2844 replies to this topic

[nupi]

Too lazy to catch up on all the thread but I figured I might try this again with a very specific objective: After trying a number of different antidepressants over the past few months, I think I can say that Fluoxetine (Prozac) has a pretty decent efficacy and close to no nasty side effects for me (it kills the GAD, does a little for SAD and definitely gives me bright mood and a noticeable energy boost without going all the way to not sleeping like on an SNRI). However, SSRI being what they are, motivation to stay on a task is gone and I feel like I have increased ADHD-PI tendencies. As my shrink is not really willing to let my try and hit Dopamine with MPH, I am looking for another option.

We know the Uridine stack modulates dopamine this seems like a decent thing to try (last time round it did not do much for me but with all the GAD and atypical depression it probably did not stand a chance). I am just wondering about three things:
1) I am not entirely sure we know the real MoA of Uridine - Do I need to consider any interactions between Uridine and the SSRI - for obvious reasons, I want to avoid serotonin syndrome?
2) Is 300mg sublingual Superior Nutraceuticals (simply because I have some left) UMP in the morning enough (or should I take it before bed)? Once that runs out, I will switch to CR TAU caps (as iHerb now carries that), how much of that should I aim for?
3) Any chance it would increase Norepinephrine? I have gotten convinced that NE makes for bad anxiety and OCDish symptoms and absolutely do not want to mess with it again...

Edited by nupi, 02 December 2012 - 01:15 PM.

[Guardian4981]

I have temporarily stopped taking uridine for the past 2 days. While I feel it helped with my D, I began to have some side effects. One is my allergies have gotten worse and I even am getting a bit of puffiness around my cheeks. My libido also has went down and it was low to begin with, I also had a difficult time "peaking." I also had some mild prickliness in my feet.

Uridine for me appears to be one of the most effective compounds for helping the serotonin side of things, but my serotonin was getting to high. Appetite was gone also.

While many here promote higher dose uridine, I may try reduced dose, something like 25 mg every 3-4 days.

Last week I started using Thorn Research multi at the full dose of 6 a day. For half a year now I have battled with lingering pain in my upper bicep and chest tie in. Every day after the Thorn this strain has gotten better and today I feel almost zero pain. I therefore believe that I must have had some kind of imbalance going on which prevented this strain from fully recovering until I introduced the Thorn, I theorize it may be the vitamin b5 which helped. I mentioned this because perhaps the imbalance I had also influenced how the uridine worked with me.

Right now I tentatively am planning to take extra Vitamin B5 and the Thorn for a few weeks and re evaluate where I am at, I may at that time again try the Uridine.

I theorize that high serotonin may cause hypoglyemia because cortisol may be reduced. This is what may cause the prickliness in the feet.

I know that its been said uridine has dopamine modes of action, but I did not experience much benefit in the way of dopamine. I know Mr Happy said it "modulates" or normalizes dopamine, but my dopamine is anything but high normally so lowering it does not seem very ideal to me.

The vitamin B5 helps the adrenaline glands, it also helps choline be processed, I am thinking higher dose B5 for a few weeks and then uridine again may have different results then what I got this time around.

I also wish to refrain from fish oil in the future, it always seems to make my nasals worst and uridine appears to enhance this, because normally astragalus will mitigate the nasal related sides of fish oil, this time astragalus was not able to do so.

[MrHappy]

I have temporarily stopped taking uridine for the past 2 days. While I feel it helped with my D, I began to have some side effects. One is my allergies have gotten worse and I even am getting a bit of puffiness around my cheeks. My libido also has went down and it was low to begin with, I also had a difficult time "peaking." I also had some mild prickliness in my feet.

Uridine for me appears to be one of the most effective compounds for helping the serotonin side of things, but my serotonin was getting to high. Appetite was gone also.

While many here promote higher dose uridine, I may try reduced dose, something like 25 mg every 3-4 days.

Last week I started using Thorn Research multi at the full dose of 6 a day. For half a year now I have battled with lingering pain in my upper bicep and chest tie in. Every day after the Thorn this strain has gotten better and today I feel almost zero pain. I therefore believe that I must have had some kind of imbalance going on which prevented this strain from fully recovering until I introduced the Thorn, I theorize it may be the vitamin b5 which helped. I mentioned this because perhaps the imbalance I had also influenced how the uridine worked with me.

Right now I tentatively am planning to take extra Vitamin B5 and the Thorn for a few weeks and re evaluate where I am at, I may at that time again try the Uridine.

I theorize that high serotonin may cause hypoglyemia because cortisol may be reduced. This is what may cause the prickliness in the feet.

I know that its been said uridine has dopamine modes of action, but I did not experience much benefit in the way of dopamine. I know Mr Happy said it "modulates" or normalizes dopamine, but my dopamine is anything but high normally so lowering it does not seem very ideal to me.

