2844 replies to this topic

[MrHappy]

just found this thread after reading this other thread... http://www.longecity...ns/page__st__90

Lots of information to go through, what is the general consensus on what to take, and the sources to get them, now that the conversation has gone on 2 years?

does it depend more on other variables?

currently 25 year old male, looking for overall increased potential, but also withdrawal from about 10 years of heavy cannabis usage (i think it messed with my dopamine/serotinin levels/production) i get really bad anxiety to the point of being almost frozen in certain work/sales situations that i am not used to.

currently taking:
multivitamin (simply one triple strength)
krill oil (one cap, morning)
bacopa (one capsule, morning) [for memory? seems to help with alcohol and cannabis related memory/cognitive impairment and damage]
vinpocetin (10MG, morning) [felt it first few times, few weeks in now, not sure, but seems to help overall cerebral circulation and as a result memory]
Ashwagandha Root, Holy Basil Supercritical Extract,Rhodiola, Schisandra, Wild Oats (gaia herbs adrenal support) [found this in the store while searching for something to calm my nerves and help me respond better in stressful situations, not sure of exact impact/feeling from this]
red ginseng extract
lecithin
hemp protein
green powder

considering taking :
uridine
alpha gpc/alcar (are these interchangeable, i still dont understand these two fully)
vs racetams/lions mane/others???

Hi!
Start at post 1 for a 'starting out' guide.

The combo works wonders for me. But i also get a stiff neck. I take vitamin b complex with it which contain only 100mg choline bitatrate. I dont wonna stop the uridine. Any other solition for the stiff neck? ( besides massage)

Stiff neck is odd. Lymphatic issue, perhaps? Do you get regular exercise?

Just as an fyi/update as someone who had a very negative reaction to the uridine stack, my 23andme results confirm that I have the polymorphisms for impaired metabolism - specifically MTHFR (Methylenetetrahydrofolate Reductase) and BHMT (Betaine-Homocysteine Methyltransferase).

Whether I'm under or over methylator I can't say for certain. I'll be getting my homocysteine checked via blood work (plasma amino test? not entirely sure which to ask for) here in the next few weeks.

I had a negative reaction at first. I assumed I had a similar problem so I used this for a month and tried the stack again so far without problems.

http://www.seekinghe...ystex-plus.html

That's a good, optimised supplement.

[blueinfinity]

just found this thread after reading this other thread... http://www.longecity...ns/page__st__90

Lots of information to go through, what is the general consensus on what to take, and the sources to get them, now that the conversation has gone on 2 years?

does it depend more on other variables?

currently 25 year old male, looking for overall increased potential, but also withdrawal from about 10 years of heavy cannabis usage (i think it messed with my dopamine/serotinin levels/production) i get really bad anxiety to the point of being almost frozen in certain work/sales situations that i am not used to.

currently taking:
multivitamin (simply one triple strength)
krill oil (one cap, morning)
bacopa (one capsule, morning) [for memory? seems to help with alcohol and cannabis related memory/cognitive impairment and damage]
vinpocetin (10MG, morning) [felt it first few times, few weeks in now, not sure, but seems to help overall cerebral circulation and as a result memory]
Ashwagandha Root, Holy Basil Supercritical Extract,Rhodiola, Schisandra, Wild Oats (gaia herbs adrenal support) [found this in the store while searching for something to calm my nerves and help me respond better in stressful situations, not sure of exact impact/feeling from this]
red ginseng extract
lecithin
hemp protein
green powder

considering taking :
uridine
alpha gpc/alcar (are these interchangeable, i still dont understand these two fully)
vs racetams/lions mane/others???

Hi!
Start at post 1 for a 'starting out' guide.

The combo works wonders for me. But i also get a stiff neck. I take vitamin b complex with it which contain only 100mg choline bitatrate. I dont wonna stop the uridine. Any other solition for the stiff neck? ( besides massage)

Stiff neck is odd. Lymphatic issue, perhaps? Do you get regular exercise?

Just as an fyi/update as someone who had a very negative reaction to the uridine stack, my 23andme results confirm that I have the polymorphisms for impaired metabolism - specifically MTHFR (Methylenetetrahydrofolate Reductase) and BHMT (Betaine-Homocysteine Methyltransferase).

