2844 replies to this topic

[killshot]

The benefits of uridine look so promising. I'd love to be able to take it.

Unfortunately, 25mg TAU gave me SIGNIFICANT irritability and a spaced out feeling. Does anyone have any recommendations? Does this sound like over methylation or could it be something else? If its over methylation, what is the solution, as I'm a little lost on the whole subject.

I'm determined to get to the bottom of this! Thanks

How much did you cut down to?

I went from 300mg down to 150mg, I'm no expert but I have read niacin helps with over methylation. I'm also supplementing with a multivitamin from seeking health for the methylfolate and b12, regular vitamins bother me.





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Edited by killshot, 10 February 2013 - 09:35 PM.

[Renegade]

What do you think is causing the side effects for you?

Does anyone know if there is any way to determine whether or not I am an over methylator?

[MrHappy]

@lucky

I wondered the same thing, I felt more aggitated than normal. I cut my does in half and it seemed to help.

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Irritability/tension will normally come from caffeine & nicotine.

[killshot]

@lucky

I wondered the same thing, I felt more aggitated than normal. I cut my does in half and it seemed to help.

Sent from my Rezound using Tapatalk 2

Irritability/tension will normally come from caffeine & nicotine.

I do still use caffeine... So there you go.

Sent from my ADR6425LVW using Tapatalk 2

[umop 3pisdn]

The thing I've been wondering about with caffeine and this stack, is it somewhat dose dependent or do you have to give it up entirely? I could give up coffee but it would be a lot harder for me to give up green or white tea.

[Dissolvedissolve]

The thing I've been wondering about with caffeine and this stack, is it somewhat dose dependent or do you have to give it up entirely? I could give up coffee but it would be a lot harder for me to give up green or white tea.

If you search through the thread and find the study that discusses the competition, you'll see that it is highly dose-dependent. There's really nothing to worry about if you're having, say, 100 mg of caffeine per day. If you're chugging coffee all day long, then perhaps, but really it just means you might need a slightly higher dose. And this should surprise no one, but if one is looking to uridine for stress-reduction and is currently drinking a ton of coffee, cutting down on the caffeine is a good place to start.

[umop 3pisdn]

If you search through the thread and find the study that discusses the competition, you'll see that it is highly dose-dependent. There's really nothing to worry about if you're having, say, 100 mg of caffeine per day. If you're chugging coffee all day long, then perhaps, but really it just means you might need a slightly higher dose. And this should surprise no one, but if one is looking to uridine for stress-reduction and is currently drinking a ton of coffee, cutting down on the caffeine is a good place to start.

Thanks. Sorry for asking an unnecessary question, I tried to do a search but I used silly terms that didn't bring anything up.

[Zen7]

The thing I've been wondering about with caffeine and this stack, is it somewhat dose dependent or do you have to give it up entirely? I could give up coffee but it would be a lot harder for me to give up green or white tea.

I don't think you'll have to give up green or white tea. There isn't a ton of caffeine in tea, unless you brew it for an extra long time. Green tea also has some theanine, which generally gives me a mild positive effect on focus, so I still enjoy drinking it while on this stack.

[Raza]

Does anyone have any experience or theories regarding the use of cocaine or amphetamines while being 'on' uridine?

Amphs and other dopaminergic stimulants I've tried together with uridine lose most if not all of their effect. Uridine levels out dopamine stimulation. OTOH, I've had weak evidence of it helping me sleep when the after-effects of such drugs would normally make that difficult, and it should presumably mitigate tolerance when taken at night after a day of stimulant use.

[Judd Crane]

Does anyone have any experience or theories regarding the use of cocaine or amphetamines while being 'on' uridine?

Amphs and other dopaminergic stimulants I've tried together with uridine lose most if not all of their effect. Uridine levels out dopamine stimulation. OTOH, I've had weak evidence of it helping me sleep when the after-effects of such drugs would normally make that difficult, and it should presumably mitigate tolerance when taken at night after a day of stimulant use.

I see, thanks for your answer. But these effects are limited to the time when uridine is still in the blood plasma? And normal effects will be seen if you space them for like 12-24 hours apart?

