2844 replies to this topic

[Mr. Pink]

uridine still just makes me depressed and irritable. been taking it regularly for a month. tried 30 to 300mg ump sublingually. with and without fish oil, choline, quality multi. if I take uridine before bed, it makes me have depressed and irritable dreams all night.only been sticking with it b/c of the supposed memory benefits. but i'm about ready to be done.

[MrHappy]

uridine still just makes me depressed and irritable. been taking it regularly for a month. tried 30 to 300mg ump sublingually. with and without fish oil, choline, quality multi. if I take uridine before bed, it makes me have depressed and irritable dreams all night.only been sticking with it b/c of the supposed memory benefits. but i'm about ready to be done.

Normally this happens if you drink coffee/energy drinks or smoke. Do you fall into that category?

Sometimes it can be a genetic issue with inability to process folate. There will undoubtably be more reasons.

[Mr. Pink]

uridine still just makes me depressed and irritable. been taking it regularly for a month. tried 30 to 300mg ump sublingually. with and without fish oil, choline, quality multi. if I take uridine before bed, it makes me have depressed and irritable dreams all night.only been sticking with it b/c of the supposed memory benefits. but i'm about ready to be done.

Normally this happens if you drink coffee/energy drinks or smoke. Do you fall into that category?

Sometimes it can be a genetic issue with inability to process folate. There will undoubtably be more reasons.

i use caffeine, but not every day, not in huge amounts (usually just drink green tea), and never after 5pm. I've tried uridine on days without caffeine and it was the same. I don't use nicotine.

the depression i feel with uridine feels like low dopamine. i know uridine sensitizes dopamine receptors. any chance that it does so by lowering dopamine (thereby causing the receptors to upregulate)?

[MrHappy]

uridine still just makes me depressed and irritable. been taking it regularly for a month. tried 30 to 300mg ump sublingually. with and without fish oil, choline, quality multi. if I take uridine before bed, it makes me have depressed and irritable dreams all night.only been sticking with it b/c of the supposed memory benefits. but i'm about ready to be done.

Normally this happens if you drink coffee/energy drinks or smoke. Do you fall into that category?

Sometimes it can be a genetic issue with inability to process folate. There will undoubtably be more reasons.

i use caffeine, but not every day, not in huge amounts (usually just drink green tea), and never after 5pm. I've tried uridine on days without caffeine and it was the same. I don't use nicotine.

the depression i feel with uridine feels like low dopamine. i know uridine sensitizes dopamine receptors. any chance that it does so by lowering dopamine (thereby causing the receptors to upregulate)?

Not by that mechanism..

You could try supplementing l-methylfolate and see if that improves things. A fasting blood test could also be useful.

[norepinephrine]

Mr. Happy - could you reiterate the connection between uridine, folate and other B-vitamins?

I recently had bloodwork done and tested fairly high on folate (upper 20's) while being at the low-end for B-12. I get occasional bouts of depression, though when endogenously-related they appear to originate from excess choline or racetam-withdrawal. Correcting a vitamin D deficiency helped, but hasn't been a magic pill. FWIW I've been supplementing fish oil for around 9 months, take 250mg uridine sublingually per day, and generally take conservative doses ALCAR on days when I'm not eating eggs.

[bobz1lla]

Regarding evenings, whether its my low(300mg ump oral) or high(300mg ump sub) dosages, Uridine has an impact on dream recall/vividness. The times I do wake up, it's an interesting sensation to be able to recall these details in a clear manner.

Edited by bobz1lla, 28 March 2013 - 05:36 AM.

[MrHappy]

Mr. Happy - could you reiterate the connection between uridine, folate and other B-vitamins?

I recently had bloodwork done and tested fairly high on folate (upper 20's) while being at the low-end for B-12. I get occasional bouts of depression, though when endogenously-related they appear to originate from excess choline or racetam-withdrawal. Correcting a vitamin D deficiency helped, but hasn't been a magic pill. FWIW I've been supplementing fish oil for around 9 months, take 250mg uridine sublingually per day, and generally take conservative doses ALCAR on days when I'm not eating eggs.

High folate can mask symptoms of a B12 deficiency, which isn't helpful. What's your diet like?

Regarding evenings, whether its my low(300mg ump oral) or high(300mg ump sub) dosages, Uridine has an impact on dream recall/vividness. The times I do wake up, it's an interesting sensation to be able to recall these details in a clear manner.

The guys on reddit in /r/luciddreaming might like to know that, too.