Whether I'm under or over methylator I can't say for certain. I'll be getting my homocysteine checked via blood work (plasma amino test? not entirely sure which to ask for) here in the next few weeks.

I had a negative reaction at first. I assumed I had a similar problem so I used this for a month and tried the stack again so far without problems.

http://www.seekinghe...ystex-plus.html

That's a good, optimised supplement.

just went to go buy this at local health food store (uridine) after looking for it, she said she could stock it because they get other products from ecological formulas but she said there were a couple red flags.

the fact that only one company makes it, usually means that risk is too high for other companies to want to take on or maybe because just too new and still in clinical trials?

causing deficiencies, she didnt point out the b9, i knew that from reading the OP but, she said from what she could remember having looked it up before, longer-term is causes a bunch of other deficiencies that without direct doctors supervision may be way more harmful than beneficial

thoughts on this?

and side question, i see lots of people taking uridine, choline/alcar and dhea, but in the OP it includes complete b spectrum supplment and vitamin e, anything else we should be aware of?

[Adaptogen]

how important is supplementing with vitamin e?

[MrHappy]

just found this thread after reading this other thread... http://www.longecity...ns/page__st__90

Lots of information to go through, what is the general consensus on what to take, and the sources to get them, now that the conversation has gone on 2 years?

does it depend more on other variables?

currently 25 year old male, looking for overall increased potential, but also withdrawal from about 10 years of heavy cannabis usage (i think it messed with my dopamine/serotinin levels/production) i get really bad anxiety to the point of being almost frozen in certain work/sales situations that i am not used to.

currently taking:
multivitamin (simply one triple strength)
krill oil (one cap, morning)
bacopa (one capsule, morning) [for memory? seems to help with alcohol and cannabis related memory/cognitive impairment and damage]
vinpocetin (10MG, morning) [felt it first few times, few weeks in now, not sure, but seems to help overall cerebral circulation and as a result memory]
Ashwagandha Root, Holy Basil Supercritical Extract,Rhodiola, Schisandra, Wild Oats (gaia herbs adrenal support) [found this in the store while searching for something to calm my nerves and help me respond better in stressful situations, not sure of exact impact/feeling from this]
red ginseng extract
lecithin
hemp protein
green powder

considering taking :
uridine
alpha gpc/alcar (are these interchangeable, i still dont understand these two fully)
vs racetams/lions mane/others???

Hi!
Start at post 1 for a 'starting out' guide.

The combo works wonders for me. But i also get a stiff neck. I take vitamin b complex with it which contain only 100mg choline bitatrate. I dont wonna stop the uridine. Any other solition for the stiff neck? ( besides massage)

Stiff neck is odd. Lymphatic issue, perhaps? Do you get regular exercise?

Just as an fyi/update as someone who had a very negative reaction to the uridine stack, my 23andme results confirm that I have the polymorphisms for impaired metabolism - specifically MTHFR (Methylenetetrahydrofolate Reductase) and BHMT (Betaine-Homocysteine Methyltransferase).

Whether I'm under or over methylator I can't say for certain. I'll be getting my homocysteine checked via blood work (plasma amino test? not entirely sure which to ask for) here in the next few weeks.

I had a negative reaction at first. I assumed I had a similar problem so I used this for a month and tried the stack again so far without problems.

http://www.seekinghe...ystex-plus.html

That's a good, optimised supplement.

just went to go buy this at local health food store (uridine) after looking for it, she said she could stock it because they get other products from ecological formulas but she said there were a couple red flags.

the fact that only one company makes it, usually means that risk is too high for other companies to want to take on or maybe because just too new and still in clinical trials?

causing deficiencies, she didnt point out the b9, i knew that from reading the OP but, she said from what she could remember having looked it up before, longer-term is causes a bunch of other deficiencies that without direct doctors supervision may be way more harmful than beneficial

thoughts on this?

and side question, i see lots of people taking uridine, choline/alcar and dhea, but in the OP it includes complete b spectrum supplment and vitamin e, anything else we should be aware of?

I'd say she is wholly inaccurate and making extraordinary claims.