[BioFreak]

Does anyone know a good source for uridine in europe? MrHappy posted a link to a french site, but thats now a 404 - and I cant find the product on their website anymore.

I could get spirulina, but I doubt that it is as effective, given the same amount of uridine. Am I wrong?

I'd order from one of the US suppliers, if the shipping isn't ridiculous.

I'd love to, but customs in europe (esp germany) is a pain in the ass, thats why I haven't tried yet. They are actually unpredictable, sometimes letting things through, sometimes not.

iHerb (best place to order from if you in Europe) now carries CR TAU and Superior Nutraceuticals has pretty decent shipping prices on their UMP, too.

Does iherb send from within europe?

I've found a source of UMP in the uk, but its 44pound for 60 caps of 300mg UMP, that sounds insanely expensive to me. Damnit!

[nupi]

iHerb ships from the US but their shipping costs are pretty reasonable

[Guardian4981]

Update

My research indicates that supplements that tend to increase serotonin like Cissus seem to reduce blood calcium levels. A reducation in calcium tends to put downward pressure on dopamine levels.

Recently I have quit all supplements except I have introduced calcium, I have found I am having more errotic dreams and libido which would suggest increased dopamine levels.

So perhaps uridine should be stacked with calcium.

I also think my calcium levels were perhaps deficient because I have used alot of magnesium and serotonin boosting supplements in the past to combat anxiety. Well now I have no anxiety but my motivation and libido were quite low until recently adding the calcium.

Mr Happy and other have claimed the research would suggest if one is low in dopamine uridine would help increase it, I found the opposite. Perhaps the reason isn't uridine itself but its side effect of lowered calcium.

Is there any research on uridine in specific and calcium?

[Raza]

Does anyone have any experience or theories regarding the use of cocaine or amphetamines while being 'on' uridine?

Amphs and other dopaminergic stimulants I've tried together with uridine lose most if not all of their effect. Uridine levels out dopamine stimulation. OTOH, I've had weak evidence of it helping me sleep when the after-effects of such drugs would normally make that difficult, and it should presumably mitigate tolerance when taken at night after a day of stimulant use.

I see, thanks for your answer. But these effects are limited to the time when uridine is still in the blood plasma? And normal effects will be seen if you space them for like 12-24 hours apart?

Yes.

For a 150mg sublingual dose of uridine, a subjectively normal stimulant response is gradually restored for me between 4 and 18 hours after, with the normalizing effect following a half-time pattern.

Edited by Raza, 13 February 2013 - 10:22 PM.

[Pirate]

This could be a dumb question, but should people with gout stay clear of taking uridine?

[norepinephrine]

Has anyone noticed a correlation as far as dosing uridine at night and getting lower quality sleep?

The standard answer I can think of is that my dopamine levels were likely sub-optimal to begin with and the increase has hurt my resting state.

[bobz1lla]

The thing I've been wondering about with caffeine and this stack, is it somewhat dose dependent or do you have to give it up entirely? I could give up coffee but it would be a lot harder for me to give up green or white tea.

I don't think you'll have to give up green or white tea. There isn't a ton of caffeine in tea, unless you brew it for an extra long time. Green tea also has some theanine, which generally gives me a mild positive effect on focus, so I still enjoy drinking it while on this stack.

I've been eating small amounts of milk chocolate with no ill effects. Caffeine content is probably minimal.



The uridine combo has modified my sleep. Quality and REM may have increased. And remembering dreams is easier.

I'm now starting in choline: 300mg a-gpc(mornings). I may drop this to 150mg if headache or tiredness ensue.

Edited by bobz1lla, 14 February 2013 - 06:01 AM.

[MrHappy]

This could be a dumb question, but should people with gout stay clear of taking uridine?

No, but are you having trouble getting rid of gout?

Has anyone noticed a correlation as far as dosing uridine at night and getting lower quality sleep?

The standard answer I can think of is that my dopamine levels were likely sub-optimal to begin with and the increase has hurt my resting state.

The opposite - uridine at night assists resetting circadian rhythms and will ultimately lead to more restful sleep. How long have you been on it and how long do you sleep?

[BioFreak]

iHerb ships from the US but their shipping costs are pretty reasonable

Thanks for the tip but I'm more concerned about confiscation of goods through the customs.