The vitamin B5 helps the adrenaline glands, it also helps choline be processed, I am thinking higher dose B5 for a few weeks and then uridine again may have different results then what I got this time around.

I also wish to refrain from fish oil in the future, it always seems to make my nasals worst and uridine appears to enhance this, because normally astragalus will mitigate the nasal related sides of fish oil, this time astragalus was not able to do so.

If your DA is low, it pulls it up and vice-versa.

Also, it's possible you may have something extra going on with the nasal issue and puffiness - sounds like either an allergy or infection. Maybe the fish oil? Could try flaxseed oil instead?

I think you might be on the money with the B5, though. Keep us posted.

Too lazy to catch up on all the thread but I figured I might try this again with a very specific objective: After trying a number of different antidepressants over the past few months, I think I can say that Fluoxetine (Prozac) has a pretty decent efficacy and close to no nasty side effects for me (it kills the GAD, does a little for SAD and definitely gives me bright mood and a noticeable energy boost without going all the way to not sleeping like on an SNRI). However, SSRI being what they are, motivation to stay on a task is gone and I feel like I have increased ADHD-PI tendencies. As my shrink is not really willing to let my try and hit Dopamine with MPH, I am looking for another option.

We know the Uridine stack modulates dopamine this seems like a decent thing to try (last time round it did not do much for me but with all the GAD and atypical depression it probably did not stand a chance). I am just wondering about three things:
1) I am not entirely sure we know the real MoA of Uridine - Do I need to consider any interactions between Uridine and the SSRI - for obvious reasons, I want to avoid serotonin syndrome?
2) Is 300mg sublingual Superior Nutraceuticals (simply because I have some left) UMP in the morning enough (or should I take it before bed)? Once that runs out, I will switch to CR TAU caps (as iHerb now carries that), how much of that should I aim for?
3) Any chance it would increase Norepinephrine? I have gotten convinced that NE makes for bad anxiety and OCDish symptoms and absolutely do not want to mess with it again...

1. No, but I'd be curious to see if you noticed it with prozac.
2. Yes, try a scoop or so, twice per day.
3. It usually does the opposite.

[nupi]

Alright, here we go. Let's see what happens (this might be slightly confounded by Prozac's famously long half life but I think I reached steady state by now, 2,5 weeks after the initial dose)

For completeness sake, my current stack is this:
Morning
1 AOR Multibasics 3 cap
1 NOW 2000 IU D3 softgel
1-2 1250mg Source Naturals Mg Malate tablets
~3g Jarrow Creatine
1 LEF Super K (1mg K1, 1mg MK4, 0.1mg MK7)
2 LEF Fish Oil soft gels
20mg Prozac
400mg NOW Green Tea extract (200mg Egcg among others)
6mg Dr Best Astaxanthin


Evening
1 AOR Multibasics 3 cap
1-2 1250mg Source Naturals Mg Malate tablets
~3g Jarrow Creatine
6mg Dr Best Astaxanthin
0.3mg Time Released LEF Melatonin

I am now adding to this (in the morning)
1 200IU NOW Mixed E softgel
300mg Superior Nutraceuticals UMP
250mg Jarrow CDP Choline

In the evening: another 300mg UMP

Plus liberal amounts of espresso (sometimes green tea) during the day. My diet is fairly clean (little processed food/sugar outside some dark chocolate) although perhaps a tad high in grains/starch (a month+ of eliminating Gluten did not change a thing so I do not think I am allergic to that, at least) and it could contain more veggies. I have eliminated bad fats as far as doable -when eating out it is not always possible to control but being in Europe, some of the nastiest offenders are not very common to start with (soybean, safflower, corn are virtually unheard of) so the main concern would be Canola and perhaps sunflower but there a shift towards high oleic seems to be underway, thankfully.

Edited by nupi, 03 December 2012 - 10:36 AM.

[Guardian4981]

If your DA is low, it pulls it up and vice-versa.

Also, it's possible you may have something extra going on with the nasal issue and puffiness - sounds like either an allergy or infection. Maybe the fish oil? Could try flaxseed oil instead?

I think you might be on the money with the B5, though. Keep us posted.

As an update to all and address your quote

The puffiness just above my cheeks has noticably diminished thankfully.

Also, I personally found I felt the best mentally the first day or two on uridine and also a day or two after the uridine. I have experienced this before with other compounds. My theory is that while one area is being boosted you feel great but perhaps something else is declining and once the ideal equilibrium shifts you no longer feel as good.

Has anyone discussed on here the possibility of stacking SAMe with uridine?

I ask this because in my experience SAMe seems to have the opposite effect of uridine. With SAMe I feel dopamine increases and I feel great the first few days but then I feel serotonin plummits. On uridine I feel my serotonin goes up but my dopamine plummits. Stacking them may be of value.