There are many manufacturers for uridine and you'll find it in a number of neuro specific formulas, including Cognitex, Fortasyn Connect and Souvenaid (and many more) that contain it.

I'd like to see her back up her other claim with even a single study. I've read quite nearly every paper published (there are always new ones) on this topic and I haven't seen anything like that.

The cofactors are DHA (fish oil, flaxseed oil or algae source), choline, B-multi, E, magnesium, selenium (if your multi doesn't have it.)

how important is supplementing with vitamin e?

Important to lipid health and prevents issues with fish oil related oxidation.

[blueinfinity]

I'd say she is wholly inaccurate and making extraordinary claims.

There are many manufacturers for uridine and you'll find it in a number of neuro specific formulas, including Cognitex, Fortasyn Connect and Souvenaid (and many more) that contain it.

I'd like to see her back up her other claim with even a single study. I've read quite nearly every paper published (there are always new ones) on this topic and I haven't seen anything like that.

The cofactors are DHA (fish oil, flaxseed oil or algae source), choline, B-multi, E, magnesium, selenium (if your multi doesn't have it.)

how important is supplementing with vitamin e?

Important to lipid health and prevents issues with fish oil related oxidation.

Good to know! I can see from your posts that you have done a great deal of research on the topic, much more than she did in 2 minutes over the phone while on hold.

my question is, would lecithin be an adequate source of choline for this, if so, how much?, or would it be recommended/required to take choline in one of its more isolated forms (ie CDP-choline, Alpha GPC, Phosphatidylserine, Bitartrate ,Phosphatidylcholine?)

also it states in OP to start choline supplmentation after 2 weeks, im already taking lecithin. should i stop for two weeks when starting uridine and then implement back two weeks in or is this for people not used to choline supplementation, and for those that are already taking choline an unneeded step?

[Adaptogen]

it prevents issues with fish oil oxidation even if it is not in the fish oil? Do you have a recommended brand?

[MrHappy]

it prevents issues with fish oil oxidation even if it is not in the fish oil? Do you have a recommended brand?

Sure, if you're taking it at the same time it'll help with large doses of fish oil.

This one is OK, but the D-alpha content will probably wipe out some of the tocotrienol content:
http://www.lef.org/V...cotrienols.html

This one is mostly tocotrienols. Should be pretty good:
http://www.vrp.com/h...to-tocotrienols

[MrHappy]

Good to know! I can see from your posts that you have done a great deal of research on the topic, much more than she did in 2 minutes over the phone while on hold.

my question is, would lecithin be an adequate source of choline for this, if so, how much?, or would it be recommended/required to take choline in one of its more isolated forms (ie CDP-choline, Alpha GPC, Phosphatidylserine, Bitartrate ,Phosphatidylcholine?)

also it states in OP to start choline supplmentation after 2 weeks, im already taking lecithin. should i stop for two weeks when starting uridine and then implement back two weeks in or is this for people not used to choline supplementation, and for those that are already taking choline an unneeded step?

Lecithin should be fine, assuming you're taking about 2500mg/day. Eggs are another good source at about 120mg of choline per egg.
There are distinct benefits from some of the other forms of choline, but there are risks of a bad reaction in some people.

You can continue taking lecithin.. the logic behind taking the choline later is to help troubleshoot any issues and it's possible that after 2 weeks of uridine supplementation, the choline reaction is more likely to be a positive one.

[Judd Crane]

You can continue taking lecithin.. the logic behind taking the choline later is to help troubleshoot any issues and it's possible that after 2 weeks of uridine supplementation, the choline reaction is more likely to be a positive one.

Could you explain the bolded part a little further? I've noticed that the citicoline took away the positive effect for me.

[MrHappy]

You can continue taking lecithin.. the logic behind taking the choline later is to help troubleshoot any issues and it's possible that after 2 weeks of uridine supplementation, the choline reaction is more likely to be a positive one.

Could you explain the bolded part a little further? I've noticed that the citicoline took away the positive effect for me.

Is more likely (but is certainly not assured) because at 2 weeks, your dopaminergic baseline and neuroplasticity should be elevated, meaning adapting to the choline supplement could be easier for some people.

If not, try a different/natural choline source.

