2844 replies to this topic

[Introspecta]

I don't believe short term memory is chemical related. You may have balanced neurotransmitters but only capable of whatever memory you have until you try to improve it through practice. Working on your memory using action which science has proved can change the brain in itself. The brain changes through our thoughts and education so I think the best way to improve it is by practicing memorization of numbers or words which may expand your limits for memory. This is just my theory because very rarely do you find anyone truly I mean truly improving their memory by supplements. If anything the supplements just allow them to pay attention with more focus allowing them to remember more.

[VII]

Just an update to my current state. I tried 5000 IU vit E, didn't help. Waited an hour or two. Ate a third of a raw garlic, and now 2 hours later the headache is almost gone. I can finally move around. I have to move slowly or it feels like it will come back. Dunno if its from the time passing by, or if the garlic had anything to do with it. :D

Gonna eat some more garlics...

[stablemind]

I don't believe short term memory is chemical related. You may have balanced neurotransmitters but only capable of whatever memory you have until you try to improve it through practice. Working on your memory using action which science has proved can change the brain in itself. The brain changes through our thoughts and education so I think the best way to improve it is by practicing memorization of numbers or words which may expand your limits for memory. This is just my theory because very rarely do you find anyone truly I mean truly improving their memory by supplements. If anything the supplements just allow them to pay attention with more focus allowing them to remember more.

I'm studying Chinese which requires a lot of memorization and I've found I have a time requirement for each word my brain registers, and no matter how much I practice (and I practice every day), the time it takes to remember each word is rather consistent. The only way I've been able to significantly improve word memory is through the use of imagination and mnemonics. Uridine has actually altered my retention and recall ability without doubt but I'm one of the few that's very sensitive to chemicals. I'm sure there are chemicals out there that can drastically enhance memory, but for the time being, I'd say using mnemonics is the best solution.

On a side note, I've noticed that cycling Uridine works best for me. After using it consistently for a while I noticed that the effects plateau and I don't get further benefits, and that this effect is maintained even after discontinuation. I find that this works very well with ALCAR out of the cholinergic substances I've taken including CDP-Choline and Alpha GPC.

[Guardian4981]

My D and OCD was returning after quiting uridine temporarily. So last Thursday I began my new stack.

Right now I am taking Uridine 25 mg, 500 mg TMG, and SAM-e Jarrow 200mg every other day to start. So far the results have been well, my libido is actually going up rather then down.

I took some vacation days and have a 4 day weekend. The real test is when I get back to work tomorrow, that is when my D tends to rise from the stress.

Its still early, but I think I am onto something with the SAM-e and Uridine combo.

Edited by Guardian4981, 10 December 2012 - 05:12 PM.

[VII]

I'm wondering if my increased blood pressure was because of tightened blood vessels(maybe as a result of also using huge amounts of tobacco) or volume expansion of the blood. Or both.

When I woke up today(monday) the headache was gone(except for some throbbing at my left temple that went away later) and I felt great. I had such a good day. Good mood, a lot of focus, I could easily express myself(at least in technical talk), the words were just flowing, I wasn't suffering any semi-panic attacks and eye contact didn't bother me. What a wonderful day!

So, I really want to see where this stack will take me, but I'm really frightened by the headaches/migraines.

[nupi]

Is there any known downside to taking the second dose of Uridine before bed? (So far, it does not seem to be disrupting sleep but with a DA related compound, who knows)

[MrHappy]

Is there any known downside to taking the second dose of Uridine before bed? (So far, it does not seem to be disrupting sleep but with a DA related compound, who knows)

It's been fine for me and a number of others here.

Some of the literature talks about uridine triggering/resetting circadian rhythms.. Link should be on post 1, if you get keen.

Its still early, but I think I am onto something with the SAM-e and Uridine combo.

Could be interesting, keep us posted.

[chrisp2]

I just ordered UMP from Superior, looking forward to trying it out SL.

[killshot]

The B vitamins are essential, make sure you are taking at least RDA.

Mr Happy,

Congrats on an AWESOME thread!

I'm intending to try out URIDINE, using 250mg UMP Sublingually.

RE: B vitamin Co-factors - I understand your logic regarding this, but do you think it would be sufficient to simply monitor one's Folate and B12 levels via blood tests so as to ascertain whether or not additional supplementation is in fact required?

My reason for asking is because I am recovering from Lyme Disease and have an un-natural sensitivity to supplemental B vitamins. I follow a ridiculously healthy diet and my recent labs showed heathly normal levels for all vitamins. I was therefore thinking of starting the Uridine WITHOUT taking any supplemental Folate and B12, and undergo regular blood tests to monitor my Folate and B12 levels. If they start to plumet I can then react accordingly by supplementing with Folate and B12 at an appropriate dosage that keeps them within the normal range...