The way I understand it, SAMe helps provide neurotransmitters directly and uridine works more at the receptor level. Its possible the uridine was helping my dopamine receptors but I simply didn't have enough dopamine going around to benefit from it. SAMe could help in this instance, perhaps TMG as an adjunct.

I also meditate daily, some research suggests meditation boosts serotonin in the brain, this also could have influenced my results with uridine. Aeorbic excercise tends to enhance both dopamine and serotonin, perhaps more aerobic excercise next time around may be of value.

I am not sure I am interested in flax seed as a replacement for fish oil. The theory behind the nasal fish oil connection is that PUFAs tend to weaken the immune system, if one is prone to allergies and nasal issues even slight immune impairment can flare this up. When I am not using any fish oil and especially when on astragalus my nasals are well under control.

As for the Choline portion of this stack, even before this stack I periodically have symptoms of high choline such as headache in morning, abdominal cramps, even nasal issues can stem from high choline. These symptoms increased somewhat after uridine. Keep in mind I eat 8 whole eggs a day so this may play a role.

My new Thorn Multi has much more B5 and I have noticed some relief, Wednesday I will be starting extra B5 from a standalone product, I will see how this goes for a couple weeks at which point I may re introduce the uridine. Depending how the uridine goes I may also add SAMe to the mix. I have niacinimide on hand, I have read this can be used for serotonin syndrome so I am prepared in event that occurs.

As an aside, months ago I tried "Fo Ti" which I was interested in more for hair health and I had an awful bout of serotonin syndrome off of it, this trigged my naicinimide purchase in case that ever happens again!

1 LEF Super K (1mg K1, 1mg MK4, 0.1mg MK7)

As an aside in my opinion the LEF super K produce is too much K to be taken on a daily basis especialy if you eat any vegetables, I take it every 3-4 days. LEF touts themselves as the life extension gurus yet most of their products I think are way overdosed.

[nupi]

Based on what do you judge Super K to be overdosed? There are (prescription but nonetheless) medications on the market with up to 45mg MK4 daily doses so I don't think 1mg is going to kill you any time soon... Besides, vegetables only contain K1, no K2 (which seems to be vastly more important if the Weston Price foundation is at all to be believed)

[Guardian4981]

K thickens the blood, I am weary of this. IMO its better to keep the dose on the lower side.

[MrHappy]

Dopamine and motivation:
http://today.uconn.e...easure-anymore/

Salamone's research over the past 15 years has attempted to find an answer to that question. His work involves artificially raising or lowering dopamine levels in animals, then giving them a choice between two rewards with different value, which can be obtained through different amounts of work.

For example, what will a rat do when on one end of a corridor there's a pile of food, but on the other end there's a pile of food twice as big with a small fence to jump over on the way?

As Salamone's studies have showed, animals with lowered levels of dopamine almost always choose the easy, low-value reward, while animals with normal levels don't mind exerting the effort to jump the fence for the high-value reward.

Other studies in humans have corroborated these results, such as research with depressed patients.

"Often, depressed people say they don't want to go out with their friends," says Salamone. But it's not that they don't experience pleasure, he says; if their friends were around, many depressed people could have fun.

"Low levels of dopamine make people and other animals less likely to work for things, so it has more to do with motivation and cost/benefit analyses than pleasure itself," he explains.

Edit: fixed ascii format issue

Edited by MrHappy, 04 December 2012 - 08:30 PM.

[killshot]

The B vitamins are essential, make sure you are taking at least RDA.

Mr Happy,

Congrats on an AWESOME thread!

I'm intending to try out URIDINE, using 250mg UMP Sublingually.

RE: B vitamin Co-factors - I understand your logic regarding this, but do you think it would be sufficient to simply monitor one's Folate and B12 levels via blood tests so as to ascertain whether or not additional supplementation is in fact required?

My reason for asking is because I am recovering from Lyme Disease and have an un-natural sensitivity to supplemental B vitamins. I follow a ridiculously healthy diet and my recent labs showed heathly normal levels for all vitamins. I was therefore thinking of starting the Uridine WITHOUT taking any supplemental Folate and B12, and undergo regular blood tests to monitor my Folate and B12 levels. If they start to plumet I can then react accordingly by supplementing with Folate and B12 at an appropriate dosage that keeps them within the normal range...

What do you think?

Wondering the same thing, b and or multi vitamins feel super strong and unpleasant. 3 days on uridine, e, and fish oils and I'm feeling good. Thinking about dropping my low dose of Zoloft after 2 weeks if things continue to go well.

Sent from my HTC rezound using tapatalk

[MrHappy]

The B vitamins are essential, make sure you are taking at least RDA.

Mr Happy,

Congrats on an AWESOME thread!

