2844 replies to this topic

[alecnevsky]

For me, up to 300mg produces no "numbing" just intensely good concentration. When people say numbing do they commonly refer to being numb around people or numb even when watching movies, reading etc? In the former case, I think it really depends on your "extraversion" baseline. The latter would imply some unrewarding and therefore unproductive numbing effects. I never experienced the numbing effects outside social situations to any noticeable extent.

I do know, that 300mg ump + 200mg Modafinil + other fun stuff will make you into a merciless efficiency zombie. Thusly, I add some Suni to function as my mood stabilizer.

Edited by alecnevsky, 12 April 2013 - 07:39 PM.

[killshot]

Ordered more Uridine this morning, found this googling Uridine ump, half tempted to try it. Uridine dose is sorta low. Is Uridine gaining popularity.



http://www.pureformu...h.DaJQRzUd.dpbs

[Strelok]

Ordered more Uridine this morning, found this googling Uridine ump, half tempted to try it. Uridine dose is sorta low. Is Uridine gaining popularity.



http://www.pureformu...h.DaJQRzUd.dpbs

Why not just order pure UMP or TAU? That does look like a nice mix, but the uridine dose is fairly low to take that formulation for the purposes of taking uridine.

[killshot]

I did order 300mg Uridine capsules, just thought it was interesting I hadn't seen that supplement before.

[BioFreak]

Yesterday, the emotional stabilizing effect of uridine did not come into play until I increased my dosage to 1200mg uridine - and that did not help either, until I increased my mucuna dosage. Seems like the brain needs more dopamine when using uridine? That would explain the initially strong effects, when enough dopamine was available, dopamine levels from there on were declining, decreasing uridines effect. Hm.
So today I'll be back at 600mg/day (ump, all subl.), and increase mucuna to see what happens.

Edited by BioFreak, 14 April 2013 - 08:27 AM.

[MrHappy]

Yesterday, the emotional stabilizing effect of uridine did not come into play until I increased my dosage to 1200mg uridine - and that did not help either, until I increased my mucuna dosage. Seems like the brain needs more dopamine when using uridine? That would explain the initially strong effects, when enough dopamine was available, dopamine levels from there on were declining, decreasing uridines effect. Hm.
So today I'll be back at 600mg/day (ump, all subl.), and increase mucuna to see what happens.

Those are very large doses - there may be extra nutritional requirements/issues with exhausting related pathways. I would also caution you in general about dosing that high..

[hani]

Where to find uridine ump powder in Europe/UK?

I found this:
http://www.detoxpeop...t_detail&p=1444 (UMP) 60caps 300mg 32gbp
http://www.detoxpeop...t_detail&p=1340 (TAU) 60caps 25mg 23gbp

But I read through the whole thread, and most seems to have positive experience on UMP not TAU.

[Renegade]

Thanks for the link. I have ordered the UMP. I had a negative reaction to TAU and will report back my experiences with UMP.

[hani]

Nobody knows of a bulk powder source for ump in europe/uk?

[sparkk51]

Are you keeping your UMP in the freezer MrHappy?

[blueinfinity]

is this a replacement for artichoke+forskolin..... Different.... or completely unrelated

im going for my uridine purchase this week after determining the right suppliers and then read good stuff about artichoke+forskolin

[MrHappy]

Are you keeping your UMP in the freezer MrHappy?

The big stash is in the freezer, yes. Current month's rations in the vitamin cupboard.

is this a replacement for artichoke+forskolin..... Different.... or completely unrelated

im going for my uridine purchase this week after determining the right suppliers and then read good stuff about artichoke+forskolin

Some complementary aspects.

[norepinephrine]

Blueinfinity - I think the idea behind uridine/DHA/choline is that it's a chronically administered stack designed to promote brain growth over the mid to long-term, though acute effects certainly exist with each individual dose (and in my experience, are fairly subtle until you break the 250mg sublingual threshold). Uridine modulates dopamine and is purported to enhance receptor density in the long-term, but it certainly doesn't act like a traditional dopaminergic in the short term.

On the other hand, CILTEP is more of an acute reaction (and that's basically the point), whereas the long-term aspects of that stack are less clear and still being actively worked out by abelard lindsay and others who take it regularly. No formal studies exist for the combination of forskolin+artichoke - it's all theoretical, but in the individual cases of multiple users on here (myself included), the combination of ingredients can be quite potent in dopaminergic nature, and a step above your regular morning coffee.

If you're going to dose both, make sure to take uridine at a different time in the day than you would caffeine.

Edited by norepinephrine, 16 April 2013 - 01:40 PM.