[norepinephrine]

I generally eat eggs, dairy, oatmeal and fresh vegetable juice at home, and a variety of meats, produce, soups and salads at work. I also drink espresso and matcha daily, though have been on a break for the last week and a half to reset tolerance. Diet-wise, a low B12 only makes sense to me in the context of a lack of intrinsic factor or other inability to metabolize properly.

[MrHappy]

I generally eat eggs, dairy, oatmeal and fresh vegetable juice at home, and a variety of meats, produce, soups and salads at work. I also drink espresso and matcha daily, though have been on a break for the last week and a half to reset tolerance. Diet-wise, a low B12 only makes sense to me in the context of a lack of intrinsic factor or other inability to metabolize properly.

Could be bowel fauna/flora or liver issues. Can you continue to stay off the coffee and add some vitamin C to your stack?

[norepinephrine]

It could very well be a gut flora issue. I've had recurring issues with that ever since taking a round of antibiotics for acne in my teens.

Alas, glutamine helps, as does homemade kefir when I actually pursue the effort to make it (and storebought yogurt when I don't) and kombucha. Nonetheless, it's been an issue ad nauseum, especially considering my athletic background and a necessity to take in simple carbs during workouts.

Quitting coffee proved to be nearly fatal to my academic career when I pursued it last. Now that I have a good run going, I could probably try to just go all-in on matcha, but no caffeine is almost entirely out of the question given my mathematical aptitude and motivation apparently relies on it.

[MrHappy]

It could very well be a gut flora issue. I've had recurring issues with that ever since taking a round of antibiotics for acne in my teens.

Alas, glutamine helps, as does homemade kefir when I actually pursue the effort to make it (and storebought yogurt when I don't) and kombucha. Nonetheless, it's been an issue ad nauseum, especially considering my athletic background and a necessity to take in simple carbs during workouts.

Quitting coffee proved to be nearly fatal to my academic career when I pursued it last. Now that I have a good run going, I could probably try to just go all-in on matcha, but no caffeine is almost entirely out of the question given my mathematical aptitude and motivation apparently relies on it.

Maybe try probiotics, also? Caffeine can cause issues for bowel flora/fauna (read up on taking iron supplements and coffee being a problem) and competes with uridine, so if you can manage to 'nix it for a month for testing, could be helpful.

[BioFreak]

try mucuna pruriens seed powder, aprox 5g/day (no extract). I don't need coffee since I am using it, and if you are suffering from a dopamine deficit this will improve it too.

[Reformed-Redan]

Hi MrHappy. Again thanks for the great thread. The uridine you ordered from your supplier had the cas # 58-96-8 or 3387-36-8? Because the supplier you ordered from made a new batch in December. Not sure if plain uridine is as effective as the 5'-monophosphate disodium...
Here is their COA:

[MrHappy]

Hi MrHappy. Again thanks for the great thread. The uridine you ordered from your supplier had the cas # 58-96-8 or 3387-36-8? Because the supplier you ordered from made a new batch in December. Not sure if plain uridine is as effective as the 5'-monophosphate disodium...
Here is their COA:

I bought CAS 3387-36-8, but vanilla uridine should be fine. 33% smaller doses, by weight, would be needed for straight uridine compared to UMP.

[Strelok]

Have you tried the plain uridine yourself, MrHappy?

[MrHappy]

Have you tried the plain uridine yourself, MrHappy?

No, I've only read about it being used in human trials.

[Strelok]

Have you tried the plain uridine yourself, MrHappy?

No, I've only read about it being used in human trials.

Ok, thanks.

[Reformed-Redan]

I'm on my phone right now. Can someone research if it degrades faster. The vanilla uridine?

[peakplasma]

I'm on my phone right now. Can someone research if it degrades faster. The vanilla uridine?

I'm really not sure.. there may not be much difference.

Here is what I found

For UMP - 3387-36-8

Chemical stability
Stable under recommended storage conditions.

Materials to avoid
Strong oxidizing agents

Conditions for safe storage
Keep container tightly closed in a dry and well ventilated place.
Recommended storage temperature: - 20 °C

For Uridine - 58-96-8

Chemical stability
Stable under recommended storage conditions.
Conditions for safe storage

Materials to avoid
Strong oxidizing agents

Keep container tightly closed in a dry and well-ventilated place.

[BioFreak]

Have you tried the plain uridine yourself, MrHappy?

No, I've only read about it being used in human trials.

Do you remember how those results were compared with ump and/or tau? Equal to one of them, better, or worse?

[MrHappy]

Have you tried the plain uridine yourself, MrHappy?

No, I've only read about it being used in human trials.

