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Epitalon (Split from Astragalus thread)


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#1651 DareDevil

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Posted 05 November 2017 - 09:19 AM

I'm for a group buy for both. In note to whomever is willing to organize the Group Buy: another member and I recently teamed up to purchase Epitalon from Genscript and got a very good price from them. I'm running out of Epi however, and wish to try higher dosages. I'm interested in buying both Epitalon and Thylamin. However, I have reserves about the later. I purchased 100mg of Thylamin from Ceretropic that I took in conjunction with their Epitalon. Their Epitalon was however far more effective when combined with TB-500 than with their Thylamin. Either the Thylamin isn't potent, or it doesn't have noticeable immediate effects, or TB-500 has greatly noticeable immediate effects that eclipsed the Thylamin's joint intake with Epitalon. II noticed this in only three days of 2mg/day intake of TB-500 while 5mg/day are best for a full ten day run of both. I would recommend adding an option of TB-500 to the Group Buy. FWIW.

 

DareDevil


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#1652 Believer

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Posted 05 November 2017 - 01:46 PM

why be so secretive about buying epitalon when it is not illegal or regulated?



#1653 Benko

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Posted 05 November 2017 - 06:11 PM

 

How long does unrecostituted epitalon stay good in the fridge?

~6 months at fridge temps, about 2yrs at -20C (freezer).

 

I thought Id read not to freeze it (in a thread on here) this is from another source:

 

Proper storage of Epitalon:


If possible, always store both the freeze dried powder and the mixed solution in refrigerator (do not freeze). 

Before mixing (lyophilized / freeze dried Epitalon powder):
  • refrigerated between 2 - 8 degrees celsius (36 - 46 Fahrenheit) it can be used for 24 months

Edited by Benko, 05 November 2017 - 06:12 PM.


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#1654 aribadabar

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Posted 05 November 2017 - 06:42 PM

 

 

How long does unrecostituted epitalon stay good in the fridge?

~6 months at fridge temps, about 2yrs at -20C (freezer).

 

I thought Id read not to freeze it (in a thread on here) this is from another source:

 

Proper storage of Epitalon:


If possible, always store both the freeze dried powder and the mixed solution in refrigerator (do not freeze). 

Before mixing (lyophilized / freeze dried Epitalon powder):
  • refrigerated between 2 - 8 degrees celsius (36 - 46 Fahrenheit) it can be used for 24 months

 

 

Don't take my word for it about the storage in freezer:

Store the remaining peptide in a freezer, preferably below -20℃, under dry conditions.


→ source (external link)

 

However,we recommend storing the lyophilized peptides at –20 ° C upon arrival and at this temperature, most lyophilizates can be stable for years without significant degradation.


→ source (external link)

 

Short term storage(1 week to 2 months) of lyophilized peptide should be done in a freezer at -200C. For longer storage, we recommend storing the peptide in a deep freezer at -800C if available.



→ source (external link)

 

Q: I received a lyophilized product at room temperature but the product label and datasheet indicate that it is to be stored at -20 ºC. Is this an error? Will product activity be compromised?
A: The product is shipped at ambient temperature by design and will not be compromised. Lyophilization increases product stability, while reducing packing materials and shipping expense. We have performed “stress tests” on our lyophilized products. These products are subjected to 37º C for 3 days in a humidified chamber and found to be stable. These data demonstrate that lyophilized products shipped ambient and received with in a 3 day window retain full activity.

→ source (external link)

 

 


However, it is more preferable to store peptides that will be used shortly in a freezer at -20C (-4F). For relatively short-term storage (about 1 week to 2 months), this will generally suffice. When storing peptides for months or even years, freezing at -80C (-112F) is optimal in order to preserve the peptide’s stability.

→ source (external link)


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#1655 mikey

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Posted 05 November 2017 - 07:34 PM

I'm for a group buy for both. In note to whomever is willing to organize the Group Buy: another member and I recently teamed up to purchase Epitalon from Genscript and got a very good price from them. I'm running out of Epi however, and wish to try higher dosages. I'm interested in buying both Epitalon and Thylamin. However, I have reserves about the later. I purchased 100mg of Thylamin from Ceretropic that I took in conjunction with their Epitalon. Their Epitalon was however far more effective when combined with TB-500 than with their Thylamin. Either the Thylamin isn't potent, or it doesn't have noticeable immediate effects, or TB-500 has greatly noticeable immediate effects that eclipsed the Thylamin's joint intake with Epitalon. II noticed this in only three days of 2mg/day intake of TB-500 while 5mg/day are best for a full ten day run of both. I would recommend adding an option of TB-500 to the Group Buy. FWIW.

