52 replies to this topic

[Ark]

I'm looking into a bulk order, pm me with interest.

[Ampa-omega]

if you guys do setup a bulk order i have some cash to split in, thats if you do though. (and depending on final price..)

Edited by Ampa-omega, 24 February 2012 - 08:44 AM.

[Googoltarian]

Does anybody know what would be good dose for a human?

Did you make some? I'll test it for you

Not yet. I`m still looking for a supplier of 5-hydroxynicotinic acid, as my usual supplier wants a fortune for small amount of it.

Nobody knows how much human dose should be? So maybe tell me what dose are you going to take then

[Ampa-omega]

if you guys do setup a bulk order i have some cash to split in, thats if you do though. (and depending on final price..)

'
actually sorry i will retract that statement, i am going to be taking a needed break from the internet to focus on some priorities, but I will be saving up money, so when you guys do setup a bulk order for this or *coluracetam*, message me, ill try to jump in on it.

might I suggest that we setup an official thread focused on the setting up of bulk orders?
we list supplier, prices, order info, people list in if they will participate on the group order and we got a system running, i definitely am interested in this.

[zeroskater6979]

how do buying groups work? (who actually places the order and pays?, shipping would be weird, etc)

[unregistered_user]

how do buying groups work? (who actually places the order and pays?, shipping would be weird, etc)

This. I've never been involved with a group buy before.

[manic_racetam]

how do buying groups work? (who actually places the order and pays?, shipping would be weird, etc)

This. I've never been involved with a group buy before.

Neither have I but I guess it would work a couple of different ways depending on the supplier.

It could be done with paypal, where you choose someone to be the "trusted agent" which means they hold all the money while people contribute. Then, once everyone has sent money to the "trusted agent" they then make payment to the supplier. This has to be a really trustworthy person though, for obvious reasons.

But as people send their portion of payment they mark it down in a google document or something, some sort of document viewable to all those participating in the purchase. Once all payments are marked as received and order is placed, then the dividing up the shipment takes place, likely from the "trusted agent".

Then they have to ship each individual package to the respective buyers... a cost that should be calculated in the original order. Well, that's the general idea that I've got in my head at least.

[unregistered_user]

That makes sense. Good explanation.

[thedevinroy]

I guess Ark would set that up, since he took initiative. I'd be down for spending $50 on a little NooGlutyl.

And the human dose is high... not that high, but considerably more than Noopept, for example. I'll get back to you on that.

[thedevinroy]

Using Allometric scaling, exponent factor of 0.75, rat weight of 0.15kg, human weight of 70kg.

Normalized D2 Dopaminergic Function in Diazepam Withdrawal
Human Equiv. of 50mg/kg in Rats: 753mg

Maximum Plasma Concentration
Human Equiv. of 500mg/kg in Rats: 7530mg
(The half life in rats was 0.73hr and 2.3hr for rabbits at smaller doses)

So... it's about the same as a Piracetam, maybe a little more on the Aniracetam spectrum of effectiveness per mg.

[Ampa-omega]

ill pitch in $50

[manic_racetam]

Using Allometric scaling, exponent factor of 0.75, rat weight of 0.15kg, human weight of 70kg.

Normalized D2 Dopaminergic Function in Diazepam Withdrawal
Human Equiv. of 50mg/kg in Rats: 753mg

Maximum Plasma Concentration
Human Equiv. of 500mg/kg in Rats: 7530mg
(The half life in rats was 0.73hr and 2.3hr for rabbits at smaller doses)

So... it's about the same as a Piracetam, maybe a little more on the Aniracetam spectrum of effectiveness per mg.

So we're thinking 750-1,000mg dose? BID?

So we'd want about a two week trial run at least to give it a chance... well, I would like that long of a trial. So twice a day dosing at .75-1g for 14 days gives 21-28 grams for a two week trial.

I'd be curious to see how much googoletarian would charge for this stuff.... unless someone else finds another supplier.