What do you think?

Wondering the same thing, b and or multi vitamins feel super strong and unpleasant. 3 days on uridine, e, and fish oils and I'm feeling good. Thinking about dropping my low dose of Zoloft after 2 weeks if things continue to go well.

Sent from my HTC rezound using tapatalk

Maybe see if you have no adverse reactions to l-methylfolate?

Also, unless you've had experience with it, tapering off zoloft rather than dropping it would be a good idea. I've seen what happens when people go cold turkey. It's not enjoyable..

Hi i got my l-methylfolate, I have been taking it and nothing else for a few days with no adverse reactions and a surge of clean energy. I'm going to start back up on my Uridine stack but I don't know what to do about other vitamins. More specifically do I need to take a b12 to prevent a unbalanced condition? And should it be methylated also?

Sent from my HTC rezound running Cyanogen Mod using tapatalk :P

[MrHappy]

The B vitamins are essential, make sure you are taking at least RDA.

Mr Happy,

Congrats on an AWESOME thread!

I'm intending to try out URIDINE, using 250mg UMP Sublingually.

RE: B vitamin Co-factors - I understand your logic regarding this, but do you think it would be sufficient to simply monitor one's Folate and B12 levels via blood tests so as to ascertain whether or not additional supplementation is in fact required?

My reason for asking is because I am recovering from Lyme Disease and have an un-natural sensitivity to supplemental B vitamins. I follow a ridiculously healthy diet and my recent labs showed heathly normal levels for all vitamins. I was therefore thinking of starting the Uridine WITHOUT taking any supplemental Folate and B12, and undergo regular blood tests to monitor my Folate and B12 levels. If they start to plumet I can then react accordingly by supplementing with Folate and B12 at an appropriate dosage that keeps them within the normal range...

What do you think?

Wondering the same thing, b and or multi vitamins feel super strong and unpleasant. 3 days on uridine, e, and fish oils and I'm feeling good. Thinking about dropping my low dose of Zoloft after 2 weeks if things continue to go well.

Sent from my HTC rezound using tapatalk

Maybe see if you have no adverse reactions to l-methylfolate?

Also, unless you've had experience with it, tapering off zoloft rather than dropping it would be a good idea. I've seen what happens when people go cold turkey. It's not enjoyable..

Hi i got my l-methylfolate, I have been taking it and nothing else for a few days with no adverse reactions and a surge of clean energy. I'm going to start back up on my Uridine stack but I don't know what to do about other vitamins. More specifically do I need to take a b12 to prevent a unbalanced condition? And should it be methylated also?

Sent from my HTC rezound running Cyanogen Mod using tapatalk :P

What's in your flintstone's vitamin? Compare that to your other multi, for reference. Might be interesting to look at the types/forms of vitamin in each brand, too.

For now, I'd start up again slowly - just add uridine to the l-mthf for a week and see if that is OK. If so, try to find your optimal dose... then slowly bring in the other components.

Edited by MrHappy, 14 December 2012 - 07:47 PM.

[chrisp2]

Recommendations for people just starting out with uridine supplementation
For the first 2 weeks:
150-250mg UMP, orally, twice per day
A *good* multi vitamin, that includes RDA of B-group Vitamins and a broad range of trace minerals, including magnesium
500IU of mixed vitamin E
A large dose of fish oil with >700mg DHA + >300mg EPA (or 3000mg ALA / flaxseed oil, if you are vegetarian)

...

Sublingual or Oral?:
Sublingual doses are predicted to be around 7x-10x the equivalent oral dose. If you are troubleshooting brainfog, you may benefit from these higher doses. People primarily looking for a mood lift would be advised to start with an oral dose first and make adjustments from there.

I tried oral TAU and didn't see a huge benefit, so just got some UMP from SN.

Above you mention 250mg UMP orally - does that mean a much smaller dose SL?

What might be an appropriate SL starting dose?

[nupi]

Kicked the UMP again - after a week I found little to no true benefits and it seemed to actually lower libido slightly vs. just straight up Prozac (especially when combining it with Caffeine which I otherwise do not actually feel). Might try again when iHerb finally delivers my TAU.

In fairness, I had more EPA than DHA in my regime but I definitely hit 700mg DHA.

Edited by nupi, 16 December 2012 - 10:26 AM.

[Hope47]

I take 1gm dha(no epa).

[nupi]

I take 1gm dha(no epa).

I just checked, my 4 LEF pills amount to 1400mg EPA, 1000mg DHA. There is some evidence that EPA can help depression (not that I truly experienced that myself) so I would prefer to keep it...