 

DareDevil

 

I found Ceretropic's Epitalon combined well with the false Thymalin that Peptide Sciences vends, that is not really the Khavinson Thymalin (glu-tryp), but Thymulin, an older and different iteration of a thymic peptide. It is not a bi-peptide, but a much longer peptide chain.

 

I found the combined two to be quite effective at eradicating numerous severe lesions on my calves that were caused by exposure to a toxin. I don't think that Epitalon all by itself works as well as it does with SOME version of a thymic peptide, but this is just subjective. 

 

I have used the Peptide Science false Thymalin one other time, with good results. (Ceretropic is now also vending the false Thymalin.)

 

TB-500, I get from a vet store, so I know that it is real as it must be FDA-approved. It has amazing healing properties. I don't know that its effects will equal true Thymalin (glu-tryp), though.

 

Based on my experiences and all that I've read I want to try true Thymalin with Epitalon, as together they should produce noticeable effects.

 

I have used it with N-acetyl Epitalon from Ceretropic. I can't say that anything acute changed, as I had no problems like the calve lesions.



#1656 brendan1

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Posted 05 November 2017 - 08:23 PM

Does the vet store require a prescription?



#1657 meatsauce

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Posted 05 November 2017 - 08:38 PM

I'm for a group buy for both. In note to whomever is willing to organize the Group Buy: another member and I recently teamed up to purchase Epitalon from Genscript and got a very good price from them. I'm running out of Epi however, and wish to try higher dosages. I'm interested in buying both Epitalon and Thylamin. However, I have reserves about the later. I purchased 100mg of Thylamin from Ceretropic that I took in conjunction with their Epitalon. Their Epitalon was however far more effective when combined with TB-500 than with their Thylamin. Either the Thylamin isn't potent, or it doesn't have noticeable immediate effects, or TB-500 has greatly noticeable immediate effects that eclipsed the Thylamin's joint intake with Epitalon. II noticed this in only three days of 2mg/day intake of TB-500 while 5mg/day are best for a full ten day run of both. I would recommend adding an option of TB-500 to the Group Buy. FWIW.

 

DareDevil

TB-500 will be expensive do to its long sequence. 

 

 

I'm for a group buy for both. In note to whomever is willing to organize the Group Buy: another member and I recently teamed up to purchase Epitalon from Genscript and got a very good price from them. I'm running out of Epi however, and wish to try higher dosages. I'm interested in buying both Epitalon and Thylamin. However, I have reserves about the later. I purchased 100mg of Thylamin from Ceretropic that I took in conjunction with their Epitalon. Their Epitalon was however far more effective when combined with TB-500 than with their Thylamin. Either the Thylamin isn't potent, or it doesn't have noticeable immediate effects, or TB-500 has greatly noticeable immediate effects that eclipsed the Thylamin's joint intake with Epitalon. II noticed this in only three days of 2mg/day intake of TB-500 while 5mg/day are best for a full ten day run of both. I would recommend adding an option of TB-500 to the Group Buy. FWIW.

 

DareDevil

 

I found Ceretropic's Epitalon combined well with the false Thymalin that Peptide Sciences vends, that is not really the Khavinson Thymalin (glu-tryp), but Thymulin, an older and different iteration of a thymic peptide. It is not a bi-peptide, but a much longer peptide chain.

 

I found the combined two to be quite effective at eradicating numerous severe lesions on my calves that were caused by exposure to a toxin. I don't think that Epitalon all by itself works as well as it does with SOME version of a thymic peptide, but this is just subjective. 

 

I have used the Peptide Science false Thymalin one other time, with good results. (Ceretropic is now also vending the false Thymalin.)

