2844 replies to this topic

[MrHappy]

That looks like a good omega-3 product - has vitamin E, also. You could always add one of the other OTC omega-3 products, which have a higher EPA ratio to fill the gap.

[choqueiro]

MrHappy, I think that I don´t understand you. Firstly you suggested to take: 400-600mg EPA and 1500-2000mg DHA, so I go to Nordic Naturals and selected the product with similar DHA:EPA ratio (more or less). Taking two pills of "Nordic Naturals DHA 1000" I´m having 1800 mg. of DHA and 360 mg. of EPA. According to your answer I need more EPA to fill the gap. I don´t really understand. I think that DHA is the important of the two compounds. I look to a study: http://www.nutraingr...for-Alzheimer-s and they don´t say anything about supplementing with EPA. It´s really necessary take at least 400 mg. of EPA??

What can you say me about Alpha GPC vs Choline CDP?? In your opinion which one is the best option??

Thanks for everything.

[Lufega]

Choqueiro,

Just take some fish oil. Don't get too hung up in the specifics. I think your body will know what to do with that.

That said, I got my TAU in the mail and took 25 mg with 1 gram krill oil. I definitely felt a strong, brain specific effect. Hard to describe but it's doing something up there. I tend to be very sensitive to supplements and low doses work best for me. I do feel slightly more focused but also a little lightheaded. I'm sure that last effect will go away with time.

[j03]

Anyone see any issues with combining choline, Uridine, DHA with Zoloft?

Also taking nicotine and NAC if that matters

[MrHappy]

Choq - just trying to get to the magic ratio. As mentioned, I don't even hit that, so don't worry too much, just try to get close enough.

J03 - any nicotine will be an issue - it competes with uridine. The good news is that should you want to, you could use TAU / UMP as a way of discontinuing nicotine, according to the available literature / patents.

My wife quit Zoloft (which is normally not fun to do for anyone involved) and now takes uridine + cofactors. Much happier, calmer and her zest for life has returned! I can't see a problem taking them side-by-side.

[Delafuente]

Anyone see any issues with combining choline, Uridine, DHA with Zoloft?

Also taking nicotine and NAC if that matters

What form of nicotine do you take (gum, patches, cigarettes, etc.)

Also, what purpose does your nicotine intake serve (social smoking, dependance, cognitive enhancement, etc.)?

Uridine may help if dependance is an issue.

[choqueiro]

Ok. Mr Happy. So I´m going to buy:

- Uridine UMP (Cardivascular Research).
- DHA 1000 (Natural Nordics)
- Alpha GPC (Jarrow Formulas or AOR)

I have doubts with the other substances to complete the stack.
1000 IU of Vitamin E; 400 mcg folate; 1 mg. b12. What brands and products do you use??

Thanks

[MrHappy]

I use vitamin e capsules from my local chemist, a cheap multi vitamin from Bayer (Berocca) and a separate B12 supplement.

Incidently, anyone with tinnitus symptoms may benefit from significantly increasing vitamins B1,2,3.

[choqueiro]

Thanks MrHappy.

Recently I took one pill of Jarrow B Complex (it was the first time I took a B complex and I only took one capsule) and I suffered a niacin flush. I´ve got red spots in my skin (specially in hands, arms, and neck). My face get also red and I experimented an increase in my general temperature (I was really warm). So, should I avoid to take a b complex and take vitamins B9 (folate) and B12 alone MrHappy??

Thanks

[nito]

So ive been taking the tau mixed with max dha (not much epa) and choline. So far i have not added the multi n the b xomplex cus i didnt have any. Well they have arrived and i will add it to the rest. However my question is whether the reason for not feeling as there's been a change in cognition due to the lack of co factors, basically is the stack incomplete and useless without the other factors?

[MrHappy]

The spots will go after a short while. I'd just stick with it.

[MrHappy]

Without sufficient levels of the cofactors, you're taking the slow train, with the brakes stuck on.

[nito]

Ok just read the last 5 posts. Folate, b12? Ive had that at home all the time, i could have added tat at least:-( Btw didnt know berroca did multi, i got their b vitamin solvable pills.