[MrHappy]

Recommendations for people just starting out with uridine supplementation
For the first 2 weeks:
150-250mg UMP, orally, twice per day
A *good* multi vitamin, that includes RDA of B-group Vitamins and a broad range of trace minerals, including magnesium
500IU of mixed vitamin E
A large dose of fish oil with >700mg DHA + >300mg EPA (or 3000mg ALA / flaxseed oil, if you are vegetarian)

...

Sublingual or Oral?:
Sublingual doses are predicted to be around 7x-10x the equivalent oral dose. If you are troubleshooting brainfog, you may benefit from these higher doses. People primarily looking for a mood lift would be advised to start with an oral dose first and make adjustments from there.

I tried oral TAU and didn't see a huge benefit, so just got some UMP from SN.

Above you mention 250mg UMP orally - does that mean a much smaller dose SL?

What might be an appropriate SL starting dose?

SL is harder to measure doses without scales, but divide by eg. 6.

Kicked the UMP again - after a week I found little to no true benefits and it seemed to actually lower libido slightly vs. just straight up Prozac (especially when combining it with Caffeine which I otherwise do not actually feel). Might try again when iHerb finally delivers my TAU.

In fairness, I had more EPA than DHA in my regime but I definitely hit 700mg DHA.

What's your dose level of UMP? Also, what else are you taking, overall?

[nupi]

250-300mg SL in the morning and 250-300mg SL in the evening.

1 AOR Multibasics 3 cap
1 NOW 2000 IU D3 softgel
1-2 1250mg Source Naturals Mg Malate tablets
~3g Jarrow Creatine
1 LEF Super K (1mg K1, 1mg MK4, 0.1mg MK7)
2 LEF Fish Oil soft gels
20mg Prozac
400mg NOW Green Tea extract (200mg Egcg among others)
3mg Dr Best Astaxanthin
1 200IU NOW Mixed E softgel


Evening
1 AOR Multibasics 3 cap
1-2 1250mg Source Naturals Mg Malate tablets
~3g Jarrow Creatine
3mg Dr Best Astaxanthin
0.3mg Time Released LEF Melatonin
2 LEF Fish Oil Softgels

Edited by nupi, 17 December 2012 - 06:31 AM.

[MrHappy]

250-300mg SL in the morning and 250-300mg SL in the evening.

1 AOR Multibasics 3 cap
1 NOW 2000 IU D3 softgel
1-2 1250mg Source Naturals Mg Malate tablets
~3g Jarrow Creatine
1 LEF Super K (1mg K1, 1mg MK4, 0.1mg MK7)
2 LEF Fish Oil soft gels
20mg Prozac
400mg NOW Green Tea extract (200mg Egcg among others)
3mg Dr Best Astaxanthin
1 200IU NOW Mixed E softgel


Evening
1 AOR Multibasics 3 cap
1-2 1250mg Source Naturals Mg Malate tablets
~3g Jarrow Creatine
3mg Dr Best Astaxanthin
0.3mg Time Released LEF Melatonin
2 LEF Fish Oil Softgels

Hmm.. How much caffeine are you consuming, overall?

Also, have you tried UMP at a lower, oral dose?

What are you feeling?

[nupi]

Say 6 espresso shots per day (which on Prozac actually do something, before they did not much of anything)?

Feeling? Not much from UMP I would argue, it may have some short term activating effect but other than that I find it hard to pinpoint anything. As for oral dosing, I generally swallowed whatever was left after 2minutes of having it below my tongue...

[chrisp2]

What might be an appropriate SL starting dose?

SL is harder to measure doses without scales, but divide by eg. 6.

Well I had seen others trying 250mg SL, and the "spoon" that comes with it is 250mg.

So that's what I have dosed the last two times.

I have not noticed an extreme mood increase or anything.

Maybe I'll stay at that dose for a while and see what, if any, negative reactions I have.

Joe

[Hope47]

I think the effects would be more noticable if you are in your 40s-50s or more.I am 25 and have not noticed any effects like mentioned here.Still,i am going to take it because it induce neurogeneis.

[Guardian4981]

Does anyone know how uridine may influence histamine levels?

[Adaptogen]

so what should I buy? and is choline citrate not good enough?

[Raza]

Choline citrate is just as good for this as it is for replenishing acetylcholine. CDP is a step up from it, though.

[MrHappy]

Say 6 espresso shots per day (which on Prozac actually do something, before they did not much of anything)?

Feeling? Not much from UMP I would argue, it may have some short term activating effect but other than that I find it hard to pinpoint anything. As for oral dosing, I generally swallowed whatever was left after 2minutes of having it below my tongue...