 

TB-500, I get from a vet store, so I know that it is real as it must be FDA-approved. It has amazing healing properties. I don't know that its effects will equal true Thymalin (glu-tryp), though.

 

Based on my experiences and all that I've read I want to try true Thymalin with Epitalon, as together they should produce noticeable effects.

 

I have used it with N-acetyl Epitalon from Ceretropic. I can't say that anything acute changed, as I had no problems like the calve lesions.

 

 

So "true Thymalin" the peptide we want is only two amino acids long: glu-tryp?



#1658 Moondancer

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Posted 05 November 2017 - 08:48 PM

Newest update for the group buy of Epitalon (+ Thymalin) (in random order):

 

  1. Meatsauce 
  2. Moondancer (incl.Thymalin)
  3. TaiChiKid (no Thymalin -- Canada)
  4. Gramson (incl. Thymalin)
  5. Benko
  6. Mikey (incl. Thymalin -- 30 x10mg depending on costs)
  7. Katkay (incl. Thymalin -- US)
  8. DeepBluC (incl. Thymalin -- US)
  9. Brendan1 (incl. Thymalin -- may be interested depending on costs -- US)
  10. DareDevil (incl. Thymalin)

​It seems we're getting pretty close to the 2 grams-mark - depending on how much everyone wants to order. If everyone please wants to say how much you want to order, perhaps we can go ahead and contact GenScript by now to see if they can offer a nice price?

If I forgot anyone in the group order please let me know.

 
  • Meatsauce,  Benko, could you please let us know if you would like to include Thymalin (perhaps you already mentioned and I missed out on it).
  • How much (in mg/g of) Epitalon does everyone want to order (also from the Thymalin)? Meatsauce asks some good questions with regard to the amount of Thymalin that is recommended to use, I have no clue either. Do we have any research that indicates what amount we should use?

Although I don't question your positive experience with the combination TB-500 and Epitalon, DareDevil, personally I would prefer the combination 'true Thymalin' + Epitalon too, as that combi was used in some of the Khavinson studies (as far as I'm aware). 


Edited by Moondancer, 05 November 2017 - 09:03 PM.


#1659 brendan1

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Posted 05 November 2017 - 09:00 PM

Yes to question above.



#1660 Moondancer

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Posted 05 November 2017 - 09:08 PM

DareDevil, you mention that you bought Epitalon from GenScript before and used it the past period: what was your (anecdotal) experience? How much of it did you use, for how long, did you see any 'results'? Did you get any telomere test done (or bloodwork)?

 

These telomere tests seem a bit controversial. I read some posts from a Reddit member that got splendid results from his Teloyears test after using Epitalon (stating his telomeres had elongated and were now considered 'long') whereas according to the Titanova test that he had done at the same time, his telomere length was average. 

I'm not sure what to make out of that and whether it is useful to get a telomere test done if we don't know how accurate they are.



#1661 mikey

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Posted 05 November 2017 - 10:31 PM

I'm for a group buy for both. In note to whomever is willing to organize the Group Buy: another member and I recently teamed up to purchase Epitalon from Genscript and got a very good price from them. I'm running out of Epi however, and wish to try higher dosages. I'm interested in buying both Epitalon and Thylamin. However, I have reserves about the later. I purchased 100mg of Thylamin from Ceretropic that I took in conjunction with their Epitalon. Their Epitalon was however far more effective when combined with TB-500 than with their Thylamin. Either the Thylamin isn't potent, or it doesn't have noticeable immediate effects, or TB-500 has greatly noticeable immediate effects that eclipsed the Thylamin's joint intake with Epitalon. II noticed this in only three days of 2mg/day intake of TB-500 while 5mg/day are best for a full ten day run of both. I would recommend adding an option of TB-500 to the Group Buy. FWIW.

DareDevil

TB-500 will be expensive do to its long sequence.