[thedevinroy]

Using Allometric scaling, exponent factor of 0.75, rat weight of 0.15kg, human weight of 70kg.

Normalized D2 Dopaminergic Function in Diazepam Withdrawal
Human Equiv. of 50mg/kg in Rats: 753mg

Maximum Plasma Concentration
Human Equiv. of 500mg/kg in Rats: 7530mg
(The half life in rats was 0.73hr and 2.3hr for rabbits at smaller doses)

So... it's about the same as a Piracetam, maybe a little more on the Aniracetam spectrum of effectiveness per mg.

So we're thinking 750-1,000mg dose? BID?

So we'd want about a two week trial run at least to give it a chance... well, I would like that long of a trial. So twice a day dosing at .75-1g for 14 days gives 21-28 grams for a two week trial.

I'd be curious to see how much googoletarian would charge for this stuff.... unless someone else finds another supplier.

Hey if its like meth, it could go for a lot more. Jk... but demand is a factor. I hope this guy is level-headed and doesn't think its the new meth or E. Nerds want it... thus, a level-header would know it ain't the type of stuff to get hooked on... unless its NZT or something. A lot of synth chems run for $25/gram, and that's not even a days dose. Sad, yet true. Who is Googletarian?

[manic_racetam]

Hey if its like meth, it could go for a lot more. Jk... but demand is a factor. I hope this guy is level-headed and doesn't think its the new meth or E. Nerds want it... thus, a level-header would know it ain't the type of stuff to get hooked on... unless its NZT or something. A lot of synth chems run for $25/gram, and that's not even a days dose. Sad, yet true. Who is Googletarian?

Word on the street is he's a chemist in poland willing to custom synth certain noots. I'd say we should keep talk of price out of it till we get a quote. Don't want to give him any $25 ideas! LOL

I've sent a couple quotes to China in the meantime. Also, South Korean company listed on most of the chemical supply websites doesn't seem to exist.

[enemy]

I'm interested in trying this.

[enemy]

This compound appears to be water soluble? (googoltarian?)

I've successfully solublized noopept at 100mg/ml in 190pr ethanol, but I still worry about that 5% water continuously hydrolyzing my product. (googoltarian?)

[zeroskater6979]

this never really went anywhere huh?

[golden1]

Looked interesting.

[Godof Smallthings]

This sounds interesting.

If the operant conditioning results in rats are applicable to humans, as far as I understand, it could be ideal to take during any kind of learning situation, and possibly also useful for therapy geared toward social problems, anger management and anxiety issues.

[Eruditus]

It is established that nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM).

http://www.ncbi.nlm....pubmed/21476267

This concerns me. Regarding claims of purported lack of tolerance and withdrawals in comparison to other nootropics yet also claiming greater efficacy. It seems to me that any chemical with a greater and therefore stronger ability to bind to a receptor as a factor is going to positively correlate into increased development of tolerance by also multiplying down-regulation factor for that receptor? This is not based on scientific studies, yet you must get the elementary logic behind my reasoning; physiological processes follow the same patterns and do not magically differ from one drug to another. Seeing as we already know noopept use can lead to withdrawal symptoms when taking higher then standard dosage, it would seem to me that whatever is being claimed prior to post-marketing in a drug's development cycle is always to be taken with a pinch of salt.

[Geoffrey]

Interesting page of info on nooglutyl here: http://nootropicsupp....com/nooglutyl/  . Shame there doesn't seem to have been any real advance with it, as it sounds like it has some unique nootropic properties, as well as being possibly an ampakine. I guess if it strongly binds to the receptor it needs to be thoroughly tested for excitotoxic potential before anyone takes it.

Edited by Geoffrey, 22 May 2014 - 07:36 PM.

[somethingstrange]

Science.bio offers it now.

[tboneduggins]

hey guys longtime lurker here, I was registered at one time. I really would like to know dosage to help with memory. Possibly to assist in Dr. Lipton subconscious reprogramming from childhood trauma and after stroke repair.