I'm intending to try out URIDINE, using 250mg UMP Sublingually.

RE: B vitamin Co-factors - I understand your logic regarding this, but do you think it would be sufficient to simply monitor one's Folate and B12 levels via blood tests so as to ascertain whether or not additional supplementation is in fact required?

My reason for asking is because I am recovering from Lyme Disease and have an un-natural sensitivity to supplemental B vitamins. I follow a ridiculously healthy diet and my recent labs showed heathly normal levels for all vitamins. I was therefore thinking of starting the Uridine WITHOUT taking any supplemental Folate and B12, and undergo regular blood tests to monitor my Folate and B12 levels. If they start to plumet I can then react accordingly by supplementing with Folate and B12 at an appropriate dosage that keeps them within the normal range...

What do you think?

Wondering the same thing, b and or multi vitamins feel super strong and unpleasant. 3 days on uridine, e, and fish oils and I'm feeling good. Thinking about dropping my low dose of Zoloft after 2 weeks if things continue to go well.

Sent from my HTC rezound using tapatalk

Maybe see if you have no adverse reactions to l-methylfolate?

Also, unless you've had experience with it, tapering off zoloft rather than dropping it would be a good idea. I've seen what happens when people go cold turkey. It's not enjoyable..

[killshot]

The B vitamins are essential, make sure you are taking at least RDA.

Mr Happy,

Congrats on an AWESOME thread!

I'm intending to try out URIDINE, using 250mg UMP Sublingually.

RE: B vitamin Co-factors - I understand your logic regarding this, but do you think it would be sufficient to simply monitor one's Folate and B12 levels via blood tests so as to ascertain whether or not additional supplementation is in fact required?

My reason for asking is because I am recovering from Lyme Disease and have an un-natural sensitivity to supplemental B vitamins. I follow a ridiculously healthy diet and my recent labs showed heathly normal levels for all vitamins. I was therefore thinking of starting the Uridine WITHOUT taking any supplemental Folate and B12, and undergo regular blood tests to monitor my Folate and B12 levels. If they start to plumet I can then react accordingly by supplementing with Folate and B12 at an appropriate dosage that keeps them within the normal range...

What do you think?

Wondering the same thing, b and or multi vitamins feel super strong and unpleasant. 3 days on uridine, e, and fish oils and I'm feeling good. Thinking about dropping my low dose of Zoloft after 2 weeks if things continue to go well.

Sent from my HTC rezound using tapatalk

Maybe see if you have no adverse reactions to l-methylfolate?

Also, unless you've had experience with it, tapering off zoloft rather than dropping it would be a good idea. I've seen what happens when people go cold turkey. It's not enjoyable..

Thanks for reply Mr Happy

I read the link you posted about over or under methylation. I just don't understand it well enough. first I thought I'm over then as I read on I thought no under, by the end I had no idea.

So just to clarify if I have a bad reaction to l-methlfolate would that tell me I'm over?

And if that is the case can I take something to compensate and still take uridine

Im only taking 12mg zoloft can't go over 25 without terrible side effects (loose stool) with lexapro more than 5mg gives me a 24/7 headache. Tried a bunch of others including snri's could not take them in any amount. In the article about methylation SSRI sensitivity was mentioned but toward the end it got confusing some stuff seemed contradictory. Don't know what or if it points to me being over / under but i do know I'm sensitive to them.



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[synaptiq]

The last few days I've been getting a mild intoxicated feeling starting an hour or so after taking 300mg sublingual UMP. It seems to be independent of choline (I've tried between 0-1800mg bitartrate with no change), and I tried swapping out my Zyrtec for quercetin to no effect. Dropping down to 150mg today reduced it greatly but it's still there. I'm also taking fish oil at 1375mg EPA/550mg DHA, 2 pills a day of Source Naturals Life Force multiple, 4000 IU D3 (to 5000 total) and 1mg methylcobalamin (1.5mg total but I'm on a proton pump inhibitor so most of that doesn't absorb). Evening is 200mg magnesium citrate and 1mg melatonin.

I wouldn't be surprised if this is an interaction with something in my multi - there's a lot of crap in there and I'm probably switching to AOR Multi Basics + individual supplements after this bottle is done. Is this a common thing with uridine, though? I'm hesitant to drop it entirely since its been great otherwise. Perhaps I should just drop down further to oral dosing?

[nupi]

K thickens the blood, I am weary of this. IMO its better to keep the dose on the lower side.

And fish oil thins it...

Besides, high levels of K are not thought to further increase blood clotting significantly above baseline. K is also implicated in reducing calcification of arteries and strengthening bones and teeth. Easily worth the small risk on the blood thickness front.

