1755 replies to this topic

[solarfingers]

Search this pdf for Epitalon...

http://www.anti-age-...10Abstracts.pdf

Conclusions: These results indicate that peptide bioregulators Epitalon, Lifagen and Vilon cause activation (deheterochromatinization) of chromatin in lymphocytes of old individuals. Our data can be important for revealing new information about the remodeling of constitutive and facultative heterochromatin induced the bioregulators in aging and aging pathology. Chromosome deheterochromatinization is an area where one should seek the ways for prolonging the lifespan.

Teimuraz Lezhava on Anti-aging peptide bioregulators indue reactivation of chromatin Session: On the Front Lines of Preventative and Anti-Aging Medicine

[solarfingers]

Retarding the cellular senescence by Epithalon and changes of telomere length and telomerase activity in the retarding process
GAO Wen-juan...

Effect of Epithalon on celluar telomere and tlomerase
GAO Wen-juan...

[solarfingers]

I do think it interesting that only after one peer reviewed study many have accepted and are taking c60-oo. Khavinson and his team of researchers performed in-depth studies of Epthialon... I think it would be easier to swallow if it were cheaper.

[solarfingers]

Peptide:#1
Name:Epitalon, Sequence Length:4, Quantity:200 mg, Purity:>98%, vials:1;
Sequence:{ALA}{GLU}{ASP}{GLY}
Modification:,

$180.49

[researchist]

This is a great thread. I have been following this and the dihexa thread for some time. This is my first post ever. Recently I have tried to obtain epitalon from biolumaresearch and found they do not sell to the US. I have put a buy order on Lookchem and I will only say don't do that. I do have a company that wants to make some for me, They are legitimate but before they quote, they want to know what form of salt, acetate, hcl or maybe amide, it needs to be. The literature I have seen indicate that different forms work, though I'm not a chemist, it seems like many forms were tried by Dr Khavinson. Can anyone tell me what form they have been successful with? Also I have seen the sequence represented as L-ALA l-GLU L-ASP GLY specifically and wonder if I should specify that exactly that as opposed to ALA-GLU-ASP-GLY. I would like to hear what this company quotes and if it is good would be glad to share the source, No doubt the price would come down with quantity. if someone could help me with the salt question I would appreciate it. What would be great, would be to get in on one of the group buys that seem to be going on. This is actually what prompted me to join at the moment, though life extension and nootropics is a long time interest. I had obtained epitalon from peptidelabs and was researching it for several weeks but they disappeared. I wonder what happened to them. I would like to continue my research as soon as possible. Can I get in on a group buy? I'm in the US.

[solarfingers]

There are a number of different sources and Genscript seems to be one that many have experience with. You can see my quote above which includes shipping. You can buy in quantities as small as 5 grams but the price is much cheaper per gram if you buy larger quantities. I personally don't see much purpose in sampling a small quantity since the effects can mostly be noticed over time. I don't know if there is any benefit in different forms as you have described. I believe most people are getting straight {ALA}{GLU}{ASP}{GLY}. You can create an account on Genscript and get up to 10 automated quotes at one time. Just enter the sequence {ALA}{GLU}{ASP}{GLY}... They currently have 25% off on peptide synthesis.

http://www.genscript.com/

[researchist]

Thanks for the feedback. Genscript registration requires a research organization. I still wonder if the L or R version of the amino acids might not make a difference unless it is somehow implied in the way sequences work. Also it seems like the form salt, amide etc, could have an influence on how the peptide is assimilated. Though I have noticed there are a lot of sharp folks here who would have caught that already if it is an issue. This is from one of Dr Khavinson's papers which seems like its saying that all forms are active. "There is proposed a pharmacological substance, which contains as its active base an effective amount of tetrapeptide of the formula L-alanyl-L-gluthamyl-L-asparagyl-glycine (L-Ala-L-Glu-L-Asp-Gly) or its salts of the amino group (acetate, hydrochloride, oxalate) and of carboxyl groups (the salts of metals - Natrium, Potassium, Calcium, Lithium, Zinc, Magnesium, and also the salts of organic and inorganic cations - ammonium and triethylammonium). The substance is proposed for parenteral, intranasal, oral administration, and local application. With respect to the invention, the method of premature ageing prevention implies prophylactic and/or therapeutic administration to a patient of the pharmacological substance in doses 0.01 to 100 mu g/kg of the body weight at least once a day for a period necessary for the achievement of a therapeutic effect.". That's all I could find anywhere about the structure. I find the synthesis specifications but to me it reads that only the amino acids are left in the end.