I already thought about sending shipments from usa to the uk, their customs should be way less restrictive, and from there to germany... hm.

[MrHappy]

iHerb ships from the US but their shipping costs are pretty reasonable

Thanks for the tip but I'm more concerned about confiscation of goods through the customs.

I already thought about sending shipments from usa to the uk, their customs should be way less restrictive, and from there to germany... hm.

It's not a restricted substance in Germany. There are also some medical / nootropic products available in Germany with uridine as a primary ingredient.

[norepinephrine]

MrHappy - I've been on uridine for a bit longer than a month, and switched to evening dosing after reading your recommendation. In that same time period, my sleep has suffered - I can't maintain 7-8 hours of uninterrupted sleep without waking at least once. At this point, I'm trying to figure out if uridine was simply correlative to that, or causative. As such, I cut it out entirely and noticed slightly improved effects, but I've also been on a brief break from coffee. The experiment continues.

Needless to say, in my own subjective experience, I've noticed best effects from uridine when taken sublingually immediately following aerobic exercise. I don't think there's any studies that strictly compare uridine supplementation following exercise, but there is a few novel studies showing how you refuel post-exercise has implication for the brain. (If you're curious, I can try to dig up the articles I read that came to said conclusion.)

[Zen7]

Does anyone have any experience or theories regarding the use of cocaine or amphetamines while being 'on' uridine?

Amphs and other dopaminergic stimulants I've tried together with uridine lose most if not all of their effect. Uridine levels out dopamine stimulation. OTOH, I've had weak evidence of it helping me sleep when the after-effects of such drugs would normally make that difficult, and it should presumably mitigate tolerance when taken at night after a day of stimulant use.

I have noticed this as well. I sometimes take ds craze as a preworkout, which seems/feels very dopaminergic (not sure on exact MOA). I find that uridine seems to dampen the stimulation caused by ds craze. However, similar to Raza, I have found that sleeping after taking ds craze has been easier ever since I started taking UMP. Quality of sleep seems to have improved slightly, and I have been dreaming a lot more while waking up relatively refreshed. Note - I also take 300mcg time-released melatonin and 1 tablet of ZMA before bed.

[BioFreak]

It's not a restricted substance in Germany. There are also some medical / nootropic products available in Germany with uridine as a primary ingredient.

Right. How could I not see that. Supplements with uridine are low dose however, and there may still be a problem with customs as bulk powder or in dosages suggested here (300mg). I can find uridine powder.. but seems like uridine and UMP are two different things.

Would it make sense to use uridine instead of ump?

edit: this ebay seller seems to have problems with customs in germany (see bottom of page):
http://www.ebay.de/i...=item33743a0dc6

Edited by BioFreak, 18 February 2013 - 12:10 PM.

[MrHappy]

It's not a restricted substance in Germany. There are also some medical / nootropic products available in Germany with uridine as a primary ingredient.

Right. How could I not see that. Supplements with uridine are low dose however, and there may still be a problem with customs as bulk powder or in dosages suggested here (300mg). I can find uridine powder.. but seems like uridine and UMP are two different things.

Would it make sense to use uridine instead of ump?

edit: this ebay seller seems to have problems with customs in germany (see bottom of page):
http://www.ebay.de/i...=item33743a0dc6

If you can get pure uridine at a reasonable price, go for it.

However, the common supplements are:
Uridine-5'-monophosphate (UMP)
or
TriAcetylUridine (TAU)

If I were you, I'd just order a 25g container and if Deutsche customs have a heart-attack about it, at worst you've lost around 60 euros. If you are concerned, maybe ask the vendor to include a note saying 'sample', and suggest a bulk order is available at, eg. 250g.

[bobz1lla]

A recent study that sheds more positive light.


Disruption of Uridine Homeostasis Links Liver Pyrimidine Metabolism to Lipid Accumulation.