[vali]

I have taken this for three weeks, and would like to report that it works as advertised. After several weeks of use, I was much more relaxed, and my mood was both stable and improved. That said, I also got the emotional dullness, which proved to be an issue, and after a bit my motivation dropped. My primary goal in taking Uridine was to increase my motivation by increasing dopamine, so it came as a surprise when the opposite seemed to happen. I'm going to take a couple days break, then try something else. Perhaps take uridine at night, and some sort of stimulant (like coffee) in the morning. Or maybe just halve my dose.

[MrHappy]

The last few days I've been getting a mild intoxicated feeling starting an hour or so after taking 300mg sublingual UMP. It seems to be independent of choline (I've tried between 0-1800mg bitartrate with no change), and I tried swapping out my Zyrtec for quercetin to no effect. Dropping down to 150mg today reduced it greatly but it's still there. I'm also taking fish oil at 1375mg EPA/550mg DHA, 2 pills a day of Source Naturals Life Force multiple, 4000 IU D3 (to 5000 total) and 1mg methylcobalamin (1.5mg total but I'm on a proton pump inhibitor so most of that doesn't absorb). Evening is 200mg magnesium citrate and 1mg melatonin.

I wouldn't be surprised if this is an interaction with something in my multi - there's a lot of crap in there and I'm probably switching to AOR Multi Basics + individual supplements after this bottle is done. Is this a common thing with uridine, though? I'm hesitant to drop it entirely since its been great otherwise. Perhaps I should just drop down further to oral dosing?

I've never had intoxicating effects from uridine at any dose level.

Could be something in the mix. I'd simplify and try to identify the culprit.

I have taken this for three weeks, and would like to report that it works as advertised. After several weeks of use, I was much more relaxed, and my mood was both stable and improved. That said, I also got the emotional dullness, which proved to be an issue, and after a bit my motivation dropped. My primary goal in taking Uridine was to increase my motivation by increasing dopamine, so it came as a surprise when the opposite seemed to happen. I'm going to take a couple days break, then try something else. Perhaps take uridine at night, and some sort of stimulant (like coffee) in the morning. Or maybe just halve my dose.

Just take less. How much / often are you dosing?

[Guardian4981]

I have taken this for three weeks, and would like to report that it works as advertised. After several weeks of use, I was much more relaxed, and my mood was both stable and improved. That said, I also got the emotional dullness, which proved to be an issue, and after a bit my motivation dropped. My primary goal in taking Uridine was to increase my motivation by increasing dopamine, so it came as a surprise when the opposite seemed to happen. I'm going to take a couple days break, then try something else. Perhaps take uridine at night, and some sort of stimulant (like coffee) in the morning. Or maybe just halve my dose.

I had the same issue even with minimual dose of 25mg TAU and I also am taking a few weeks off.

As I stated in a prior post, stacking Uridine with SAMe may be one possibility to try. While experiences differ by the individual, overall user feedback seems to indicate SAMe favors dopamine.

[Guardian4981]

The last few days I've been getting a mild intoxicated feeling starting an hour or so after taking 300mg sublingual UMP. It seems to be independent of choline (I've tried between 0-1800mg bitartrate with no change), and I tried swapping out my Zyrtec for quercetin to no effect. Dropping down to 150mg today reduced it greatly but it's still there. I'm also taking fish oil at 1375mg EPA/550mg DHA, 2 pills a day of Source Naturals Life Force multiple, 4000 IU D3 (to 5000 total) and 1mg methylcobalamin (1.5mg total but I'm on a proton pump inhibitor so most of that doesn't absorb). Evening is 200mg magnesium citrate and 1mg melatonin.

I wouldn't be surprised if this is an interaction with something in my multi - there's a lot of crap in there and I'm probably switching to AOR Multi Basics + individual supplements after this bottle is done. Is this a common thing with uridine, though? I'm hesitant to drop it entirely since its been great otherwise. Perhaps I should just drop down further to oral dosing?

Try dropping the fish oil for a few days, when I used fish oil I also experienced somewhat of an intoxicating feeling, I still did without the fish oil but not as severe.

Serotonin may constrict blood vessels, this may influence various processes especially if there is also not a corresponding rise in dopamine.

[FunkOdyssey]

Reading through the read it appears some people experiences loss of libido on uridine. If uridine boosts dopamine shouldn't it raise libido?

Fish oil is a notorious libido-killer (depending on the individual and dosage) so I'd suggest anyone who thinks uridine is negatively affecting their libido to rule out fish oil first. I suspect many people are starting fish oil for the first time, or starting larger amounts than they've used before, alongside uridine and then blaming uridine for negative reactions.

[killshot]

http://jdmoyer.com/2...ts-complicated/

More on methylation for anybody like me needing more info.