[solarfingers]

The substance is proposed for parenteral, intranasal, oral administration, and local application. With respect to the invention, the method of premature ageing prevention implies prophylactic and/or therapeutic administration to a patient of the pharmacological substance in doses 0.01 to 100 mu g/kg of the body weight at least once a day for a period necessary for the achievement of a therapeutic effect.".

Please post the source for this and all references from now on. It helps if we all understand the sources people are getting their information from.

Thanks!

[researchist]

My bad. The reference for the above extract is: Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application:
US Patent : US 6727227. January 20, 2000. That's the only information I have found that mentions the form it could take.

http://www.google.co...tents/US6727227http://www.google.co...tents/US6727227http://www.google.co...tents/US6727227http://www.google.co...tents/US6727227http://www.google.co...tents/US6727227 http://www.google.co...tents/US6727227

Sorry, nasty pasting accident

[solarfingers]

The substance is proposed for parenteral, intranasal, oral administration, and local application. With respect to the invention, the method of premature ageing prevention implies prophylactic and/or therapeutic administration to a patient of the pharmacological substance in doses 0.01 to 100 mu g/kg of the body weight at least once a day for a period necessary for the achievement of a therapeutic effect.".

So, if you do the math anyone who weighs approximately 185 lbs (84kg) could take anywhere between .84 gm to to 8.4 grams daily. Am I reading that correctly?

[researchist]

It depends on what mu means. If it is microgram (.000001 gram), which I think it is, then I think your calculations are off a bit.

[researchist]

8.4 milligrams is more along the lines that I have heard. Since I think 1 to 3 milligrams a day is what I was thinking is an average dosage. 8.4 might be a high end but I also think there are studies showing it is not toxic at much higher dosages than that. The smallest bioactive dose according to those numbers would be very very small. if that's true than 10 milligrams could last a long time..

[researchist]

Did you double check your math, I may be wrong. My order is under consideration at GenScript

[solarfingers]

"With respect to the invention, the method of premature ageing prevention involves prophylactic and/or therapeutic administration to a patient of the pharmacological substance in doses of 0.01 to 100 μg/kg of the body weight at least once a day for a period necessary for the achievement of a therapeutic effect."

This is a bit confusing... Let's see.

100 micrograms = 0.0001 gm

.01 micrograms = 0.00000001 gm

So dosages would be 0.00000084 gm to 0.0084 gm for a person weighing 84k (185lbs). God if that doesn't sound like a low number... Could that be correct? Everyone here is taking anywhere from 3 to 5 mg a day! If this is the case 1gm isn't even a conservative dosage.

I checked the reference and it is μg not mg or mu. μg is micrograms (corrected).

Edited by solarfingers, 16 July 2013 - 06:15 PM.

[daouda]

If they're considering up to 0.1mg per kg of bodyweight as a therapeutic dosage then 3 or 5 mg per day is not insanely high at all but rather spot on IMHO... (for a non toxic affordable substance why not take the upper range)


Mu is the Greek letter mu which stands for "micro"

Edited by daouda, 16 July 2013 - 06:14 PM.

[researchist]

right, so it has to be very potent if it is effective at 0.00000084 gm. That's nano scale. 8.4 milligrams is the high range. It would imply 100 micrograms could be a reasonable dose and mostly people are mega dosing it. If it is not toxic and its effectiveness scales with dosage then 1 to 3 milligrams is a good strong dose. If it scales linearly. Increasing the dosage of some things hits a point of diminishing returns.

[daouda]

Greek letter looking like a "u" is the letter "mu" and stands for "micro" in the metric system
They just wrote "mu g" because the Greek letter mu was not available in that font/keyboard/coding

Edited by daouda, 16 July 2013 - 06:24 PM.

[solarfingers]

If they're considering up to 0.1mg per kg of bodyweight as a therapeutic dosage then 3 or 5 mg per day is not insanely high at all but rather spot on IMHO... (for a non toxic affordable substance why not take the upper range)


Mu is the Greek letter mu which stands for "micro"

Not sure how you come by this...