I'm for a group buy for both. In note to whomever is willing to organize the Group Buy: another member and I recently teamed up to purchase Epitalon from Genscript and got a very good price from them. I'm running out of Epi however, and wish to try higher dosages. I'm interested in buying both Epitalon and Thylamin. However, I have reserves about the later. I purchased 100mg of Thylamin from Ceretropic that I took in conjunction with their Epitalon. Their Epitalon was however far more effective when combined with TB-500 than with their Thylamin. Either the Thylamin isn't potent, or it doesn't have noticeable immediate effects, or TB-500 has greatly noticeable immediate effects that eclipsed the Thylamin's joint intake with Epitalon. II noticed this in only three days of 2mg/day intake of TB-500 while 5mg/day are best for a full ten day run of both. I would recommend adding an option of TB-500 to the Group Buy. FWIW.

DareDevil


I found Ceretropic's Epitalon combined well with the false Thymalin that Peptide Sciences vends, that is not really the Khavinson Thymalin (glu-tryp), but Thymulin, an older and different iteration of a thymic peptide. It is not a bi-peptide, but a much longer peptide chain.

I found the combined two to be quite effective at eradicating numerous severe lesions on my calves that were caused by exposure to a toxin. I don't think that Epitalon all by itself works as well as it does with SOME version of a thymic peptide, but this is just subjective.

I have used the Peptide Science false Thymalin one other time, with good results. (Ceretropic is now also vending the false Thymalin.)

TB-500, I get from a vet store, so I know that it is real as it must be FDA-approved. It has amazing healing properties. I don't know that its effects will equal true Thymalin (glu-tryp), though.

Based on my experiences and all that I've read I want to try true Thymalin with Epitalon, as together they should produce noticeable effects.

I have used it with N-acetyl Epitalon from Ceretropic. I can't say that anything acute changed, as I had no problems like the calve lesions.

So "true Thymalin" the peptide we want is only two amino acids long: glu-tryp?


#1662 mikey

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Posted 05 November 2017 - 10:44 PM

So "true Thymalin" the peptide we want is only two amino acids long: glu-tryp?

 

Correct. Notice on Peptide Sciences description they say that the peptide sequence is Pyr-L-Ala-L-Lys-L-Ser-L-Gln-Gly-Gly-L-Ser-L-Asn-OH. 

https://www.peptides...es.com/thymalin

 

This is not a bi-peptide. It is, I think, 9 aminos. 

 

I am not a chemist, so it might be another number, but it is definitely not a bi-peptide - glu-tryp - two aminos, which is true Thymalin, as created by Khavinson.

 

Ceretropic disappointed me, after I requested that they vend Thymalin, they turned up vending this older iteration of a thymic peptide, which is FALSE Thymalin.

 

It is actually Thymulin. https://en.wikipedia.org/wiki/Thymulin

 

It does have beneficial effects.

 

However, I expect that Khavinson's version produces superior effects, as he produced his version some years later.



#1663 mikey

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Posted 05 November 2017 - 10:50 PM

Does the vet store require a prescription?

 

No.

www.Racehorsemeds.com

 

Anyone can own a horse.

 

They serve people that own horses.

 

"I have seven draft horses in my stable here in Los Angeles," I might tell them if they asked.

 

Just kidding, but they have never questioned me. I do have business licenses, and can buy from commercial producers, including Sigma. But this is an easy buy. Enjoy!



#1664 mikey

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Posted 05 November 2017 - 10:55 PM

Newest update for the group buy of Epitalon (+ Thymalin) (in random order):

 

  1. Meatsauce 
  2. Moondancer (incl.Thymalin)
  3. TaiChiKid (no Thymalin -- Canada)
  4. Gramson (incl. Thymalin)
  5. Benko
  6. Mikey (incl. Thymalin -- 30 x10mg depending on costs)
  7. Katkay (incl. Thymalin -- US)
  8. DeepBluC (incl. Thymalin -- US)
  9. Brendan1 (incl. Thymalin -- may be interested depending on costs -- US)
  10. DareDevil (incl. Thymalin)

​It seems we're getting pretty close to the 2 grams-mark - depending on how much everyone wants to order. If everyone please wants to say how much you want to order, perhaps we can go ahead and contact GenScript by now to see if they can offer a nice price?

If I forgot anyone in the group order please let me know.

 
  • Meatsauce,  Benko, could you please let us know if you would like to include Thymalin (perhaps you already mentioned and I missed out on it).
  • How much (in mg/g of) Epitalon does everyone want to order (also from the Thymalin)? Meatsauce asks some good questions with regard to the amount of Thymalin that is recommended to use, I have no clue either. Do we have any research that indicates what amount we should use?

