2844 replies to this topic

[Droplet33]

Only if i take too much of it, lower your dosage and you should be ok.

[Lufega]

Ive also noticed that taking zinc at the same time speeds me up. To avoid this, i take uridine in the am and zinc later in the afternoon.

Does it make a difference if i take fish oil at a different time from uridine? When i take it in the morning, i get some depressive sx. Figured id take it at night as well. Ideas ?

[happy santa]

Does anybody feel any different effects of alcohol while on the uridine stack? I did not notice any difference but at the time I consumed only one beer

[cgriffin]

Hey Santa, Havnen't you been taking this stack for the last 3 years or so? You've only had one beer during that time? haha. I drank a bunch of beer last week and didn't feel any different. I had a terrible hangover the next day as well but I think thats just because I don't think very often and I'm getting old.

BTW - Does anyone do a few days on and a few days off? My brother started taking weekends off so he can drink coffee then and he likes it more. Any thoughts?

[happy santa]

Hey Santa, Havnen't you been taking this stack for the last 3 years or so? You've only had one beer during that time? haha. I drank a bunch of beer last week and didn't feel any different. I had a terrible hangover the next day as well but I think thats just because I don't think very often and I'm getting old.

Haha no I have been on this stack for about the last 3 months my friend, not years .

[cgriffin]

Ohh ok I think I assumed since the thread was started by you in 2011 you were also taking it at that time.

[MrSliz1724]

The combination of TAU + zinc seems like it will be great for increasing dopamine levels, decreasing uptake of dopamine, and modulating dopamine receptors.

Magnesium along this will be act as an NMDA agonist along with its long list of neruological functions.

Forskolin and PDE4 inhibitor (artichoke or luteolin) will increase potentiation. Also will result in increase in acetylcholineesterase as well as deplete dopamine levels.

Alpha-GPC/ALCAR will work to increase acetylcholine levels to balance out the loss from ciltep as well as provide the additional benefit alongside TAU.

Some have noticed anxiety, jitters, highly stimmed out feeling etc. from ciltep and/or uridine stack and so for this 5-HTP could be a great bonus to increase serotnin to provide a nice calming effect.

Now with this in mind, obvioulsly a very precise ratio will need to be tested out for to be able to combine these together but do we think the TAU + Zinc will be enough to increase dopamine levels for CILTEP or do we think phenylalanine will be needed?

Thoughts on this?

[happy santa]

Now with this in mind, obvioulsly a very precise ratio will need to be tested out for to be able to combine these together but do we think the TAU + Zinc will be enough to increase dopamine levels for CILTEP or do we think phenylalanine will be needed?

Thoughts on this?

Is there any specific reason why you only mentioned TAU? I have not tried TAU yet, but I definately feel the stimulating effect of zinc together with UMP.

[MrSliz1724]

Now with this in mind, obvioulsly a very precise ratio will need to be tested out for to be able to combine these together but do we think the TAU + Zinc will be enough to increase dopamine levels for CILTEP or do we think phenylalanine will be needed?

Thoughts on this?

Is there any specific reason why you only mentioned TAU? I have not tried TAU yet, but I definately feel the stimulating effect of zinc together with UMP.

UMP is best when used sublingually and TAU will have better bioavailability when taken orally.

[happy santa]

Now with this in mind, obvioulsly a very precise ratio will need to be tested out for to be able to combine these together but do we think the TAU + Zinc will be enough to increase dopamine levels for CILTEP or do we think phenylalanine will be needed?

Thoughts on this?

Is there any specific reason why you only mentioned TAU? I have not tried TAU yet, but I definately feel the stimulating effect of zinc together with UMP.

UMP is best when used sublingually and TAU will have better bioavailability when taken orally.

Yes, that I know, but I was more inclining if you meant TAU had an advantage over UMP in its effect when combined with zinc. I mean that UMP works very well, too, together with zinc

Edited by happy santa, 14 March 2014 - 09:31 PM.

[MrSliz1724]

Now with this in mind, obvioulsly a very precise ratio will need to be tested out for to be able to combine these together but do we think the TAU + Zinc will be enough to increase dopamine levels for CILTEP or do we think phenylalanine will be needed?

Thoughts on this?

Is there any specific reason why you only mentioned TAU? I have not tried TAU yet, but I definately feel the stimulating effect of zinc together with UMP.

UMP is best when used sublingually and TAU will have better bioavailability when taken orally.