[blueinfinity]

You can continue taking lecithin.. the logic behind taking the choline later is to help troubleshoot any issues and it's possible that after 2 weeks of uridine supplementation, the choline reaction is more likely to be a positive one.

Could you explain the bolded part a little further? I've noticed that the citicoline took away the positive effect for me.

Is more likely (but is certainly not assured) because at 2 weeks, your dopaminergic baseline and neuroplasticity should be elevated, meaning adapting to the choline supplement could be easier for some people.

If not, try a different/natural choline source.

so i will keep taking lecithin but i only take about a tablespoon or two of granules a day,

would would say that after two weeks of uridine it would help/hurt/neither to add in choline?

personally, would you say that each choline type causes a different result altogether or rather some have negative side effects that occur in some but overall the benefits are the same across the board?

[MrHappy]

You can continue taking lecithin.. the logic behind taking the choline later is to help troubleshoot any issues and it's possible that after 2 weeks of uridine supplementation, the choline reaction is more likely to be a positive one.

Could you explain the bolded part a little further? I've noticed that the citicoline took away the positive effect for me.

Is more likely (but is certainly not assured) because at 2 weeks, your dopaminergic baseline and neuroplasticity should be elevated, meaning adapting to the choline supplement could be easier for some people.

If not, try a different/natural choline source.

so i will keep taking lecithin but i only take about a tablespoon or two of granules a day,

would would say that after two weeks of uridine it would help/hurt/neither to add in choline?

personally, would you say that each choline type causes a different result altogether or rather some have negative side effects that occur in some but overall the benefits are the same across the board?

There are potential benefits for the other types of choline that are not critical to this combination. For instance, I like alpha-GPC because it raises levels of human growth hormone in response to exercise. However, any dietary source of choline is good.

[bobz1lla]

GPC should be more readily available for the brain, so per mg, we could take less of it than other forms? I've been spotting 600mg GPC morning with subdermal UMP 300mg morning/night. What do you think of this 1:1 ratio?

On the vitamin E issue, I believe there's study where patients reported better success with uridine, if VitE was supplemented in conjunction. It's like halfway back thru the thread.

Also read something where our brain doesn't utilize more than 5mg of dha/epa at any given time. Any truth? And that there is a battle for space among dha/epa at any given time.


Anyone had success blending in the ciltep stack with the uridine stack? "tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine (& other catecholamine) synthesis. cAMP plays a role in TH transcription and therefore, can significantly increase DA in the long-term (without downregulation via homeostasis). CILTEP already comes with a built-in dopamine increase via an increase in phosphorylation of TH."

Someone care to speculate how uridine's dopamine regulating properties might increase or decrease the effectiveness of ciltep? DA seems to be pretty important to the effectiveness.

[norepinephrine]

I take uridine+DHA along with CILTEP on most days.

Overall, CILTEP, especially if you're not carefully measuring your caffeine intake, is a much more potent stack in terms of perceived effects. It's likely the closest thing I've found to an herbal Adderall, though they're still not one and one to eachother. Thus, sublingual uridine seems to mildly reduce the effects, but as with most nootropics discussed on here, it's to a fairly subtle degree. CILTEP broadly overpowers most of whatever perceived effect uridine brings. (I personally don't notice anything much unless I've taken >500mg sublingually, in which case the melancholic 'zen' vibe that a few others have described kicks in. I take a 250mg dosage more for the long-term benefits than any real short-term effect, though I have seemed to notice a subjective difference when taking uridine immediately after exercise.)

[bobz1lla]

I noticed my rep counts for aerobic and strength training have gone up noticeably. I think my muscles ache less the next day. There is a mental clarity effect there too.

Edited by bobz1lla, 22 February 2013 - 11:24 PM.

[alecnevsky]

Does anyone know what phospholipids are in Souvenaid? I assume it's at least PC and PS but I am not sure. Isn't Choline somehow related to PC? I heard people supplementing with the latter to get the memory effects of choline and the cellular membrane protection of PC. It's pleasantly surprising to see my entire stack reflected in the Souvenaid formula but I am missing the phospholipids (in supplement form, probably not in diet though.) Is there one supplement to satisfy your choline and phospholipid "requirement?"


Edit: Also it seems like everything in Souvenaid is fat soluble but choline. What kind of source are they using to make it soluble with the lipids and the dha/epa?