[MrHappy]

Blueinfinity - I think the idea behind uridine/DHA/choline is that it's a chroncially administered stack designed to promote brain growth over the mid to longterm, though acute effects certainly exist with each individual dose (and in my experience, are fairly subtle until you break the 250mg sublingual threshold). Uridine modulates dopamine and is purported to enhance receptor density in the long-term, but it certainly doesn't act like a traditional dopaminergic in the short term.

On the other hand, CILTEP is more of an acute reaction (and that's basically the point), whereas the longterm aspects of that stack are still less clear and being actively worked out by abelard lindsay and others who take it regularly. No formal studies exist for the combination of forskolin+artichoke - it's all theoretical, but in the individual cases of multiple users on here (myself included), the combination of ingredients can be quite potent in dopaminergic nature, and a step above your regular morning coffee.

If you're going to dose both, make sure to take uridine at a different time in the day than you would caffeine.

Bingo - I can't stress enough how much uridine and caffeine don't go together. I wouldn't normally suggest them within 14 hours of each other.

[Judd Crane]

MrHappy - I've been on uridine for a bit longer than a month, and switched to evening dosing after reading your recommendation. In that same time period, my sleep has suffered - I can't maintain 7-8 hours of uninterrupted sleep without waking at least once. At this point, I'm trying to figure out if uridine was simply correlative to that, or causative. As such, I cut it out entirely and noticed slightly improved effects, but I've also been on a brief break from coffee. The experiment continues.

Are you still having trouble with waking up during the night? I'm having the same experience.

[norepinephrine]

Not as much anymore - I've targeted a few different things that have proven beneficial to my sleep.

1) Previously, magnesium was having almost no effect on enhancing my sleep (whereas a year ago, it was one of the most dependent supplements in my arsenal for sleep quality). Correcting a vitamin D deficiency has once again made magnesium effective - this makes perfect sense given the synergistic relationship between calcium, magnesium, vitamin D and vitamin K.
2) I've also been taking SN Theanine Serene, which aside from the title ingredient, contains taurine, magnesium, GABA, Relora and holy basil. That's proven immensely effective for staying asleep, though the effects stay even if I miss a dosage. I'd speculate magnesium (and possibly taurine) would be the reasons why.
3) Taking a temporary break from caffeine also helped, as well as taking adrenal adaptogens (i.e., Jarrow and Gaia's herbal adrenal supplements), though nowhere near as much as the first two. (Well, the caffeine holiday did help reduce tolerance, which was a plus - but ceasing use didn't completely improve sleep on its own.)

In sum, I'm not really sure uridine was causing impaired sleep so much as a lack of vitamin D and magnesium, at least for my individual case. I did quit taking uridine right before bed though, just in case.

[BioFreak]

@MrHappy

I've doubled my mucuna dosage, and while I could not reproduce the initial strong effects of higher dose uridine, it seems to go well now at 600-900mg/day. I wish I knew how to reproduce it. Increasing uridine seems to be the wrong way. Maybe there is still not enough dopamine.

Is there somewhere a list of pathways that I could look into? I *should* have addressed catecholamines with the increased mucuna seed powder, but I don't know what else I should check. I also take o3's but I take lecithin instead of gpc-choline. Maybe supplementing with magnesium could be worth a shot.

Why is caffeine so bad in combination with uridine?

Edited by BioFreak, 16 April 2013 - 02:22 PM.

[hani]

My order of Uridine UMP has just shipped. It's in capsules, so you think taking 300mg in the morning, 300mg before bed orally should be enough? If not, should I try emptying the content of the capsules under my tongue?

By the way, anyone with bipolar have had a consistently good experience with Uridine? I have a history of bipolar in the family (mom, aunt) and I personally have obsessive thoughts, anxiety problems and sometimes insomnia.

[hani]

Have you guys seen this:
http://www.pharmatim...ug_failure.aspx
old news but still..

[MrHappy]

Have you guys seen this:
http://www.pharmatim...ug_failure.aspx
old news but still..

Yes, whereas in other trials there were much better results. I haven't seen all of the parameters for that trial, but from memory, they were taking 18000mg of TAU per day and unsurprisingly having issues - at the very least, male diarrhea and compliance... Probably had a lot to do with it.

My order of Uridine UMP has just shipped. It's in capsules, so you think taking 300mg in the morning, 300mg before bed orally should be enough? If not, should I try emptying the content of the capsules under my tongue?

By the way, anyone with bipolar have had a consistently good experience with Uridine? I have a history of bipolar in the family (mom, aunt) and I personally have obsessive thoughts, anxiety problems and sometimes insomnia.

Just start with 1 capsule morning and night + cofactors.

There have been a few people here that have seen success for ocd, bipolar, anxiety, etc. Jchief has a thread 'positive result from uridine, etc'.