Do you remember how those results were compared with ump and/or tau? Equal to one of them, better, or worse?

Same as UMP as far as I know.

[BioFreak]

Sounds great... cause I can get the powder here. I am in a good position to judge the differences now too, cause yesterday I received uridine 300mg capsules from cardiovascular research. So I gonna try and get the powder and see what the differences are.
Question is, if there is some kind of adaptation to uridine, if there is, then the first one would always feel the best...

Took 1 in the evening and 1 just prior to going to bed, each time together with o-3. Also, I happen to take mucuna pruriens seed powder regularly, so dopamine should be in check.

So far I feel great, motivated, a little bit of "I was just on vacation" feeling, I feel more aware of my reality (not a "higher resolution" effect like what I had when I increased dopamine, more like I am more aware of all the sensory input). This morning after I woke up one thought kept repeating itself in my mind: "I want to get things DONE!!" which is not usual for me, normally I have to force myself to do stuff.

Also I seem to have a small tinnitus... no biggie though.

BUT... all of what I wrote could be placebo, since I've read a lot about its effects and side effects, so I knew what to expect. I hope it is not, but only time will tell... If it stays that way... I'm sold.

Only problem is that in europe its very expensive, its, depending on source about 1,6-3€ a day, thats about 2-4 US dollars a day. And the cheapest source, that is 1,6€/day is only available if I purchase uridine powder 250g for about 500€ :/ Guaranteed pharma quality then, though. These prices are for a dosage of 600mg/day.

[BioFreak]

Yesterday I was emotionally easily irritable in the morning (had some negative situations, and they affected me big time emotionally)... but after the second dose of ump in the evening nothing could shake my emotions. I was just in control.
I am not sure it is the uridine(could also have been that the negative effects were 6 hours in the past and I just got over it), but the effect was pretty strong.

Now I am wondering - anyone used higher dosages of ump to keep emotions in check? Right now I'm doing home care for my grandma, and its emotionally very taxing so this would be great.

[MrHappy]

Yesterday I was emotionally easily irritable in the morning (had some negative situations, and they affected me big time emotionally)... but after the second dose of ump in the evening nothing could shake my emotions. I was just in control.
I am not sure it is the uridine(could also have been that the negative effects were 6 hours in the past and I just got over it), but the effect was pretty strong.

Now I am wondering - anyone used higher dosages of ump to keep emotions in check? Right now I'm doing home care for my grandma, and its emotionally very taxing so this would be great.

Yes..

Dose twice a day and consider sublingual doses @ around 250mg.

Maybe warn your partner that you may be a bit unemotional for a few days?

[blueinfinity]

what are some good teas in replacement of green tea if you do not recommend caffeine, or is that ok? i usually drink 5-6 cups a day

[bobz1lla]

Maybe warn your partner that you may be a bit unemotional for a few days?

This ^

I've been liking 150mg ump sub in the morning. It feels less intense. The emotional dullness was becoming apparent at 300mg.

what are some good teas in replacement of green tea if you do not recommend caffeine, or is that ok? i usually drink 5-6 cups a day

I'm a fan of Rooibos from South Africa. I'm pretty sure there's no caffeine.

[alecnevsky]

I'm on my phone right now. Can someone research if it degrades faster. The vanilla uridine?

I'm really not sure.. there may not be much difference.

Here is what I found

For UMP - 3387-36-8

Chemical stability
Stable under recommended storage conditions.

Materials to avoid
Strong oxidizing agents

Conditions for safe storage
Keep container tightly closed in a dry and well ventilated place.
Recommended storage temperature: - 20 °C

For Uridine - 58-96-8

Chemical stability
Stable under recommended storage conditions.
Conditions for safe storage

Materials to avoid
Strong oxidizing agents

Keep container tightly closed in a dry and well-ventilated place.

-20C does this mean we should be storing the UMP in the fridge?

[peakplasma]

-20C does this mean we should be storing the UMP in the fridge?

In the freezer.

[BioFreak]

I have to take 900mg/day plus to get rock hard emotional stability... (this is with cardiovascular research ump 300mg/cap, sublingual). 300-600mg/day are good for elevated mood, motivation so far. Maybe, once the body is adapting/repairing the brain, less will be more effective?

I'm already getting more productive. yay! But, I also started with forskolin + artichoke extract.

[MrHappy]

what are some good teas in replacement of green tea if you do not recommend caffeine, or is that ok? i usually drink 5-6 cups a day

I like jasmine, rose or chamomile, personally. The first 2 go well with milk.