Although I don't question your positive experience with the combination TB-500 and Epitalon, DareDevil, personally I would prefer the combination 'true Thymalin' + Epitalon too, as that combi was used in some of the Khavinson studies (as far as I'm aware). 

 

I expect that both true Thymalin and TB-500 have their own specific beneficial effects. 

 

But while I've had lots of experience with TB-500 when I needed it I have yet to experience Thymalin.



#1665 aribadabar

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Posted 05 November 2017 - 10:56 PM

glu-tryp - two aminos, which is true Thymalin, as created by Khavinson.

 

 

Would you point me to a publication that confirms this?

 

Thanks!



#1666 mikey

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Posted 05 November 2017 - 11:01 PM

 

glu-tryp - two aminos, which is true Thymalin, as created by Khavinson.

 

 

Would you point me to a publication that confirms this?

 

Thanks!

 

 

 

https://www.google.c...tents/US5538951


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#1667 mikey

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Posted 05 November 2017 - 11:03 PM

 

 

glu-tryp - two aminos, which is true Thymalin, as created by Khavinson.

 

 

Would you point me to a publication that confirms this?

 

Thanks!

 

 

 

https://www.google.c...tents/US5538951

 

 

Note further that the date it was patented is 10+ years after Thymulin was produced. 

 

Khavinson, et al, did something that was new.



#1668 aribadabar

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Posted 05 November 2017 - 11:32 PM

 

 

glu-tryp - two aminos, which is true Thymalin, as created by Khavinson.

 

 

Would you point me to a publication that confirms this?

 

Thanks!

 

 

 

https://www.google.c...tents/US5538951

 

Thanks again for the pointer!

 

I see that this dipeptide Glu-Trp (one-letter: EW) structure is also called Thymogen:

http://www.activepep...oduct/thymogen/

 

Perhaps that's the better way of calling it as ThymAlin is an alternative name to ThymUlin as per WIkipedia while Thymogen and ThymAlin were never used interchangeably.


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#1669 Bushi84

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Posted 05 November 2017 - 11:52 PM

why be so secretive about buying epitalon when it is not illegal or regulated?

 

I think that one is directed at me. 

 

That's really relative to what country you live in. And the same could be said about the country you live in.  ;) 

 

In my country everything which is regarded a medicine and is imported outside the EU is illegal. And last time I got a warning, second time I won't. 

As I said before, I don't see epitalon as a medicine, since it's a combination of amino acids and I see it more as a supplement. But I think my opinion means rats ass to the government.



#1670 YOLF

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Posted 06 November 2017 - 01:04 AM

 

 

 

How long does unrecostituted epitalon stay good in the fridge?

~6 months at fridge temps, about 2yrs at -20C (freezer).

 

I thought Id read not to freeze it (in a thread on here) this is from another source:

 

Proper storage of Epitalon:


If possible, always store both the freeze dried powder and the mixed solution in refrigerator (do not freeze). 

Before mixing (lyophilized / freeze dried Epitalon powder):
  • refrigerated between 2 - 8 degrees celsius (36 - 46 Fahrenheit) it can be used for 24 months

 

 

Don't take my word for it about the storage in freezer:

Store the remaining peptide in a freezer, preferably below -20℃, under dry conditions.


→ source (external link)

 

However,we recommend storing the lyophilized peptides at –20 ° C upon arrival and at this temperature, most lyophilizates can be stable for years without significant degradation.


→ source (external link)

 

Short term storage(1 week to 2 months) of lyophilized peptide should be done in a freezer at -200C. For longer storage, we recommend storing the peptide in a deep freezer at -800C if available.



→ source (external link)

 

Q: I received a lyophilized product at room temperature but the product label and datasheet indicate that it is to be stored at -20 ºC. Is this an error? Will product activity be compromised?
A: The product is shipped at ambient temperature by design and will not be compromised. Lyophilization increases product stability, while reducing packing materials and shipping expense. We have performed “stress tests” on our lyophilized products. These products are subjected to 37º C for 3 days in a humidified chamber and found to be stable. These data demonstrate that lyophilized products shipped ambient and received with in a 3 day window retain full activity.