Well, the 2 things I would be suggesting are -
The caffeine will be competing with uridine, as they occupy the same receptors. I'd taper off the caffeine.

Try swapping to 150mg of UMP, orally.

What might be an appropriate SL starting dose?

SL is harder to measure doses without scales, but divide by eg. 6.

Well I had seen others trying 250mg SL, and the "spoon" that comes with it is 250mg.

So that's what I have dosed the last two times.

I have not noticed an extreme mood increase or anything.

Maybe I'll stay at that dose for a while and see what, if any, negative reactions I have.

Joe

Try lowering the dose - a lot. I would normally start at 250mg, orally for a week or so.

[nupi]

I might try the no caffeine thing over christmas (if only decaf did not taste as nasty). Funnily enough, ever since I went on Prozac, I can feel caffeine and it gets me high in a weird sort of way... Before that, it just gave me headaches when I had way too much (like 12 espressos or something)

But how would LESS UMP help?

Edited by nupi, 18 December 2012 - 07:54 PM.

[Adaptogen]

reading the majority of this topic took so long..anyways... could someone direct me towards a well balanced (cheap) b vitamin?

also, is the gpc being recommended for it's growth hormone stimulating properties? If so, at what dose(if any) of choline citrate could i achieve similar results?

and in regards to fish oil, how important is the dha/epa ratio? my current fish oil is 650epa /450 dha per teaspoon and i drink maybe 3 teaspoons a day

Thanks

Edited by Adaptogen, 19 December 2012 - 08:13 AM.

[MrHappy]

I might try the no caffeine thing over christmas (if only decaf did not taste as nasty). Funnily enough, ever since I went on Prozac, I can feel caffeine and it gets me high in a weird sort of way... Before that, it just gave me headaches when I had way too much (like 12 espressos or something)

But how would LESS UMP help?

Larger doses of uridine can be great for getting on with life/work/study, but go too high and you can also over-modulate dopamine levels, making you temporarily slightly emotionally dull..

250mg sublingual is a big dose. Twice a day is a very big, accumulating, dose.. for most people. Some people treating brain fog may see bigger gains at this dose level.

For depression, anxiety, OCD, etc., I'd normally start at 250mg, orally, twice a day for 2 weeks and adjust from there. Finding your optimal dose makes a big difference to effectiveness.

BTW, have a flick through post 1.. I've been updating it with the key points/papers from throughout the thread.

[cap3]

I'm going to have to admit defeat with the uridine.
After trying various dosages from just 50mg sub to 350mg orally it just makes me feel emotionally flat and irritable.

It's frustrating as I had high hopes for it considering 2grams of tyrosine gives me such good results. And with my social anxiety I am sure my problems are dopamine related.

May have to look at meds instead now.

[nupi]

Too much uridine and you'll likely feel emotionally dull / overly focused.

That's my usual state (on a good day, on a bad day the slightest disruption sends me spinning and I get little if anything done) but does not actually bother me much. When it does not delve into worrying about irrational stuff, it's actually a highly productive state to be in... And emotionally dull beats depressed, by a long shot. I rarely get into enthusiasm or euphoria either way, so I don't really miss them.

[Guardian4981]

I'm going to have to admit defeat with the uridine.
After trying various dosages from just 50mg sub to 350mg orally it just makes me feel emotionally flat and irritable.

It's frustrating as I had high hopes for it considering 2grams of tyrosine gives me such good results. And with my social anxiety I am sure my problems are dopamine related.

May have to look at meds instead now.

Social anxiety can be tricky, sometimes its dopamine, sometimes its serotonin, sometimes its both.

My personal opinion is most peoples dopamine issues are more likely to be chemical and serotonin issues more likely to be psychological. As we get older the pleasure seeking naturally reduces because we have less variety in our life and have done things repeatedly, this is likely to lower dopamine levels. Serotonin for many probably goes down due to poor self esteem and higher stress levels. Lifestyle changes I think helps serotonin where dopamine needs a chemical boost. Reason I say this is even if you do pleasurable activities like sex, without enough dopamine the activity will seem dull. On the other hand I do think stress reduction and close relationships help serotonin even if no chemical aid is introduced.

That said yet again I found uridine seemed to dampen my dopamine a bit too much, so I dropped it for the time being.

I am currently using SAMe, I notice a marked improvement when I introduce TMG even though I am taking a very high quality multi with all the Bs. This would indicate to me perhaps the b12/folate pathway in me is weak and hence the alternative pathway using TMG yields better results.

I may introduce the uridine again after I have been on the SAMe for a few weeks.