Yes, that I know, but I was more inclining if you meant TAU had an advantage over UMP in its effect when combined with zinc. I mean that UMP works very well, too, together with zinc

Ahh haha no. Just convienience factor =p.

[MrSliz1724]

Lol so any into in that happy?

[hephaestus]

Ohh ok I think I assumed since the thread was started by you in 2011 you were also taking it at that time.

Mr. Happy is not happy santa.

[happy santa]

yeah I chuckle ho-ho-ho whenever I get happy, thats the major difference between us

[hephaestus]

I just opened the ump I bought from nootropics depot and it is definitely different from the superior nutraceuticals ump. It is more powdery and doesn't taste salty like the sn ump. It tastes a bit solventy, maybe a hint of ether. CAS matches ump disodium, lot number 20130315.

[Babychris]

I think I will try this stack soon, I'm already taking fish oïl (that's tricky because I wasn't able to bear capsules AT ALL now I'm taking Carlson finest liquid bottle it's ok but It increase my anxiety and makes me kind of drowsy/Weird head feeling) B vitamins don't know too because it makes me sleepy and anxious, and for choline I already have CDP choline which is good, not faboulous but better on my chemistry than Alpha GPC but I think that Huperzine fit better on me particurly for my short-mid term goal.. I'm currently taking phosphatidylserine too which I will couple for sure with some creatine MH

Edited by Babychris, 17 March 2014 - 08:16 PM.

[Strangelove]

I just opened the ump I bought from nootropics depot and it is definitely different from the superior nutraceuticals ump. It is more powdery and doesn't taste salty like the sn ump. It tastes a bit solventy, maybe a hint of ether. CAS matches ump disodium, lot number 20130315.

Same here, I have used it for couple days now, and although I am having same good effects with my previous batch, the taste bothers me. The positive side is the really good price and some helpful arrangement they did for me, in order to easily place an order as an international costumer. I ll order again from them, but probably not this specific batch of uridine, even when its half the price from any other store I searched on line. Although can be an option if you are very short on cash.

[chemicalambrosia]

I just opened the ump I bought from nootropics depot and it is definitely different from the superior nutraceuticals ump. It is more powdery and doesn't taste salty like the sn ump. It tastes a bit solventy, maybe a hint of ether. CAS matches ump disodium, lot number 20130315.

What a shame, I just ordered some from them too because of their coupon code. I can give another subjective comparison to Superior Nutraceutical's product when it arrives. The uridine UMP is pretty tasteless other than that slight salty taste, so I imagine any slight impurity would chance the taste quite a bit...

[uekte]

Does anybody know how Cod Liver Oil measures up in terms of DHA/EPA and whether it would be suitable for this stack? After having tried numerous brands of Fish/Flax Seed oil I am left in know doubt that it is responsible for some very undesirable side effects involving both my skin and my digestion.

High quality fermented CLO on the other hand causes me no such problems. Anyone have any experience using high quality CLO + GPC + Uridine?

[chemicalambrosia]

I just opened the ump I bought from nootropics depot and it is definitely different from the superior nutraceuticals ump. It is more powdery and doesn't taste salty like the sn ump. It tastes a bit solventy, maybe a hint of ether. CAS matches ump disodium, lot number 20130315.

Same here, I have used it for couple days now, and although I am having same good effects with my previous batch, the taste bothers me. The positive side is the really good price and some helpful arrangement they did for me, in order to easily place an order as an international costumer. I ll order again from them, but probably not this specific batch of uridine, even when its half the price from any other store I searched on line. Although can be an option if you are very short on cash.

Mine appears to be basically the same as the current stuff from Superior Nutraceuticals. I've tasted it a few times and can't detect the taste of any solvent, though I think the jar itself might give off an odor. It is lot number 20131215.

[Mr. Pink]

does Uridine make anyone else irritable?

yes, even tiny amounts of ump made me irritable and depressed. mr happy said it was likely cause i still use caffeine, but i'm not willing to give that proven cognitive enhancer up quite yet.

[Strangelove]

I just opened the ump I bought from nootropics depot and it is definitely different from the superior nutraceuticals ump. It is more powdery and doesn't taste salty like the sn ump. It tastes a bit solventy, maybe a hint of ether. CAS matches ump disodium, lot number 20130315.