→ source (external link)

 

 


However, it is more preferable to store peptides that will be used shortly in a freezer at -20C (-4F). For relatively short-term storage (about 1 week to 2 months), this will generally suffice. When storing peptides for months or even years, freezing at -80C (-112F) is optimal in order to preserve the peptide’s stability.

→ source (external link)

 

 

What kind of freezer goes down to -800C? -196C, or maybe -150C is a reasonable achievement for like cells in cryostorage that survive for 50+ years and contain these peptides and naturally contain more complex and numerous molecules in a soup of reactivity... yet they don't rot. The real reason to store at ultra low temperatures is to keep the sample cold in the event of a power outage or shortage of LN2 (Liquid Nitrogen)... Lower temperature just means more time. Then there's the benefits of vitrification around -150ish iirc.

 

Only stress tested to 3 days? Surely the expect delays... I've used peptides years after ordering them and they retained full activity. I store in a standard fridge, though I suppose a few more degrees would be nice, but you can just block out some space (shrink the area to be cooled) in a regular freezer to get down a little cooler.

 

I think this is a case of doing inappropriate science to make more money cuz you believe your supply got too old or won't be good anymore. I guess there are some other reasons this fallacy is continued, but this is a patient's rights matter, so let's not raise the cost of medicine any higher.



#1671 YOLF

  • Location:Delaware Delawhere, Delahere, Delathere!

Posted 06 November 2017 - 01:10 AM

 

Does the vet store require a prescription?

 

No.

www.Racehorsemeds.com

 

Anyone can own a horse.

 

They serve people that own horses.

 

"I have seven draft horses in my stable here in Los Angeles," I might tell them if they asked.

 

Just kidding, but they have never questioned me. I do have business licenses, and can buy from commercial producers, including Sigma. But this is an easy buy. Enjoy!

 

Only seven? What is it a lawnmower?  I have 200+ horses in front of my house!


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#1672 aribadabar

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Posted 06 November 2017 - 01:14 AM

 

 

Don't take my word for it about the storage in freezer:

Store the remaining peptide in a freezer, preferably below -20℃, under dry conditions.


→ source (external link)

 

However,we recommend storing the lyophilized peptides at –20 ° C upon arrival and at this temperature, most lyophilizates can be stable for years without significant degradation.


→ source (external link)

 

Short term storage(1 week to 2 months) of lyophilized peptide should be done in a freezer at -200C. For longer storage, we recommend storing the peptide in a deep freezer at -800C if available.



→ source (external link)

 

Q: I received a lyophilized product at room temperature but the product label and datasheet indicate that it is to be stored at -20 ºC. Is this an error? Will product activity be compromised?
A: The product is shipped at ambient temperature by design and will not be compromised. Lyophilization increases product stability, while reducing packing materials and shipping expense. We have performed “stress tests” on our lyophilized products. These products are subjected to 37º C for 3 days in a humidified chamber and found to be stable. These data demonstrate that lyophilized products shipped ambient and received with in a 3 day window retain full activity.

→ source (external link)

 

 


However, it is more preferable to store peptides that will be used shortly in a freezer at -20C (-4F). For relatively short-term storage (about 1 week to 2 months), this will generally suffice. When storing peptides for months or even years, freezing at -80C (-112F) is optimal in order to preserve the peptide’s stability.

→ source (external link)

 

 

What kind of freezer goes down to -800C? -196C, or maybe -150C is a reasonable achievement for like cells in cryostorage that survive for 50+ years and contain these peptides and naturally contain more complex and numerous molecules in a soup of reactivity... yet they don't rot. The real reason to store at ultra low temperatures is to keep the sample cold in the event of a power outage or shortage of LN2 (Liquid Nitrogen)... Lower temperature just means more time. Then there's the benefits of vitrification around -150ish iirc.

 

Only stress tested to 3 days? Surely the expect delays... I've used peptides years after ordering them and they retained full activity. I store in a standard fridge, though I suppose a few more degrees would be nice, but you can just block out some space (shrink the area to be cooled) in a regular freezer to get down a little cooler.