[pamojja]

I have doubts with the other substances to complete the stack.
1000 IU of Vitamin E; 400 mcg folate; 1 mg. b12. What brands and products do you use??
Thanks

I would have worries supplementing 1000 IU of vitamin E daily, which I understand to mean about 670 milligrams of alpha-tocopherol. Since some studies showed depletion of the other vitamin E isomers at already much less than that.

And it would be difficult to balance such a high vitamin E intake with mixed tocopherols, because they cost a lot more at that amound.

But maybe dividing the 670mg between, just for example: 300mg alpha-tocopherol, 300 mg mixed tocopherol and 70mg tocotrienol could also do?

[Hebbeh]

So ive been taking the tau mixed with max dha (not much epa) and choline. So far i have not added the multi n the b xomplex cus i didnt have any. Well they have arrived and i will add it to the rest. However my question is whether the reason for not feeling as there's been a change in cognition due to the lack of co factors, basically is the stack incomplete and useless without the other factors?

More than likely the biggest reason you may not be experiencing an obvious effect would probably be due to the smoking and nicotine. Apparently nicotine and uridine compete as referenced in several papers that uridine may assist with nicotine cessation. You are more than likely spinning you wheels by continuing to smoke while expecting cognitive benefits from uridine,

[choqueiro]

Hi MrHappy.

Here it is what I´m going to order:

1) Uridine UMP (Cardiovascular Research). 200-300 mg. sublingually.

2) DHA 1000 (Natural Nordics). 2 capsules per day: 360 mg. EPA, 1800 mg. DHA.

3) Alpha GPC (AOR). 2 capsules per day: 500 mg.

4) Multivitamin Ortho Core (AOR) http://www.aor.ca/ht...ducts.php?id=96. With this product I think that I can take the rest of the substances in the quantities suggested more or less. With 6 capsules per day of Ortho Core, I´m taking:
- 800 mcg Folic Acid
- 647 mcg. B12
- 109.6 mg. Vitamin E (99.6 mg of mixed Tocopherols and 10 mg. of mixed Tocotrienols)
- The rest of the vitamins and minerals.

What dou you think?? It will be enough with AOR Ortho Core or should I take more from any of these substances?? I know that 109.6 mg. of vitamin E is very far from the 1000 IU suggested but it´s really necessary 1000 IU of vitamin E?? Don´t you think as pamojja said that it´s a lot??

I aso find a product from Thorne Research http://www.iherb.com...Caps/18545?at=0. Each capsule contains: 1 mg. vitamin B12 and 800 mcg. Folic Acid. Instead of taking the Ortho Core I could take this one (more B12 and the same quantity of folic acid) but with this one I should take vitamin E alone. Another problem with this second option is that I shoul avoid take any multivitamin because every multivitamin include vitamin B12 and folic acid and I will raise excessively the intake of this two compounds.

What dou you think??. Is the multivitamin AOR Ortho Core enough or should I go for the second option??

Thanks

[MrHappy]

I looked up the full AOR ortho core specs and it looks excellent.

[MrHappy]

Nito, read the contents of the Berocca soluble B-multi....

I think you'll facepalm - if it's the same one I'm using, it has a lot of other vitamins and minerals in it.

[MrHappy]

Pamojja, 500IU to 1000IU is probably fine. I've been using 1000IU for a few months - it's just the standard OTC from the chemist, here.

[choqueiro]

So, with AOR ortho core you think that I don't need to add any cofactor?? As you can see with this multivitamin I'm getting very little vitamin E in comparison to yours suggested 500 or 1000 IU. It's really necessary a hughe amount of vitamin E in the stack??

[Hebbeh]

So, with AOR ortho core you think that I don't need to add any cofactor?? As you can see with this multivitamin I'm getting very little vitamin E in comparison to yours suggested 500 or 1000 IU. It's really necessary a hughe amount of vitamin E in the stack??

I'm dosing 400iu multi-spectrum E and am very pleased with the results. I believe, at least for me, that the absolute amounts of co-factors are not critical....you should see results regardless. Some may be trying to over analyze the stack...the ideal quantities and ratios probably will vary from individual to individual and determining the perfect "ideal" is probably impossible...and probably not necessary.