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[synaptiq]

The last few days I've been getting a mild intoxicated feeling starting an hour or so after taking 300mg sublingual UMP. It seems to be independent of choline (I've tried between 0-1800mg bitartrate with no change), and I tried swapping out my Zyrtec for quercetin to no effect. Dropping down to 150mg today reduced it greatly but it's still there. I'm also taking fish oil at 1375mg EPA/550mg DHA, 2 pills a day of Source Naturals Life Force multiple, 4000 IU D3 (to 5000 total) and 1mg methylcobalamin (1.5mg total but I'm on a proton pump inhibitor so most of that doesn't absorb). Evening is 200mg magnesium citrate and 1mg melatonin.

I wouldn't be surprised if this is an interaction with something in my multi - there's a lot of crap in there and I'm probably switching to AOR Multi Basics + individual supplements after this bottle is done. Is this a common thing with uridine, though? I'm hesitant to drop it entirely since its been great otherwise. Perhaps I should just drop down further to oral dosing?

Try dropping the fish oil for a few days, when I used fish oil I also experienced somewhat of an intoxicating feeling, I still did without the fish oil but not as severe.

Serotonin may constrict blood vessels, this may influence various processes especially if there is also not a corresponding rise in dopamine.

I spread out my stack today to see if I could correlate the buzz with any specific supplement, and the fish oil is looking like a probable culprit here. For now, I'll halve the dose and move it to the bedtime stack. I think I'll try something with a higher DHA to EPA ratio or maybe krill oil and see if that makes a difference. I was liking this high-EPA stuff pre-uridine (and I hadn't changed much else) but it seems like the uridine makes me a lot more sensitive to it.

[Guardian4981]

More and more I believe fish oil is not worth supplementing, PUFAs are pro oxidative and can hamper the immune system.

I think most use fish oil for inflammation, but the inflammation could be reduced through diet changes rather then using fish oil.

[Mr_G]

Fairly new to this site, mostly been lurking. I have ADHD-i and am prone to depression because it went untreated for so long (I'm 24 now, just figured this out).

I am currently on Wellbutrin XL 150mg daily, and I occasionally use 10mg of Ritalin when I really need the boost.

I don't smoke, I never drink, and I exercise (weight-lift) 4 days a week vigorously. The rest of my time is dedicated to my career.
I also take:
100% mineral & multivitamin supplement daily
Siberian Ginseng (500mg daily)
Ginkgo 120mg every other day

I've ordered UMP from superior-nutraceuticals and have been taking 250mg twice daily for the last 6 days (along with fish oil which I've always taken), the only thing I've noticed is a stiff-neck and a feeling of a lump in my throat.
I'm concerned I'm having some kind of bad reaction to it, but I want to keep going for at least 2 weeks. I don't have any Alpha-GPC but I do have ALCAR, I haven't noticed any headaches (I've never been very prone to headaches) so I haven't supplemented with ALCAR except on the third day (still had the same feeling of a stiff neck/lump in my throat).

Has anyone else experienced this, or have any suggestions?

[MrHappy]

Fairly new to this site, mostly been lurking. I have ADHD-i and am prone to depression because it went untreated for so long (I'm 24 now, just figured this out).

I am currently on Wellbutrin XL 150mg daily, and I occasionally use 10mg of Ritalin when I really need the boost.

I don't smoke, I never drink, and I exercise (weight-lift) 4 days a week vigorously. The rest of my time is dedicated to my career.
I also take:
100% mineral & multivitamin supplement daily
Siberian Ginseng (500mg daily)
Ginkgo 120mg every other day

I've ordered UMP from superior-nutraceuticals and have been taking 250mg twice daily for the last 6 days (along with fish oil which I've always taken), the only thing I've noticed is a stiff-neck and a feeling of a lump in my throat.
I'm concerned I'm having some kind of bad reaction to it, but I want to keep going for at least 2 weeks. I don't have any Alpha-GPC but I do have ALCAR, I haven't noticed any headaches (I've never been very prone to headaches) so I haven't supplemented with ALCAR except on the third day (still had the same feeling of a stiff neck/lump in my throat).

Has anyone else experienced this, or have any suggestions?

Unfortunately, sounds like you may have caught some kind of 'flu. I can't see uridine causing that one.

Edited by MrHappy, 08 December 2012 - 11:32 PM.

[FunkOdyssey]

I've ordered UMP from superior-nutraceuticals and have been taking 250mg twice daily for the last 6 days (along with fish oil which I've always taken), the only thing I've noticed is a stiff-neck and a feeling of a lump in my throat.

.. have any suggestions?

Yes, stop taking UMP and see if the stiff neck and lump-in-throat disappear. If they do, try UMP again and see if the symptoms reappear. Report back with your results.

[synaptiq]

When I was on Wellbutrin (and for about a year after I discontinued it), I'd get that "lump in the throat" feeling whenever I had too much caffeine. I'd agree that you should stop the uridine for a bit, but when you add it back in, be very careful with caffeine consumption since the uridine will increase your sensitivity to it.