 

I think this is a case of doing inappropriate science to make more money cuz you believe your supply got too old or won't be good anymore. I guess there are some other reasons this fallacy is continued, but this is a patient's rights matter, so let's not raise the cost of medicine any higher.

 

If you go to the original link you will see that it is actually -20oC and -80oC, respectively. The pasting removed the superscript and made it look like 200 and 800.

We are not going into LN2 temps.

 

How do you know they had FULL activity after years stored in the fridge (not freezer) - you can discern between 85%, 90% and 100% ? My guess is you can't do that empirically.

We are not that sensitive beings. You had some degradation for sure.


Edited by aribadabar, 06 November 2017 - 01:15 AM.

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#1673 YOLF

  • Location:Delaware Delawhere, Delahere, Delathere!

Posted 06 November 2017 - 01:39 AM

 

 

 

Don't take my word for it about the storage in freezer:

Store the remaining peptide in a freezer, preferably below -20℃, under dry conditions.


→ source (external link)

 

However,we recommend storing the lyophilized peptides at –20 ° C upon arrival and at this temperature, most lyophilizates can be stable for years without significant degradation.


→ source (external link)

 

Short term storage(1 week to 2 months) of lyophilized peptide should be done in a freezer at -200C. For longer storage, we recommend storing the peptide in a deep freezer at -800C if available.



→ source (external link)

 

Q: I received a lyophilized product at room temperature but the product label and datasheet indicate that it is to be stored at -20 ºC. Is this an error? Will product activity be compromised?
A: The product is shipped at ambient temperature by design and will not be compromised. Lyophilization increases product stability, while reducing packing materials and shipping expense. We have performed “stress tests” on our lyophilized products. These products are subjected to 37º C for 3 days in a humidified chamber and found to be stable. These data demonstrate that lyophilized products shipped ambient and received with in a 3 day window retain full activity.

→ source (external link)

 

 


However, it is more preferable to store peptides that will be used shortly in a freezer at -20C (-4F). For relatively short-term storage (about 1 week to 2 months), this will generally suffice. When storing peptides for months or even years, freezing at -80C (-112F) is optimal in order to preserve the peptide’s stability.

→ source (external link)

 

 

What kind of freezer goes down to -800C? -196C, or maybe -150C is a reasonable achievement for like cells in cryostorage that survive for 50+ years and contain these peptides and naturally contain more complex and numerous molecules in a soup of reactivity... yet they don't rot. The real reason to store at ultra low temperatures is to keep the sample cold in the event of a power outage or shortage of LN2 (Liquid Nitrogen)... Lower temperature just means more time. Then there's the benefits of vitrification around -150ish iirc.

 

Only stress tested to 3 days? Surely the expect delays... I've used peptides years after ordering them and they retained full activity. I store in a standard fridge, though I suppose a few more degrees would be nice, but you can just block out some space (shrink the area to be cooled) in a regular freezer to get down a little cooler.

 

I think this is a case of doing inappropriate science to make more money cuz you believe your supply got too old or won't be good anymore. I guess there are some other reasons this fallacy is continued, but this is a patient's rights matter, so let's not raise the cost of medicine any higher.

 

If you go to the original link you will see that it is actually -20oC and -80oC, respectively. The pasting removed the superscript and made it look like 200 and 800.

We are not going into LN2 temps.

 

How do you know they had FULL activity after years stored in the fridge (not freezer) - you can discern between 85%, 90% and 100% ? My guess is you can't do that empirically.

We are not that sensitive beings. You had some degradation for sure.

 

 

Well, the label says it was good for 120 days and it's volatile, with a biological half-life under 3 minutes, I've had it for 6 years (24x longer than it was good for) sitting on my dresser between 50-85F and it still feels the same when I take it... Other stuff that I feel the need to keep free of pathogens I will refrigerate or freeze though. Oh and if I think it got weaker and I take more to compensate, I'm in for a doozy as the dosing range is very tight... It's all about simple preservatives, and depending on what you're taking it can be more dangerous to believe that something has expired in such a short time. These are pure substances with biologically appropriate pH buffers and preservatives. I simply can't imagine this stuff has lost more than 5% in all that time. Heck, there had been times when I left it in the car in summer heat and those bottles didn't lose much subjective efficacy. It's a sublingual preparation btw.