We report in this study an intrinsic link between pyrimidine metabolism and liver lipid accumulation utilizing a uridine phosphorylase 1 transgenic mouse model UPase1-TG. Hepatic microvesicular steatosis is induced by disruption of uridine homeostasis through transgenic overexpression of UPase1, an enzyme of the pyrimidine catabolism and salvage pathway. Microvesicular steatosis is also induced by the inhibition of dihydroorotate dehydrogenase (DHODH), an enzyme of the de novo pyrimidine biosynthesis pathway. Interestingly, uridine supplementation completely suppresses microvesicular steatosis in both scenarios. The effective concentration (EC50) for uridine to suppress microvesicular steatosis is approximately 20 uM in primary hepatocytes of UPase1-TG mice. We find that uridine does not have any effect on in vitro DHODH enzymatic activity. On the other hand, uridine supplementation alters the liver NAD+/NADH and NADP+/NADPH ratios and the acetylation profile of metabolic, oxidation-reduction, and antioxidation enzymes. Protein acetylation is emerging as a key regulatory mechanism for cellular metabolism. Therefore, we propose that uridine suppresses fatty liver by modulating liver protein acetylation profile. Our findings reveal a novel link between uridine homeostasis, pyrimidine metabolism, and liver lipid metabolism.

http://www.ncbi.nlm....pubmed/23355744

Edited by bobz1lla, 18 February 2013 - 01:13 PM.

[blueinfinity]

just found this thread after reading this other thread... http://www.longecity...ns/page__st__90

Lots of information to go through, what is the general consensus on what to take, and the sources to get them, now that the conversation has gone on 2 years?

does it depend more on other variables?

currently 25 year old male, looking for overall increased potential, but also withdrawal from about 10 years of heavy cannabis usage (i think it messed with my dopamine/serotinin levels/production) i get really bad anxiety to the point of being almost frozen in certain work/sales situations that i am not used to.

currently taking:
multivitamin (simply one triple strength)
krill oil (one cap, morning)
bacopa (one capsule, morning) [for memory? seems to help with alcohol and cannabis related memory/cognitive impairment and damage]
vinpocetin (10MG, morning) [felt it first few times, few weeks in now, not sure, but seems to help overall cerebral circulation and as a result memory]
Ashwagandha Root, Holy Basil Supercritical Extract,Rhodiola, Schisandra, Wild Oats (gaia herbs adrenal support) [found this in the store while searching for something to calm my nerves and help me respond better in stressful situations, not sure of exact impact/feeling from this]
red ginseng extract
lecithin
hemp protein
green powder

considering taking :
uridine
alpha gpc/alcar (are these interchangeable, i still dont understand these two fully)
vs racetams/lions mane/others???

Edited by blueinfinity, 19 February 2013 - 06:54 AM.

[RJ100]

Just as an fyi/update as someone who had a very negative reaction to the uridine stack, my 23andme results confirm that I have the polymorphisms for impaired metabolism - specifically MTHFR (Methylenetetrahydrofolate Reductase) and BHMT (Betaine-Homocysteine Methyltransferase).

Whether I'm under or over methylator I can't say for certain. I'll be getting my homocysteine checked via blood work (plasma amino test? not entirely sure which to ask for) here in the next few weeks.

Edited by RJ100, 19 February 2013 - 05:28 PM.

[killshot]

Just as an fyi/update as someone who had a very negative reaction to the uridine stack, my 23andme results confirm that I have the polymorphisms for impaired metabolism - specifically MTHFR (Methylenetetrahydrofolate Reductase) and BHMT (Betaine-Homocysteine Methyltransferase).

Whether I'm under or over methylator I can't say for certain. I'll be getting my homocysteine checked via blood work (plasma amino test? not entirely sure which to ask for) here in the next few weeks.

I had a negative reaction at first. I assumed I had a similar problem so I used this for a month and tried the stack again so far without problems.

http://www.seekinghe...ystex-plus.html

[RJ100]

I had a negative reaction at first. I assumed I had a similar problem so I used this for a month and tried the stack again so far without problems.

http://www.seekinghe...ystex-plus.html

That looks like a good supp if you're under-methylated. I could be over-methylated for all I know.

[evodude]

The combo works wonders for me. But i also get a stiff neck. I take vitamin b complex with it which contain only 100mg choline bitatrate. I dont wonna stop the uridine. Any other solition for the stiff neck? ( besides massage)