[killshot]

Day 6 after work took uridine 300 mg sub, GPC 250mg no fish oil. I found I can take a flinstone vitamin with no adverse reaction. Still can't handle adult multivitamin. (could it be the copper?) I ordered the l-methylfolate should be here next Thursday. Will be interesting to find out how my body reacts.

Edit...

Oh yea I feel pretty f'n good atm

Sent from my HTC rezound running Cyanogen mod using tapatalk :P

Edited by killshot, 09 December 2012 - 04:54 AM.

[nupi]

5th day of twice daily 300mg UMP (for now without the CDP Choline, I am a little worried that might be counter productive considering my underlying depression/anxiety). So far no real differences observed but I had a week of vacation so mental exercise was kind of subdued

[VII]

Hi everyone!

I originally planned to start a log somewhere around here, where I'd introduce myself, but never got around to it. To sum it up I'm a 29 year old introverted programmer. Quite happy, somewhat demotivated, bad short-term memory, slow thinker. A bit confused.

I decided to try out the "uridine stack" a couple of weeks ago hoping it could act as a foundation in my attempt better my memory and help me translate thoughts to words quicker. So I ordered UMP, cdp-choline, alcar, a b-50-complex and fish oil. I all ready had a supply of other vitamins and minerals.

When the stuff first arrived, a week ago, I basically tried it all at once to see where that would get me, which ended up being one hell of a headache. I stayed of it for the week to reset, during which I started to cut down heavily on coffee and tobacco. During the week I read a lot about methylation, but it didn't get me anywhere. I tried the niacin flush test at 50mg and 100mg that, supposedly, could give you an indication of methylation problems, but I reacted normally. That is, I flushed at 100mg, but not at 50mg. Don't know how much that test is worth, but anyway..

Then, two days ago(friday), it was time to give it another go. This time a bit more methodically, as originally planned(emphasis on 'a bit'). The plan was to take one supplement every 1-2 hours to try to pin-point down what worked and what didn't.

Again I ended up with a really bad headache, still lasting today (sunday).

I'd so much appreciate any help in troubleshooting this. I find it hard, and even harder with this headache of mine. Any advice on what to try next, and what not to try next, would help me a lot.

I'll paste my log below, first I just want to declare what's in the supplements, so that the log wont be cluttered:

Spoiler

B-50:
Thiamine mononitrate (b1) 50mg
Riboflavin (b2) 50mg
Niacinamide (b3) 50mg
Calcium d-pantothenate (b5) 50mg
Pyridoxine hydrochloride (b6) 50mg
Biotin (b7) 50ug
Folic acid (b9) 400ug
Methylcobalamin (b12) 50ug
Choline bitartrate 50mg,
Inositol 50mg,
PABA 50mg

Calmag:
Calcium carbonate 1000mg
Magnesium oxide & citrate 500mg

Fish oil (5ml):
DHA 600mg
EPA 400mg

This is my log so far:

Spoiler

Friday 2012-12-07

08:00 - One cup of coffee with milk

10:00 - One cup of red tea.

13:00 - Lunch. A small-medium sized portion of chinese food with extra wooked vegetables. Got a short burst of anxiety attack lasting for only a few seconds right after finishing. A had a big anxiety attack after eating a large portion of chinese food some weeks ago. I wonder what this might be.

19:00 - Two enchiladas, a soda and 4 big big cookies. It's friday after all.

20:00 - 1 B-50, Ascorbic acid 1000mg, zinc citrate 50mg, 5ml fish oil.

22:00 - I have a high blood pressure headache with ear ringing. I don't know if this is caffeine withdrawal, the fast carbs, the suplements or a combination.


Saturday 2012-12-08

09:00 - Woke up, the headache was gone, still feeling dull though. A small cup of coffee, that woke me up.

10:00 - 5ml Fish oil

10:45 - Something is wrong with my cognition. When I, an hour ago, started to grade my well-being from 1 to 5 I thought 2.5 was neutral, just realized 3 is neutral.

10:55 - Something is wrong with my working memory. I was choosing between taking zinc or vit C but after taking one of the two I couldn't remember which one I took. I'm still not sure, but I think I went for the zinc. I'm in a good mood though. Zinc citrate 50mg.

11:15 - Got a very vague headache. My head feels a bit heavier and thicker.

11: 20 - For a moment I was afraid the headache from yesterday would return, but now it's calmed down. Head still feel a bit heavy though. I wish I had the equipment, and knowledge, to measure blood pressure. My pulse is at 71, I've never had this low pulse in at least 10 years. Very odd, I usually have a problem with a too high pulse, around 90-120.

11:35 - I think I do have a headache, but so vague I can barely notice it. I've started to feel a very vague dizzyness/drunkness.