Edited by alecnevsky, 23 February 2013 - 12:59 AM.

[MrHappy]

Does anyone know what phospholipids are in Souvenaid? I assume it's at least PC and PS but I am not sure. Isn't Choline somehow related to PC? I heard people supplementing with the latter to get the memory effects of choline and the cellular membrane protection of PC. It's pleasantly surprising to see my entire stack reflected in the Souvenaid formula but I am missing the phospholipids (in supplement form, probably not in diet though.) Is there one supplement to satisfy your choline and phospholipid "requirement?"


Edit: Also it seems like everything in Souvenaid is fat soluble but choline. What kind of source are they using to make it soluble with the lipids and the dha/epa?

PC = phosphatidylcholine, which is partly constructed with choline.

Uridine + DHA alone raises PC and PS levels significantly. There is a PDF link on page 1 with some charts.

Not having seen the Souvenaid product label, I'd be guessing they advise consuming around meal-time.

[alecnevsky]

Found it! Thanks. Although, I am still wondering why the Souvenaid guys are putting PS+PC and DHA+Uridine+Choline into same formula.

[Mr. Pink]

today's my 3rd day on the combo, and i'm having some sort of depressive reaction to it.

the first day i took about 50mg ump under the tongue with fish oil, about 300mg choline bitartrate, and life force multiple vitamin. felt spacey, but didn't think anything of it.

yesterday took a similar combo early morning, but bumped to ump to about 80mg sublingual. felt very spacey, extremely irritable and depressed. later in the day, realized that UMP turns into choline, and choline may be doing it, so I took about 1200mg piracetam and 10mg noopept to use up some of that choline and my mood improved.

today i took UMP 60mg sublingual, fishoil, and vitamins, no choline. Again felt really spacey, depressed, irritable. later in the day, took some phenyl piracetam and drank a double serving rockstar and felt a lot better (drank it a lot later in the day, the horrible ump fishoil vitamin feeling wouldn't go away).

now here's a little history - i have depression, but i get very good results from wellbutrin (dopeamine and norepinephrine reuptake inhibitor). over a decade ago, when i was a teen, i was going through some rough stuff, and was on an snri for a few months and it got me feeling better enough to make some lifechanging decisions which saved my life. so i respond well to serotonin. i respond better to dopeamine/norepinephrine. here's the kicker, when i experience depression, it feels like an absence of emotion and anxiety (irritability). maybe i'm getting that flattening of emotion from the UMP?

also, the spacey feeling. i had that feeling when i started wellbutrin, for the first 2 weeks, and it turned out to be the best thing in the world for me in terms of mood and memory. i also experienced a similar feeling when first trialing CILTEP before I added enough caffeine and l-phenylalanine (dopeamine precursor) to turn it into concentration.

anyway, it's early, will be day 4 tomorrow, but all i really want out of this stack is better memory. i want my mood to be left alone. i don't get things done when i'm spaced out, irritable and depressed. So any advice on tweaking it? at the moment i'm thinking of taking a smaller sublingual dose, maybe 25mg UMP, no choline, fishoil, vitamin and doing my normal racetams.

Was also considering adding some 5htp which i've been taking about 2wice a week for the last 2 weeks or so. I have some stuff to do tomorrow that i feel anxious about and that a boost in people skills could help with.

[MrHappy]

today's my 3rd day on the combo, and i'm having some sort of depressive reaction to it.

the first day i took about 50mg ump under the tongue with fish oil, about 300mg choline bitartrate, and life force multiple vitamin. felt spacey, but didn't think anything of it.

yesterday took a similar combo early morning, but bumped to ump to about 80mg sublingual. felt very spacey, extremely irritable and depressed. later in the day, realized that UMP turns into choline, and choline may be doing it, so I took about 1200mg piracetam and 10mg noopept to use up some of that choline and my mood improved.

today i took UMP 60mg sublingual, fishoil, and vitamins, no choline. Again felt really spacey, depressed, irritable. later in the day, took some phenyl piracetam and drank a double serving rockstar and felt a lot better (drank it a lot later in the day, the horrible ump fishoil vitamin feeling wouldn't go away).