Same here, I have used it for couple days now, and although I am having same good effects with my previous batch, the taste bothers me. The positive side is the really good price and some helpful arrangement they did for me, in order to easily place an order as an international costumer. I ll order again from them, but probably not this specific batch of uridine, even when its half the price from any other store I searched on line. Although can be an option if you are very short on cash.

Mine appears to be basically the same as the current stuff from Superior Nutraceuticals. I've tasted it a few times and can't detect the taste of any solvent, though I think the jar itself might give off an odor. It is lot number 20131215.

Mine has a different lot number: 20130315
editing to say that is the same lot with hephaestus, but different to chemicalambrosia, so it makes sense with the different experiences mentioned.

Edited by Strangelove, 23 March 2014 - 01:29 PM.

[Strangelove]

does Uridine make anyone else irritable?

yes, even tiny amounts of ump made me irritable and depressed. mr happy said it was likely cause i still use caffeine, but i'm not willing to give that proven cognitive enhancer up quite yet.

As I have privately discussed with Lucky Pierre I have the same experience from larger doses.

[Mr. Pink]

As I have privately discussed with Lucky Pierre I have the same experience from larger doses.

interesting, what amounts do you use and do you still drink caffeine? even like 50mg ump would mess up my mood

[penisbreath]

I'm pretty sensitive to stuff and found I could tolerate about 50-100mg, though it still kinda flattened and depressed my mood. I never drank caffeine with it.

[Strangelove]

As I have privately discussed with Lucky Pierre I have the same experience from larger doses.

interesting, what amounts do you use and do you still drink caffeine? even like 50mg ump would mess up my mood

Unfortunately I developed a quick tolerance to the positive effects, having a "stressed anxiety" over 70-80mg myself, still I maintain a better baseline than when I started. I ll continue with smaller doses to see how things goes. I do not drink coffee with it.

[happy santa]

Some users have reported that they feel a serotonergic effect when taking uridine. I found a study that could support this theory, showing how uridine modulated serotonin release, in mice exposed to social isolation.

"Uridine, a pyrimidine nucleoside present in many foods, is a modulator in the central nervous system. Uridine behaves as an anticonvulsant in a number of seizure models and also promotes sleep. In this study, we exposed mice to social isolation stress for 4 weeks and then investigated the effects of uridine on the changes induced by stress. Social isolation stress increased locomotor activity in an open field. This increase in locomotor activity was suppressed by uridine. Moreover, uridine prevented social isolation stress-induced aggressive behavior. To investigate how uridine administration modifies neurotransmitters, we estimated the concentration and release of neurotransmitters in the prefrontal cortex. Uridine modulated serotonin release. Our results suggest that uridine attenuates the behavioral changes due to social isolation stress in mice."

https://www.jstage.j...19_455/_article

[Arjuna]

So it modulates seratonin and dopamine both, as well as being somewhat of a nmda antagonist effect so TAKE IT AT NIGHT. You need bursts and ebbs and flows of neurotransmitters for social responses and emotional inspiration. Only exception is if you have bipolar that is too far out of control.

Uridine and nmda: http://www.ncbi.nlm....ubmed/19039933/

So take uridine and magnesium at night for happy receptors in the morning. Also take zinc in the morning, it is a dopamine reputable inhibitor (it lowered my sleep quality at night).

Edited by Arjuna, 27 March 2014 - 05:37 PM.

[happy santa]

So it modulates seratonin and dopamine both, as well as being somewhat of a nmda antagonist effect so TAKE IT AT NIGHT. You need bursts and ebbs and flows of neurotransmitters for social responses and emotional inspiration. Only exception is if you have bipolar that is too far out of control.

Uridine and nmda: http://www.ncbi.nlm....ubmed/19039933/

So take uridine and magnesium at night for happy receptors in the morning. Also take zinc in the morning, it is a dopamine reputable inhibitor (it lowered my sleep quality at night).

This is the only study I've found far that shows uridine modulating serotonin, so one could still argue that it is seen as as too little sources to establish serotonin-release as one of uridine's primary mechanisms of action. So if anyone could find more studies showing uridine having a serotonergic effect, that would be great.

Also as a sidenote for people who take zinc, since it might help someone here, zinc is better to be taken without high-fibre food, calcium and magnesium, since it interferes with zinc's absorbtion.

Edited by happy santa, 27 March 2014 - 07:36 PM.

[celebes]

Uridine and Uridine Monophosphate are not the same thing.