[nito]

So ive been taking the tau mixed with max dha (not much epa) and choline. So far i have not added the multi n the b xomplex cus i didnt have any. Well they have arrived and i will add it to the rest. However my question is whether the reason for not feeling as there's been a change in cognition due to the lack of co factors, basically is the stack incomplete and useless without the other factors?

More than likely the biggest reason you may not be experiencing an obvious effect would probably be due to the smoking and nicotine. Apparently nicotine and uridine compete as referenced in several papers that uridine may assist with nicotine cessation. You are more than likely spinning you wheels by continuing to smoke while expecting cognitive benefits from uridine,

I don't really smoke, only now and then in the weekend. But i use snuff daily http://snus2.se/. They are pouches that has nicotine in them that you place in your upper lip. The pack looks like an ice hockey puck. I have done this daily for 1 and a half years. It's 22 gram and contains 8mg/g nicotine. I would find it hard to permanently quit this as it gets me through stressful and boring times wherever that may be. It's also social for me as it gets me a buzz and some excitement for a short period. I really hoped nicotine would not be that much of a problem, darn!

[MrHappy]

Perhaps at first, but tolerance soon sets in and now you're just dosing to get back to your old baseline, thinking you're getting a buzz and not realising you'd feel that way all the time without it.
http://www.ncbi.nlm....ubmed/20170672/

Meanwhile, times in between doses get irritable, stressful and less fulfilling. You'll start looking for new things to make you feel better, ignoring the elephant in the room.

Think how much energy you once had as a kid..

Edited by MrHappy, 29 December 2011 - 01:58 PM.

[ScienceGuy]

The B vitamins are essential, make sure you are taking at least RDA.

Mr Happy,

Congrats on an AWESOME thread!

I'm intending to try out URIDINE, using 250mg UMP Sublingually.

RE: B vitamin Co-factors - I understand your logic regarding this, but do you think it would be sufficient to simply monitor one's Folate and B12 levels via blood tests so as to ascertain whether or not additional supplementation is in fact required?

My reason for asking is because I am recovering from Lyme Disease and have an un-natural sensitivity to supplemental B vitamins. I follow a ridiculously healthy diet and my recent labs showed heathly normal levels for all vitamins. I was therefore thinking of starting the Uridine WITHOUT taking any supplemental Folate and B12, and undergo regular blood tests to monitor my Folate and B12 levels. If they start to plumet I can then react accordingly by supplementing with Folate and B12 at an appropriate dosage that keeps them within the normal range...

What do you think?

[MrHappy]

Uridine + vitamins as a treatment for anemia:
http://www.moreirajr...id_materia=3707

[sparkk51]

Sorry, but I'm confused as to what this combination will help with.

Will taking the combination listed in the title help by increasing dopamine?

Edited by sparkk51, 29 December 2011 - 10:34 PM.

[nito]

Got my ump, b comples and multi. Firstly didnt know te berroca was sufficient for te b side cus i have tat, which means i wasted money on jarrow b complex. Secondly my multi contains 100iu vitamin e per tree pills. Id have to take 15 pills just to get 500 iu vitamin e. Do i really need 500 iu vitamin e?

[X_Danny_X]

I am trying to get the necessities from Foods. Uridine I can get from spirulina, choline from eggs, and ofcourse though I will buy a Carlson's Fish Oil for DHA/EPA.

I do chew on my Spirulina to try to get it sublingually.

It is best to get vitamins and minerals from foods anyway. Ofcourse you can get a multi to make sure you get enough.

[Lufega]

I skipped my dose of TAU today. I find it to be very stimulating and yesterday, I was having problems with memory recall. Maybe it's just a transient state. Maybe it's not the uridine alone, as I am taking other stimulants at the same time. Uridine just seems to potentiate that effect. Anyone else experience this ?

[Hebbeh]

I skipped my dose of TAU today. I find it to be very stimulating and yesterday, I was having problems with memory recall. Maybe it's just a transient state. Maybe it's not the uridine alone, as I am taking other stimulants at the same time. Uridine just seems to potentiate that effect. Anyone else experience this ?

Yes, I've had to limit my caffeine intake which never used to be a problem.