now here's a little history - i have depression, but i get very good results from wellbutrin (dopeamine and norepinephrine reuptake inhibitor). over a decade ago, when i was a teen, i was going through some rough stuff, and was on an snri for a few months and it got me feeling better enough to make some lifechanging decisions which saved my life. so i respond well to serotonin. i respond better to dopeamine/norepinephrine. here's the kicker, when i experience depression, it feels like an absence of emotion and anxiety (irritability). maybe i'm getting that flattening of emotion from the UMP?

also, the spacey feeling. i had that feeling when i started wellbutrin, for the first 2 weeks, and it turned out to be the best thing in the world for me in terms of mood and memory. i also experienced a similar feeling when first trialing CILTEP before I added enough caffeine and l-phenylalanine (dopeamine precursor) to turn it into concentration.

anyway, it's early, will be day 4 tomorrow, but all i really want out of this stack is better memory. i want my mood to be left alone. i don't get things done when i'm spaced out, irritable and depressed. So any advice on tweaking it? at the moment i'm thinking of taking a smaller sublingual dose, maybe 25mg UMP, no choline, fishoil, vitamin and doing my normal racetams.

Was also considering adding some 5htp which i've been taking about 2wice a week for the last 2 weeks or so. I have some stuff to do tomorrow that i feel anxious about and that a boost in people skills could help with.

Were you already supplementing choline? If not, read post 1 and start again.

[Mr. Pink]

today's my 3rd day on the combo, and i'm having some sort of depressive reaction to it.

the first day i took about 50mg ump under the tongue with fish oil, about 300mg choline bitartrate, and life force multiple vitamin. felt spacey, but didn't think anything of it.

yesterday took a similar combo early morning, but bumped to ump to about 80mg sublingual. felt very spacey, extremely irritable and depressed. later in the day, realized that UMP turns into choline, and choline may be doing it, so I took about 1200mg piracetam and 10mg noopept to use up some of that choline and my mood improved.

today i took UMP 60mg sublingual, fishoil, and vitamins, no choline. Again felt really spacey, depressed, irritable. later in the day, took some phenyl piracetam and drank a double serving rockstar and felt a lot better (drank it a lot later in the day, the horrible ump fishoil vitamin feeling wouldn't go away).

now here's a little history - i have depression, but i get very good results from wellbutrin (dopeamine and norepinephrine reuptake inhibitor). over a decade ago, when i was a teen, i was going through some rough stuff, and was on an snri for a few months and it got me feeling better enough to make some lifechanging decisions which saved my life. so i respond well to serotonin. i respond better to dopeamine/norepinephrine. here's the kicker, when i experience depression, it feels like an absence of emotion and anxiety (irritability). maybe i'm getting that flattening of emotion from the UMP?

also, the spacey feeling. i had that feeling when i started wellbutrin, for the first 2 weeks, and it turned out to be the best thing in the world for me in terms of mood and memory. i also experienced a similar feeling when first trialing CILTEP before I added enough caffeine and l-phenylalanine (dopeamine precursor) to turn it into concentration.

anyway, it's early, will be day 4 tomorrow, but all i really want out of this stack is better memory. i want my mood to be left alone. i don't get things done when i'm spaced out, irritable and depressed. So any advice on tweaking it? at the moment i'm thinking of taking a smaller sublingual dose, maybe 25mg UMP, no choline, fishoil, vitamin and doing my normal racetams.

Was also considering adding some 5htp which i've been taking about 2wice a week for the last 2 weeks or so. I have some stuff to do tomorrow that i feel anxious about and that a boost in people skills could help with.

Were you already supplementing choline? If not, read post 1 and start again.

i was already supplementing choline (for the last 4 months or so)

[health_nutty]

Has anyone tried a lower sublingual dose than the 300mg dose recommened in this thread? The reason I ask is: there is a limit to the amount of a substance that can be sublingually absorbed. Adding more of the substance just means more is orally absorbed.

