trying uridine if its some synthetic shit. and update me what was UMP again ?

UMP is Uridine (Uridine MonoPhosphate). I dont understand how a synthetic substance would be any different from a "natural" one, in this case. Uridine Monophosphate is Uridine Monophosphate.

Edited by sparkk51, 03 August 2012 - 09:44 PM.

[hephaestus]

im not keen to trying uridine if its some synthetic shit. and update me what was UMP again ?

That sort of attitude isn't going to make you any friends here.

[MrHappy]

i was wondering, i saw supplements stating RNA/DNA and i avoided them before cuz i thought thats weird use for supplement but now im realizing what it means is, it contains uridine in natural form. is this good idea to get one of those and give it a try ??

im trying to get anything that i can directly with cash. i have no use for the website you cited because i dont have ability to buy things online and i cannot pay for them with cc.

Hmm.. Breast milk, organ meats and semen are all rich sources that are available offline for cash, barter or free in the right circumstances..

[MrHappy]

..or, perhaps spirulina.. however the effects won't be anywhere near as pronounced from natural/food sources.

I'd stick to UMP, personally.

[MrHappy]

Been using UMP sublingual for 9 months with no breaks and I still experience the same positive effects now that I did 9 months ago. Absolutely no tolerence, to date.

I haven't seen tolerance, either. Just being conservative around cycling growth promoters.

[dear mrclock]

so natural sources you will need a lot more and it wont be as noticable.
oh well, i guess if i can find it in some store locally. i dont trust any sites.

[MrHappy]

so natural sources you will need a lot more and it wont be as noticable.
oh well, i guess if i can find it in some store locally. i dont trust any sites.

...You have considered that most products discussed on here are not generally available in shops? If they were, you'd be reading about them in womens' magazines and not a nootropics forum.

I think perhaps using the same online product and vendor used and recommended by half the people in this thread is a pretty safe bet?

[dear mrclock]

alright man. i just dont have cc to use online right now but i get your point. what about choline ? i read in general it is not bioavailable orally. they always put it in the b vitamin supplements. and i read its not easily crossing bbb in its usual form that is most often sold as supplement.

[MrHappy]

alright man. i just dont have cc to use online right now but i get your point. what about choline ? i read in general it is not bioavailable orally. they always put it in the b vitamin supplements. and i read its not easily crossing bbb in its usual form that is most often sold as supplement.

The one in most B vitamin supplements is choline bitartate, which will likely make you smell like fish in large doses.

The preferred versions are CDP-choline or alpha-GPC. They'll both cross the BBB quite readily and have some extra benefits. Some people can have a bad reaction to alpha-GPC.

Thinking out loud, you could organise a visa debit card within a few days, with no credit check required. That'd expand your purchasing options?

[MrHappy]

Can I use Lovaza in place of the DHA/EPA?

Just ordered my UMP also. I'm psyched!

I am also using Cognitex from Life Extension for the time being...

For sure!

[sparkk51]

Could anyone confirm the reliability of this brand and this product, specifically? Nexus

[tintinet]

UMP orally, not sublingually? Or does it not matter?