 

I suppose that if this stuff isn't manufactured in a clean room before being sealed that a microbe might be able to eat it... but this stuff should be pretty clean for the most part. as long as you clean the top each time you use it, it should stay that way.



#1674 DareDevil

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Posted 06 November 2017 - 02:38 AM

 

why be so secretive about buying epitalon when it is not illegal or regulated?

 

I think that one is directed at me. 

 

That's really relative to what country you live in. And the same could be said about the country you live in.  ;)

 

In my country everything which is regarded a medicine and is imported outside the EU is illegal. And last time I got a warning, second time I won't. 

As I said before, I don't see epitalon as a medicine, since it's a combination of amino acids and I see it more as a supplement. But I think my opinion means rats ass to the government.

 

 

Belgium is a special case as it is seen by other European countries as a hub for drug shipments throughout Europe. So what do they do? Leave the mobsters alone except for independent smugglers and crack down on anyone who gets unknown substances in any shape or form. That way they mask complacency / complicity with alleged harsh enforcement against those not involved. FWIW.



#1675 mikey

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Posted 06 November 2017 - 03:26 AM

 

 

Does the vet store require a prescription?

 

No.

www.Racehorsemeds.com

 

Anyone can own a horse.

 

They serve people that own horses.

 

"I have seven draft horses in my stable here in Los Angeles," I might tell them if they asked.

 

Just kidding, but they have never questioned me. I do have business licenses, and can buy from commercial producers, including Sigma. But this is an easy buy. Enjoy!

 

Only seven? What is it a lawnmower?  I have 200+ horses in front of my house!

 

 

Actually, seven provide enough horseshit to grow a lot of mycelium.


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#1676 calm--

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Posted 06 November 2017 - 10:57 AM

I already ordered epi from ceretropic, so I would like to join the group buy only for thymalin. Not sure about the dosage, but I'll have 2 x 100 mg. Shipping to Indonesia.

 

Off-topic, how long does a bacteriostatic water can be use past it's expiration date?


Edited by calm--, 06 November 2017 - 10:58 AM.


#1677 TaiChiKid

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Posted 07 November 2017 - 06:05 AM

If the thymalin is the two amino acid version, I would be in for 5 x 100mg as well as 10 x 100mg of the epitalon.  I believe if Meatsauce handles the group buy that he accepted PayPal cash transfer in the recent past.

 



#1678 Moondancer

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Posted 08 November 2017 - 02:36 AM

Newest update for the group buy of Epitalon (+ Thymalin) (in random order):

 

  1. Meatsauce 
  2. Moondancer (incl.Thymalin)
  3. TaiChiKid (incl. 5 x 100mg Thymalin (if it is the two amino acid version) and 10 x 100mg epitalon -- Canada)
  4. Gramson (incl. Thymalin)
  5. Benko
  6. Mikey (incl. Thymalin -- 30 x10mg epitalon depending on costs)
  7. Katkay (incl. Thymalin -- US)
  8. DeepBluC (incl. Thymalin -- US)
  9. Brendan1 (incl. Thymalin -- may be interested depending on costs -- US)
  10. DareDevil (incl. Thymalin)
  11. Calm (no Epitalon; only Thymalin -- 2x 100mg -- Indonesia).

​It seems we will certainly make the 2 grams-mark. If everyone please wants to say how much you want to order, perhaps we can go ahead and contact GenScript by now to see if they can offer a nice price?

If I forgot anyone in the group order please let me know.

 

Meatsauce, do you accept payment via Paypal?



#1679 YOLF

  • Location:Delaware Delawhere, Delahere, Delathere!

Posted 08 November 2017 - 02:36 AM

Does the Khavinson lineup have a kidney derived peptide?



#1680 Moondancer

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Posted 08 November 2017 - 02:51 AM

Somehow I can't find the Khavinson paper wherein is discussed how much Epitalon was used twice per year; was it 10mg per day for 10 consecutive days, twice per year? 

I see some here are using Epitalon daily. Wouldn't we think Khavinson used the above protocol since (previous) studies confirmed that gave the most results? Why use more if it wouldn't yield extra results (and may perhaps cause harm)? 






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