[Adaptogen]

i have been taking 100mg sublingual. it might be placebo but sometimes it makes me feel a little jittery

[Joiedevivre62]

Mr. H, thanks for your thread on uridine. My husband has mitochondrial toxicity from a viral treatment (Ribivirin/Interferon for a year for hepatitis C), and while I was feeding him a large supplemnt cocktail (CoQ10, Carnitine, ALA, phosphatadyl serine, etc), it seemed that the uridine really started fixing things that got screwed up with the treatment (just about every symptom of mitochondrial toxicity you could have). We consulted with three neurologists who provided no help as there's no cure for mitochondrial toxicity and disease. The Mito toxicity caused insulin resistance which caused cognitive difficulties among other things, so we've recently switched to a nutrient intensive, diabetic type diet and that has also helped. Do you know of anyone who could consult with me on the supplement cocktail that I'm giving him? All of his doctors are mildly interested, but know of no one. He'd be drooling and sleeping in a chair with out them instead of being an employed PhD scientist.
Cheers.

[MrHappy]

Mr. H, thanks for your thread on uridine. My husband has mitochondrial toxicity from a viral treatment (Ribivirin/Interferon for a year for hepatitis C), and while I was feeding him a large supplemnt cocktail (CoQ10, Carnitine, ALA, phosphatadyl serine, etc), it seemed that the uridine really started fixing things that got screwed up with the treatment (just about every symptom of mitochondrial toxicity you could have). We consulted with three neurologists who provided no help as there's no cure for mitochondrial toxicity and disease. The Mito toxicity caused insulin resistance which caused cognitive difficulties among other things, so we've recently switched to a nutrient intensive, diabetic type diet and that has also helped. Do you know of anyone who could consult with me on the supplement cocktail that I'm giving him? All of his doctors are mildly interested, but know of no one. He'd be drooling and sleeping in a chair with out them instead of being an employed PhD scientist.
Cheers.

I'm really glad you are seeing success.

The difficulty is that we are effectively working/self-medicating with 'research' substances, rather than universally accepted treatments.

Unfortunately, it's unlikely that you will find a mainstream neurologist to consult on your husband's protocol, as it can land them in 'hot water.'

Your best bet is probably to discuss this with a medical researcher, or depending on your goal, there may be real value in discussing your husband's history/treatment here on Longecity.

[health_nutty]

I've started sublingual UMP twice a day (was already taking higher dose fish oil and a decent multi).

[jerichodotm]

I've been taking ~200 mg under the tounge twice daily. I haven't noticed anything yet.

Have some people not noticed differences instantly but did notice them after a couple weeks?

[evodude]

I only took it for 2 weeks now. all the things mentioned bu mrHappy i noticed myself. I need less sleep and normally i find it hard to get up, let alone clearheaded like now. The only thing i get is a stiff neck. I take between 150-200 UMP subl now. In the morning like suggested with the other stuff. I do notice i need the NGF, ciltep stack ( noopept., prami) together. I took that one for a long time but .The UMP wad definitely the missing link for me. I cant imagine it getting any better for me at the moment. Maybe the tension is causing my neckpane, choline. Bubble bath helped so maybe its blood circulation

Btw first time i didnt notice that much. I had to wait like a couple of days

Edited by evodude, 01 March 2013 - 07:56 AM.

[Adaptogen]

I have noticed my scalp has been a little itchy lately...neurogenesis or fleas?

[MrHappy]

I have noticed my scalp has been a little itchy lately...neurogenesis or fleas?

Scalp bacteria with a new food source, perhaps. A lot of bacteria use uridine for replication.

I've been taking ~200 mg under the tounge twice daily. I haven't noticed anything yet.

Have some people not noticed differences instantly but did notice them after a couple weeks?

I normally suggest up to 2 weeks. I also suggest oral dosage to start for most situations.

I only took it for 2 weeks now. all the things mentioned bu mrHappy i noticed myself. I need less sleep and normally i find it hard to get up, let alone clearheaded like now. The only thing i get is a stiff neck. I take between 150-200 UMP subl now. In the morning like suggested with the other stuff. I do notice i need the NGF, ciltep stack ( noopept., prami) together. I took that one for a long time but .The UMP wad definitely the missing link for me. I cant imagine it getting any better for me at the moment. Maybe the tension is causing my neckpane, choline. Bubble bath helped so maybe its blood circulation

Btw first time i didnt notice that much. I had to wait like a couple of days

Tension.. any caffeine or nicotine in your daily routine?