@MrHappy

I've doubled my mucuna dosage, and while I could not reproduce the initial strong effects of higher dose uridine, it seems to go well now at 600-900mg/day. I wish I knew how to reproduce it. Increasing uridine seems to be the wrong way. Maybe there is still not enough dopamine.

Is there somewhere a list of pathways that I could look into? I *should* have addressed catecholamines with the increased mucuna seed powder, but I don't know what else I should check. I also take o3's but I take lecithin instead of gpc-choline. Maybe supplementing with magnesium could be worth a shot.

Why is caffeine so bad in combination with uridine?

What multi are you taking?

Caffeine - competes with uridine for some of the same receptors. Also, uridine amplifies caffeine's effects, so anxiety and sleep issues usually follow.

[hani]

Have you guys seen this:
http://www.pharmatim...ug_failure.aspx
old news but still..

Yes, whereas in other trials there were much better results. I haven't seen all of the parameters for that trial, but from memory, they were taking 18000mg of TAU per day and unsurprisingly having issues - at the very least, male diarrhea and compliance... Probably had a lot to do with it.

And I'm guessing they didn't use fish oil either? Got a link for the parameters of the study?

[MrHappy]

Have you guys seen this:
http://www.pharmatim...ug_failure.aspx
old news but still..

Yes, whereas in other trials there were much better results. I haven't seen all of the parameters for that trial, but from memory, they were taking 18000mg of TAU per day and unsurprisingly having issues - at the very least, male diarrhea and compliance... Probably had a lot to do with it.

And I'm guessing they didn't use fish oil either? Got a link for the parameters of the study?

Think it is in the first 2 or 3 pages of this thread.

[bobz1lla]

Does anyone know where the uridine in SN's bulk product originates from? I'm gonna guess Brewer's Yeast?

[Hebbeh]

Does anyone know where the uridine in SN's bulk product originates from? I'm gonna guess Brewer's Yeast?

I don't believe it's an extract. I believe chemical synthesis. Probably in a Chinese Lab.

[BioFreak]

What multi are you taking?

Caffeine - competes with uridine for some of the same receptors. Also, uridine amplifies caffeine's effects, so anxiety and sleep issues usually follow.

Just a b complex, one a day:

Nutritional Information for B50 Complex Tablets
Each tablet provides: %ECRDA
Thiamin 50.0mg 4545
Riboflavin 50.0mg 3571
Niacin 50.0mg 312
Vitamin B6 50.0mg 3571
Folic Acid 400.0μg 200
VitaminB12 50.0μg 2000
Biotin 50.0µg 100
Pantothenic Acid 50.0mg 833
Choline Bitartate 50.0mg *
Inositol 50.0mg *
Para-Amino Benzoic Acid (PABA) 15.0mg *

Anything else I should consider?

Edited by BioFreak, 17 April 2013 - 07:13 AM.

[MrHappy]

What multi are you taking?

Caffeine - competes with uridine for some of the same receptors. Also, uridine amplifies caffeine's effects, so anxiety and sleep issues usually follow.

Just a b complex, one a day:

Nutritional Information for B50 Complex Tablets
Each tablet provides: %ECRDA
Thiamin 50.0mg 4545
Riboflavin 50.0mg 3571
Niacin 50.0mg 312
Vitamin B6 50.0mg 3571
Folic Acid 400.0μg 200
VitaminB12 50.0μg 2000
Biotin 50.0µg 100
Pantothenic Acid 50.0mg 833
Choline Bitartate 50.0mg *
Inositol 50.0mg *
Para-Amino Benzoic Acid (PABA) 15.0mg *

Anything else I should consider?

Zinc, magnesium, selenium.. and other trace minerals.

[BioFreak]

I'm taking iodine and selenium already... just started with mg. Gotta get a zinc supplement though. Maybe I'll find a good multi for the other ones. Thanks for your replies MrHappy!

[DamnedOwl]

I'm just getting together the components of this stack, and hopefully everything should be with me in a week or so.

One question though:

Would there be any problems taking this stack with ALCAR?

I take 3000mg of ALCAR per day split into two equal doses morning and early afternoon.

[MrHappy]

I'm just getting together the components of this stack, and hopefully everything should be with me in a week or so.

One question though:

Would there be any problems taking this stack with ALCAR?

I take 3000mg of ALCAR per day split into two equal doses morning and early afternoon.

ALCAR is fine. You should probably skip the choline component if you are taking ALCAR.

[DamnedOwl]

I'm just getting together the components of this stack, and hopefully everything should be with me in a week or so.

One question though:

Would there be any problems taking this stack with ALCAR?

I take 3000mg of ALCAR per day split into two equal doses morning and early afternoon.

ALCAR is fine. You should probably skip the choline component if you are taking ALCAR.

Okay. Thank you.