11:55 - Ascorbic acid 1000mg.

12:05 - The headache seems to be gone, replaced by some weird tension in my head and neck. It's not painful I feel somewhat more focused. When turning my head I get a vague motion blur. If this change is because if the vit C it sure has absorbed fast. Quite unlikely. Worth noting is this vit C contained an unknown amount of rose hip, I guess that's the origin.

12:25 - I feel really well. All tensions are gone and so is the dizziness. I'm feeling some sort of "focus tension" in my forehead, which intuitively feels like a good thing.

12:30 - Low GI lunch. Before getting to the b-complex and uridine phase, I want some antioxidants.

13:55 - 300mg Trans-resveratrol sublingual and 1 dl blueberries.

14:10 - I think I feel a bit more focused. Hard to tell when it's this vague. It could be anything, fro the supplements, to the lunch to the time of day.

14:55 - 1st B-50. I feel in good shape, nothing special, but better than when I woke up.

16:25 - I haven't gotten any bad effects from the B's so I'll go ahead with 200mg UMP sublingual.

16:50 - I experience some sort of rush. It reminds me of the rush in a anxiety attack in a social setting, but without the fear/shame. Maybe the element of fear/shame isn't there because I'm alone. Who knows. This only lasted for 5-10 minutes. During the rush I played around with having my eyes wide open, I don't know why but it felt quite natural..or fitting.

17:05 - 5ml fish oil

18:55 - My head feels heavy and I have a tension in my forehead. It feels like I'm frowning. Hard to tell if this is because of the uridine, the fact that the caffeine has passed it's halving time many hours ago or the fact that I've been sitting in front of the lap top since I woke up(nothing new there though). Either way, it wont get better on it's own. 150mg CDP-choline.

21:55 - The tension in my forehead is gone by now my temples are aching really bad. Let's see what 1g of alcar will do.

22:55 - I haven't logged much the last 5 hours, I have a headache and very low motivation. And I'm somewhat in a bad mood, might be because of this damn headache. I don't feel brain fogged except for the headache induced fog which is more of an unwillingness to think because of pain rather than an inability. Also, worth mentioning, I don't feel itchy and don't have muscle pains or anything like that. Not that I normally do. But anyway. 1 calmag. That's enough of experimenting for today. Time for bed.

Sunday 2012-12-08

09:25 - Woke and the headache started within 5 minutes. It seems to be located at the back of the head, stretching to the temples. I quite easily remembered my last dream though. This has been very rare the last years. In case the headache is caused by a lack of uridine co-factors: 5ml fish oil, 1st B-50 and Ascorbic acid 1000mg.

10:30 - Still having a bad headache. I feel a bit more awake and in a better mood though than yesterday evening and an hour ago. I want to see how I'll react to 100mg niacin. I flushed.

10:45 - Still headache, time to see if it's related to a lack of caffeine. One small cup of coffee.

11:10 - Low GI lunch.

12:30 - Bad bad headache. I don't want to get rid of the headache with a painkiller, that would ruin my experimentation. But I can't stand it anymore. 1g acetylsalicylic acid.

13:30 - Still a bad bad headache.

Best Regards!

[Introspecta]

Sounds like too much much CDP Choline. Lower your dose. Even if you have to lower it down to 50mgs. I really can't take the effects of AGPC or CDP Choline so if I were to dose it, it would have to be very low. If you have capsules pull them apart and take half or 1/4 the powder. Did you get anxious and somewhat irritable also?

[VII]

Hi Joelski, the headache always started before I took the cdp-choline. I know some of the uridine get converted to cdp-choline, so the extra supplementation could had made it worse. Hard to tell.

Nope, neither anxious or irritable. Quite the opposite. Calm and happy enough, but with a pounding headache. It's hard to assess the cognitive functioning when it's pounding. Might have been brilliant, might had been retarded for all I know.

What I'm leaning towards is of course, no more cdp-choline and a lower dose of uridine. What my uneducated brain is afriad of is, in case uridine is bad for me then a lower dose might damage me in the long run, but I wouldn't notice it until later.

Also, seeing as the full on headache started after the uridine on saturday, it doesnt explain the headache on friday when I basically used the same sups, but without uridine/choline/alcar.

I read somewhere that introverts primarily uses acetycholine-pathways while extroverts primarily uses dopamine-pathways. Being a heavily introverted programmer, I guess that could mean more choline is too much choline for me. If that's the case, then where is the good short-term memory that should follow..

Edit: I want to add that last friday(I don't remember exactly what happened last weekend) I tried 800mg piracetam, and then 1600mg on saturday. On monday I had something similar to what I would experience as a youngster the days after having used mdma. I was cold and sweating, but instead of cycling between good and bad mood I was cycling in and out of focus.

Edited by VII, 09 December 2012 - 04:08 PM.