100 micrograms = 0.1 mg which means a person who weighs in at 84 kg will have a high end effective dosage of .84 mg. How is even 3 mg spot on? I could see stretching it to 1 or 2 mg but 3 or 5? I'm pretty fuzzy working with small numbers. Perhaps I am missing something.

[researchist]

μg/kg is what I cut and pasted from the article. This is what wiki says:
In the metric system, a microgram (µg or mcg) is a unit of mass equal to one millionth (1/1,000,000) of a gram (1 × 10⁻⁶), or 1/1000 of a milligram. It is one of the smallest units of mass (or weight) used in a macroscopic context. The symbol "µg" (mu-g) conforms to the International System of Units and is often used in scientific literature, but the United States-based JCAHO recommends that hospitals do not use this symbol in handwritten orders due to the risk that the symbol µ might be misread as the prefix m, resulting in a thousandfold overdose. The abbreviation mcg is recommended instead.^[1]

[researchist]

I don't know. You spotted the reference in the article. It seems like a good catch. I hadn't noticed it. You may be right, it could be some other notation, we ought to figure it out for sure. Either way 1 to 3 milligrams are what Bioluma recommends I think and I have seen it other places. So that's reasonable.

[solarfingers]

I think I read back that Hugo had dropped his dosage to 1.5 mg a day...

[daouda]

If they're considering up to 0.1mg per kg of bodyweight as a therapeutic dosage then 3 or 5 mg per day is not insanely high at all but rather spot on IMHO... (for a non toxic affordable substance why not take the upper range)


Mu is the Greek letter mu which stands for "micro"

Not sure how you come by this...

100 micrograms = 0.1 mg which means a person who weighs in at 84 kg will have a high end effective dosage of .84 mg. How is even 3 mg spot on? I could see stretching it to 1 or 2 mg but 3 or 5? I'm pretty fuzzy working with small numbers. Perhaps I am missing something.

0.1x84=8.4

[solarfingers]

If they're considering up to 0.1mg per kg of bodyweight as a therapeutic dosage then 3 or 5 mg per day is not insanely high at all but rather spot on IMHO... (for a non toxic affordable substance why not take the upper range)


Mu is the Greek letter mu which stands for "micro"

Not sure how you come by this...

100 micrograms = 0.1 mg which means a person who weighs in at 84 kg will have a high end effective dosage of .84 mg. How is even 3 mg spot on? I could see stretching it to 1 or 2 mg but 3 or 5? I'm pretty fuzzy working with small numbers. Perhaps I am missing something.

0.1x84=8.4

You are correct... I don't know why my brain keeps wanting to go with .01... So 3 or 5 mg would be conservative...

[solarfingers]

Genscript on BBB

[Amesz]

Hi,

Amesz, long time reader, first time poster on this impressive thread.

What do you think of this product ?

https://www.super-nu...nti-aging--H644

Supersmart/Supernutrition seems to be a reliable company, offering a lot of supplements with good customer service and rich scientifical background.

I've ordered a lot of products there and have been satisfied concerning the efficiency and concentrations, comparing to others big providers, so i was just wondering if this could be a good option, they've just put it online a few days ago.

[sciwalk]

Hi,

Amesz, long time reader, first time poster on this impressive thread.

What do you think of this product ?

This was a link for an affiliate program at this companies website.

Supersmart/Supernutrition seems to be a reliable company, offering a lot of supplements with good customer service and rich scientifical background.

I've ordered a lot of products there and have been satisfied concerning the efficiency and concentrations, comparing to others big providers, so i was just wondering if this could be a good option, they've just put it online a few days ago.

Amesz,

You want to talk about a place that has it for sale, cool. You want to let people know that you are offering a link to the item for sale through your affiliate program, great. But don't come on here acting like you are a long time reader and just want to know if everyone things that is a good product, good deal or what. A shill is a shill and you, my friend, are a shill. Come clean and no foul!

[Amesz]

I am a longtime reader of a lot of longecity topics and you can see my profile, i signed in february
I've particulary read nearly every piracetam posts and like everyone here i found that Isochroma is an incredible and unknown writer of our era.

I'm so so sorry that you think i'm a shill as a read all your posts since the beginning but i am not a shill, but re-reading my post i understand why it could be interpreted like that, i tried to keep it short because i am not an epithalon expert, just wanted to know if it could be an interesting offer/product, and let now that it was also available there, as everyone including me seems hard to find a simple and reliable way to see what epithalone can do for them.

It's so sad that you pinpoint me like that, you've been facing this kinds of accusations so i'd never imagined that someone like you would be so quick to judge.

By the way you want me to come clear and know who i am ?

Here we go, my real name is Eric il live in Brittany, France not far from the beautiful seaside i'm 37 years old and still live with my parents because i'm too exhausted with SFC to have a real professional life for now, i only had one girlfriend in my life who left me three years ago because of my lack of energy in terms of sexuality.

My Porphyrins urinary tests show that i've got a serious mercury intoxication, as there's an elevation in precoproporphyrins (it's something i tried to fix by myself with high doses of chlorella but i only succeed to make my symptoms worse, i got to try another way but for now i have to recover a bit) and the Dr i see these day (That has a very funny name Cornette De Saint Cyr !) as found that my lymphocytes are fighting something, wich can be found in all my analysis, he also ordered me an expensive HLA grouping test that shows a predisposition to coeliac illness and Rumathoid Polyarthris. It also show, according to Shoemaker that i should be "Multisusceptible" Lyme suscepible" and Mold Susceptible, wich i'm still trying to understand.
For now i follow an antibiotic prescription wich is Zythromax 250 Mg, 1 by day next weeks will be Triflucan 200 mg 1 by day.
When it hurts too much and i don't know in wich position put my body for release, i take one Zaldiar (Paracetamol+Tramadol) and i'm proud to say that i've reduced my Zopiclone dose to one quarter in order to sleep.
I wonder if Epithalone would make my case better or worse as it seems that i have some kind of auto-immune disase and telomerase inhibitor will boost my immunatory system.

Now even if i should be flattered that you mistake me for some kind of commercial, wich means that my english is quite correct and effective, excuses would be appreciated.

Regards.

[blood]

just wanted to know if it could be an interesting offer/product, and let now that it was also available there, as everyone including me seems hard to find a simple and reliable way to see what epithalone can do for them.

The product is interesting. Tablet format represents a big improvement in convenience. The pricing is problematic, though.

[researchist]

Is it available in the US? Bioluma does not sell to US. The cost of 234usd for 180mg is high but less than bioluma. May its retail availability is part of the trade off lower price vs. difficulty of acquiring. Interesting to see a retail product though.

[sciwalk]

Amesz,

I was not asking you to expose your life story. What I was saying is, when you are going to make a post to promote sales of something, does not matter what it is, and you are gaining from those sales, please just say so. When you do not, this is called shilling. The link you provided is for an affiliate site for Supersmart website. As you were presenting the page I would assume that you are the affiliate. If you are not, and you got advertisement for it from someone else, then it would be very strange that it is an English speaking affiliate instead of French. Customers of Supersmart have been sent an advanced notice about the Epitalon release but it is not even officially released in France yet.
No, I have never been accused of shilling Epitalon, I have always been totally upfront, from the very beginning, my full intent and my association with it.

I am not angry with you, I don't even want to inhibit your potential sales. I was just asking that you are upfront about it from the beginning so that someone does not point it out later and it comes back to haunt you. if you really are not the affiliate for that page, then, you should get an affiliate page of your own and post that instead of this one.

On the topic of your condition, AEDG has been shown to have fast improvements in immunity.

Amesz,

I was not asking you to expose your life story. What I was saying is, when you are going to make a post to promote sales of something, does not matter what it is, and you are gaining from those sales, please just say so. When you do not, this is called shilling. The link you provided is for an affiliate site for Supersmart website. As you were presenting the page I would assume that you are the affiliate. If you are not, and you got advertisement for it from someone else, then it would be very strange that it is an English speaking affiliate instead of French. Customers of Supersmart have been sent an advanced notice about the Epitalon release but it is not even officially released in France yet.
No, I have never been accused of shilling Epitalon, I have always been totally upfront, from the very beginning, my full intent and my association with it.

I am not angry with you, I don't even want to inhibit your potential sales. I was just asking that you are upfront about it from the beginning so that someone does not point it out later and it comes back to haunt you. if you really are not the affiliate for that page, then, you should get an affiliate page of your own and post that instead of this one.

On the topic of your condition, AEDG has been shown to have fast improvements in immunity.

Whoa, that is bizzare, why did it double my post??? Mod's, any idea??